The Experts below are selected from a list of 306 Experts worldwide ranked by ideXlab platform
Dheeraj Gupta - One of the best experts on this subject based on the ideXlab platform.
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Cytologic appearance of sinus histiocytosis with massive Lymphadenopathy : A case report
Acta Cytologica, 1996Co-Authors: Sanjiv Gupta, Dheeraj GuptaAbstract:BACKGROUND: Sinus histiocytosis with massive Lymphadenopathy is a benign, massive Lymphadenopathy, usually cervical, of unknown etiology. CASE: Cytologic smears revealed a polymorphic population of cells consisting of mature lymphocytes, plasma cells, occasional neutrophils and many histiocytes, characteristically showing emperipolesis. A reactive Lymphadenopathy was diagnosed. The histopathologic diagnosis on open biopsy specimen was sinus histiocytosis with massive Lymphadenopathy. CONCLUSION: Cytologic diagnosis of sinus histiocytosis with massive Lymphadenopathy is possible with high accuracy provided that the cytologic findings are interpreted in the appropriate clinical context. The cytologic examination also can help with follow-up.
Anna Sander - One of the best experts on this subject based on the ideXlab platform.
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role of cat scratch disease in Lymphadenopathy in the head and neck
Clinical Infectious Diseases, 2002Co-Authors: Gerd Jurgen Ridder, Carsten Christof Boedeker, Katja Technauihling, Roland Grunow, Anna SanderAbstract:Bartonella henselae is the causative agent of cat-scratch disease (CSD), which usually manifests as acute regional Lymphadenopathy. The causes of cervical Lymphadenopathy, with special regard to CSD, were investigated in a study of 454 patients who presented with unclear masses in the head and neck from January 1997 through January 2001. Sixty-one patients (13.4%) experienced CSD; 54 (11.9%) had primary Lymphadenopathy due to other infectious agents, and 41 (9.0%) had Lymphadenopathy that occurred in association with primary infections of other organs. For 171 patients (37.7%), the cause of the cervical lymph node enlargement could not be found. B. henselae DNA was detected in extirpated lymph nodes only during the first 6 weeks of Lymphadenopathy, which indicates that the results of polymerase chain reaction strongly depend on the duration of illness. CSD should be included in the differential diagnosis of adenopathy in the otorhinolaryngologic patient population, to avoid unnecessary treatment.
Savvas Andronikou - One of the best experts on this subject based on the ideXlab platform.
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transthoracic mediastinal ultrasound in childhood tuberculosis a review
Paediatric Respiratory Reviews, 2020Co-Authors: Lisa Ruby, Savvas Andronikou, Martin P. Grobusch, Charlotte C Heuvelings, Sabine BélardAbstract:Abstract Diagnosing childhood tuberculosis (TB) is challenging, and novel diagnostic tools are urgently needed. Mediastinal Lymphadenopathy is a hallmark of primary pulmonary TB (PTB) in children. We aimed to summarise available methodological and diagnostic data of transthoracic mediastinal ultrasound for childhood TB. Literature review identified two prospective and three retrospective studies, a case report, and a technical report including cases. All reported on suprasternal scanning of the mediastinum; additional parasternal scanning was reported by five studies. The proportion of children with Lymphadenopathy detected by mediastinal ultrasound ranged between 15% and 85%, with studies including both supra- and parasternal scanning achieving higher detection ratios. Three retrospective studies reported mediastinal Lymphadenopathy on ultrasound for most cases presenting with a normal or inconclusive CXR. Data on ultrasound for mediastinal Lymphadenopathy in children are limited but indicate that mediastinal ultrasound can successfully detect mediastinal Lymphadenopathy in children with TB.
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Comparing axillary and mediastinal Lymphadenopathy on CT in children with suspected pulmonary tuberculosis.
Pediatric Radiology, 2005Co-Authors: Salomine Theron, Savvas AndronikouAbstract:Background: Radiographic demonstration of mediastinal Lymphadenopathy is important for the diagnosis of pulmonary tuberculosis (PTB). Plain radiographs are unreliable for this and CT, which is relatively more expensive and carries a high radiation burden, remains the gold standard. No studies correlating the presence of axillary with mediastinal Lymphadenopathy have been reported. Such a correlation would allow for clinical or ultrasound diagnosis of PTB via the axilla. Objective: To correlate the presence of axillary Lymphadenopathy with mediastinal Lymphadenopathy in children with suspected PTB. Materials and methods: CT scans were performed and reviewed in 100 children (prospectively recruited) with suspected PTB. The axilla and mediastinum were reviewed separately by covering the non-relevant sections on the CT scans prior to reading. Only nodes greater than 1 cm were regarded as pathological. Results: Mediastinal Lymphadenopathy was present in 46% of children; 70% had Lymphadenopathy in either axilla. Bilateral axillary Lymphadenopathy was identified in 47%. Axillary Lymphadenopathy showed a sensitivity of 74% and a specificity of 33% for the presence of mediastinal adenopathy. Bilateral axillary adenopathy had a sensitivity of 50% and a specificity of 56%. Conclusions: Axillary Lymphadenopathy has a moderate sensitivity and low specificity for the presence of mediastinal and hilar Lymphadenopathy in children with suspected PTB. Further research should be aimed at correlating ultrasound-detected axillary Lymphadenopathy with FNA results in children.
Philip J Klapper - One of the best experts on this subject based on the ideXlab platform.
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Intrathoracic Lymphadenopathy in hospitalized patients with pneumococcal pneumonia.
Chest, 2005Co-Authors: Deborah L Stein, Linda B. Haramati, Hugo Spindola-franco, Joseph H. Friedman, Philip J KlapperAbstract:Pneumococcal pneumonia is the most common etiology for community-acquired pneumonia. The prevalence of Lymphadenopathy seen on CT scans in these patients is uncertain. The purpose of this series was to assess the prevalence of intrathoracic Lymphadenopathy in hospitalized patients with pneumococcal pneumonia. We retrospectively identified 35 hospitalized patients with pneumococcal pneumonia who had been evaluated with CT scanning between January 1998 and April 2002. There were 18 men and 17 women with a mean age of 56 years. The study inclusion criteria were as follows: blood culture positive for Streptococcus pneumoniae, clinical diagnosis of pneumonia, and chest CT scan. The study exclusion criteria were known causes of Lymphadenopathy. Charts were reviewed for HIV status, smoking history, and comorbidities. CT scans were reviewed for the presence and degree of Lymphadenopathy, and the characteristics of pneumonia. The number of enlarged lymph nodes was graded as few (one to two), moderate (three to five), or many (six or more). Pneumonias were described by location, the number of involved lobes, the presence of cavitation, and the presence of pleural effusion. Patients with different comorbidities and different imaging characteristics of pneumonia were compared. Among the 35 patients with pneumococcal pneumonia, intrathoracic Lymphadenopathy was present on CT scans in 54% of patients (19 of 35 patients). The Lymphadenopathy was ipsilateral to the pneumonia in 100% of patients (19 of 19 patients). One patient also had contralateral Lymphadenopathy. The Lymphadenopathy was graded as few in 37% of patients (7 of 19 patients), moderate in 37% of patients (7 of 19 patients), and many in 26% of patients (5 of 19 patients). The pneumonia was right-sided in 26% of patients (9 of 35 patients), left-sided in 17% of patients (6 of 35 patients), and bilateral in 57% of patients (20 of 35 patients). Comorbidities included the following: HIV infection (n = 15); smoking (n = 21); emphysema (n = 5); hepatitis C (n = 5); and diabetes (n = 3). The characteristics of pneumonia included the following: multilobar (n = 25); pleural effusion (n = 25); and cavitation (n = 5). The prevalence of Lymphadenopathy according to comorbidities and characteristics of pneumonia ranged from 40 to 100%. None of the differences in prevalence of Lymphadenopathy among the subgroups was statistically significant. Lymphadenopathy is a common CT scan feature of pneumococcal pneumonia in hospitalized patients, in a variety of settings. Therefore, when a patient with pneumococcal pneumonia has Lymphadenopathy seen on a CT scan, other etiologies for the Lymphadenopathy need not be suspected.
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Intrathoracic Lymphadenopathy in hospitalized patients with pneumococcal pneumonia.
Chest, 2005Co-Authors: Deborah L Stein, Linda B. Haramati, Hugo Spindola-franco, Joseph H. Friedman, Philip J KlapperAbstract:Purpose Pneumococcal pneumonia is the most common etiology for community-acquired pneumonia. The prevalence of Lymphadenopathy seen on CT scans in these patients is uncertain. The purpose of this series was to assess the prevalence of intrathoracic Lymphadenopathy in hospitalized patients with pneumococcal pneumonia Materials and methods We retrospectively identified 35 hospitalized patients with pneumococcal pneumonia who had been evaluated with CT scanning between January 1998 and April 2002. There were 18 men and 17 women with a mean age of 56 years. The study inclusion criteria were as follows: blood culture positive for Streptococcus pneumoniae , clinical diagnosis of pneumonia, and chest CT scan. The study exclusion criteria were known causes of Lymphadenopathy. Charts were reviewed for HIV status, smoking history, and comorbidities. CT scans were reviewed for the presence and degree of Lymphadenopathy, and the characteristics of pneumonia. The number of enlarged lymph nodes was graded as few (one to two), moderate (three to five), or many (six or more). Pneumonias were described by location, the number of involved lobes, the presence of cavitation, and the presence of pleural effusion. Patients with different comorbidities and different imaging characteristics of pneumonia were compared Results Among the 35 patients with pneumococcal pneumonia, intrathoracic Lymphadenopathy was present on CT scans in 54% of patients (19 of 35 patients). The Lymphadenopathy was ipsilateral to the pneumonia in 100% of patients (19 of 19 patients). One patient also had contralateral Lymphadenopathy. The Lymphadenopathy was graded as few in 37% of patients (7 of 19 patients), moderate in 37% of patients (7 of 19 patients), and many in 26% of patients (5 of 19 patients). The pneumonia was right-sided in 26% of patients (9 of 35 patients), left-sided in 17% of patients (6 of 35 patients), and bilateral in 57% of patients (20 of 35 patients). Comorbidities included the following: HIV infection (n = 15); smoking (n = 21); emphysema (n = 5); hepatitis C (n = 5); and diabetes (n = 3). The characteristics of pneumonia included the following: multilobar (n = 25); pleural effusion (n = 25); and cavitation (n = 5). The prevalence of Lymphadenopathy according to comorbidities and characteristics of pneumonia ranged from 40 to 100%. None of the differences in prevalence of Lymphadenopathy among the subgroups was statistically significant Conclusion Lymphadenopathy is a common CT scan feature of pneumococcal pneumonia in hospitalized patients, in a variety of settings. Therefore, when a patient with pneumococcal pneumonia has Lymphadenopathy seen on a CT scan, other etiologies for the Lymphadenopathy need not be suspected
Sanjiv Gupta - One of the best experts on this subject based on the ideXlab platform.
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Cytologic appearance of sinus histiocytosis with massive Lymphadenopathy : A case report
Acta Cytologica, 1996Co-Authors: Sanjiv Gupta, Dheeraj GuptaAbstract:BACKGROUND: Sinus histiocytosis with massive Lymphadenopathy is a benign, massive Lymphadenopathy, usually cervical, of unknown etiology. CASE: Cytologic smears revealed a polymorphic population of cells consisting of mature lymphocytes, plasma cells, occasional neutrophils and many histiocytes, characteristically showing emperipolesis. A reactive Lymphadenopathy was diagnosed. The histopathologic diagnosis on open biopsy specimen was sinus histiocytosis with massive Lymphadenopathy. CONCLUSION: Cytologic diagnosis of sinus histiocytosis with massive Lymphadenopathy is possible with high accuracy provided that the cytologic findings are interpreted in the appropriate clinical context. The cytologic examination also can help with follow-up.
