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Masazumi Tsuneyoshi - One of the best experts on this subject based on the ideXlab platform.
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VEGF-C and VEGFR-3 in a series of Lymphangiomas: Is superficial Lymphangioma a true Lymphangioma?
Virchows Archiv, 2009Co-Authors: Eijun Itakura, Hidetaka Yamamoto, Masutaka Furue, Masazumi TsuneyoshiAbstract:Lymphangiomas are commonly regarded as vascular malformations during embryonic development rather than as true neoplasms. VEGF-C and VEGFR-3 are known to be active in the formation of Lymphangiomas. However, the significance of the disorders seems to be obscured by confusing different entities. In 114 Lymphangiomas, we investigated the clinicopathological features and the expression of VEGF-C and VEGFR-3. The age of patients with Lymphangioma circumscriptum or intraabdominal Lymphangioma was significantly higher than in patients with cavernous Lymphangioma and in patients with cystic hygroma. In cavernous Lymphangioma, the age of female patients was significantly higher than in male patients. Five adult cystic hygromas were identified. VEGF-C was detected in 21 of 58 (36%) cavernous Lymphangiomas, ten of 28 (36%) cystic hygromas, 0 of 12 (0%) Lymphangioma circumscriptum, and four of ten (40%) intraabdominal Lymphangiomas. VEGFR-3 was detected in 43 of 58 (72%) cavernous Lymphangiomas, 20 of 28 (71%) cystic hygromas, six of 12 (50%) Lymphangiomas circumscriptum, and seven of ten (70%) intraabdominal Lymphangiomas. VEGF-C was absent from superficial Lymphangiomas associated with cavernous Lymphangiomas. In typical cases of cavernous Lymphangioma, VEGF-C was strongly expressed, suggesting that these cases possessed proliferative activity. In cystic hygroma and intraabdominal Lymphangioma, VEGF-C was limited in its distribution. Superficial Lymphangiomas more likely represent from peripheral lymphatic dilatation rather than due to growth factor.
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VEGF-C and VEGFR-3 in a series of Lymphangiomas: Is superficial Lymphangioma a true Lymphangioma?
Virchows Archiv, 2009Co-Authors: Eijun Itakura, Hidetaka Yamamoto, Masutaka Furue, Masazumi TsuneyoshiAbstract:Lymphangiomas are commonly regarded as vascular malformations during embryonic development rather than as true neoplasms. VEGF-C and VEGFR-3 are known to be active in the formation of Lymphangiomas. However, the significance of the disorders seems to be obscured by confusing different entities. In 114 Lymphangiomas, we investigated the clinicopathological features and the expression of VEGF-C and VEGFR-3. The age of patients with Lymphangioma circumscriptum or intraabdominal Lymphangioma was significantly higher than in patients with cavernous Lymphangioma and in patients with cystic hygroma. In cavernous Lymphangioma, the age of female patients was significantly higher than in male patients. Five adult cystic hygromas were identified. VEGF-C was detected in 21 of 58 (36%) cavernous Lymphangiomas, ten of 28 (36%) cystic hygromas, 0 of 12 (0%) Lymphangioma circumscriptum, and four of ten (40%) intraabdominal Lymphangiomas. VEGFR-3 was detected in 43 of 58 (72%) cavernous Lymphangiomas, 20 of 28 (71%) cystic hygromas, six of 12 (50%) Lymphangiomas circumscriptum, and seven of ten (70%) intraabdominal Lymphangiomas. VEGF-C was absent from superficial Lymphangiomas associated with cavernous Lymphangiomas. In typical cases of cavernous Lymphangioma, VEGF-C was strongly expressed, suggesting that these cases possessed proliferative activity. In cystic hygroma and intraabdominal Lymphangioma, VEGF-C was limited in its distribution. Superficial Lymphangiomas more likely represent from peripheral lymphatic dilatation rather than due to growth factor.
Eijun Itakura - One of the best experts on this subject based on the ideXlab platform.
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VEGF-C and VEGFR-3 in a series of Lymphangiomas: Is superficial Lymphangioma a true Lymphangioma?
Virchows Archiv, 2009Co-Authors: Eijun Itakura, Hidetaka Yamamoto, Masutaka Furue, Masazumi TsuneyoshiAbstract:Lymphangiomas are commonly regarded as vascular malformations during embryonic development rather than as true neoplasms. VEGF-C and VEGFR-3 are known to be active in the formation of Lymphangiomas. However, the significance of the disorders seems to be obscured by confusing different entities. In 114 Lymphangiomas, we investigated the clinicopathological features and the expression of VEGF-C and VEGFR-3. The age of patients with Lymphangioma circumscriptum or intraabdominal Lymphangioma was significantly higher than in patients with cavernous Lymphangioma and in patients with cystic hygroma. In cavernous Lymphangioma, the age of female patients was significantly higher than in male patients. Five adult cystic hygromas were identified. VEGF-C was detected in 21 of 58 (36%) cavernous Lymphangiomas, ten of 28 (36%) cystic hygromas, 0 of 12 (0%) Lymphangioma circumscriptum, and four of ten (40%) intraabdominal Lymphangiomas. VEGFR-3 was detected in 43 of 58 (72%) cavernous Lymphangiomas, 20 of 28 (71%) cystic hygromas, six of 12 (50%) Lymphangiomas circumscriptum, and seven of ten (70%) intraabdominal Lymphangiomas. VEGF-C was absent from superficial Lymphangiomas associated with cavernous Lymphangiomas. In typical cases of cavernous Lymphangioma, VEGF-C was strongly expressed, suggesting that these cases possessed proliferative activity. In cystic hygroma and intraabdominal Lymphangioma, VEGF-C was limited in its distribution. Superficial Lymphangiomas more likely represent from peripheral lymphatic dilatation rather than due to growth factor.
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VEGF-C and VEGFR-3 in a series of Lymphangiomas: Is superficial Lymphangioma a true Lymphangioma?
Virchows Archiv, 2009Co-Authors: Eijun Itakura, Hidetaka Yamamoto, Masutaka Furue, Masazumi TsuneyoshiAbstract:Lymphangiomas are commonly regarded as vascular malformations during embryonic development rather than as true neoplasms. VEGF-C and VEGFR-3 are known to be active in the formation of Lymphangiomas. However, the significance of the disorders seems to be obscured by confusing different entities. In 114 Lymphangiomas, we investigated the clinicopathological features and the expression of VEGF-C and VEGFR-3. The age of patients with Lymphangioma circumscriptum or intraabdominal Lymphangioma was significantly higher than in patients with cavernous Lymphangioma and in patients with cystic hygroma. In cavernous Lymphangioma, the age of female patients was significantly higher than in male patients. Five adult cystic hygromas were identified. VEGF-C was detected in 21 of 58 (36%) cavernous Lymphangiomas, ten of 28 (36%) cystic hygromas, 0 of 12 (0%) Lymphangioma circumscriptum, and four of ten (40%) intraabdominal Lymphangiomas. VEGFR-3 was detected in 43 of 58 (72%) cavernous Lymphangiomas, 20 of 28 (71%) cystic hygromas, six of 12 (50%) Lymphangiomas circumscriptum, and seven of ten (70%) intraabdominal Lymphangiomas. VEGF-C was absent from superficial Lymphangiomas associated with cavernous Lymphangiomas. In typical cases of cavernous Lymphangioma, VEGF-C was strongly expressed, suggesting that these cases possessed proliferative activity. In cystic hygroma and intraabdominal Lymphangioma, VEGF-C was limited in its distribution. Superficial Lymphangiomas more likely represent from peripheral lymphatic dilatation rather than due to growth factor.
Hidetaka Yamamoto - One of the best experts on this subject based on the ideXlab platform.
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VEGF-C and VEGFR-3 in a series of Lymphangiomas: Is superficial Lymphangioma a true Lymphangioma?
Virchows Archiv, 2009Co-Authors: Eijun Itakura, Hidetaka Yamamoto, Masutaka Furue, Masazumi TsuneyoshiAbstract:Lymphangiomas are commonly regarded as vascular malformations during embryonic development rather than as true neoplasms. VEGF-C and VEGFR-3 are known to be active in the formation of Lymphangiomas. However, the significance of the disorders seems to be obscured by confusing different entities. In 114 Lymphangiomas, we investigated the clinicopathological features and the expression of VEGF-C and VEGFR-3. The age of patients with Lymphangioma circumscriptum or intraabdominal Lymphangioma was significantly higher than in patients with cavernous Lymphangioma and in patients with cystic hygroma. In cavernous Lymphangioma, the age of female patients was significantly higher than in male patients. Five adult cystic hygromas were identified. VEGF-C was detected in 21 of 58 (36%) cavernous Lymphangiomas, ten of 28 (36%) cystic hygromas, 0 of 12 (0%) Lymphangioma circumscriptum, and four of ten (40%) intraabdominal Lymphangiomas. VEGFR-3 was detected in 43 of 58 (72%) cavernous Lymphangiomas, 20 of 28 (71%) cystic hygromas, six of 12 (50%) Lymphangiomas circumscriptum, and seven of ten (70%) intraabdominal Lymphangiomas. VEGF-C was absent from superficial Lymphangiomas associated with cavernous Lymphangiomas. In typical cases of cavernous Lymphangioma, VEGF-C was strongly expressed, suggesting that these cases possessed proliferative activity. In cystic hygroma and intraabdominal Lymphangioma, VEGF-C was limited in its distribution. Superficial Lymphangiomas more likely represent from peripheral lymphatic dilatation rather than due to growth factor.
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VEGF-C and VEGFR-3 in a series of Lymphangiomas: Is superficial Lymphangioma a true Lymphangioma?
Virchows Archiv, 2009Co-Authors: Eijun Itakura, Hidetaka Yamamoto, Masutaka Furue, Masazumi TsuneyoshiAbstract:Lymphangiomas are commonly regarded as vascular malformations during embryonic development rather than as true neoplasms. VEGF-C and VEGFR-3 are known to be active in the formation of Lymphangiomas. However, the significance of the disorders seems to be obscured by confusing different entities. In 114 Lymphangiomas, we investigated the clinicopathological features and the expression of VEGF-C and VEGFR-3. The age of patients with Lymphangioma circumscriptum or intraabdominal Lymphangioma was significantly higher than in patients with cavernous Lymphangioma and in patients with cystic hygroma. In cavernous Lymphangioma, the age of female patients was significantly higher than in male patients. Five adult cystic hygromas were identified. VEGF-C was detected in 21 of 58 (36%) cavernous Lymphangiomas, ten of 28 (36%) cystic hygromas, 0 of 12 (0%) Lymphangioma circumscriptum, and four of ten (40%) intraabdominal Lymphangiomas. VEGFR-3 was detected in 43 of 58 (72%) cavernous Lymphangiomas, 20 of 28 (71%) cystic hygromas, six of 12 (50%) Lymphangiomas circumscriptum, and seven of ten (70%) intraabdominal Lymphangiomas. VEGF-C was absent from superficial Lymphangiomas associated with cavernous Lymphangiomas. In typical cases of cavernous Lymphangioma, VEGF-C was strongly expressed, suggesting that these cases possessed proliferative activity. In cystic hygroma and intraabdominal Lymphangioma, VEGF-C was limited in its distribution. Superficial Lymphangiomas more likely represent from peripheral lymphatic dilatation rather than due to growth factor.
Masutaka Furue - One of the best experts on this subject based on the ideXlab platform.
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VEGF-C and VEGFR-3 in a series of Lymphangiomas: Is superficial Lymphangioma a true Lymphangioma?
Virchows Archiv, 2009Co-Authors: Eijun Itakura, Hidetaka Yamamoto, Masutaka Furue, Masazumi TsuneyoshiAbstract:Lymphangiomas are commonly regarded as vascular malformations during embryonic development rather than as true neoplasms. VEGF-C and VEGFR-3 are known to be active in the formation of Lymphangiomas. However, the significance of the disorders seems to be obscured by confusing different entities. In 114 Lymphangiomas, we investigated the clinicopathological features and the expression of VEGF-C and VEGFR-3. The age of patients with Lymphangioma circumscriptum or intraabdominal Lymphangioma was significantly higher than in patients with cavernous Lymphangioma and in patients with cystic hygroma. In cavernous Lymphangioma, the age of female patients was significantly higher than in male patients. Five adult cystic hygromas were identified. VEGF-C was detected in 21 of 58 (36%) cavernous Lymphangiomas, ten of 28 (36%) cystic hygromas, 0 of 12 (0%) Lymphangioma circumscriptum, and four of ten (40%) intraabdominal Lymphangiomas. VEGFR-3 was detected in 43 of 58 (72%) cavernous Lymphangiomas, 20 of 28 (71%) cystic hygromas, six of 12 (50%) Lymphangiomas circumscriptum, and seven of ten (70%) intraabdominal Lymphangiomas. VEGF-C was absent from superficial Lymphangiomas associated with cavernous Lymphangiomas. In typical cases of cavernous Lymphangioma, VEGF-C was strongly expressed, suggesting that these cases possessed proliferative activity. In cystic hygroma and intraabdominal Lymphangioma, VEGF-C was limited in its distribution. Superficial Lymphangiomas more likely represent from peripheral lymphatic dilatation rather than due to growth factor.
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VEGF-C and VEGFR-3 in a series of Lymphangiomas: Is superficial Lymphangioma a true Lymphangioma?
Virchows Archiv, 2009Co-Authors: Eijun Itakura, Hidetaka Yamamoto, Masutaka Furue, Masazumi TsuneyoshiAbstract:Lymphangiomas are commonly regarded as vascular malformations during embryonic development rather than as true neoplasms. VEGF-C and VEGFR-3 are known to be active in the formation of Lymphangiomas. However, the significance of the disorders seems to be obscured by confusing different entities. In 114 Lymphangiomas, we investigated the clinicopathological features and the expression of VEGF-C and VEGFR-3. The age of patients with Lymphangioma circumscriptum or intraabdominal Lymphangioma was significantly higher than in patients with cavernous Lymphangioma and in patients with cystic hygroma. In cavernous Lymphangioma, the age of female patients was significantly higher than in male patients. Five adult cystic hygromas were identified. VEGF-C was detected in 21 of 58 (36%) cavernous Lymphangiomas, ten of 28 (36%) cystic hygromas, 0 of 12 (0%) Lymphangioma circumscriptum, and four of ten (40%) intraabdominal Lymphangiomas. VEGFR-3 was detected in 43 of 58 (72%) cavernous Lymphangiomas, 20 of 28 (71%) cystic hygromas, six of 12 (50%) Lymphangiomas circumscriptum, and seven of ten (70%) intraabdominal Lymphangiomas. VEGF-C was absent from superficial Lymphangiomas associated with cavernous Lymphangiomas. In typical cases of cavernous Lymphangioma, VEGF-C was strongly expressed, suggesting that these cases possessed proliferative activity. In cystic hygroma and intraabdominal Lymphangioma, VEGF-C was limited in its distribution. Superficial Lymphangiomas more likely represent from peripheral lymphatic dilatation rather than due to growth factor.
Jochen A. Werner - One of the best experts on this subject based on the ideXlab platform.
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Sclerotherapy of Lymphangiomas of the head and neck.
Head & Neck, 2010Co-Authors: Susanne Wiegand, Behfar Eivazi, Annette P. Zimmermann, And Andreas M. Sesterhenn, Jochen A. WernerAbstract:Lymphangiomas are congenital malformations of the lymphatic system that consist of cysts of varying size. Although they are benign, they can undergo progressive growth with compression and infiltration of adjacent structures. Surgical excision has been the cornerstone of treatment, although total excision of the Lymphangioma can be a major challenge and may be associated with severe complications. Therefore, a variety of nonsurgical methods have been proposed to reduce the surgical morbidity and to decrease the recurrence rate. Percutaneous sclerotherapy of Lymphangioma involves the injection of sclerosing substances into the Lymphangioma cysts. During the past years, different sclerosants and sclerosant techniques have been developed. This review summarizes the current knowledge on sclerotherapy of Lymphangiomas of the head and neck. © 2010 Wiley Periodicals, Inc. Head Neck, 2011
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Pathogenesis of Lymphangiomas
Virchows Archiv, 2008Co-Authors: Susanne Wiegand, Behfar Eivazi, Peter J. Barth, Dirk Berens Rautenfeld, Benedikt J. Folz, Robert Mandic, Jochen A. WernerAbstract:Based on various hypotheses concerning lymphangiogenesis published in the literature, different putative mechanisms of Lymphangioma development are discussed including failure of the lymphatic system to connect with or separate from the venous system, abnormal budding of the lymphatic system from the cardinal vein, or acquired processes such as traumata, infections, chronic inflammations, and obstructions. Increasingly, the possible influence of lymphangiogenic growth factors on the development of Lymphangiomas is discussed. The proved expression of different growth factors in the endothelium of Lymphangiomas leads to new hypotheses regarding the pathogenesis of Lymphangiomas. Thus, further studies on the lymphangiogenesis and the development of Lymphangiomas will have to clarify as to whether Lymphangiomas are true malformations or neoplastic in nature.
