The Experts below are selected from a list of 198 Experts worldwide ranked by ideXlab platform
Philip D Hodgkin - One of the best experts on this subject based on the ideXlab platform.
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evidence from the generation of immunoglobulin g secreting cells that stochastic mechanisms regulate Lymphocyte Differentiation
Nature Immunology, 2004Co-Authors: Jhagvaral Hasbold, Lynn M Corcoran, David M Tarlinton, Stuart G Tangye, Philip D HodgkinAbstract:Evidence from the generation of immunoglobulin G–secreting cells that stochastic mechanisms regulate Lymphocyte Differentiation
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Evidence from the generation of immunoglobulin G–secreting cells that stochastic mechanisms regulate Lymphocyte Differentiation
Nature immunology, 2003Co-Authors: Jhagvaral Hasbold, Lynn M Corcoran, David M Tarlinton, Stuart G Tangye, Philip D HodgkinAbstract:Evidence from the generation of immunoglobulin G–secreting cells that stochastic mechanisms regulate Lymphocyte Differentiation
Jhagvaral Hasbold - One of the best experts on this subject based on the ideXlab platform.
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evidence from the generation of immunoglobulin g secreting cells that stochastic mechanisms regulate Lymphocyte Differentiation
Nature Immunology, 2004Co-Authors: Jhagvaral Hasbold, Lynn M Corcoran, David M Tarlinton, Stuart G Tangye, Philip D HodgkinAbstract:Evidence from the generation of immunoglobulin G–secreting cells that stochastic mechanisms regulate Lymphocyte Differentiation
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Evidence from the generation of immunoglobulin G–secreting cells that stochastic mechanisms regulate Lymphocyte Differentiation
Nature immunology, 2003Co-Authors: Jhagvaral Hasbold, Lynn M Corcoran, David M Tarlinton, Stuart G Tangye, Philip D HodgkinAbstract:Evidence from the generation of immunoglobulin G–secreting cells that stochastic mechanisms regulate Lymphocyte Differentiation
Ronald Palacios - One of the best experts on this subject based on the ideXlab platform.
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Heterogeneity of thymic epithelial cells in promoting T-Lymphocyte Differentiation in vivo.
Proceedings of the National Academy of Sciences of the United States of America, 1991Co-Authors: Jose C. Gutierrez, Ronald PalaciosAbstract:To study in vivo the contribution of different thymic epithelial cells to T-Lymphocyte Differentiation, we have established several nontransformed thymic epithelial cell lines and developed an in vivo assay, not involving exposure to drugs or radiation, that permitted us to study the capacity of these epithelial lines to support T-cell Differentiation. We found that cell lines EA2 and ET, which express markers of cortical epithelial cells, produce interleukin 7 mRNA and after being injected into the spleens of young athymic nude mice support in vivo generation of CD4+CD8- T-cell receptor alpha beta+ T Lymphocytes (ET line) or both CD4+CD8- and CD4-CD8+ T-cell receptor alpha beta+ T cells (EA2 line). Both cell lines also supported generation of T-cell receptor gamma delta+ T cells but appear not to support development of double-positive (CD4+CD8+) cells. One cell line, EB3, which expresses markers of medullary epithelial cells, produces interleukin 1 alpha RNA transcripts but does not support T-Lymphocyte Differentiation. The results provide direct evidence for functional heterogeneity of thymic epithelial cells in vivo and show the involvement of different cortical epithelial cells in the Differentiation of T-cell progenitors into distinct thymocyte subsets.
François Ghiringhelli - One of the best experts on this subject based on the ideXlab platform.
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Red wine extract disrupts Th17 Lymphocyte Differentiation in a colorectal cancer context
Molecular Nutrition and Food Research, 2020Co-Authors: Pauline Chalons, Flavie Courtaut, Emeric Limagne, Fanny Chalmin, Emma Cantos-villar, Tristan Richard, Cyril Auger, Philippe Chabert, Valérie Schini- Kerth, François GhiringhelliAbstract:Scope: Scope: It is well established that immune response and inflammation promote tumoral progression. Immune cells communicate through direct contact or through cytokine secretion, and it is the pro-inflammatory status that will tip the balance toward tumor progression or anti-tumor immunity. It is demonstrated here that a red wine extract (RWE) can decrease inflammation through its action on the inflammasome complex. This study determines whether an RWE could impact other key actors of inflammation, including T helper 17 (Th17) immune cells in particular. Methods and results: Methods and results: Using an RWE containing 4.16 g of polyphenols/liter of wine, it is shown that RWE decreases colorectal cancer cells in vitro and induces a reduction in colorectal tumor growth associated with a decrease in tumor-infiltrating Lymphocytes in vivo. The process of T-Lymphocyte Differentiation in Th17 cells is altered by RWE, as revealed by the decrease in the expression of key actors controlling this process, such as signal transducer and activator of transcription 3 and retinoid acid-related orphan receptor t. This disruption is associated with an inhibition of inflammatory interleukin 17 secretion. Conclusion: The data highlights the major involvement of Th17 immune cells in the biological effects of an RWE.
Jose C. Gutierrez - One of the best experts on this subject based on the ideXlab platform.
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Heterogeneity of thymic epithelial cells in promoting T-Lymphocyte Differentiation in vivo.
Proceedings of the National Academy of Sciences of the United States of America, 1991Co-Authors: Jose C. Gutierrez, Ronald PalaciosAbstract:To study in vivo the contribution of different thymic epithelial cells to T-Lymphocyte Differentiation, we have established several nontransformed thymic epithelial cell lines and developed an in vivo assay, not involving exposure to drugs or radiation, that permitted us to study the capacity of these epithelial lines to support T-cell Differentiation. We found that cell lines EA2 and ET, which express markers of cortical epithelial cells, produce interleukin 7 mRNA and after being injected into the spleens of young athymic nude mice support in vivo generation of CD4+CD8- T-cell receptor alpha beta+ T Lymphocytes (ET line) or both CD4+CD8- and CD4-CD8+ T-cell receptor alpha beta+ T cells (EA2 line). Both cell lines also supported generation of T-cell receptor gamma delta+ T cells but appear not to support development of double-positive (CD4+CD8+) cells. One cell line, EB3, which expresses markers of medullary epithelial cells, produces interleukin 1 alpha RNA transcripts but does not support T-Lymphocyte Differentiation. The results provide direct evidence for functional heterogeneity of thymic epithelial cells in vivo and show the involvement of different cortical epithelial cells in the Differentiation of T-cell progenitors into distinct thymocyte subsets.
