The Experts below are selected from a list of 81903 Experts worldwide ranked by ideXlab platform
Federica Marchesi - One of the best experts on this subject based on the ideXlab platform.
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Tertiary Lymphoid Tissue: A gateway for T cells in the tumor microenvironment.
Oncoimmunology, 2014Co-Authors: Giuseppe Di Caro, Federica MarchesiAbstract:Tumor-infiltrating lymphocytes influence colorectal cancer progression. We have recently documented that tertiary Lymphoid Tissue in the colorectal cancer microenvironment orchestrates lymphocyte infiltration and that tertiary Lymphoid Tissue and lymphocytes cooperate in a coordinated antitumor immune response to improve patient outcome. Thus, tertiary Lymphoid Tissue represents a potential target in the design of tailored immune-based therapeutic approaches.
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Tertiary Intratumor Lymphoid Tissue in Colo-Rectal Cancer
Cancers, 2011Co-Authors: Francesca Bergomas, Fabio Grizzi, Andrea Doni, Samantha Pesce, Luigi Laghi, Paola Allavena, Alberto Mantovani, Federica MarchesiAbstract:Ectopic (or tertiary) Lymphoid Tissue develops at sites of inflammation or infection in non Lymphoid organs and is associated with chronic inflammation. In colon mucosa, small Lymphoid aggregates are already present in homeostatic conditions, as part of the gut-associated Lymphoid Tissue and play an essential role in the immune response to perturbations of the mucosal microenvironment. Despite the recognized role of inflammation in tumor progression, the presence and biological function of Lymphoid Tissue in cancer has been poorly investigated. We identified aggregates of lymphocytes resembling tertiary Lymphoid Tissue in human colorectal cancer specimens; intratumor accumulations of lymphocytes display a high degree of compartmentalization, with B and T cells, mature dendritic cells and a network of CD21+ follicular dendritic cells (FDC). We analyzed the adaptation of colon Lymphoid Tissue in a murine model of colitis-associated cancer (AOM/DSS). B cell follicle formation increases in the context of the chronic inflammation associated to intestinal neoplasia, in this model. A network of lymphatic and haematic vessels surrounding B cell follicles is present and includes high endothelial venules (HEV). Future task is to determine whether Lymphoid Tissue contributes to the persistence of the tumor-associated inflammatory reaction, rather than represent a functional immune compartment, potentially participating to the anti tumor response.
Troy D Randall - One of the best experts on this subject based on the ideXlab platform.
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bronchus associated Lymphoid Tissue balt structure and function
Advances in Immunology, 2010Co-Authors: Troy D RandallAbstract:Bronchus-associated Lymphoid Tissue (BALT) is a constitutive mucosal Lymphoid Tissue adjacent to major airways in some mammalian species, including rats and rabbits, but not humans or mice. A related Tissue, inducible BALT (iBALT), is an ectopic Lymphoid Tissue that is formed upon inflammation or infection in both mice and humans and can be found throughout the lung. Both BALT and iBALT acquire antigens from the airways and initiate local immune responses and maintain memory cells in the lungs. Here, we discuss the development and function of BALT and iBALT in the context of pulmonary immunity to infectious agents, tumors, and allergens as well as autoimmunity and inflammatory diseases of the lung.
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Advances in Immunology - Bronchus-Associated Lymphoid Tissue (BALT)
Advances in immunology, 2010Co-Authors: Troy D RandallAbstract:Bronchus-associated Lymphoid Tissue (BALT) is a constitutive mucosal Lymphoid Tissue adjacent to major airways in some mammalian species, including rats and rabbits, but not humans or mice. A related Tissue, inducible BALT (iBALT), is an ectopic Lymphoid Tissue that is formed upon inflammation or infection in both mice and humans and can be found throughout the lung. Both BALT and iBALT acquire antigens from the airways and initiate local immune responses and maintain memory cells in the lungs. Here, we discuss the development and function of BALT and iBALT in the context of pulmonary immunity to infectious agents, tumors, and allergens as well as autoimmunity and inflammatory diseases of the lung.
Peter G. Isaacson - One of the best experts on this subject based on the ideXlab platform.
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Mucosa-associated Lymphoid Tissue lymphoma.
Seminars in hematology, 1999Co-Authors: Peter G. IsaacsonAbstract:A distinctive type of low-grade extranodal lymphoma recapitulates the cytomorphologic features of mucosa-associated Lymphoid Tissue (MALT). Typically, these MALT lymphomas arise from sites normally devoid of Lymphoid Tissue, but are preceded by chronic inflammatory, usually autoimmune, disorders that result in the accumulation of Lymphoid Tissue. The stomach is the most common site of MALT lymphoma, which arises from Lymphoid Tissue acquired as the result of Helicobacter pylori infection. The indolent clinical behavior of gastric MALT lymphoma coupled with certain histologic features suggests that its growth is subject to immunologic stimuli, and the role of H pylori in this respect has been examined in detail. In vitro experiments have shown that the growth of lymphoma cells is stimulated by contact with T cells, which, in turn, show strain specific responses to heat-killed H pylori. Clinically, approximately 70% of cases of stage IE gastric MALT lymphoma regress following eradication of H pylori with antibiotics. Large, deeply invasive tumors and those that have undergone high-grade transformation typically do not respond to antibiotic therapy. Other common sites of MALT lymphoma include the salivary glands, lung, and ocular adnexa. The clinicopathologic features of these lymphomas are remarkably similar to gastric MALT lymphoma, which suggests that they, too, may be antigen-driven.
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Mucosal-Associated Lymphoid Tissue Lymphoma of the Conjunctiva
Archives of ophthalmology (Chicago Ill. : 1960), 1994Co-Authors: Simon Hardman-lea, Andrew Wotherspoon, Malcolm Kerr-muir, William T. Green, Andrew Morell, Peter G. IsaacsonAbstract:The recognition of mucosal-associated Lymphoid Tissue as a distinct entity has lead to the separate classification of tumors arising in this Tissue, ie, the mucosal-associated Lymphoid Tissue lymphoma. Five patients with mucosal-associated Lymphoid Tissue lymphoma of the conjunctiva are described herein; four of the five patients had bilateral tumors. Laboratory analysis was done using microscopy, immunophenotyping, gene rearrangement analysis using both Southern blot and polymerase chain reaction techniques, and oncogene ( bcl -1, bcl -2, and c- myc ) rearrangment studies. Typical mucosal-associated Lymphoid Tissue lymphoma features were seen in all patients; three of four patients who underwent testing with immunphenotyping had light-chain restriction, four of five patients had a clone detected using Southern blot analysis, and all five patients showed clones on polymerase chain reaction analysis. No patient demonstrated oncogene rearrangement. In all patients, complete physical examinations and laboratory tests did not detect any evidence of systemic spread. After treatment, no evidence of local recurrence or dissemination was found during follow-up ranging from 2 to 3 years.
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Mucosa-associated Lymphoid Tissue (MALT) in the human conjunctiva.
The Journal of pathology, 1994Co-Authors: Andrew Wotherspoon, Hardman-lea S, Peter G. IsaacsonAbstract:The recent description of conjunctival lymphomas with features of lymphomas that arise in mucosa-associated Lymphoid Tissue (MALT) infers the presence of MALT in the human conjunctiva. Some authors suggest that organized MALT is found in the normal human conjunctiva, but others disagree. In order to resolve this problem, we have examined the conjunctival fornix from unselected autopsies with no prior history of conjunctival or ocular disease for the presence of organized MALT. In only 31 per cent of cases was organized Lymphoid Tissue found with the morphological and immunophenotypic features of MALT. This finding suggests that MALT is not found in the normal human conjunctiva but is acquired during life in a proportion of apparently asymptomatic individuals.
Yasuhiro Kon - One of the best experts on this subject based on the ideXlab platform.
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Vasculature-Associated Lymphoid Tissue: A Unique Tertiary Lymphoid Tissue Correlates With Renal Lesions in Lupus Nephritis Mouse Model.
Frontiers in immunology, 2020Co-Authors: Abdul Masum, Osamu Ichii, Yaser Hosny Ali Elewa, Yuki Otani, Takashi Namba, Yasuhiro KonAbstract:Lupus nephritis (LN) is a common complication in young patients and the most predominant cause of glomerulonephritis. Infiltrating immune cells and presence of immunocomplexes in the kidney are hallmarks of LN, which is closely associated with renal lesions (RLs). However, their regulatory mechanism in the kidney remains unclear, which is valuable for prevention of RL development. Here, we show the development of vasculature-associated Lymphoid Tissue (VALT) in LN, which is related to renal inflammatory cytokines, indicating that VALT is a unique tertiary Lymphoid Tissue. Transcriptomic analysis revealed different chemokines and costimulatory molecules for VALT induction and organization. Vascular and perivascular structures showed Lymphoid Tissue organization through lymphorganogenic chemokine production. Transcriptional profile and intracellular interaction also demonstrated antigen presentation, lymphocyte activity, clonal expansion, follicular, and germinal center activity in VALT. Importantly, VALT size was correlated with infiltrating immune cells in kidney and RLs, indicating its direct correlation with the development of RLs. In addition, dexamethasone administration reduced VALT size. Therefore, inhibition of VALT formation would be a novel therapeutic strategy against LN.
Janet E. Kuhlman - One of the best experts on this subject based on the ideXlab platform.
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Pulmonary mucosa-associated Lymphoid Tissue lymphoma: CT and pathologic findings.
AJR. American journal of roentgenology, 1999Co-Authors: B L Kinsely, L A Mastey, Patricia J. Mergo, M C Voytovich, Dani S. Zander, Nidal M. Almasri, Jannette Collins, Janet E. KuhlmanAbstract:OBJECTIVE: The objective of this study was to determine the CT findings in pulmonary mucosa-associated Lymphoid Tissue lymphoma and to correlate these CT findings with histologic specimens. CONCLUSION: In the 11 patients reviewed, the most common CT appearance of pulmonary mucosa-associated Lymphoid Tissue lymphoma was consolidation with air bronchograms, correlating histologically with a cellular lymphocytic infiltrate expanding the interstitium and compressing adjacent alveoli, producing air bronchograms.
