The Experts below are selected from a list of 87 Experts worldwide ranked by ideXlab platform
Albert Haas - One of the best experts on this subject based on the ideXlab platform.
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Turn up the Lysosome
Nature Cell Biology, 2016Co-Authors: Paul Saftig, Albert HaasAbstract:Lysosomes are digestive organelles of the endocytic and autophagic pathways. Increasing Lysosome Enzyme activities could help to clear pathological cellular waste. A recent study shows that lysosomal digestive functions can be promoted in isolated cells and mice by pharmacologically stimulating the autophagy- and Lysosome-regulating transcription factors TFEB and ZKSCAN3 through previously unrecognized mTORC1-independent pathways acting via PKC.
C. C. Orsi - One of the best experts on this subject based on the ideXlab platform.
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Cytoskeleton Alteration in Mouse Tissues by Postnatal Exposure to Heavy Metal Air Pollutants
Environmental Hygiene III, 1992Co-Authors: E. V. Orsi, G. Ahmad, D. Brois, B. Billings, C. C. OrsiAbstract:In past experiments (Orsi et al 1988, Orsi et al 1990) mice born and raised in an urban area (SHU) showed less weight gain, decreased Lysosome Enzyme activity and higher levels of lead and copper in their hearts and lungs than those born and raised in cleaner (BW) air. Studies of the effects of lead on cytoskeleton depletion in cell cultures ( Orsi et al 1987) suggested that the (SHU) progeny might show a similar depletion. Consequently, fixed heart and lung tissues saved from the third experiment (Orsi et al 1990) and those from this experiment a year later were utilized for comparing cytoskeleton levels in progeny from high and low air pollution regions.
Paul Saftig - One of the best experts on this subject based on the ideXlab platform.
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Turn up the Lysosome
Nature Cell Biology, 2016Co-Authors: Paul Saftig, Albert HaasAbstract:Lysosomes are digestive organelles of the endocytic and autophagic pathways. Increasing Lysosome Enzyme activities could help to clear pathological cellular waste. A recent study shows that lysosomal digestive functions can be promoted in isolated cells and mice by pharmacologically stimulating the autophagy- and Lysosome-regulating transcription factors TFEB and ZKSCAN3 through previously unrecognized mTORC1-independent pathways acting via PKC.
John J. Shacka - One of the best experts on this subject based on the ideXlab platform.
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Oxidative stress and autophagy in the regulation of Lysosome-dependent neuron death.
Antioxidants & Redox Signaling, 2009Co-Authors: Violetta N. Pivtoraiko, Sara L. Stone, Kevin A. Roth, John J. ShackaAbstract:Lysosomes critically regulate the pH-dependent catabolism of extracellular and intracellular macromolecules delivered from the endocytic/heterophagy and autophagy pathways, respectively. The importance of Lysosomes to cell survival is underscored not only by their unique ability effectively to degrade metalloproteins and oxidatively damaged macromolecules, but also by the distinct potential for induction of both caspase-dependent and -independent cell death with a compromise in the integrity of Lysosome function. Oxidative stress and free radical damage play a principal role in cell death induced by Lysosome dysfunction and may be linked to several upstream and downstream stimuli, including alterations in the autophagy degradation pathway, inhibition of Lysosome Enzyme function, and Lysosome membrane damage. Neurons are sensitive to Lysosome dysfunction, and the contribution of oxidative stress and free radical damage to Lysosome dysfunction may contribute to the etiology of neurodegenerative disease. This review provides a broad overview of Lysosome function and explores the contribution of oxidative stress and autophagy to Lysosome dysfunction–induced neuron death. Putative signaling pathways that either induce Lysosome dysfunction or result from Lysosome dysfunction or both, and the role of oxidative stress, free radical damage, and Lysosome dysfunction in pediatric lysosomal storage disorders (neuronal ceroid lipofuscinoses or NCL/Batten disease) and in Alzheimer's disease are emphasized. Antioxid. Redox Signal. 11, 481–496.
Levachev Mm - One of the best experts on this subject based on the ideXlab platform.
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Effects of the degree of fish oil oxidation on the state of xenobiotic metabolism Enzymes
Voprosy pitaniia, 1994Co-Authors: Kravchenko Lv, Kuz'mina Ee, Avren'eva Li, Pozdniakov Al, Kulakova Sn, Levachev MmAbstract:Wistar male rats received polysynthetic diets incorporating lard or fish of different oxidation degree as the sourse of fat. The feeding lasted 4 weeks. In the liver of rats on fish oil diet the activity of the Enzymes of xenobiotic metabolism phase I (monooxigenase system, epoxide hydrolase, carboxyl esterase) and phase II (native and activated UDP-glucuronosyl transferase, glutathione transferase) located both in microsoma membranes and in cytozole was higher than in the animals on lard diet. The Enzyme activity was much more enhanced in the use of oxidated fish oil. No effect of fish oil on serum and Lysosome Enzyme activity and rat hepatic structure was found.
