The Experts below are selected from a list of 285 Experts worldwide ranked by ideXlab platform
Frank T Griffin - One of the best experts on this subject based on the ideXlab platform.
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A comparison of ovine monocyte-derived Macrophage Function following infection with Mycobacterium avium ssp. avium and Mycobacterium avium ssp. paratuberculosis
Immunology and cell biology, 2006Co-Authors: Sven Berger, Frank T GriffinAbstract:A comparison of ovine monocyte-derived Macrophage Function following infection with Mycobacterium avium ssp. avium and Mycobacterium avium ssp. paratuberculosis
Sven Berger - One of the best experts on this subject based on the ideXlab platform.
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A comparison of ovine monocyte-derived Macrophage Function following infection with Mycobacterium avium ssp. avium and Mycobacterium avium ssp. paratuberculosis
Immunology and cell biology, 2006Co-Authors: Sven Berger, Frank T GriffinAbstract:A comparison of ovine monocyte-derived Macrophage Function following infection with Mycobacterium avium ssp. avium and Mycobacterium avium ssp. paratuberculosis
Maxim N. Artyomov - One of the best experts on this subject based on the ideXlab platform.
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Itaconate: the poster child of metabolic reprogramming in Macrophage Function
Nature Reviews Immunology, 2019Co-Authors: Luke A. J. O’neill, Maxim N. ArtyomovAbstract:During an immune response, Macrophage metabolism is diverted to produce the metabolite itaconate, which has anti-inflammatory effects. This Review recounts the story of itaconate, from its discovery to its potentially far-reaching consequences for immunity, host defence and tumorigenesis. Itaconate is one of the best examples of the consequences of metabolic reprogramming during immunity. It is made by diverting aconitate away from the tricarboxylic acid cycle during inflammatory Macrophage activation. The main reason Macrophages exhibit this response currently appears to be for an anti-inflammatory effect, with itaconate connecting cell metabolism, oxidative and electrophilic stress responses and immune responses. A role for itaconate in the regulation of type I interferons during viral infection has also been described, as well as in M2 Macrophage Function under defined circumstances. Finally, Macrophage-specific itaconate production has also been shown to have a pro-tumour effect. All of these studies point towards itaconate being a critical immunometabolite that could have far-reaching consequences for immunity, host defence and tumorigenesis.
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Itaconate: the poster child of metabolic reprogramming in Macrophage Function.
Nature reviews. Immunology, 2019Co-Authors: Luke A. J. O'neill, Maxim N. ArtyomovAbstract:Itaconate is one of the best examples of the consequences of metabolic reprogramming during immunity. It is made by diverting aconitate away from the tricarboxylic acid cycle during inflammatory Macrophage activation. The main reason Macrophages exhibit this response currently appears to be for an anti-inflammatory effect, with itaconate connecting cell metabolism, oxidative and electrophilic stress responses and immune responses. A role for itaconate in the regulation of type I interferons during viral infection has also been described, as well as in M2 Macrophage Function under defined circumstances. Finally, Macrophage-specific itaconate production has also been shown to have a pro-tumour effect. All of these studies point towards itaconate being a critical immunometabolite that could have far-reaching consequences for immunity, host defence and tumorigenesis.
Fudi Wang - One of the best experts on this subject based on the ideXlab platform.
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The Role of Zinc and Zinc Homeostasis in Macrophage Function
Journal of immunology research, 2018Co-Authors: Hong Gao, Wei Dai, Lu Zhao, Junxia Min, Fudi WangAbstract:Zinc has long been recognized as an essential trace element, playing roles in the growth and development of all living organisms. In recent decades, zinc homeostasis was also found to be important for the innate immune system, especially for maintaining the Function of Macrophages. It is now generally accepted that dysregulated zinc homeostasis in Macrophages causes impaired phagocytosis and an abnormal inflammatory response. However, many questions remain with respect to the mechanisms that underlie these processes, particularly at the cellular and molecular levels. Here, we review our current understanding of the roles that zinc and zinc transporters play in regulating Macrophage Function.
John M. Daly - One of the best experts on this subject based on the ideXlab platform.
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Impairment of pulmonary Macrophage Function with total parenteral nutrition.
Annals of surgery, 1994Co-Authors: Jian Shou, Jacqueline Lappin, John M. DalyAbstract:ObjectiveThe effects of total parenteral nutrition (TPN) administration on pulmonary Macrophage Function and host response to gram-negative pulmonary infection were evaluated.Summary Background DataAdministration of TPN resulted in increased infectious complications in traumatized and perioperative
