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Mali Ram Gupta - One of the best experts on this subject based on the ideXlab platform.
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application of multivariate methods to evaluate the functionality of bovine and vegetable derived magnesium stearate
Journal of Pharmaceutical Sciences, 2014Co-Authors: Rahul V. Haware, Ramya Shivagari, Paul R. Johnson, Scott Staton, William C. Stagner, Mali Ram GuptaAbstract:ABSTRACT This work distinguishes and quantifies the effects of bovine- and vegetable-derived magnesium stearate (MgSt) molecular and Macroscopic properties on lubrication efficiency using multivariate analysis. Principal component analysis (PCA) and partial least-square regression (PLS) were used to evaluate and quantify the lubricant effectiveness on a model tablet formulation. PCA score and loading plots showed a separation of model formulations based on the MgSt sources, which indicated different bovine- and vegetable-derived MgSt lubrication potential. PLS quantified the MgSt molecular [enthalpy of dehydration (ΔHd), enthalpy of melting (ΔHm), percent crystallinity, and moisture content] and Macroscopic [Particle size ( d 50 ), specific surface area (SSA-MgSt), and MgSt Hausner ratio (HF-MgSt)] properties, their interactions, and square effects on formulation powder flow and tableting properties relating to MgSt's lubrication effectiveness. For crystalline MgSt, moisture content, HF-MgSt, d 50 , and SSA-MgSt showed a major influence on the lubrication efficiency compared with the other MgSt molecular properties (percent crystallinity, ΔHm, and ΔHd). Amorphous MgSt showed poor lubrication, and none of its molecular or Macroscopic properties showed significant effects on lubrication efficiency. © 2014 Wiley Periodicals, Inc. and the American Pharmacists Association.
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Application of Multivariate Methods to Evaluate the Functionality of Bovine‐ and Vegetable‐Derived Magnesium Stearate
Journal of Pharmaceutical Sciences, 2014Co-Authors: Rahul V. Haware, Ramya Shivagari, Paul R. Johnson, Scott Staton, William C. Stagner, Mali Ram GuptaAbstract:ABSTRACT This work distinguishes and quantifies the effects of bovine- and vegetable-derived magnesium stearate (MgSt) molecular and Macroscopic properties on lubrication efficiency using multivariate analysis. Principal component analysis (PCA) and partial least-square regression (PLS) were used to evaluate and quantify the lubricant effectiveness on a model tablet formulation. PCA score and loading plots showed a separation of model formulations based on the MgSt sources, which indicated different bovine- and vegetable-derived MgSt lubrication potential. PLS quantified the MgSt molecular [enthalpy of dehydration (ΔHd), enthalpy of melting (ΔHm), percent crystallinity, and moisture content] and Macroscopic [Particle size ( d 50 ), specific surface area (SSA-MgSt), and MgSt Hausner ratio (HF-MgSt)] properties, their interactions, and square effects on formulation powder flow and tableting properties relating to MgSt's lubrication effectiveness. For crystalline MgSt, moisture content, HF-MgSt, d 50 , and SSA-MgSt showed a major influence on the lubrication efficiency compared with the other MgSt molecular properties (percent crystallinity, ΔHm, and ΔHd). Amorphous MgSt showed poor lubrication, and none of its molecular or Macroscopic properties showed significant effects on lubrication efficiency. © 2014 Wiley Periodicals, Inc. and the American Pharmacists Association.
Rahul V. Haware - One of the best experts on this subject based on the ideXlab platform.
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Physico-Mechanical Properties of Coprocessed Excipient MicroceLac^® 100 by DM^3 Approach
Pharmaceutical Research, 2015Co-Authors: Rahul V. Haware, Scott Staton, Joseph P. Kancharla, Aishwarya K. Udupa, Mali R. Gupta, Antoine Al-achi, William C. StagnerAbstract:Purpose To determine the effect of relative humidity (RH) and hydroxypropyl methylcellulose (HPMC) on the physico-mechanical properties of coprocessed MacroceLac^® 100 using ‘DM^3’ approach. Methods Effects of RH and 5% w/w HPMC on MacroceLac^® 100 Compressibility Index (CI) and tablet mechanical strength (TMS) were evaluated by ‘DM^3’. The ‘DM^3’ approach evaluates material properties by combining ‘design of experiments’, material’s ‘Macroscopic’ properties, ‘molecular’ properties, and ‘multivariate analysis’ tools. A 4X4 full-factorial experimental design was used to study the relationship of MacroceLac^® 100 molecular properties (moisture content, dehydration, crystallization, fusion enthalpy, and moisture uptake) and Macroscopic Particle size and shape on CI and TMS. A physical binary mixture (PBM) of similar composition to MacroceLac^® 100 was also evaluated. Multivariate analysis of variance (MANOVA), principle component analysis, and partial least squares (PLS) were used to analyze the data. Results MANOVA CI ranking was: PBM-HPMC > PBM > MicroceLac^®100 > MicroceLac^®100-HPMC ( p
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application of multivariate methods to evaluate the functionality of bovine and vegetable derived magnesium stearate
Journal of Pharmaceutical Sciences, 2014Co-Authors: Rahul V. Haware, Ramya Shivagari, Paul R. Johnson, Scott Staton, William C. Stagner, Mali Ram GuptaAbstract:ABSTRACT This work distinguishes and quantifies the effects of bovine- and vegetable-derived magnesium stearate (MgSt) molecular and Macroscopic properties on lubrication efficiency using multivariate analysis. Principal component analysis (PCA) and partial least-square regression (PLS) were used to evaluate and quantify the lubricant effectiveness on a model tablet formulation. PCA score and loading plots showed a separation of model formulations based on the MgSt sources, which indicated different bovine- and vegetable-derived MgSt lubrication potential. PLS quantified the MgSt molecular [enthalpy of dehydration (ΔHd), enthalpy of melting (ΔHm), percent crystallinity, and moisture content] and Macroscopic [Particle size ( d 50 ), specific surface area (SSA-MgSt), and MgSt Hausner ratio (HF-MgSt)] properties, their interactions, and square effects on formulation powder flow and tableting properties relating to MgSt's lubrication effectiveness. For crystalline MgSt, moisture content, HF-MgSt, d 50 , and SSA-MgSt showed a major influence on the lubrication efficiency compared with the other MgSt molecular properties (percent crystallinity, ΔHm, and ΔHd). Amorphous MgSt showed poor lubrication, and none of its molecular or Macroscopic properties showed significant effects on lubrication efficiency. © 2014 Wiley Periodicals, Inc. and the American Pharmacists Association.
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Application of Multivariate Methods to Evaluate the Functionality of Bovine‐ and Vegetable‐Derived Magnesium Stearate
Journal of Pharmaceutical Sciences, 2014Co-Authors: Rahul V. Haware, Ramya Shivagari, Paul R. Johnson, Scott Staton, William C. Stagner, Mali Ram GuptaAbstract:ABSTRACT This work distinguishes and quantifies the effects of bovine- and vegetable-derived magnesium stearate (MgSt) molecular and Macroscopic properties on lubrication efficiency using multivariate analysis. Principal component analysis (PCA) and partial least-square regression (PLS) were used to evaluate and quantify the lubricant effectiveness on a model tablet formulation. PCA score and loading plots showed a separation of model formulations based on the MgSt sources, which indicated different bovine- and vegetable-derived MgSt lubrication potential. PLS quantified the MgSt molecular [enthalpy of dehydration (ΔHd), enthalpy of melting (ΔHm), percent crystallinity, and moisture content] and Macroscopic [Particle size ( d 50 ), specific surface area (SSA-MgSt), and MgSt Hausner ratio (HF-MgSt)] properties, their interactions, and square effects on formulation powder flow and tableting properties relating to MgSt's lubrication effectiveness. For crystalline MgSt, moisture content, HF-MgSt, d 50 , and SSA-MgSt showed a major influence on the lubrication efficiency compared with the other MgSt molecular properties (percent crystallinity, ΔHm, and ΔHd). Amorphous MgSt showed poor lubrication, and none of its molecular or Macroscopic properties showed significant effects on lubrication efficiency. © 2014 Wiley Periodicals, Inc. and the American Pharmacists Association.
Kohei Ogawa - One of the best experts on this subject based on the ideXlab platform.
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A Numerical Study on InterParticle Collisions in a Microseparator/Classifier by a Macroscopic Particle Model
JOURNAL OF CHEMICAL ENGINEERING OF JAPAN, 2010Co-Authors: Shinichi Ookawara, Madhusuden Agrawal, Kohei OgawaAbstract:An effect of feed concentration on Particle focusing in an arc microchannel is numerically examined. A Macroscopic Particle model, which does not need any drag and lift force correlations and hence can be regarded as quasi-direct numerical simulation, is employed to model interParticle collisions due to high shear rates in the microchannel. The model can take into account physical boundaries of Particles in contact. In dilute conditions, all Particle trajectories formed smooth inward spirals over the transverse plane. In dense flow conditions, the Particle trajectories were distorted by collisions, and then the Particle focusing declined. It suggests that a Particle concentration, which is regarded as dilute in terms of volume concentration, can be regarded as hydraulically dense due to shear-induced Particle collisions in a microchannel. It is predicted that the angle between Particle-velocity vectors at successive time steps during collision is rather small. The importance of collision mechanism is discussed for the device application to various materials.
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a numerical study of the influence of Particle density on lift force induced separation in a micro separator classifier by a Macroscopic Particle model
Journal of Chemical Engineering of Japan, 2007Co-Authors: Shinichi Ookawara, Madhusuden Agrawal, David Street, Kohei OgawaAbstract:A Macroscopic Particle Model (MPM), which can be regarded as a quasi direct numerical simulation and hence does not need any drag and lift force models, is applied to examine the effect of Particle density on lift force-induced separation in a micro-separator/classifier. The computational domain is a 30-degrees arc channel with a radius of 20 mm connecting to 5-mm straight channels at the both ends. In this study the modeled is an upper-half of the channel with a width of 200 μm and a depth of 75 μm. The Particle diameter was chosen to be 20 μm, which is well separable in experiments and is suitable for MPM in which a Particle should contain several fluid cells. The density was examined in the range of slightly lighter to denser, compared with water. The Particle trajectories from representative points are predicted by MPM and also by a traditional Particle tracking method (DPM) for comparison. The DPM without a lift force model predicted that the trajectories expanded over the cross-sectional plane with an increase of Particle density since a secondary flow pattern called Dean vortices caused strong centrifugal force acting outwards from its center. On the other hand, the trajectories predicted by MPM were almost confined in the outer-half of the plane due to the lift force acting inwards to the vortex center. It seems that encountering lift force due to a steep shear and centrifugal force due to the Dean vortices are balanced regardless of the Particle density since both forces likely increase with Particle inertia. It is notable that Particles can be hydraulically separable regardless of the density ranging slightly lighter to denser compared to the medium.
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Quasi-direct numerical simulation of lift force-induced Particle separation in a curved microchannel by use of a Macroscopic Particle model
Chemical Engineering Science, 2007Co-Authors: Shinichi Ookawara, Madhusuden Agrawal, David Street, Kohei OgawaAbstract:Abstract The Macroscopic Particle model (MPM) based on the finite volume method is employed to validate a mechanism of lift force-induced Particle separation in a curved microchannel. According to the Particle velocity at each time step in the unsteady simulation, the MPM gives momentum to those fluid cells touching the Particle physical boundary. The summation of the given momentum with the reversed sign is divided by the time step to obtain the hydrodynamic force acting on the Particle. Namely, the existence and motion of the Particle causes fluid flow around the Particle, while the flow field caused by the Particle determines the Particle motion by means of the hydrodynamic force. Therefore, the MPM can be regarded as implementing a quasi-direct numerical simulation over the static computational cells. The lift force acting on a spherical Particle in a shear flow is a purely hydrodynamic force caused by the flow field around the Particle. It is expected, therefore, that the MPM could predict the lift force effect without any additional model. At first, it is shown that the MPM is capable of predicting Particle migration away from the wall of a straight microchannel due to the lift force. In a curved microchannel, subsequently, the Particle trajectories from representative release points predicted by the MPM are compared to those predicted by a common Particle tracking method without any lift force model. The MPM predicted that the Particle trajectories are confined in the outer region of the channel cross-section. On the other hand, the circulating trajectories predicted by the tracking method tend to expand due to centrifugal force caused by the Dean vortices. It is concluded, therefore, that the lift force due to the steep shear rate is a significant factor to cause Particle separation in a curved microchannel.
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A Numerical Study of the Influence of Particle Density on Lift Force-Induced Separation in a Micro-Separator/Classifier by a Macroscopic Particle Model
JOURNAL OF CHEMICAL ENGINEERING OF JAPAN, 2007Co-Authors: Shinichi Ookawara, Madhusuden Agrawal, David Street, Kohei OgawaAbstract:A Macroscopic Particle Model (MPM), which can be regarded as a quasi direct numerical simulation and hence does not need any drag and lift force models, is applied to examine the effect of Particle density on lift force-induced separation in a micro-separator/classifier. The computational domain is a 30-degrees arc channel with a radius of 20 mm connecting to 5-mm straight channels at the both ends. In this study the modeled is an upper-half of the channel with a width of 200 μm and a depth of 75 μm. The Particle diameter was chosen to be 20 μm, which is well separable in experiments and is suitable for MPM in which a Particle should contain several fluid cells. The density was examined in the range of slightly lighter to denser, compared with water. The Particle trajectories from representative points are predicted by MPM and also by a traditional Particle tracking method (DPM) for comparison. The DPM without a lift force model predicted that the trajectories expanded over the cross-sectional plane with an increase of Particle density since a secondary flow pattern called Dean vortices caused strong centrifugal force acting outwards from its center. On the other hand, the trajectories predicted by MPM were almost confined in the outer-half of the plane due to the lift force acting inwards to the vortex center. It seems that encountering lift force due to a steep shear and centrifugal force due to the Dean vortices are balanced regardless of the Particle density since both forces likely increase with Particle inertia. It is notable that Particles can be hydraulically separable regardless of the density ranging slightly lighter to denser compared to the medium.
William C. Stagner - One of the best experts on this subject based on the ideXlab platform.
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Physico-Mechanical Properties of Coprocessed Excipient MicroceLac^® 100 by DM^3 Approach
Pharmaceutical Research, 2015Co-Authors: Rahul V. Haware, Scott Staton, Joseph P. Kancharla, Aishwarya K. Udupa, Mali R. Gupta, Antoine Al-achi, William C. StagnerAbstract:Purpose To determine the effect of relative humidity (RH) and hydroxypropyl methylcellulose (HPMC) on the physico-mechanical properties of coprocessed MacroceLac^® 100 using ‘DM^3’ approach. Methods Effects of RH and 5% w/w HPMC on MacroceLac^® 100 Compressibility Index (CI) and tablet mechanical strength (TMS) were evaluated by ‘DM^3’. The ‘DM^3’ approach evaluates material properties by combining ‘design of experiments’, material’s ‘Macroscopic’ properties, ‘molecular’ properties, and ‘multivariate analysis’ tools. A 4X4 full-factorial experimental design was used to study the relationship of MacroceLac^® 100 molecular properties (moisture content, dehydration, crystallization, fusion enthalpy, and moisture uptake) and Macroscopic Particle size and shape on CI and TMS. A physical binary mixture (PBM) of similar composition to MacroceLac^® 100 was also evaluated. Multivariate analysis of variance (MANOVA), principle component analysis, and partial least squares (PLS) were used to analyze the data. Results MANOVA CI ranking was: PBM-HPMC > PBM > MicroceLac^®100 > MicroceLac^®100-HPMC ( p
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application of multivariate methods to evaluate the functionality of bovine and vegetable derived magnesium stearate
Journal of Pharmaceutical Sciences, 2014Co-Authors: Rahul V. Haware, Ramya Shivagari, Paul R. Johnson, Scott Staton, William C. Stagner, Mali Ram GuptaAbstract:ABSTRACT This work distinguishes and quantifies the effects of bovine- and vegetable-derived magnesium stearate (MgSt) molecular and Macroscopic properties on lubrication efficiency using multivariate analysis. Principal component analysis (PCA) and partial least-square regression (PLS) were used to evaluate and quantify the lubricant effectiveness on a model tablet formulation. PCA score and loading plots showed a separation of model formulations based on the MgSt sources, which indicated different bovine- and vegetable-derived MgSt lubrication potential. PLS quantified the MgSt molecular [enthalpy of dehydration (ΔHd), enthalpy of melting (ΔHm), percent crystallinity, and moisture content] and Macroscopic [Particle size ( d 50 ), specific surface area (SSA-MgSt), and MgSt Hausner ratio (HF-MgSt)] properties, their interactions, and square effects on formulation powder flow and tableting properties relating to MgSt's lubrication effectiveness. For crystalline MgSt, moisture content, HF-MgSt, d 50 , and SSA-MgSt showed a major influence on the lubrication efficiency compared with the other MgSt molecular properties (percent crystallinity, ΔHm, and ΔHd). Amorphous MgSt showed poor lubrication, and none of its molecular or Macroscopic properties showed significant effects on lubrication efficiency. © 2014 Wiley Periodicals, Inc. and the American Pharmacists Association.
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Application of Multivariate Methods to Evaluate the Functionality of Bovine‐ and Vegetable‐Derived Magnesium Stearate
Journal of Pharmaceutical Sciences, 2014Co-Authors: Rahul V. Haware, Ramya Shivagari, Paul R. Johnson, Scott Staton, William C. Stagner, Mali Ram GuptaAbstract:ABSTRACT This work distinguishes and quantifies the effects of bovine- and vegetable-derived magnesium stearate (MgSt) molecular and Macroscopic properties on lubrication efficiency using multivariate analysis. Principal component analysis (PCA) and partial least-square regression (PLS) were used to evaluate and quantify the lubricant effectiveness on a model tablet formulation. PCA score and loading plots showed a separation of model formulations based on the MgSt sources, which indicated different bovine- and vegetable-derived MgSt lubrication potential. PLS quantified the MgSt molecular [enthalpy of dehydration (ΔHd), enthalpy of melting (ΔHm), percent crystallinity, and moisture content] and Macroscopic [Particle size ( d 50 ), specific surface area (SSA-MgSt), and MgSt Hausner ratio (HF-MgSt)] properties, their interactions, and square effects on formulation powder flow and tableting properties relating to MgSt's lubrication effectiveness. For crystalline MgSt, moisture content, HF-MgSt, d 50 , and SSA-MgSt showed a major influence on the lubrication efficiency compared with the other MgSt molecular properties (percent crystallinity, ΔHm, and ΔHd). Amorphous MgSt showed poor lubrication, and none of its molecular or Macroscopic properties showed significant effects on lubrication efficiency. © 2014 Wiley Periodicals, Inc. and the American Pharmacists Association.
Scott Staton - One of the best experts on this subject based on the ideXlab platform.
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Physico-Mechanical Properties of Coprocessed Excipient MicroceLac^® 100 by DM^3 Approach
Pharmaceutical Research, 2015Co-Authors: Rahul V. Haware, Scott Staton, Joseph P. Kancharla, Aishwarya K. Udupa, Mali R. Gupta, Antoine Al-achi, William C. StagnerAbstract:Purpose To determine the effect of relative humidity (RH) and hydroxypropyl methylcellulose (HPMC) on the physico-mechanical properties of coprocessed MacroceLac^® 100 using ‘DM^3’ approach. Methods Effects of RH and 5% w/w HPMC on MacroceLac^® 100 Compressibility Index (CI) and tablet mechanical strength (TMS) were evaluated by ‘DM^3’. The ‘DM^3’ approach evaluates material properties by combining ‘design of experiments’, material’s ‘Macroscopic’ properties, ‘molecular’ properties, and ‘multivariate analysis’ tools. A 4X4 full-factorial experimental design was used to study the relationship of MacroceLac^® 100 molecular properties (moisture content, dehydration, crystallization, fusion enthalpy, and moisture uptake) and Macroscopic Particle size and shape on CI and TMS. A physical binary mixture (PBM) of similar composition to MacroceLac^® 100 was also evaluated. Multivariate analysis of variance (MANOVA), principle component analysis, and partial least squares (PLS) were used to analyze the data. Results MANOVA CI ranking was: PBM-HPMC > PBM > MicroceLac^®100 > MicroceLac^®100-HPMC ( p
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application of multivariate methods to evaluate the functionality of bovine and vegetable derived magnesium stearate
Journal of Pharmaceutical Sciences, 2014Co-Authors: Rahul V. Haware, Ramya Shivagari, Paul R. Johnson, Scott Staton, William C. Stagner, Mali Ram GuptaAbstract:ABSTRACT This work distinguishes and quantifies the effects of bovine- and vegetable-derived magnesium stearate (MgSt) molecular and Macroscopic properties on lubrication efficiency using multivariate analysis. Principal component analysis (PCA) and partial least-square regression (PLS) were used to evaluate and quantify the lubricant effectiveness on a model tablet formulation. PCA score and loading plots showed a separation of model formulations based on the MgSt sources, which indicated different bovine- and vegetable-derived MgSt lubrication potential. PLS quantified the MgSt molecular [enthalpy of dehydration (ΔHd), enthalpy of melting (ΔHm), percent crystallinity, and moisture content] and Macroscopic [Particle size ( d 50 ), specific surface area (SSA-MgSt), and MgSt Hausner ratio (HF-MgSt)] properties, their interactions, and square effects on formulation powder flow and tableting properties relating to MgSt's lubrication effectiveness. For crystalline MgSt, moisture content, HF-MgSt, d 50 , and SSA-MgSt showed a major influence on the lubrication efficiency compared with the other MgSt molecular properties (percent crystallinity, ΔHm, and ΔHd). Amorphous MgSt showed poor lubrication, and none of its molecular or Macroscopic properties showed significant effects on lubrication efficiency. © 2014 Wiley Periodicals, Inc. and the American Pharmacists Association.
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Application of Multivariate Methods to Evaluate the Functionality of Bovine‐ and Vegetable‐Derived Magnesium Stearate
Journal of Pharmaceutical Sciences, 2014Co-Authors: Rahul V. Haware, Ramya Shivagari, Paul R. Johnson, Scott Staton, William C. Stagner, Mali Ram GuptaAbstract:ABSTRACT This work distinguishes and quantifies the effects of bovine- and vegetable-derived magnesium stearate (MgSt) molecular and Macroscopic properties on lubrication efficiency using multivariate analysis. Principal component analysis (PCA) and partial least-square regression (PLS) were used to evaluate and quantify the lubricant effectiveness on a model tablet formulation. PCA score and loading plots showed a separation of model formulations based on the MgSt sources, which indicated different bovine- and vegetable-derived MgSt lubrication potential. PLS quantified the MgSt molecular [enthalpy of dehydration (ΔHd), enthalpy of melting (ΔHm), percent crystallinity, and moisture content] and Macroscopic [Particle size ( d 50 ), specific surface area (SSA-MgSt), and MgSt Hausner ratio (HF-MgSt)] properties, their interactions, and square effects on formulation powder flow and tableting properties relating to MgSt's lubrication effectiveness. For crystalline MgSt, moisture content, HF-MgSt, d 50 , and SSA-MgSt showed a major influence on the lubrication efficiency compared with the other MgSt molecular properties (percent crystallinity, ΔHm, and ΔHd). Amorphous MgSt showed poor lubrication, and none of its molecular or Macroscopic properties showed significant effects on lubrication efficiency. © 2014 Wiley Periodicals, Inc. and the American Pharmacists Association.
