The Experts below are selected from a list of 18270 Experts worldwide ranked by ideXlab platform
Taolei Sun - One of the best experts on this subject based on the ideXlab platform.
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Sialic acid-triggered Macroscopic properties switching on a smart polymer surface
Applied Surface Science, 2018Co-Authors: Yuting Xiong, Guangyan Qing, Hongxi Wang, Taolei SunAbstract:Abstract Constructing smart surfaces with responsive polymers capable of dynamically and reversibly changing their chemical and physical properties by responding to the recognition of biomolecules remains a challenging task. And, the key to achieving this purpose relies on the design of polymers to precisely interact with the target molecule and successfully transform the interaction signal into tunable Macroscopic properties, further achieve special bio-functions. Herein, inspired by carbohydrate–carbohydrate interaction (CCI) in life system, we developed a three-component copolymer poly(NIPAAm- co -PT- co -Glc) bearing a binding unit glucose (Glc) capable of recognizing sialic acid, a type of important molecular targets for cancer diagnosis and therapy, and reported the sialic acid triggered Macroscopic properties switching on this smart polymer surface. Detailed mechanism studies indicated that multiple hydrogen bonding interactions between Glc unit and Neu5Ac destroyed the initial hydrogen bond network of the copolymer, leading to a reversible “ contraction -to- swelling ” conformational transition of the copolymer chains, accompanied with distinct Macroscopic Property switching (i.e., surface wettability, morphology, stiffness) of the copolymer film. And these features enabled this copolymer to selectively capture sialic acid-containing glycopeptides from complex protein samples. This work provides an inspiration for the design of novel smart polymeric materials with sensitive responsiveness to sialic acid, which would promote the development of sialic acid-specific bio-devices and drug delivery systems.
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sialic acid responsive polymeric interface material from molecular recognition to Macroscopic Property switching
Scientific Reports, 2017Co-Authors: Yuting Xiong, Ge Jiang, Guangyan Qing, Xinmiao Liang, Taolei SunAbstract:Biological systems that utilize multiple weak non-covalent interactions and hierarchical assemblies to achieve various bio-functions bring much inspiration for the design of artificial biomaterials. However, it remains a big challenge to correlate underlying biomolecule interactions with Macroscopic level of materials, for example, recognizing such weak interaction, further transforming it into regulating material's Macroscopic Property and contributing to some new bio-applications. Here we designed a novel smart polymer based on polyacrylamide (PAM) grafted with lactose units (PAM-g-lactose0.11), and reported carbohydrate-carbohydrate interaction (CCI)-promoted Macroscopic properties switching on this smart polymer surface. Detailed investigations indicated that the binding of sialic acid molecules with the grafted lactose units via the CCIs induced conformational transformation of the polymer chains, further resulted in remarkable and reversible switching in surface topography, wettability and stiffness. With these excellent recognition and response capacities towards sialic acid, the PAM-g-lactose0.11 further facilitated good selectivity, strong anti-interference and high adsorption capacity in the capture of sialylated glycopeptides (important biomarkers for cancers). This work provides some enlightenment for the development of biointerface materials with tunable Property, as well as high-performance glycopeptide enrichment materials.
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CH-π Interaction Driven Macroscopic Property Transition on Smart Polymer Surface.
Scientific reports, 2015Co-Authors: Guangyan Qing, Yuting Xiong, Yuekun Lai, Taolei SunAbstract:Life systems have evolved to utilize weak noncovalent interactions, particularly CH-π interaction, to achieve various biofunctions, for example cellular communication, immune response, and protein folding. However, for artificial materials, it remains a great challenge to recognize such weak interaction, further transform it into tunable Macroscopic properties and realize special functions. Here we integrate monosaccharide-based CH-π receptor capable of recognizing aromatic peptides into a smart polymer with three-component "Recognition-Mediating-Function" design, and report the CH-π interaction driven surface Property switching on smart polymer film, including wettability, adhesion, viscoelasticity and stiffness. Detailed studies indicate that, the CH-π interaction induces the complexation between saccharide unit and aromatic peptide, which breaks the initial amphiphilic balance of the polymer network, resulting in contraction-swelling conformational transition for polymer chains and subsequent dramatic switching in surface properties. This work not only presents a new approach to control the surface Property of materials, but also points to a broader research prospect on CH-π interaction at a Macroscopic level.
Yuting Xiong - One of the best experts on this subject based on the ideXlab platform.
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Sialic acid-triggered Macroscopic properties switching on a smart polymer surface
Applied Surface Science, 2018Co-Authors: Yuting Xiong, Guangyan Qing, Hongxi Wang, Taolei SunAbstract:Abstract Constructing smart surfaces with responsive polymers capable of dynamically and reversibly changing their chemical and physical properties by responding to the recognition of biomolecules remains a challenging task. And, the key to achieving this purpose relies on the design of polymers to precisely interact with the target molecule and successfully transform the interaction signal into tunable Macroscopic properties, further achieve special bio-functions. Herein, inspired by carbohydrate–carbohydrate interaction (CCI) in life system, we developed a three-component copolymer poly(NIPAAm- co -PT- co -Glc) bearing a binding unit glucose (Glc) capable of recognizing sialic acid, a type of important molecular targets for cancer diagnosis and therapy, and reported the sialic acid triggered Macroscopic properties switching on this smart polymer surface. Detailed mechanism studies indicated that multiple hydrogen bonding interactions between Glc unit and Neu5Ac destroyed the initial hydrogen bond network of the copolymer, leading to a reversible “ contraction -to- swelling ” conformational transition of the copolymer chains, accompanied with distinct Macroscopic Property switching (i.e., surface wettability, morphology, stiffness) of the copolymer film. And these features enabled this copolymer to selectively capture sialic acid-containing glycopeptides from complex protein samples. This work provides an inspiration for the design of novel smart polymeric materials with sensitive responsiveness to sialic acid, which would promote the development of sialic acid-specific bio-devices and drug delivery systems.
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sialic acid responsive polymeric interface material from molecular recognition to Macroscopic Property switching
Scientific Reports, 2017Co-Authors: Yuting Xiong, Ge Jiang, Guangyan Qing, Xinmiao Liang, Taolei SunAbstract:Biological systems that utilize multiple weak non-covalent interactions and hierarchical assemblies to achieve various bio-functions bring much inspiration for the design of artificial biomaterials. However, it remains a big challenge to correlate underlying biomolecule interactions with Macroscopic level of materials, for example, recognizing such weak interaction, further transforming it into regulating material's Macroscopic Property and contributing to some new bio-applications. Here we designed a novel smart polymer based on polyacrylamide (PAM) grafted with lactose units (PAM-g-lactose0.11), and reported carbohydrate-carbohydrate interaction (CCI)-promoted Macroscopic properties switching on this smart polymer surface. Detailed investigations indicated that the binding of sialic acid molecules with the grafted lactose units via the CCIs induced conformational transformation of the polymer chains, further resulted in remarkable and reversible switching in surface topography, wettability and stiffness. With these excellent recognition and response capacities towards sialic acid, the PAM-g-lactose0.11 further facilitated good selectivity, strong anti-interference and high adsorption capacity in the capture of sialylated glycopeptides (important biomarkers for cancers). This work provides some enlightenment for the development of biointerface materials with tunable Property, as well as high-performance glycopeptide enrichment materials.
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CH-π Interaction Driven Macroscopic Property Transition on Smart Polymer Surface.
Scientific reports, 2015Co-Authors: Guangyan Qing, Yuting Xiong, Yuekun Lai, Taolei SunAbstract:Life systems have evolved to utilize weak noncovalent interactions, particularly CH-π interaction, to achieve various biofunctions, for example cellular communication, immune response, and protein folding. However, for artificial materials, it remains a great challenge to recognize such weak interaction, further transform it into tunable Macroscopic properties and realize special functions. Here we integrate monosaccharide-based CH-π receptor capable of recognizing aromatic peptides into a smart polymer with three-component "Recognition-Mediating-Function" design, and report the CH-π interaction driven surface Property switching on smart polymer film, including wettability, adhesion, viscoelasticity and stiffness. Detailed studies indicate that, the CH-π interaction induces the complexation between saccharide unit and aromatic peptide, which breaks the initial amphiphilic balance of the polymer network, resulting in contraction-swelling conformational transition for polymer chains and subsequent dramatic switching in surface properties. This work not only presents a new approach to control the surface Property of materials, but also points to a broader research prospect on CH-π interaction at a Macroscopic level.
Guangyan Qing - One of the best experts on this subject based on the ideXlab platform.
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Sialic acid-triggered Macroscopic properties switching on a smart polymer surface
Applied Surface Science, 2018Co-Authors: Yuting Xiong, Guangyan Qing, Hongxi Wang, Taolei SunAbstract:Abstract Constructing smart surfaces with responsive polymers capable of dynamically and reversibly changing their chemical and physical properties by responding to the recognition of biomolecules remains a challenging task. And, the key to achieving this purpose relies on the design of polymers to precisely interact with the target molecule and successfully transform the interaction signal into tunable Macroscopic properties, further achieve special bio-functions. Herein, inspired by carbohydrate–carbohydrate interaction (CCI) in life system, we developed a three-component copolymer poly(NIPAAm- co -PT- co -Glc) bearing a binding unit glucose (Glc) capable of recognizing sialic acid, a type of important molecular targets for cancer diagnosis and therapy, and reported the sialic acid triggered Macroscopic properties switching on this smart polymer surface. Detailed mechanism studies indicated that multiple hydrogen bonding interactions between Glc unit and Neu5Ac destroyed the initial hydrogen bond network of the copolymer, leading to a reversible “ contraction -to- swelling ” conformational transition of the copolymer chains, accompanied with distinct Macroscopic Property switching (i.e., surface wettability, morphology, stiffness) of the copolymer film. And these features enabled this copolymer to selectively capture sialic acid-containing glycopeptides from complex protein samples. This work provides an inspiration for the design of novel smart polymeric materials with sensitive responsiveness to sialic acid, which would promote the development of sialic acid-specific bio-devices and drug delivery systems.
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sialic acid responsive polymeric interface material from molecular recognition to Macroscopic Property switching
Scientific Reports, 2017Co-Authors: Yuting Xiong, Ge Jiang, Guangyan Qing, Xinmiao Liang, Taolei SunAbstract:Biological systems that utilize multiple weak non-covalent interactions and hierarchical assemblies to achieve various bio-functions bring much inspiration for the design of artificial biomaterials. However, it remains a big challenge to correlate underlying biomolecule interactions with Macroscopic level of materials, for example, recognizing such weak interaction, further transforming it into regulating material's Macroscopic Property and contributing to some new bio-applications. Here we designed a novel smart polymer based on polyacrylamide (PAM) grafted with lactose units (PAM-g-lactose0.11), and reported carbohydrate-carbohydrate interaction (CCI)-promoted Macroscopic properties switching on this smart polymer surface. Detailed investigations indicated that the binding of sialic acid molecules with the grafted lactose units via the CCIs induced conformational transformation of the polymer chains, further resulted in remarkable and reversible switching in surface topography, wettability and stiffness. With these excellent recognition and response capacities towards sialic acid, the PAM-g-lactose0.11 further facilitated good selectivity, strong anti-interference and high adsorption capacity in the capture of sialylated glycopeptides (important biomarkers for cancers). This work provides some enlightenment for the development of biointerface materials with tunable Property, as well as high-performance glycopeptide enrichment materials.
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CH-π Interaction Driven Macroscopic Property Transition on Smart Polymer Surface.
Scientific reports, 2015Co-Authors: Guangyan Qing, Yuting Xiong, Yuekun Lai, Taolei SunAbstract:Life systems have evolved to utilize weak noncovalent interactions, particularly CH-π interaction, to achieve various biofunctions, for example cellular communication, immune response, and protein folding. However, for artificial materials, it remains a great challenge to recognize such weak interaction, further transform it into tunable Macroscopic properties and realize special functions. Here we integrate monosaccharide-based CH-π receptor capable of recognizing aromatic peptides into a smart polymer with three-component "Recognition-Mediating-Function" design, and report the CH-π interaction driven surface Property switching on smart polymer film, including wettability, adhesion, viscoelasticity and stiffness. Detailed studies indicate that, the CH-π interaction induces the complexation between saccharide unit and aromatic peptide, which breaks the initial amphiphilic balance of the polymer network, resulting in contraction-swelling conformational transition for polymer chains and subsequent dramatic switching in surface properties. This work not only presents a new approach to control the surface Property of materials, but also points to a broader research prospect on CH-π interaction at a Macroscopic level.
Antonio Stocco - One of the best experts on this subject based on the ideXlab platform.
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Mesoporous Silica Colloids: Wetting, Surface Diffusion, and Cationic Surfactant Adsorption
Journal of Physical Chemistry C, 2019Co-Authors: Elise Azar, Christophe Blanc, Ahmad Mehdi, Maurizio Nobili, Antonio StoccoAbstract:We have investigated the wetting and surface diffusion of mesoporous colloidal silica particles at the water surface and the adsorption of cationic cetyltrimethylammonium (CTA+) surfactant on these particles. Porous silica colloids diffuse at the surface of water and in the volume, interacting with cationic surfactants that can adsorb inside the pores of the particles. We observed that surfactant adsorption on mesoporous silica depends dramatically not only on the particle pore size but also on specific counterion effects. We measured striking differences both on a Macroscopic Property of the interface, i.e., surface tension, and also at a single particle level by evaluating the translational diffusion of partially wetted particles at the fluid interface. We varied the pore size from 2 to 7 nm and explored the effects of ions possessing different hydration number and kosmotropic/chaotropic character. At concentrations lower than the critical micellar concentration, we evidence that cationic surfactants adsorb on silica as surface micelles and surfactant adsorption inside the pores occurs only if the pore diameter is larger than the size of surface micelles. With a view to understand the surprising different adsorption behavior of CTA+OH– and CTA+Br– on porous silica particles, we investigated the effect of counterions on the surfactant adsorption on porous silica colloids by tuning the pH and the counterion properties.
Evamaria Schoetz - One of the best experts on this subject based on the ideXlab platform.
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coaction of intercellular adhesion and cortical tension specifies tissue surface tension
Proceedings of the National Academy of Sciences of the United States of America, 2010Co-Authors: Lisa M Manning, Ramsey A Foty, Malcolm S Steinberg, Evamaria SchoetzAbstract:In the course of animal morphogenesis, large-scale cell movements occur, which involve the rearrangement, mutual spreading, and compartmentalization of cell populations in specific configurations. Morphogenetic cell rearrangements such as cell sorting and mutual tissue spreading have been compared with the behaviors of immiscible liquids, which they closely resemble. Based on this similarity, it has been proposed that tissues behave as liquids and possess a characteristic surface tension, which arises as a collective, Macroscopic Property of groups of mobile, cohering cells. But how are tissue surface tensions generated? Different theories have been proposed to explain how mesoscopic cell properties such as cell–cell adhesion and contractility of cell interfaces may underlie tissue surface tensions. Although recent work suggests that both may be contributors, an explicit model for the dependence of tissue surface tension on these mesoscopic parameters has been missing. Here we show explicitly that the ratio of adhesion to cortical tension determines tissue surface tension. Our minimal model successfully explains the available experimental data and makes predictions, based on the feedback between mechanical energy and geometry, about the shapes of aggregate surface cells, which we verify experimentally. This model indicates that there is a crossover from adhesion dominated to cortical-tension dominated behavior as a function of the ratio between these two quantities.
