The Experts below are selected from a list of 291 Experts worldwide ranked by ideXlab platform
Yasuhiro Maruyama - One of the best experts on this subject based on the ideXlab platform.
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Patterns of diabetic Macular Edema with optical coherence tomography.
American journal of ophthalmology, 1999Co-Authors: Tomohiro Otani, Shoji Kishi, Yasuhiro MaruyamaAbstract:Abstract PURPOSE: We report cross-sectional images of diabetic Macular Edema and correlation between tomographic features and visual acuity with best correction by means of optical coherence tomography. METHOD: In a prospective study, optical coherence tomography was performed in 59 eyes of 42 patients with diabetic Macular Edema and in 10 eyes of 10 normal control subjects. RESULTS: Optical coherence tomography showed three patterns of structural changes in diabetic Macular Edema: sponge-like retinal swelling (52 [88%] of 59 eyes), cystoid Macular Edema (28 [47%] of 59 eyes), and serous retinal detachment (9 [15%] of 59 eyes). Some eyes had more than one pathologic change. Retinal swelling was more pronounced in the outer rather than the inner retinal layers. Cystoid Macular Edema was located mainly in the outer retinal layers. In eyes with long-standing cystoid Macular Edema, cystoid spaces had fused, resulting in a large cystoid cavity involving almost the entire retinal layer. Hard exudates were seen as highly reflective areas located in the outer retinal layers. The retinal thickness at the central fovea and the visual acuity with best correction showed an intermediate negative correlation in eyes without cystoid Macular Edema (correlation coefficient: −0.61, P CONCLUSIONS: Diabetic Macular Edema involved three structural changes, including sponge-like retinal swelling (88%), cystoid Macular Edema (47%), and serous retinal detachment (15%). Visual acuity with best correction moderately correlated with retinal thickness regardless of the different tomographic features.
Jerry A Shields - One of the best experts on this subject based on the ideXlab platform.
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early subclinical Macular Edema in eyes with uveal melanoma association with future cystoid Macular Edema
Ophthalmology, 2015Co-Authors: Arman Mashayekhi, Etienne M Schonbach, Carol L Shields, Jerry A ShieldsAbstract:Purpose To determine the frequency of early subclinical Macular Edema in eyes with uveal melanoma and its association with future cystoid Macular Edema (CME). Design Retrospective cohort study. Participants A total of 306 patients with uveal melanoma; 260 patients had follow-up of 1 or more years after plaque radiotherapy (follow-up cohort). Methods Review of medical records and spectral-domain optical coherence tomography (OCT) images. Main Outcome Measures Frequency of early subclinical Macular Edema (increased central Macular thickness of >10 μm without cystoid changes before or at 4 months after plaque radiotherapy); rate of future CME. Results At baseline, 164 patients (54%) had subclinical Macular Edema in the involved eye. On multivariate analysis, factors associated with subclinical Macular Edema at baseline were increasing tumor diameter ( P = 0.001), increasing tumor thickness ( P = 0.010), and subretinal fluid ( P = 0.001). Of 260 patients in the follow-up cohort, 105 (40%) developed CME during a median follow-up of 31 months (mean, 34; range, 12–70 months). Eyes with subclinical Macular Edema at baseline (and at 4 months after plaque radiotherapy) had a significantly higher rate of future CME (n = 66; 50%) compared with eyes without subclinical Macular Edema at baseline (n = 39; 30%) ( P = 0.005; hazard ratio, 1.77; 95% confidence interval, 1.19–2.64). On multivariate analysis, the factors associated with future development of CME included female gender ( P = 0.004), increasing tumor thickness ( P P = 0.002), hemorrhage over tumor ( P = 0.017), and increased CMT of >10% at baseline in the involved eyes compared with the opposite eyes ( P = 0.012). Conclusions Subclinical Macular Edema is common in eyes with uveal melanoma before and at 4 months after plaque radiotherapy and is associated with initial larger tumor size. Eyes with early subclinical Macular Edema are at significantly higher risk for future CME. These findings suggest that tumor-related factors, most likely mediated through proinflammatory cytokines, may play an important role in development of post-radiation CME.
Zhang Xiao-fen - One of the best experts on this subject based on the ideXlab platform.
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Advances in treatment of Macular Edema with VEGF inhibitors
Clinical Ophthalmology, 2012Co-Authors: Zhang Xiao-fenAbstract:Macular Edema is a common clinical disease signs,which is the major cause of blindness for a variety of eye diseases.How to treat Macular Edema is of great concern with the treatment of primary disease.With the development and application of vascular endothelial growth factor(VEGF) inhibitors,anti-VEGF therapy occupy an important position in the treatment of Macular Edema,and has opened up a new direction for the treatment.This article introduces three kinds of VEGF drugs for the treatment of Macular Edema research progress.
Tomohiro Otani - One of the best experts on this subject based on the ideXlab platform.
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Patterns of diabetic Macular Edema with optical coherence tomography.
American journal of ophthalmology, 1999Co-Authors: Tomohiro Otani, Shoji Kishi, Yasuhiro MaruyamaAbstract:Abstract PURPOSE: We report cross-sectional images of diabetic Macular Edema and correlation between tomographic features and visual acuity with best correction by means of optical coherence tomography. METHOD: In a prospective study, optical coherence tomography was performed in 59 eyes of 42 patients with diabetic Macular Edema and in 10 eyes of 10 normal control subjects. RESULTS: Optical coherence tomography showed three patterns of structural changes in diabetic Macular Edema: sponge-like retinal swelling (52 [88%] of 59 eyes), cystoid Macular Edema (28 [47%] of 59 eyes), and serous retinal detachment (9 [15%] of 59 eyes). Some eyes had more than one pathologic change. Retinal swelling was more pronounced in the outer rather than the inner retinal layers. Cystoid Macular Edema was located mainly in the outer retinal layers. In eyes with long-standing cystoid Macular Edema, cystoid spaces had fused, resulting in a large cystoid cavity involving almost the entire retinal layer. Hard exudates were seen as highly reflective areas located in the outer retinal layers. The retinal thickness at the central fovea and the visual acuity with best correction showed an intermediate negative correlation in eyes without cystoid Macular Edema (correlation coefficient: −0.61, P CONCLUSIONS: Diabetic Macular Edema involved three structural changes, including sponge-like retinal swelling (88%), cystoid Macular Edema (47%), and serous retinal detachment (15%). Visual acuity with best correction moderately correlated with retinal thickness regardless of the different tomographic features.
Marco A. Zarbin - One of the best experts on this subject based on the ideXlab platform.
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Diabetic Macular Edema: pathogenesis and treatment.
Survey of ophthalmology, 2009Co-Authors: Neelakshi Bhagat, Ruben Grigorian, A.c. Tutela, Marco A. ZarbinAbstract:Diabetic Macular Edema is a major cause of visual impairment. The pathogenesis of Macular Edema appears to be multifactorial. Laser photocoagulation is the standard of care for Macular Edema. However, there are cases that are not responsive to laser therapy. Several therapeutic options have been proposed for the treatment of this condition. In this review we discuss several factors and mechanisms implicated in the etiology of Macular Edema (vasoactive factors, biochemical pathways, anatomical abnormalities). It seems that combined pharmacologic and surgical therapy may be the best approach for the management of Macular Edema in diabetic patients.
