The Experts below are selected from a list of 321 Experts worldwide ranked by ideXlab platform
Antonino Romano - One of the best experts on this subject based on the ideXlab platform.
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Recognising Antibacterial Hypersensitivity In Children
Pediatric Drugs, 2000Co-Authors: Antonino RomanoAbstract:Adverse reactions to antibacterial agents are not uncommon in children. They are classified as ‘immediate’ or ‘nonimmediate’ according to the time interval between drug administration and onset. Immediate reactions occur within 1 hour and are manifested by urticaria and/or angioedema, bronchospasm and anaphylactic shock; immunological reactions are mediated by IgE antibodies. The main nonimmediate reactions (occuring after more than 1 hour) are Maculopapular Rash, urticaria and serum sickness; T lymphocytes may participate in Maculopapular Rash. Clinical assessment of such reactions is complex. The patient’s history is fundamental; the allergological examination includes in vivo and in vitro tests selected on the basis of the clinical features and the phase of reaction. In the late phase, prick and intradermal tests are sensitive in evaluating β-lactam allergy. Together with delayed-reading intradermal testing, patch testing seems to be useful in diagnosing Maculopapular reactions to systemically administered aminopenicillins. Determination of specific IgE levels is the most common in vitro method for diagnosing immediate reactions. In the acute phase, serum tryptase and urinary N -methylhistamine assays are reliable in diagnosing type I pathogenic mechanisms in immediate reactions. Unfortunately, there are few in vitro tests for evaluating other reactions, and most are not fully validated. In selected cases, provocation tests should be performed.
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Recognising Antibacterial Hypersensitivity In Children
Pediatric Drugs, 2000Co-Authors: Antonino RomanoAbstract:Adverse reactions to antibacterial agents are not uncommon in children. They are classified as ‘immediate’ or ‘nonimmediate’ according to the time interval between drug administration and onset. Immediate reactions occur within 1 hour and are manifested by urticaria and/or angioedema, bronchospasm and anaphylactic shock; immunological reactions are mediated by IgE antibodies. The main nonimmediate reactions (occuring after more than 1 hour) are Maculopapular Rash, urticaria and serum sickness; T lymphocytes may participate in Maculopapular Rash.
Dario Conte - One of the best experts on this subject based on the ideXlab platform.
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severe chronic diarrhea and Maculopapular Rash a case report
World Journal of Gastroenterology, 2011Co-Authors: Alessandra Elvevi, Federica Irene Grifoni, Federica Branchi, Umberto Gianelli, Dario ConteAbstract:Systemic mastocytosis (SM) is a heterogeneous disease of the bone marrow characterized by abnormal growth, accumulation and activation of clonal mast cells (MCs). We report a case of SM with multi-organ involvement. A 30-year-old man presented with diarrhea, flushing, Maculopapular Rash with itching and weight loss. The upper and lower gastrointestinal endoscopies showed macroscopic involvement of stomach and duodenum; mucosal samples from stomach, duodenum, colon and distal ileum showed mucosal infiltration by large, spindle-shaped MCs with abnormal surface molecule expression (CD2 and CD25), a picture fully consistent with SM, according to the World Health Organization diagnostic criteria. A computed tomography scan showed diffuse lymphadenopathy, hepatosplenomegaly and diffuse small bowel involvement. Bone marrow aspirate and biopsy were diagnostic for SM; serum tryptase levels were increased (209 ng/mL, normal values < 20 ng/mL). The conclusive diagnosis was smouldering SM. There were no therapeutic indications except for treatment of symptoms. The patient was strictly followed up because of the risk of aggressive evolution.
Taskin Duman - One of the best experts on this subject based on the ideXlab platform.
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widespread Maculopapular Rash due to intramuscular interferon beta 1a during the treatment of multiple sclerosis
Multiple Sclerosis Journal, 2007Co-Authors: Gamze Serarslan, Esra Okuyucu, Ismet Melek, S Hakverdi, Taskin DumanAbstract:We describe a 41-year-old woman with multiple sclerosis, who presented erythematous Maculopapular Rash on the trunk and extremities after the second injection of interferon beta-1a. Histopathologic...
Harry Strokol - One of the best experts on this subject based on the ideXlab platform.
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agranulocytosis and Maculopapular Rash after treatment with ticlopidine case report
Slovenian Medical Journal, 2003Co-Authors: Janja Blatnik, Gorazd Lesnicar, Branko Sibanc, Stella Cvitan, Harry StrokolAbstract:Background. Ticlopidine is one of inhibitors of platelet aggregation indicated for reducing the risk of thrombotic stroke in patients who have experienced thrombotic stroke, ischemic attacks, unstable angina pectoris, coronary artery stenting and peripheral vascular bypass grafting. The weak point of this treatment are many serious adverse effects, the most serious of them being neutropenia. Patient and therapy. We report a case of a 70-years old woman who developed agranulocytosis and skin Rash by the end of the 4-week therapy with ticlopidine. After discontinued therapy with ticlopidine and when lenograstim was administered, agranulocytosis, anemia and Rash subsided in one week. Conclusions. As ticlopidine is associated with serious complications, its application has to be reserved for those patients who are intolerant to aspirin therapy.
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AGRANULOCYTOSIS AND Maculopapular Rash AFTER TREATMENT WITH TICLOPIDINE – CASE REPORT
Slovenian Medical Journal, 2003Co-Authors: Janja Blatnik, Gorazd Lesnicar, Branko Sibanc, Stella Cvitan, Harry StrokolAbstract:Background. Ticlopidine is one of inhibitors of platelet aggregation indicated for reducing the risk of thrombotic stroke in patients who have experienced thrombotic stroke, ischemic attacks, unstable angina pectoris, coronary artery stenting and peripheral vascular bypass grafting. The weak point of this treatment are many serious adverse effects, the most serious of them being neutropenia. Patient and therapy. We report a case of a 70-years old woman who developed agranulocytosis and skin Rash by the end of the 4-week therapy with ticlopidine. After discontinued therapy with ticlopidine and when lenograstim was administered, agranulocytosis, anemia and Rash subsided in one week. Conclusions. As ticlopidine is associated with serious complications, its application has to be reserved for those patients who are intolerant to aspirin therapy.
Alessandra Elvevi - One of the best experts on this subject based on the ideXlab platform.
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severe chronic diarrhea and Maculopapular Rash a case report
World Journal of Gastroenterology, 2011Co-Authors: Alessandra Elvevi, Federica Irene Grifoni, Federica Branchi, Umberto Gianelli, Dario ConteAbstract:Systemic mastocytosis (SM) is a heterogeneous disease of the bone marrow characterized by abnormal growth, accumulation and activation of clonal mast cells (MCs). We report a case of SM with multi-organ involvement. A 30-year-old man presented with diarrhea, flushing, Maculopapular Rash with itching and weight loss. The upper and lower gastrointestinal endoscopies showed macroscopic involvement of stomach and duodenum; mucosal samples from stomach, duodenum, colon and distal ileum showed mucosal infiltration by large, spindle-shaped MCs with abnormal surface molecule expression (CD2 and CD25), a picture fully consistent with SM, according to the World Health Organization diagnostic criteria. A computed tomography scan showed diffuse lymphadenopathy, hepatosplenomegaly and diffuse small bowel involvement. Bone marrow aspirate and biopsy were diagnostic for SM; serum tryptase levels were increased (209 ng/mL, normal values < 20 ng/mL). The conclusive diagnosis was smouldering SM. There were no therapeutic indications except for treatment of symptoms. The patient was strictly followed up because of the risk of aggressive evolution.
