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Subhash L Bodhankar - One of the best experts on this subject based on the ideXlab platform.
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elucidation of protective efficacy of pentahydroxy flavone isolated from Madhuca Indica against arsenite induced cardiomyopathy role of nrf 2 ppar γ c fos and c jun
Environmental Toxicology and Pharmacology, 2017Co-Authors: Anwesha A Mukherjee, Amit D Kandhare, Subhash L BodhankarAbstract:Abstract Background Madhuca Indica J. F. Gmel. (Sapotaceae) is widely used ethnobotanically as anti-diabetic, antipyretic, hepatoprotective, anti-inflammatory and analgesic. It was shown to possess potent anti-apoptotic property. The aim of the study To evaluate the possible mechanism of action of isolated phytoconstituent from Madhuca Indica Leaves methanolic extract (MI-ALC) on arsenic-induced cardiotoxicity in rats. Materials and methods The 3,5,7,3′,4′-Pentahydroxy flavone (QTN) was isolated and characterized by using HPTLC, 1 H NMR, and LC–MS from MI-ALC. QTN (5, 10 and 20 mg/kg, p.o.) was administered in arsenic intoxicated rats (5 mL/kg, p.o.) for 28 days and evaluated for various behavioral, biochemical, molecular and ultra-histological changes. Results Treatment with QTN (10 and 20 mg/kg, p.o.) significantly inhibited ( p 0.05) arsenic-induced electrocardiographic, hemodynamic and left ventricular function alterations. Elevated levels of cardiac markers (LDH, CK-MB, AST, ALT, and ALP), altered lipid metabolism (total cholesterol, triglyceride, LDL, HDL, and VLDL) was significantly restored ( p 0.05) by QTN. It also significantly inhibited ( p 0.05) altered cardiac oxido-nitrosative stress, Na-K-ATPase level and mitochondrial enzymes (I–IV) activity after arsenite administration. QTN significantly increased ( p 0.05) myocardial Nrf-2, PPAR-γ and significantly decreased ( p 0.05) myocardial c-fos and c-jun mRNA expressions. Flow cytometric analysis showed that treatment with QTN (10 and 20 mg/kg) significantly inhibited ( p Conclusion Administration of 3,5,7,3′,4′- Pentahydroxy flavone (i.e. Quercetin (QTN)) isolated from MI-ALC showed significant protection against arsenic-induced oxido-nitrosative stress and myocardial injury via modulation of Nrf2, PPAR-γ, and apoptosis.
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gastroprotective potential of pentahydroxy flavone isolated from Madhuca Indica j f gmel leaves against acetic acid induced ulcer in rats the role of oxido inflammatory and prostaglandins markers
Journal of Ethnopharmacology, 2016Co-Authors: Smeeta M Mohod, Amit D Kandhare, Subhash L BodhankarAbstract:Abstract Ethnopharmacological relevance Madhuca Indica J. F. Gmel. (Sapotaceae) has shown antioxidant, anti-inflammatory, analgesic, anti-diabetic and hepatoprotective potential. It has been traditionally used as laxative, tonic, anti-burn, anti-earthworm, wound healing and headache. Aim of the study To investigate the efficacy and possible mechanism of Madhuca Indica J. F. Gmel. leaves methanolic extract (MI-ALC) and its isolated chloroform fraction (D3) against experimental induced gastric ulcers. Materials and methods D3 was isolated from MI-ALC, well characterized (HPTLC, FT-IR, 1H-NMR and LC–MS) and evaluated for its gastroprotective activity by using acetic acid induced ulcer in male Wistar rats (150–200 g). D3 (2.5, 5 and 10 mg/kg, p.o.) were administered for the period of 14 days. At the end of treatment, rats were sacrificed to collect the stomach sample for evaluation of antioxidant (SOD, GSH, and MDA) enzyme, oxido-inflammatory (TNF-α, IL-1, iNOs) and prostaglandins (COX-II) markers by using RT-PCR. Results The structure and molecular weight (MW) of the isolated compound (D3) were confirmed by 1D and 2D spectral data and characterized as 3,5,7,3′,4′-Pentahydroxy flavone with MW C15H10O7. Administration of 3,5,7,3′,4′-Pentahydroxy flavone (5 and 10 mg/kg) significantly and dose-dependently inhibited (P Conclusion Finding of present investigation suggests that MI-ALC possessed potent antiulcer activity due to the presence of 3,5,7,3′,4′-Pentahydroxy flavone via its oxido-inflammatory and prostaglandins modulatory potential.
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Antiulcer activity of aqueous extract of leaves of Madhuca Indica J. F. Gmel against naproxen induced gastric mucosal injury in rats
Wolters Kluwer Medknow Publications, 2013Co-Authors: Smeeta M Mohod, Subhash L BodhankarAbstract:Objective: To evaluate antiulcer potential of aqueous extract of Madhuca Indica (M. Indica) J. F. Gmel leaves in rats. Methods: Aqueous extract of M. Indica J.F. Gmel leaves was tested at the dose of 100, 200 and 400 mg/kg, p.o. against naproxen (30 mg/kg, p.o) induced gastric ulcer. Omeprazole (30 mg kg, p.o.) was used as a positive standard. Ulcerated area was measured by Image J software. Various antioxidant parameter like SOD, GSH, MDA, MPO, NO and histamine were also determined. Results: After 4 week treatment period, desired aim was achieved using aqueous extract of plant of M. Indica at the dose of 200 and 400 mg/kg, p.o. (P
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antiulcer activity of aqueous extract of leaves of Madhuca Indica j f gmel against naproxen induced gastric mucosal injury in rats
Journal of acute disease, 2013Co-Authors: Smeeta M Mohod, Subhash L BodhankarAbstract:Abstract Objective To evaluate antiulcer potential of aqueous extract of Madhuca Indica (M. Indica) J. F. Gmel leaves in rats. Methods Aqueous extract of M. Indica J.F. Gmel leaves was tested at the dose of 100, 200 and 400 mg/kg, p.o. against naproxen (30 mg/kg, p.o) induced gastric ulcer. Omeprazole (30 mg kg, p.o.) was used as a positive standard. Ulcerated area was measured by Image J software. Various antioxidant parameter like SOD, GSH, MDA, MPO, NO and histamine were also determined. Results After 4 week treatment period, desired aim was achieved using aqueous extract of plant of M. Indica at the dose of 200 and 400 mg/kg, p.o. (P Conclusions Our finding suggests that aqueous extract of M. Indica J.F. Gmel leaves is effective in gastric ulcer protection.
Hifjur Raheman - One of the best experts on this subject based on the ideXlab platform.
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performance of compression ignition engine with mahua Madhuca Indica biodiesel
Fuel, 2007Co-Authors: Hifjur Raheman, S V GhadgeAbstract:Abstract The performance of biodiesel obtained from mahua oil and its blend with high speed diesel in a Ricardo E6 engine has been presented in this paper together with some of its fuel properties. These properties were found to be comparable to diesel and confirming to both the American and European standards. Engine performance (brake specific fuel consumption, brake thermal efficiency and exhaust gas temperature) and emissions (CO, smoke density and NO x ) were measured to evaluate and compute the behaviour of the diesel engine running on biodiesel. The reductions in exhaust emissions and brake specific fuel consumption together with increase brake power, brake thermal efficiency made the blend of biodiesel (B20) a suitable alternative fuel for diesel and thus could help in controlling air pollution.
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process optimization for biodiesel production from mahua Madhuca Indica oil using response surface methodology
Bioresource Technology, 2006Co-Authors: S V Ghadge, Hifjur RahemanAbstract:A central composite rotatable design was used to study the effect of methanol quantity, acid concentration and reaction time on the reduction of free fatty acids content of mahua oil during its pretreatment for making biodiesel. All the three variables significantly affected the acid value of the product, methanol being the most effective followed by reaction time and acid catalyst concentration. Using response surface methodology, a quadratic polynomial equation was obtained for acid value by multiple regression analysis. Verification experiments confirmed the validity of the predicted model. The optimum combinations for reducing the acid level of mahua oil to less than 1% after pretreatment was 0.32 v/v methanol-to-oil ratio, 1.24% v/v H2SO4 catalyst and 1.26 h reaction time at 60 degrees C. After the pretreatment of mahua oil, transesterification reaction was carried out with 0.25 v/v methanol-to-oil ratio (6:1 molar ratio) and 0.7% w/v KOH as an alkaline catalyst to produce biodiesel. The fuel properties of mahua biodiesel so obtained complied the requirements of both the American and European standards for biodiesel.
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process optimization for biodiesel production from mahua Madhuca Indica oil using response surface methodology
Bioresource Technology, 2006Co-Authors: S V Ghadge, Hifjur RahemanAbstract:Abstract A central composite rotatable design was used to study the effect of methanol quantity, acid concentration and reaction time on the reduction of free fatty acids content of mahua oil during its pretreatment for making biodiesel. All the three variables significantly affected the acid value of the product, methanol being the most effective followed by reaction time and acid catalyst concentration. Using response surface methodology, a quadratic polynomial equation was obtained for acid value by multiple regression analysis. Verification experiments confirmed the validity of the predicted model. The optimum combinations for reducing the acid level of mahua oil to less than 1% after pretreatment was 0.32 v/v methanol-to-oil ratio, 1.24% v/v H 2 SO 4 catalyst and 1.26 h reaction time at 60 °C. After the pretreatment of mahua oil, transesterification reaction was carried out with 0.25 v/v methanol-to-oil ratio (6:1 molar ratio) and 0.7% w/v KOH as an alkaline catalyst to produce biodiesel. The fuel properties of mahua biodiesel so obtained complied the requirements of both the American and European standards for biodiesel.
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biodiesel production from mahua Madhuca Indica oil having high free fatty acids
Biomass & Bioenergy, 2005Co-Authors: S V Ghadge, Hifjur RahemanAbstract:Abstract A technique to produce biodiesel from mahua oil ( Madhuca Indica ) having high free fatty acids (19% FFA) has been developed. The high FFA level of mahua oil was reduced to less than 1% by a two-step pretreatment process. Each step was carried out with 0.30–0.35 v/v methanol-to-oil ratio in the presence of 1% v/v H 2 SO 4 as an acid catalyst in 1-hour reaction at 60°C. After the reaction, the mixture was allowed to settle for an hour and methanol–water mixture that separated at the top was removed. The second step product at the bottom was transesterified using 0.25 v/v methanol and 0.7% w/v KOH as alkaline catalyst to produce biodiesel. The fuel properties of mahua biodiesel were found to be comparable to those of diesel and conforming to both the American and European standards.
S V Ghadge - One of the best experts on this subject based on the ideXlab platform.
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performance of compression ignition engine with mahua Madhuca Indica biodiesel
Fuel, 2007Co-Authors: Hifjur Raheman, S V GhadgeAbstract:Abstract The performance of biodiesel obtained from mahua oil and its blend with high speed diesel in a Ricardo E6 engine has been presented in this paper together with some of its fuel properties. These properties were found to be comparable to diesel and confirming to both the American and European standards. Engine performance (brake specific fuel consumption, brake thermal efficiency and exhaust gas temperature) and emissions (CO, smoke density and NO x ) were measured to evaluate and compute the behaviour of the diesel engine running on biodiesel. The reductions in exhaust emissions and brake specific fuel consumption together with increase brake power, brake thermal efficiency made the blend of biodiesel (B20) a suitable alternative fuel for diesel and thus could help in controlling air pollution.
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process optimization for biodiesel production from mahua Madhuca Indica oil using response surface methodology
Bioresource Technology, 2006Co-Authors: S V Ghadge, Hifjur RahemanAbstract:A central composite rotatable design was used to study the effect of methanol quantity, acid concentration and reaction time on the reduction of free fatty acids content of mahua oil during its pretreatment for making biodiesel. All the three variables significantly affected the acid value of the product, methanol being the most effective followed by reaction time and acid catalyst concentration. Using response surface methodology, a quadratic polynomial equation was obtained for acid value by multiple regression analysis. Verification experiments confirmed the validity of the predicted model. The optimum combinations for reducing the acid level of mahua oil to less than 1% after pretreatment was 0.32 v/v methanol-to-oil ratio, 1.24% v/v H2SO4 catalyst and 1.26 h reaction time at 60 degrees C. After the pretreatment of mahua oil, transesterification reaction was carried out with 0.25 v/v methanol-to-oil ratio (6:1 molar ratio) and 0.7% w/v KOH as an alkaline catalyst to produce biodiesel. The fuel properties of mahua biodiesel so obtained complied the requirements of both the American and European standards for biodiesel.
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process optimization for biodiesel production from mahua Madhuca Indica oil using response surface methodology
Bioresource Technology, 2006Co-Authors: S V Ghadge, Hifjur RahemanAbstract:Abstract A central composite rotatable design was used to study the effect of methanol quantity, acid concentration and reaction time on the reduction of free fatty acids content of mahua oil during its pretreatment for making biodiesel. All the three variables significantly affected the acid value of the product, methanol being the most effective followed by reaction time and acid catalyst concentration. Using response surface methodology, a quadratic polynomial equation was obtained for acid value by multiple regression analysis. Verification experiments confirmed the validity of the predicted model. The optimum combinations for reducing the acid level of mahua oil to less than 1% after pretreatment was 0.32 v/v methanol-to-oil ratio, 1.24% v/v H 2 SO 4 catalyst and 1.26 h reaction time at 60 °C. After the pretreatment of mahua oil, transesterification reaction was carried out with 0.25 v/v methanol-to-oil ratio (6:1 molar ratio) and 0.7% w/v KOH as an alkaline catalyst to produce biodiesel. The fuel properties of mahua biodiesel so obtained complied the requirements of both the American and European standards for biodiesel.
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biodiesel production from mahua Madhuca Indica oil having high free fatty acids
Biomass & Bioenergy, 2005Co-Authors: S V Ghadge, Hifjur RahemanAbstract:Abstract A technique to produce biodiesel from mahua oil ( Madhuca Indica ) having high free fatty acids (19% FFA) has been developed. The high FFA level of mahua oil was reduced to less than 1% by a two-step pretreatment process. Each step was carried out with 0.30–0.35 v/v methanol-to-oil ratio in the presence of 1% v/v H 2 SO 4 as an acid catalyst in 1-hour reaction at 60°C. After the reaction, the mixture was allowed to settle for an hour and methanol–water mixture that separated at the top was removed. The second step product at the bottom was transesterified using 0.25 v/v methanol and 0.7% w/v KOH as alkaline catalyst to produce biodiesel. The fuel properties of mahua biodiesel were found to be comparable to those of diesel and conforming to both the American and European standards.
Smeeta M Mohod - One of the best experts on this subject based on the ideXlab platform.
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gastroprotective potential of pentahydroxy flavone isolated from Madhuca Indica j f gmel leaves against acetic acid induced ulcer in rats the role of oxido inflammatory and prostaglandins markers
Journal of Ethnopharmacology, 2016Co-Authors: Smeeta M Mohod, Amit D Kandhare, Subhash L BodhankarAbstract:Abstract Ethnopharmacological relevance Madhuca Indica J. F. Gmel. (Sapotaceae) has shown antioxidant, anti-inflammatory, analgesic, anti-diabetic and hepatoprotective potential. It has been traditionally used as laxative, tonic, anti-burn, anti-earthworm, wound healing and headache. Aim of the study To investigate the efficacy and possible mechanism of Madhuca Indica J. F. Gmel. leaves methanolic extract (MI-ALC) and its isolated chloroform fraction (D3) against experimental induced gastric ulcers. Materials and methods D3 was isolated from MI-ALC, well characterized (HPTLC, FT-IR, 1H-NMR and LC–MS) and evaluated for its gastroprotective activity by using acetic acid induced ulcer in male Wistar rats (150–200 g). D3 (2.5, 5 and 10 mg/kg, p.o.) were administered for the period of 14 days. At the end of treatment, rats were sacrificed to collect the stomach sample for evaluation of antioxidant (SOD, GSH, and MDA) enzyme, oxido-inflammatory (TNF-α, IL-1, iNOs) and prostaglandins (COX-II) markers by using RT-PCR. Results The structure and molecular weight (MW) of the isolated compound (D3) were confirmed by 1D and 2D spectral data and characterized as 3,5,7,3′,4′-Pentahydroxy flavone with MW C15H10O7. Administration of 3,5,7,3′,4′-Pentahydroxy flavone (5 and 10 mg/kg) significantly and dose-dependently inhibited (P Conclusion Finding of present investigation suggests that MI-ALC possessed potent antiulcer activity due to the presence of 3,5,7,3′,4′-Pentahydroxy flavone via its oxido-inflammatory and prostaglandins modulatory potential.
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Antiulcer activity of aqueous extract of leaves of Madhuca Indica J. F. Gmel against naproxen induced gastric mucosal injury in rats
Wolters Kluwer Medknow Publications, 2013Co-Authors: Smeeta M Mohod, Subhash L BodhankarAbstract:Objective: To evaluate antiulcer potential of aqueous extract of Madhuca Indica (M. Indica) J. F. Gmel leaves in rats. Methods: Aqueous extract of M. Indica J.F. Gmel leaves was tested at the dose of 100, 200 and 400 mg/kg, p.o. against naproxen (30 mg/kg, p.o) induced gastric ulcer. Omeprazole (30 mg kg, p.o.) was used as a positive standard. Ulcerated area was measured by Image J software. Various antioxidant parameter like SOD, GSH, MDA, MPO, NO and histamine were also determined. Results: After 4 week treatment period, desired aim was achieved using aqueous extract of plant of M. Indica at the dose of 200 and 400 mg/kg, p.o. (P
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antiulcer activity of aqueous extract of leaves of Madhuca Indica j f gmel against naproxen induced gastric mucosal injury in rats
Journal of acute disease, 2013Co-Authors: Smeeta M Mohod, Subhash L BodhankarAbstract:Abstract Objective To evaluate antiulcer potential of aqueous extract of Madhuca Indica (M. Indica) J. F. Gmel leaves in rats. Methods Aqueous extract of M. Indica J.F. Gmel leaves was tested at the dose of 100, 200 and 400 mg/kg, p.o. against naproxen (30 mg/kg, p.o) induced gastric ulcer. Omeprazole (30 mg kg, p.o.) was used as a positive standard. Ulcerated area was measured by Image J software. Various antioxidant parameter like SOD, GSH, MDA, MPO, NO and histamine were also determined. Results After 4 week treatment period, desired aim was achieved using aqueous extract of plant of M. Indica at the dose of 200 and 400 mg/kg, p.o. (P Conclusions Our finding suggests that aqueous extract of M. Indica J.F. Gmel leaves is effective in gastric ulcer protection.
Sukumar Puhan - One of the best experts on this subject based on the ideXlab platform.
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mahua oil Madhuca Indica oil derivatives as a renewable fuel for diesel engine systems in india a performance and emissions comparative study
International Journal of Green Energy, 2007Co-Authors: Sukumar Puhan, N Vedaraman, G Nagarajan, B V RamabramhmamAbstract:In the present investigation methyl and ethyl ester of mahua oil was prepared by trensesterification, using sulfuric acid (H2SO4) as a catalyst, and tested in a 4-stroke direct injection naturally-aspirated diesel engine. Tests were conducted at a constant speed of 1500 rev/min at varying brake mean effective pressures. Results showed that brake thermal efficiency of mahua oil ethyl ester was comparable to diesel. It was observed that the thermal efficiency at full load for diesel was 26.36%, whereas it was 28.3% for mahua oil methyl (MOME) and 26.42% for ethyl ester (MOEE). Emissions of hydrocarbon (HC), carbon monoxide (CO) and Bosch smoke numbers (BSN) were comparatively lower than that of diesel fuel. The highest reduction in HC emission observed in methyl ester was 60%, compared to 49% for ethyl ester. In the case of CO emission, 79% reduction was observed with methyl ester and 67% for ethyl ester. Oxides of nitrogen emission were comparatively lower and the data observed was 9% for methyl ester and ...
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mahua Madhuca Indica seed oil a source of renewable energy in india
Journal of Scientific & Industrial Research, 2005Co-Authors: Sukumar Puhan, N Vedaraman, B V Rambrahamam, G NagarajanAbstract:Mahua oil methyl, ethyl and butyl esters were prepared and studied in a four stroke, direct injection diesel engine for their performance and emissions. The engine test results showed high thermal efficiency in case of methyl ester compared to all other esters and diesel fuel. Different emissions such as carbon monoxide (CO), oxides of nitrogen (NO x ), hydrocarbons (HC) is low for alkyl esters compared to diesel. Among alkyl esters except NO, all tail pipe emissions are lower in case of methyl ester compared to other esters. The ethyl ester shows lower NO x emission compared to other esters. Based on this study mahua oil methyl ester performs well compared to other esters on the basis of performance and emissions.
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performance and emission study of mahua oil Madhuca Indica oil ethyl ester in a 4 stroke natural aspirated direct injection diesel engine
Renewable Energy, 2005Co-Authors: Sukumar Puhan, N Vedaraman, G SankaranarayananAbstract:In this investigation, Mahua Oil Ethyl Ester was prepared by transesterification using sulfuric acid (H2SO4) as catalyst and tested in a 4-stroke direct injection natural aspirated diesel engine. Tests were carried out at constant speed of 1500rev/min at different brake mean effective pressures. Results showed that brake thermal efficiency of Mahua Oil Ethyl Ester (MOEE) was comparable with diesel and it was observed that 26.36% for diesel whereas 26.42% for MOEE. Emissions of carbon monoxide, hydrocarbons, oxides of nitrogen and Bosch smoke number were reduced around 58, 63, 12 and 70%, respectively, in case of MOEE compared to diesel. Based on this study, MOEE can be used a substitute for diesel in diesel engine.
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mahua oil Madhuca Indica seed oil methyl ester as biodiesel preparation and emission characterstics
Biomass & Bioenergy, 2005Co-Authors: Sukumar Puhan, N Vedaraman, G Sankarnarayanan, K JeychandranAbstract:Abstract There is an increasing interest in many countries to search for suitable alternative fuels that are environment friendly. Although straight vegetable oils can be used in diesel engines, their high viscosities, low volatilities and poor cold flow properties have led to the investigation of various derivatives. Biodiesel is a fatty acid alkyl ester, which can be derived from any vegetable oil by transesterification. Biodiesel is a renewable, biodegradable and non-toxic fuel. In this study, Mahua oil (Madhuca Indica seed oil) was transesterified with methanol using sodium hydroxide as catalyst to obtain mahua oil methyl ester. This biodiesel was tested in a single cylinder, four stroke, direct injection, constant speed, compression ignition diesel engine (Kirloskar) to evaluate the performance and emissions.
