The Experts below are selected from a list of 15 Experts worldwide ranked by ideXlab platform
Marine Saint-riquier - One of the best experts on this subject based on the ideXlab platform.
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Calcium pyrophosphate deposition (CPPD) in a liver transplant patient: are hypomagnesemia, tacrolimus or both guilty? A case-based literature review
Rheumatology International, 2021Co-Authors: Simon Cadiou, Pascal Guggenbuhl, Antonia Gruyer, Baptiste Giguet, François Robin, Morgane Milin, Xavier Guennoc, Marine Saint-riquierAbstract:Calcium pyrophosphate deposition (CPPD) can be induced by a persistent hypomagnesemia. Tacrolimus is an immunosuppressive treatment especially used in organ transplant, potentially inducer of hypomagnesemia by renal loss. A 53-year-old man, liver transplant 10 months earlier, developed an acute peripheral oligoarthritis of wrist, hip and elbow with fever, associated with acute low back pain. Synovial fluid was sterile, and revealed calcium pyrophosphate crystals. Spinal imaging showed inflammatory changes. Magnesium Blood Level was low at 0.51 mmol/l, with high fractional excretion in favor of renal loss. Tacrolimus was changed for everolimus, proton pump inhibitor was stopped, and Magnesium oral supplementation was started. After 8 months follow-up and slow prednisone tapering, he did not relapse pain. Persistent hypomagnesemia is a rare secondary cause of CPPD. In this entity, drug liability should be investigated such as tacrolimus in organ transplant patient.
Tat'yana Igorevna Ushakova - One of the best experts on this subject based on the ideXlab platform.
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Magnesium DEFICIENCY OF PATIENTS WITH HORMONE DEPENDENT DISEASES: PHARMACOEPIDEMIOLOGICAL PROFILE AND LIFE QUALITY ASSESSMENT
Farmakoèkonomika, 2015Co-Authors: Dmitry Vladislavovich Blinov, Juliana Vladimirovna Zimovina, Elena Anatol'evna Sandakova, Tat'yana Igorevna UshakovaAbstract:Magnesium deficiency (MD) as a condition connected with wide spectrum of obstetric pathology is more studied and known than in gynecology. Prevalence of MD in patients with gynecological diseases is unknown. The most interesting is connection with hormonal dependent conditions because Magnesium plays important role in hormonal metabolism. Objective. Describe the profile of outpatient women in hormone dependent conditions with MD and evaluate the effectiveness of therapy against MD including quality of life (QoL). Materials and methods. Study was performed in 21 cities of 7 Russian regions. The disease part included outpatient women in hormone dependent conditions and the product part included outpatient women in hormone dependent conditions with Magnesium deficiency and receiving fixed dose combination of Magnesium citrate and pyridoxine. For diagnostic of MD doctors used MD questionnaires and Magnesium Blood Level. For estimation of efficacy of the therapy additionally 10-point scale of changes in the MD symptoms severity as well as quality of life questionnaire the World Health Organization WHOQOL-BREF after 4 weeks therapy were used. Study results. A total of 9.168 women were enrolled. The disease part included 9.168 women and the product part – 2.101 women. Prevalence of MD in group of patients taken hormonal contraceptives was 67.3%; in women with premenstrual syndrome – 73.8%; in patients with climacteric syndrome without menopausal hormonal therapy (MHT) – 72.3%; in patient with climacteric syndrome taken MHT – 79.4%; in patients with osteoporosis – 82.1%; in women with other hormone depended conditions – 76.2%. Effectiveness of the therapy was estimated as full well and well in 89.4%, tolerability – in 92.4% patients. QoL was statistically improved. The survey results indicate that after 4 weeks of the therapy the satisfaction of patients with their physical and well-being significantly increased from 21.1±4.5 to 26.2±3.5 points (p
Simon Cadiou - One of the best experts on this subject based on the ideXlab platform.
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Calcium pyrophosphate deposition (CPPD) in a liver transplant patient: are hypomagnesemia, tacrolimus or both guilty? A case-based literature review
Rheumatology International, 2021Co-Authors: Simon Cadiou, Pascal Guggenbuhl, Antonia Gruyer, Baptiste Giguet, François Robin, Morgane Milin, Xavier Guennoc, Marine Saint-riquierAbstract:Calcium pyrophosphate deposition (CPPD) can be induced by a persistent hypomagnesemia. Tacrolimus is an immunosuppressive treatment especially used in organ transplant, potentially inducer of hypomagnesemia by renal loss. A 53-year-old man, liver transplant 10 months earlier, developed an acute peripheral oligoarthritis of wrist, hip and elbow with fever, associated with acute low back pain. Synovial fluid was sterile, and revealed calcium pyrophosphate crystals. Spinal imaging showed inflammatory changes. Magnesium Blood Level was low at 0.51 mmol/l, with high fractional excretion in favor of renal loss. Tacrolimus was changed for everolimus, proton pump inhibitor was stopped, and Magnesium oral supplementation was started. After 8 months follow-up and slow prednisone tapering, he did not relapse pain. Persistent hypomagnesemia is a rare secondary cause of CPPD. In this entity, drug liability should be investigated such as tacrolimus in organ transplant patient.
Dmitry Vladislavovich Blinov - One of the best experts on this subject based on the ideXlab platform.
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Magnesium DEFICIENCY OF PATIENTS WITH HORMONE DEPENDENT DISEASES: PHARMACOEPIDEMIOLOGICAL PROFILE AND LIFE QUALITY ASSESSMENT
Farmakoèkonomika, 2015Co-Authors: Dmitry Vladislavovich Blinov, Juliana Vladimirovna Zimovina, Elena Anatol'evna Sandakova, Tat'yana Igorevna UshakovaAbstract:Magnesium deficiency (MD) as a condition connected with wide spectrum of obstetric pathology is more studied and known than in gynecology. Prevalence of MD in patients with gynecological diseases is unknown. The most interesting is connection with hormonal dependent conditions because Magnesium plays important role in hormonal metabolism. Objective. Describe the profile of outpatient women in hormone dependent conditions with MD and evaluate the effectiveness of therapy against MD including quality of life (QoL). Materials and methods. Study was performed in 21 cities of 7 Russian regions. The disease part included outpatient women in hormone dependent conditions and the product part included outpatient women in hormone dependent conditions with Magnesium deficiency and receiving fixed dose combination of Magnesium citrate and pyridoxine. For diagnostic of MD doctors used MD questionnaires and Magnesium Blood Level. For estimation of efficacy of the therapy additionally 10-point scale of changes in the MD symptoms severity as well as quality of life questionnaire the World Health Organization WHOQOL-BREF after 4 weeks therapy were used. Study results. A total of 9.168 women were enrolled. The disease part included 9.168 women and the product part – 2.101 women. Prevalence of MD in group of patients taken hormonal contraceptives was 67.3%; in women with premenstrual syndrome – 73.8%; in patients with climacteric syndrome without menopausal hormonal therapy (MHT) – 72.3%; in patient with climacteric syndrome taken MHT – 79.4%; in patients with osteoporosis – 82.1%; in women with other hormone depended conditions – 76.2%. Effectiveness of the therapy was estimated as full well and well in 89.4%, tolerability – in 92.4% patients. QoL was statistically improved. The survey results indicate that after 4 weeks of the therapy the satisfaction of patients with their physical and well-being significantly increased from 21.1±4.5 to 26.2±3.5 points (p
Pascal Guggenbuhl - One of the best experts on this subject based on the ideXlab platform.
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Calcium pyrophosphate deposition (CPPD) in a liver transplant patient: are hypomagnesemia, tacrolimus or both guilty? A case-based literature review
Rheumatology International, 2021Co-Authors: Simon Cadiou, Pascal Guggenbuhl, Antonia Gruyer, Baptiste Giguet, François Robin, Morgane Milin, Xavier Guennoc, Marine Saint-riquierAbstract:Calcium pyrophosphate deposition (CPPD) can be induced by a persistent hypomagnesemia. Tacrolimus is an immunosuppressive treatment especially used in organ transplant, potentially inducer of hypomagnesemia by renal loss. A 53-year-old man, liver transplant 10 months earlier, developed an acute peripheral oligoarthritis of wrist, hip and elbow with fever, associated with acute low back pain. Synovial fluid was sterile, and revealed calcium pyrophosphate crystals. Spinal imaging showed inflammatory changes. Magnesium Blood Level was low at 0.51 mmol/l, with high fractional excretion in favor of renal loss. Tacrolimus was changed for everolimus, proton pump inhibitor was stopped, and Magnesium oral supplementation was started. After 8 months follow-up and slow prednisone tapering, he did not relapse pain. Persistent hypomagnesemia is a rare secondary cause of CPPD. In this entity, drug liability should be investigated such as tacrolimus in organ transplant patient.
