The Experts below are selected from a list of 94170 Experts worldwide ranked by ideXlab platform
Jinhao Gao - One of the best experts on this subject based on the ideXlab platform.
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multifunctional Magnetic Nanoparticles design synthesis and biomedical applications
Accounts of Chemical Research, 2009Co-Authors: Jinhao Gao, Hongwei Gu, Bing XuAbstract:The combination of nanotechnology and molecular biology has developed into an emerging research area: nanobiotechnology. Magnetic Nanoparticles are well-established nanomaterials that offer controlled size, ability to be manipulated externally, and enhancement of contrast in Magnetic resonance imaging (MRI). As a result, these Nanoparticles could have many applications in biology and medicine, including protein purification, drug delivery, and medical imaging. Because of the potential benefits of multimodal functionality in biomedical applications, researchers would like to design and fabricate multifunctional Magnetic Nanoparticles. Currently, there are two strategies to fabricate Magnetic nanoparticle-based multifunctional nanostructures. The first, molecular functionalization, involves attaching antibodies, proteins, and dyes to the Magnetic Nanoparticles. The other method integrates the Magnetic Nanoparticles with other functional nanocomponents, such as quantum dots (QDs) or metallic Nanoparticles. B...
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multifunctional Magnetic Nanoparticles design synthesis and biomedical applications
Accounts of Chemical Research, 2009Co-Authors: Jinhao GaoAbstract:The combination of nanotechnology and molecular biology has developed into an emerging research area: nanobiotechnology. Magnetic Nanoparticles are well-established nanomaterials that offer controlled size, ability to be manipulated externally, and enhancement of contrast in Magnetic resonance imaging (MRI). As a result, these Nanoparticles could have many applications in biology and medicine, including protein purification, drug delivery, and medical imaging. Because of the potential benefits of multimodal functionality in biomedical applications, researchers would like to design and fabricate multifunctional Magnetic Nanoparticles. Currently, there are two strategies to fabricate Magnetic nanoparticle-based multifunctional nanostructures. The first, molecular functionalization, involves attaching antibodies, proteins, and dyes to the Magnetic Nanoparticles. The other method integrates the Magnetic Nanoparticles with other functional nanocomponents, such as quantum dots (QDs) or metallic Nanoparticles. Because they can exhibit several features synergistically and deliver more than one function simultaneously, such multifunctional Magnetic Nanoparticles could have unique advantages in biomedical applications. In this Account, we review examples of the design and biomedical application of multifunctional Magnetic Nanoparticles. After their conjugation with proper ligands, antibodies, or proteins, the biofunctional Magnetic Nanoparticles exhibit highly selective binding. These results indicate that such Nanoparticles could be applied to biological medical problems such as protein purification, bacterial detection, and toxin decorporation. The hybrid nanostructures, which combine Magnetic Nanoparticles with other nanocomponents, exhibit paramagnetism alongside features such as fluorescence or enhanced optical contrast. Such structures could provide a platform for enhanced medical imaging and controlled drug delivery. We expect that the combination of unique structural characteristics and integrated functions of multicomponent Magnetic Nanoparticles will attract increasing research interest and could lead to new opportunities in nanomedicine.
Takeshi Kobayashi - One of the best experts on this subject based on the ideXlab platform.
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Cancer hyperthermia using Magnetic Nanoparticles
Biotechnology Journal, 2011Co-Authors: Takeshi KobayashiAbstract:Magnetic-nanoparticle-mediated intracellular hyperthermia has the potential to achieve localized tumor heating without any side effects. The technique consists of targeting Magnetic Nanoparticles to tumor tissue followed by application of an external alternating Magnetic field that induces heat through Neel relaxation loss of the Magnetic Nanoparticles. The temperature in tumor tissue is increased to above 43°C, which causes necrosis of cancer cells, but does not damage surrounding normal tissue. Among Magnetic Nanoparticles available, magnetite has been extensively studied. Recent years have seen remarkable advances in magnetite-nanoparticle-mediated hyperthermia; both functional magnetite Nanoparticles and alternating-Magnetic-field generators have been developed. In addition to the expected tumor cell death, hyperthermia treatment has also induced unexpected biological responses, such as tumor-specific immune responses as a result of heat-shock protein expression. These results suggest that hyperthermia is able to kill not only local tumors exposed to heat treatment, but also tumors at distant sites, including metastatic cancer cells. Currently, several research centers have begun clinical trials with promising results, suggesting that the time may have come for clinical applications. This review describes recent advances in magnetite nanoparticle-mediated hyperthermia.
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Medical application of functionalized Magnetic Nanoparticles
Journal of Bioscience and Bioengineering, 2005Co-Authors: Akira Ito, Masashige Shinkai, Hiroyuki Honda, Takeshi KobayashiAbstract:Since Magnetic particles have unique features, the development of a variety of medical applications has been possible. The most unique feature of Magnetic particles is their reaction to a Magnetic force, and this feature has been utilized in applications such as drug targeting and bioseparation including cell sorting. Recently, Magnetic Nanoparticles have attracted attention because of their potential as contrast agents for Magnetic resonance imaging (MRI) and heating mediators for cancer therapy (hyperthermia). Magnetite cationic liposomes (MCLs), one of the groups of cationic Magnetic particles, can be used as carriers to introduce magnetite Nanoparticles into target cells since their positively charged surface interacts with the negatively charged cell surface; furthermore, they find applications to hyperthermic treatments. Magnetite Nanoparticles conjugated with antibodies (antibody-conjugated magnetoliposomes, AMLs) are also applied to hyperthermia and have enabled tumor-specific contrast enhancement in MRI via systemic administration. Since Magnetic Nanoparticles are attracted to a high Magnetic flux density, it is possible to manipulate cells labeled with Magnetic Nanoparticles using magnets; this feature has been applied in tissue engineering. Magnetic force and MCLs were used to construct multilayered cell structures and a heterotypic layered 3D coculture system. Thus, the applications of these functionalized Magnetic Nanoparticles with their unique features will further improve medical techniques.
Bing Xu - One of the best experts on this subject based on the ideXlab platform.
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multifunctional Magnetic Nanoparticles design synthesis and biomedical applications
Accounts of Chemical Research, 2009Co-Authors: Jinhao Gao, Hongwei Gu, Bing XuAbstract:The combination of nanotechnology and molecular biology has developed into an emerging research area: nanobiotechnology. Magnetic Nanoparticles are well-established nanomaterials that offer controlled size, ability to be manipulated externally, and enhancement of contrast in Magnetic resonance imaging (MRI). As a result, these Nanoparticles could have many applications in biology and medicine, including protein purification, drug delivery, and medical imaging. Because of the potential benefits of multimodal functionality in biomedical applications, researchers would like to design and fabricate multifunctional Magnetic Nanoparticles. Currently, there are two strategies to fabricate Magnetic nanoparticle-based multifunctional nanostructures. The first, molecular functionalization, involves attaching antibodies, proteins, and dyes to the Magnetic Nanoparticles. The other method integrates the Magnetic Nanoparticles with other functional nanocomponents, such as quantum dots (QDs) or metallic Nanoparticles. B...
Hongwei Gu - One of the best experts on this subject based on the ideXlab platform.
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multifunctional Magnetic Nanoparticles design synthesis and biomedical applications
Accounts of Chemical Research, 2009Co-Authors: Jinhao Gao, Hongwei Gu, Bing XuAbstract:The combination of nanotechnology and molecular biology has developed into an emerging research area: nanobiotechnology. Magnetic Nanoparticles are well-established nanomaterials that offer controlled size, ability to be manipulated externally, and enhancement of contrast in Magnetic resonance imaging (MRI). As a result, these Nanoparticles could have many applications in biology and medicine, including protein purification, drug delivery, and medical imaging. Because of the potential benefits of multimodal functionality in biomedical applications, researchers would like to design and fabricate multifunctional Magnetic Nanoparticles. Currently, there are two strategies to fabricate Magnetic nanoparticle-based multifunctional nanostructures. The first, molecular functionalization, involves attaching antibodies, proteins, and dyes to the Magnetic Nanoparticles. The other method integrates the Magnetic Nanoparticles with other functional nanocomponents, such as quantum dots (QDs) or metallic Nanoparticles. B...
Domingo F. Barber - One of the best experts on this subject based on the ideXlab platform.
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Development of Magnetic Nanoparticles for Cancer Gene Therapy: A Comprehensive Review
Nanomaterials, 2013Co-Authors: Vladimir Mulens, María Del Puerto Morales, Domingo F. BarberAbstract:Since they were first proposed as nonviral transfection agents for their gene-carrying capacity, Magnetic Nanoparticles have been studied thoroughly, both in vitro and in vivo. Great effort has been made to manufacture biocompatible Magnetic Nanoparticles for use in the theragnosis of cancer and other diseases. Here we survey recent advances in the study of Magnetic Nanoparticles, as well as the polymers and other coating layers currently available for gene therapy, their synthesis, and bioconjugation processes. In addition, we review several gene therapy models based on Magnetic Nanoparticles.
