The Experts below are selected from a list of 30651 Experts worldwide ranked by ideXlab platform
F Parent - One of the best experts on this subject based on the ideXlab platform.
-
endothelial cell dysfunction a Major Player in sars cov 2 infection covid 19
European Respiratory Journal, 2020Co-Authors: Alice Huertas, David Montani, Laurent Savale, Jeremie Pichon, F ParentAbstract:Coronavirus disease 2019 (COVID-19) represents a public health crisis of pandemic proportions. Caused by SARS-CoV-2, which stands for severe acute respiratory syndrome (SARS) coronavirus 2, the symptoms most commonly reported include cough, fever, and shortness of breath, but also extra-pulmonary symptoms, such as neurological and gastroenterological manifestations.
Goodman Giora - One of the best experts on this subject based on the ideXlab platform.
-
Star Power: Kirk Douglas, celebrity activism and the Hollywood-Israel connection
'Oxford University Press (OUP)', 2022Co-Authors: Shaw Tony, Goodman GioraAbstract:© The Author(s) 2020. Published by Oxford University Press on behalf of Institute of Historical Research. All rights reservedThis article scrutinizes the actor Kirk Douglas’s pro-Israeli advocacy over six decades, both on the screen and off it, setting this within the contexts of the Arab-Israeli conflict and the links between Hollywood and Zionism. It looks at why and how Douglas supported Israel and considers what the star’s advocacy says about the history of celebrity activism and the interconnections between the American Jewish community, Hollywood and Israel. The article argues that Douglas was a Major Player in the special relationship that developed between Hollywood and Israel after 1948, one that, despite recent troubles, endures to this day.Peer reviewe
-
Star Power: Kirk Douglas, celebrity activism and the Hollywood-Israel connection
'Oxford University Press (OUP)', 2022Co-Authors: Shaw Tony, Goodman GioraAbstract:© The Author(s) 2020. Published by Oxford University Press on behalf of Institute of Historical Research. All rights reservedThis article scrutinizes the actor Kirk Douglas’s pro-Israeli advocacy over six decades, both on the screen and off it, setting this within the contexts of the Arab-Israeli conflict and the links between Hollywood and Zionism. It looks at why and how Douglas supported Israel and considers what the star’s advocacy says about the history of celebrity activism and the interconnections between the American Jewish community, Hollywood and Israel. The article argues that Douglas was a Major Player in the special relationship that developed between Hollywood and Israel after 1948, one that, despite recent troubles, endures to this day.Peer reviewedFinal Accepted Versio
Sabina A Antoniu - One of the best experts on this subject based on the ideXlab platform.
-
Terguride for pulmonary arterial hypertension.
Expert Opinion on Therapeutic Targets, 2011Co-Authors: Sabina A AntoniuAbstract:Introduction: The serotonin pathway was initially identified as a Major Player in the pathogenesis of a subset of anorexigen-induced pulmonary arterial hypertension (PAH). It has subsequently been shown to be involved in other forms of PAH. Areas covered: In preclinical experiments, terguride (an anatagonist of type 2 serotonin receptors) was found to reduce proliferation of smooth muscle cells and accumulation of collagen, and decrease pulmonary arterial pressure. Expert opinion: Most therapies currently available for PAH primarily tackle vasoconstriction and endothelial dysfunction, whereas vascular remodeling, which is an early pathogenic event in PAH development, is secondary. If terguride demonstrates a prominent antiremodelling effect in PAH, it could be used as a specific therapy for this rare disease.
Alice Huertas - One of the best experts on this subject based on the ideXlab platform.
-
endothelial cell dysfunction a Major Player in sars cov 2 infection covid 19
European Respiratory Journal, 2020Co-Authors: Alice Huertas, David Montani, Laurent Savale, Jeremie Pichon, F ParentAbstract:Coronavirus disease 2019 (COVID-19) represents a public health crisis of pandemic proportions. Caused by SARS-CoV-2, which stands for severe acute respiratory syndrome (SARS) coronavirus 2, the symptoms most commonly reported include cough, fever, and shortness of breath, but also extra-pulmonary symptoms, such as neurological and gastroenterological manifestations.
Pieter Evenepoel - One of the best experts on this subject based on the ideXlab platform.
-
from skeletal to cardiovascular disease in 12 steps the evolution of sclerostin as a Major Player in ckd mbd
Pediatric Nephrology, 2016Co-Authors: Vincent Brandenburg, Annika Deck, Djalila Mekahli, Björn Meijers, Ellen Neven, Patrick C Dhaese, Pieter EvenepoelAbstract:Canonical Wnt signaling activity contributes to physiological and adaptive bone mineralization and is an essential Player in bone remodeling. Sclerostin is a prototypic soluble canonical Wnt signaling pathway inhibitor that is produced in osteocytes and blocks osteoblast differentiation and function. Therefore, sclerostin is a potent inhibitor of bone formation and mineralization. Accordingly, rodent sclerostin-deficiency models exhibit a strong bone phenotype. Moreover, blocking sclerostin represents a promising treatment perspective against osteoporosis. Beyond the bone field novel data definitely associate Wnt signaling in general and sclerostin in particular with ectopic extraosseous mineralization processes, as is evident in cardiovascular calcification or calciphylaxis. Uremia is characterized by parallel occurrence of disordered bone mineralization and accelerated cardiovascular calcification (chronic kidney disease – mineral and bone disorder, CKD-MBD), linking skeletal and cardiovascular disease—the so-called bone-vascular calcification paradox. In consequence, sclerostin may qualify as an emerging Player in CKD-MBD. We present a stepwise review approach regarding the rapidly evolving field sclerostin participation in CKD-MBD. Starting from data originating in the classical bone field we look separately at three Major areas of CKD-MBD: disturbed mineral metabolism, renal osteodystrophy, and uremic cardiovascular disease. Our review is intended to help the nephrologist revise the potential importance of sclerostin in CKD by focusing on how sclerostin research is gradually evolving from the classical osteoporosis niche into the area of CKD-MBD. In particular, we integrate the limited amount of available data in the context of pediatric nephrology.
