The Experts below are selected from a list of 327 Experts worldwide ranked by ideXlab platform
Michael B Cook - One of the best experts on this subject based on the ideXlab platform.
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tobacco and alcohol in relation to Male Breast cancer an analysis of the Male Breast cancer pooling project consortium
Cancer Epidemiology Biomarkers & Prevention, 2015Co-Authors: Michael B Cook, Pascal Guenel, Susan M Gapstur, Piet A Van Den Brandt, Karin B Michels, John T Casagrande, Rosie Cooke, Stephen K Van Den Eeden, Marianne EwertzAbstract:Background: The etiology of Male Breast cancer is poorly understood, partly due to its relative rarity. Although tobacco and alcohol exposures are known carcinogens, their association with Male Breast cancer risk remains ill-defined. Methods: The Male Breast Cancer Pooling Project consortium provided 2,378 cases and 51,959 controls for analysis from 10 case-control and 10 cohort studies. Individual participant data were harmonized and pooled. Unconditional logistic regression was used to estimate study design-specific (case-control/cohort) odds ratios (OR) and 95% confidence intervals (CI), which were then combined using fixed effects meta-analysis. Results: Cigarette smoking status, smoking pack-years, duration, intensity, and age at initiation were not associated with Male Breast cancer risk. Relations with cigar and pipe smoking, tobacco chewing, and snuff use were also null. Recent alcohol consumption and average grams of alcohol consumed per day were also not associated with risk; only one sub-analysis of very high recent alcohol consumption (>60 grams/day) was tentatively associated with Male Breast cancer (ORunexposed referent=1.29, 95%CI:0.97-1.71; OR>0-<7 g/day referent=1.36, 95%CI:1.04-1.77). Specific alcoholic beverage types were not associated with Male Breast cancer. Relations were not altered when stratified by age or body mass index. Conclusions: In this analysis of the Male Breast Cancer Pooling Project we found little evidence that tobacco and alcohol exposures were associated with risk of Male Breast cancer. Impact: Tobacco and alcohol do not appear to be carcinogenic for Male Breast cancer. Future studies should aim to assess these exposures in relation to subtypes of Male Breast cancer.
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Tobacco and Alcohol in Relation to Male Breast Cancer: An Analysis of the Male Breast Cancer Pooling Project Consortium
Cancer Epidemiology Biomarkers & Prevention, 2014Co-Authors: Michael B Cook, Pascal Guenel, Susan M Gapstur, Piet A Van Den Brandt, Karin B Michels, John T Casagrande, Rosie Cooke, Stephen K Van Den Eeden, Marianne Ewertz, Roni T. FalkAbstract:Background: The etiology of Male Breast cancer is poorly understood, partly due to its relative rarity. Although tobacco and alcohol exposures are known carcinogens, their association with Male Breast cancer risk remains ill-defined. Methods: The Male Breast Cancer Pooling Project consortium provided 2,378 cases and 51,959 controls for analysis from 10 case-control and 10 cohort studies. Individual participant data were harmonized and pooled. Unconditional logistic regression was used to estimate study design-specific (case-control/cohort) odds ratios (OR) and 95% confidence intervals (CI), which were then combined using fixed effects meta-analysis. Results: Cigarette smoking status, smoking pack-years, duration, intensity, and age at initiation were not associated with Male Breast cancer risk. Relations with cigar and pipe smoking, tobacco chewing, and snuff use were also null. Recent alcohol consumption and average grams of alcohol consumed per day were also not associated with risk; only one sub-analysis of very high recent alcohol consumption (>60 grams/day) was tentatively associated with Male Breast cancer (ORunexposed referent=1.29, 95%CI:0.97-1.71; OR>0-
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anthropometric and hormonal risk factors for Male Breast cancer Male Breast cancer pooling project results
Journal of the National Cancer Institute, 2014Co-Authors: Louise A Brinton, Michael B Cook, Susan M Gapstur, John T Casagrande, Rosie Cooke, Roni T. Falk, Valerie Mccormack, Kenneth C Johnson, Hakan Olsson, Mia M GaudetAbstract:The etiology of Male Breast cancer is poorly understood, partly because of its relative rarity. Although genetic factors are involved, less is known regarding the role of anthropometric and hormonally related risk factors.
Valerie Speirs - One of the best experts on this subject based on the ideXlab platform.
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Male Breast carcinoma increased awareness needed
Breast Cancer Research, 2011Co-Authors: Jonathan White, O Kearins, David Dodwell, Kieran Horgan, Andrew M Hanby, Valerie SpeirsAbstract:Male Breast carcinoma is a rare condition. Few Male Breast cancer-specific epidemiological or clinical trial data are available - our understanding of Male Breast cancer thus comes from studies of feMale Breast cancer, painting an inaccurate picture when it comes to determining contributing factors. Clinicians report an increase in diagnoses of Male Breast cancer but this has not been formally reported. We therefore undertook a review of data obtained from four western nations: England, Scotland, Canada and Australia. When adjusted for age, this review clearly showed an increase in the incidence of Male Breast cancer over a 15-year period. Reasons for the increased incidence are discussed in the context of suggested risk factors such as BRCA2 and lifestyle changes over the past few decades. The clinical management of Male Breast carcinoma is considered, in particular the potential role of aromatase inhibitors and fulvestrant and targeting pathways involving prolactin and androgen receptor.
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Conditions of the Male Breast: Gynaecomastia and Male Breast cancer (Review).
Molecular Medicine Reports, 2009Co-Authors: Laila Alali, Abeer M. Shaaban, Helen Honarpisheh, Valerie SpeirsAbstract:: Breast disease most commonly affects feMales; however, a small percentage of men are also affected. Understandably given its low incidence, awareness of Male Breast disease is low, particularly among the general population. We searched the Medline database from 1950 onwards using the search terms Male, Breast, neoplasms and gynaecomastia, and reviewed the conditions associated with Male Breast disease, examining some of the risk factors and discussing how these conditions are diagnosed and treated, and finally putting forward some suggestions for their future management.
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the rising incidence of Male Breast cancer
Breast Cancer Research and Treatment, 2009Co-Authors: Valerie Speirs, Abeer M. ShaabanAbstract:Although Breast cancer rates are declining in Western societies, quoted figures are restricted to feMale Breast cancer. Recently in this journal, Stang and Thomssen reversed this trend by analysing Male Breast cancer data from the SEER Program of the National Cancer Institute, which showed an increased incidence in Male Breast cancer of 1.0 per 100,000 in the late 1970s to around 1.2 per 100,000 at the start of this decade [1]. In the UK around 350 cases of Male Breast cancer are diagnosed annually [2]. To determine if this figure is changing, we reviewed data obtained from members of the United Kingdom Association of Cancer Registries (UKACR). In most cases data was provided directly from UKACR members both as absolute numbers (1981–2004) and European Age Standardised Rates (EASR; 1991– 2004). As shown in Fig. 1, Male Breast cancer incidence is increasing in the UK, paralleling US data which shows a concordant increase over a similar time period [1, 3]. This begs the question of why Male rates are rising. Age is the single biggest risk factor for Male Breast cancer. We are an ageing population and increased Male Breast cancer may well parallel increased longevity. However this increase is also reflected in ASR rates, which accounts for this. Nowadays, men are more health conscious and with increased public awareness of Breast cancer in general e.g. through pink ribbon campaigns, they may be much more likely to seek medical attention for Breast symptoms than ever before, which could contribute to increased diagnosis. Men who have been repeatedly exposed to radiation from a young age and over a long time period are at greater risk of developing Breast cancer [4]. One might expect that Males living within the fallout zone from the 1986 Chernobyl nuclear disaster (which included the UK) may be at greater risk. Although reports are sketchy, an article published in Croatian suggests that post-Chernobyl, the ratio of Male Breast cancer increased from 1:139 to 1:79 [5]. Rising levels of obesity resulting from physical inactivity and poor diet is a serious public health issue in both the US and UK and may be contributory to increasing Male Breast cancer. High estrogen levels are linked to Breast cancer and local estrogen biosynthesis by Breast tissue adipocytes may be an important factor in obese individuals. Increased use of pesticides, many of which are weakly estrogenic, by the agricultural industry and their subsequent introduction into the food chain could also add to rising trends. Increased alcohol intake has been associated with Male Breast cancer [6] and this is probably indirectly linked to alcohol-induced liver damage and subsequent hyperestrogenism. Liver cirrhosis is associated with increased estrogen levels which could increase Breast cancer risk. There are suggestions that this risk is higher when cirrhotic patients live longer [7]. The so-called ‘binge drinking’ culture that has developed in recent years, particularly in the UK could also be a casual factor. Although Male Breast cancer is rare, for the patient a diagnosis is often unexpected but it should be regarded as no less important than other ‘Male’ illnesses. Its rarity precludes randomised clinical trials but its rising trend, which seems likely to continue, suggests coordinated multi-centre approaches are necessary to accumulate V. Speirs (&) Leeds Institute of Molecular Medicine, Wellcome Trust Brenner Building, St James’s University Hospital, Leeds LS9 7TF, UK e-mail: v.speirs@leeds.ac.uk
Rosie Cooke - One of the best experts on this subject based on the ideXlab platform.
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tobacco and alcohol in relation to Male Breast cancer an analysis of the Male Breast cancer pooling project consortium
Cancer Epidemiology Biomarkers & Prevention, 2015Co-Authors: Michael B Cook, Pascal Guenel, Susan M Gapstur, Piet A Van Den Brandt, Karin B Michels, John T Casagrande, Rosie Cooke, Stephen K Van Den Eeden, Marianne EwertzAbstract:Background: The etiology of Male Breast cancer is poorly understood, partly due to its relative rarity. Although tobacco and alcohol exposures are known carcinogens, their association with Male Breast cancer risk remains ill-defined. Methods: The Male Breast Cancer Pooling Project consortium provided 2,378 cases and 51,959 controls for analysis from 10 case-control and 10 cohort studies. Individual participant data were harmonized and pooled. Unconditional logistic regression was used to estimate study design-specific (case-control/cohort) odds ratios (OR) and 95% confidence intervals (CI), which were then combined using fixed effects meta-analysis. Results: Cigarette smoking status, smoking pack-years, duration, intensity, and age at initiation were not associated with Male Breast cancer risk. Relations with cigar and pipe smoking, tobacco chewing, and snuff use were also null. Recent alcohol consumption and average grams of alcohol consumed per day were also not associated with risk; only one sub-analysis of very high recent alcohol consumption (>60 grams/day) was tentatively associated with Male Breast cancer (ORunexposed referent=1.29, 95%CI:0.97-1.71; OR>0-<7 g/day referent=1.36, 95%CI:1.04-1.77). Specific alcoholic beverage types were not associated with Male Breast cancer. Relations were not altered when stratified by age or body mass index. Conclusions: In this analysis of the Male Breast Cancer Pooling Project we found little evidence that tobacco and alcohol exposures were associated with risk of Male Breast cancer. Impact: Tobacco and alcohol do not appear to be carcinogenic for Male Breast cancer. Future studies should aim to assess these exposures in relation to subtypes of Male Breast cancer.
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Tobacco and Alcohol in Relation to Male Breast Cancer: An Analysis of the Male Breast Cancer Pooling Project Consortium
Cancer Epidemiology Biomarkers & Prevention, 2014Co-Authors: Michael B Cook, Pascal Guenel, Susan M Gapstur, Piet A Van Den Brandt, Karin B Michels, John T Casagrande, Rosie Cooke, Stephen K Van Den Eeden, Marianne Ewertz, Roni T. FalkAbstract:Background: The etiology of Male Breast cancer is poorly understood, partly due to its relative rarity. Although tobacco and alcohol exposures are known carcinogens, their association with Male Breast cancer risk remains ill-defined. Methods: The Male Breast Cancer Pooling Project consortium provided 2,378 cases and 51,959 controls for analysis from 10 case-control and 10 cohort studies. Individual participant data were harmonized and pooled. Unconditional logistic regression was used to estimate study design-specific (case-control/cohort) odds ratios (OR) and 95% confidence intervals (CI), which were then combined using fixed effects meta-analysis. Results: Cigarette smoking status, smoking pack-years, duration, intensity, and age at initiation were not associated with Male Breast cancer risk. Relations with cigar and pipe smoking, tobacco chewing, and snuff use were also null. Recent alcohol consumption and average grams of alcohol consumed per day were also not associated with risk; only one sub-analysis of very high recent alcohol consumption (>60 grams/day) was tentatively associated with Male Breast cancer (ORunexposed referent=1.29, 95%CI:0.97-1.71; OR>0-
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anthropometric and hormonal risk factors for Male Breast cancer Male Breast cancer pooling project results
Journal of the National Cancer Institute, 2014Co-Authors: Louise A Brinton, Michael B Cook, Susan M Gapstur, John T Casagrande, Rosie Cooke, Roni T. Falk, Valerie Mccormack, Kenneth C Johnson, Hakan Olsson, Mia M GaudetAbstract:The etiology of Male Breast cancer is poorly understood, partly because of its relative rarity. Although genetic factors are involved, less is known regarding the role of anthropometric and hormonally related risk factors.
Susan M Gapstur - One of the best experts on this subject based on the ideXlab platform.
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tobacco and alcohol in relation to Male Breast cancer an analysis of the Male Breast cancer pooling project consortium
Cancer Epidemiology Biomarkers & Prevention, 2015Co-Authors: Michael B Cook, Pascal Guenel, Susan M Gapstur, Piet A Van Den Brandt, Karin B Michels, John T Casagrande, Rosie Cooke, Stephen K Van Den Eeden, Marianne EwertzAbstract:Background: The etiology of Male Breast cancer is poorly understood, partly due to its relative rarity. Although tobacco and alcohol exposures are known carcinogens, their association with Male Breast cancer risk remains ill-defined. Methods: The Male Breast Cancer Pooling Project consortium provided 2,378 cases and 51,959 controls for analysis from 10 case-control and 10 cohort studies. Individual participant data were harmonized and pooled. Unconditional logistic regression was used to estimate study design-specific (case-control/cohort) odds ratios (OR) and 95% confidence intervals (CI), which were then combined using fixed effects meta-analysis. Results: Cigarette smoking status, smoking pack-years, duration, intensity, and age at initiation were not associated with Male Breast cancer risk. Relations with cigar and pipe smoking, tobacco chewing, and snuff use were also null. Recent alcohol consumption and average grams of alcohol consumed per day were also not associated with risk; only one sub-analysis of very high recent alcohol consumption (>60 grams/day) was tentatively associated with Male Breast cancer (ORunexposed referent=1.29, 95%CI:0.97-1.71; OR>0-<7 g/day referent=1.36, 95%CI:1.04-1.77). Specific alcoholic beverage types were not associated with Male Breast cancer. Relations were not altered when stratified by age or body mass index. Conclusions: In this analysis of the Male Breast Cancer Pooling Project we found little evidence that tobacco and alcohol exposures were associated with risk of Male Breast cancer. Impact: Tobacco and alcohol do not appear to be carcinogenic for Male Breast cancer. Future studies should aim to assess these exposures in relation to subtypes of Male Breast cancer.
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Tobacco and Alcohol in Relation to Male Breast Cancer: An Analysis of the Male Breast Cancer Pooling Project Consortium
Cancer Epidemiology Biomarkers & Prevention, 2014Co-Authors: Michael B Cook, Pascal Guenel, Susan M Gapstur, Piet A Van Den Brandt, Karin B Michels, John T Casagrande, Rosie Cooke, Stephen K Van Den Eeden, Marianne Ewertz, Roni T. FalkAbstract:Background: The etiology of Male Breast cancer is poorly understood, partly due to its relative rarity. Although tobacco and alcohol exposures are known carcinogens, their association with Male Breast cancer risk remains ill-defined. Methods: The Male Breast Cancer Pooling Project consortium provided 2,378 cases and 51,959 controls for analysis from 10 case-control and 10 cohort studies. Individual participant data were harmonized and pooled. Unconditional logistic regression was used to estimate study design-specific (case-control/cohort) odds ratios (OR) and 95% confidence intervals (CI), which were then combined using fixed effects meta-analysis. Results: Cigarette smoking status, smoking pack-years, duration, intensity, and age at initiation were not associated with Male Breast cancer risk. Relations with cigar and pipe smoking, tobacco chewing, and snuff use were also null. Recent alcohol consumption and average grams of alcohol consumed per day were also not associated with risk; only one sub-analysis of very high recent alcohol consumption (>60 grams/day) was tentatively associated with Male Breast cancer (ORunexposed referent=1.29, 95%CI:0.97-1.71; OR>0-
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anthropometric and hormonal risk factors for Male Breast cancer Male Breast cancer pooling project results
Journal of the National Cancer Institute, 2014Co-Authors: Louise A Brinton, Michael B Cook, Susan M Gapstur, John T Casagrande, Rosie Cooke, Roni T. Falk, Valerie Mccormack, Kenneth C Johnson, Hakan Olsson, Mia M GaudetAbstract:The etiology of Male Breast cancer is poorly understood, partly because of its relative rarity. Although genetic factors are involved, less is known regarding the role of anthropometric and hormonally related risk factors.
John T Casagrande - One of the best experts on this subject based on the ideXlab platform.
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tobacco and alcohol in relation to Male Breast cancer an analysis of the Male Breast cancer pooling project consortium
Cancer Epidemiology Biomarkers & Prevention, 2015Co-Authors: Michael B Cook, Pascal Guenel, Susan M Gapstur, Piet A Van Den Brandt, Karin B Michels, John T Casagrande, Rosie Cooke, Stephen K Van Den Eeden, Marianne EwertzAbstract:Background: The etiology of Male Breast cancer is poorly understood, partly due to its relative rarity. Although tobacco and alcohol exposures are known carcinogens, their association with Male Breast cancer risk remains ill-defined. Methods: The Male Breast Cancer Pooling Project consortium provided 2,378 cases and 51,959 controls for analysis from 10 case-control and 10 cohort studies. Individual participant data were harmonized and pooled. Unconditional logistic regression was used to estimate study design-specific (case-control/cohort) odds ratios (OR) and 95% confidence intervals (CI), which were then combined using fixed effects meta-analysis. Results: Cigarette smoking status, smoking pack-years, duration, intensity, and age at initiation were not associated with Male Breast cancer risk. Relations with cigar and pipe smoking, tobacco chewing, and snuff use were also null. Recent alcohol consumption and average grams of alcohol consumed per day were also not associated with risk; only one sub-analysis of very high recent alcohol consumption (>60 grams/day) was tentatively associated with Male Breast cancer (ORunexposed referent=1.29, 95%CI:0.97-1.71; OR>0-<7 g/day referent=1.36, 95%CI:1.04-1.77). Specific alcoholic beverage types were not associated with Male Breast cancer. Relations were not altered when stratified by age or body mass index. Conclusions: In this analysis of the Male Breast Cancer Pooling Project we found little evidence that tobacco and alcohol exposures were associated with risk of Male Breast cancer. Impact: Tobacco and alcohol do not appear to be carcinogenic for Male Breast cancer. Future studies should aim to assess these exposures in relation to subtypes of Male Breast cancer.
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Tobacco and Alcohol in Relation to Male Breast Cancer: An Analysis of the Male Breast Cancer Pooling Project Consortium
Cancer Epidemiology Biomarkers & Prevention, 2014Co-Authors: Michael B Cook, Pascal Guenel, Susan M Gapstur, Piet A Van Den Brandt, Karin B Michels, John T Casagrande, Rosie Cooke, Stephen K Van Den Eeden, Marianne Ewertz, Roni T. FalkAbstract:Background: The etiology of Male Breast cancer is poorly understood, partly due to its relative rarity. Although tobacco and alcohol exposures are known carcinogens, their association with Male Breast cancer risk remains ill-defined. Methods: The Male Breast Cancer Pooling Project consortium provided 2,378 cases and 51,959 controls for analysis from 10 case-control and 10 cohort studies. Individual participant data were harmonized and pooled. Unconditional logistic regression was used to estimate study design-specific (case-control/cohort) odds ratios (OR) and 95% confidence intervals (CI), which were then combined using fixed effects meta-analysis. Results: Cigarette smoking status, smoking pack-years, duration, intensity, and age at initiation were not associated with Male Breast cancer risk. Relations with cigar and pipe smoking, tobacco chewing, and snuff use were also null. Recent alcohol consumption and average grams of alcohol consumed per day were also not associated with risk; only one sub-analysis of very high recent alcohol consumption (>60 grams/day) was tentatively associated with Male Breast cancer (ORunexposed referent=1.29, 95%CI:0.97-1.71; OR>0-
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anthropometric and hormonal risk factors for Male Breast cancer Male Breast cancer pooling project results
Journal of the National Cancer Institute, 2014Co-Authors: Louise A Brinton, Michael B Cook, Susan M Gapstur, John T Casagrande, Rosie Cooke, Roni T. Falk, Valerie Mccormack, Kenneth C Johnson, Hakan Olsson, Mia M GaudetAbstract:The etiology of Male Breast cancer is poorly understood, partly because of its relative rarity. Although genetic factors are involved, less is known regarding the role of anthropometric and hormonally related risk factors.