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Yeonsoon Ahn - One of the best experts on this subject based on the ideXlab platform.
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p202 the association between blood lead level and clinical mental disorders in fifty thousand lead exposed Male Workers
Occupational and Environmental Medicine, 2016Co-Authors: Yeonsoon Ahn, Jinha YoonAbstract:While there has been research into the relationship between blood lead (BPb) level and mental disorders, there have been few investigations that use clinically diagnosed mental disorders in the adult population with a retrospective cohort study design. Hence, our study investigated the association between BPb level and risk of clinically diagnosed mental disorders. The data of Male Workers exposed to lead (Pb; n = 54,788) were collected from annual Pb associated medical check-ups from 2000 to 2004 in Korea. The Workers’ hospital admission histories due to mental disorders (International Classification of Diseases, 10th revision, F00–F99) were used to identify clinically diagnosed mental disorders. After merging the data, the hazard ratio (HR) with a 95% confidence interval (95% CI) was calculated by survival analysis using the Cox proportional hazards model according to the quartile level of BPb (1st quartile In a total of 54,788 Workers, there were 223 admission cases of mental disorders (F00–F99) during the follow-up period. The HR (95% CI) of total mental and behavioural disorders (F00–F99) was 1.63 (1.12–2.39) in the 4th quartile group compared to the HR of the 1st quartile group after adjusting for age. The HR (95% CI) of the 4th quartile group was 2.59 (1.15–5.82) for mood (affective) disorders (F30–F39). Our study highlighted that Pb exposure can cause clinical mental disorders that require hospital admission in adult Male Workers. Our relatively large sample size strengthens the evidence of the association between BPb level and risk of clinically diagnosed mental disorders.
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the association between blood lead level and clinical mental disorders in fifty thousand lead exposed Male Workers
Journal of Affective Disorders, 2016Co-Authors: Jinha Yoon, Yeonsoon AhnAbstract:Background While there has been research into the relationship between blood lead (BPb) level and mental disorders, there have been few investigations that use clinically diagnosed mental disorders in the adult population with a retrospective cohort study design. Hence, our study investigated the association between BPb level and risk of clinically diagnosed mental disorders. Methods The data of Male Workers exposed to lead (Pb; n=54,788) were collected from annual Pb associated medical check-ups from 2000 to 2004 in Korea. The Workers' hospital admission histories due to mental disorders (International Classification of Diseases, 10th revision, F00–F99) were used to identify clinically diagnosed mental disorders. After merging the data, the hazard ratio (HR) with a 95% confidence interval (95% CI) was calculated by survival analysis using the Cox proportional hazards model according to the quartile level of BPb (1st quartile<4.10 μg/dl, 2nd quartile<6.04 μg/dl, 3rd quartile<10.00 μg/dl, and 4th quartile≥10 μg/dl). Results In a total of 54,788 Workers, there were 223 admission cases of mental disorders (F00–F99) during the follow-up period. The HR (95% CI) of total mental and behavioral disorders (F00–F99) was 1.63 (1.12–2.39) in the 4th quartile group compared to the HR of the 1st quartile group after adjusting for age. The HR (95% CI) of the 4th quartile group was 2.59 (1.15–5.82) for mood (affective) disorders (F30–F39). Limitation The hospital admission data, not outpatient data, were used for current study while almost affective disorder treated at outpatient clinic level. Conclusion Our study highlighted that Pb exposure can cause clinical mental disorders that require hospital admission in adult Male Workers. Our relatively large sample size strengthens the evidence of the association between BPb level and risk of clinically diagnosed mental disorders.
Jinha Yoon - One of the best experts on this subject based on the ideXlab platform.
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p202 the association between blood lead level and clinical mental disorders in fifty thousand lead exposed Male Workers
Occupational and Environmental Medicine, 2016Co-Authors: Yeonsoon Ahn, Jinha YoonAbstract:While there has been research into the relationship between blood lead (BPb) level and mental disorders, there have been few investigations that use clinically diagnosed mental disorders in the adult population with a retrospective cohort study design. Hence, our study investigated the association between BPb level and risk of clinically diagnosed mental disorders. The data of Male Workers exposed to lead (Pb; n = 54,788) were collected from annual Pb associated medical check-ups from 2000 to 2004 in Korea. The Workers’ hospital admission histories due to mental disorders (International Classification of Diseases, 10th revision, F00–F99) were used to identify clinically diagnosed mental disorders. After merging the data, the hazard ratio (HR) with a 95% confidence interval (95% CI) was calculated by survival analysis using the Cox proportional hazards model according to the quartile level of BPb (1st quartile In a total of 54,788 Workers, there were 223 admission cases of mental disorders (F00–F99) during the follow-up period. The HR (95% CI) of total mental and behavioural disorders (F00–F99) was 1.63 (1.12–2.39) in the 4th quartile group compared to the HR of the 1st quartile group after adjusting for age. The HR (95% CI) of the 4th quartile group was 2.59 (1.15–5.82) for mood (affective) disorders (F30–F39). Our study highlighted that Pb exposure can cause clinical mental disorders that require hospital admission in adult Male Workers. Our relatively large sample size strengthens the evidence of the association between BPb level and risk of clinically diagnosed mental disorders.
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the association between blood lead level and clinical mental disorders in fifty thousand lead exposed Male Workers
Journal of Affective Disorders, 2016Co-Authors: Jinha Yoon, Yeonsoon AhnAbstract:Background While there has been research into the relationship between blood lead (BPb) level and mental disorders, there have been few investigations that use clinically diagnosed mental disorders in the adult population with a retrospective cohort study design. Hence, our study investigated the association between BPb level and risk of clinically diagnosed mental disorders. Methods The data of Male Workers exposed to lead (Pb; n=54,788) were collected from annual Pb associated medical check-ups from 2000 to 2004 in Korea. The Workers' hospital admission histories due to mental disorders (International Classification of Diseases, 10th revision, F00–F99) were used to identify clinically diagnosed mental disorders. After merging the data, the hazard ratio (HR) with a 95% confidence interval (95% CI) was calculated by survival analysis using the Cox proportional hazards model according to the quartile level of BPb (1st quartile<4.10 μg/dl, 2nd quartile<6.04 μg/dl, 3rd quartile<10.00 μg/dl, and 4th quartile≥10 μg/dl). Results In a total of 54,788 Workers, there were 223 admission cases of mental disorders (F00–F99) during the follow-up period. The HR (95% CI) of total mental and behavioral disorders (F00–F99) was 1.63 (1.12–2.39) in the 4th quartile group compared to the HR of the 1st quartile group after adjusting for age. The HR (95% CI) of the 4th quartile group was 2.59 (1.15–5.82) for mood (affective) disorders (F30–F39). Limitation The hospital admission data, not outpatient data, were used for current study while almost affective disorder treated at outpatient clinic level. Conclusion Our study highlighted that Pb exposure can cause clinical mental disorders that require hospital admission in adult Male Workers. Our relatively large sample size strengthens the evidence of the association between BPb level and risk of clinically diagnosed mental disorders.
Sei Jin Chang - One of the best experts on this subject based on the ideXlab platform.
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Job stress and cardiovascular risk factors in Male Workers
Preventive Medicine, 2005Co-Authors: Myung Gun Kang, Sang Baek Koh, Bong Suk Cha, Jong-ku Park, Soon Koo Baik, Sei Jin ChangAbstract:Abstract Background . This study examined whether job stress (work demand and decision latitude) is associated with smoking, blood pressure, lipid level (total cholesterol, triglyceride, HDL cholesterol), and homocystein as risk factors for cardiovascular disease in Korean Male Workers. Methods . Study subjects of this study were recruited from a sample of 1,071 Workers in 20 companies of W city and H counties, and they were grouped into four categories (high strain group, active group, passive group, and low strain group) based on the postulation of Karasek's Job Strain Model. Of them, we invited 160 Male Workers (40 people each subgroup) using a stratified sampling, and finally, 152 eligible participants were analyzed. Results . In multivariate analyses, we found that decision latitude was associated with cholesterol, triglyceride, and homocystein and that work demand was related to smoking and systolic blood pressure. Job strain (the combination of high work demand with low decision latitude) was significantly related to higher levels of homocystein after controlling for age, BMI, smoking, and social support at workplace. Conclusions . These results indicate that job stress is associated with cardiovascular risk factors and might contribute to the development of cardiovascular disease. Some considerations for the future research were discussed.
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analysis of the role of social support on job stress and psychosocial stress in automobile factory Workers using structural equation model
Annals of occupational and environmental medicine, 2005Co-Authors: Dong Hee Koh, Sei Jin Chang, Sun Sil Han, Hyoung Ryoul Kim, Sun Haeng Choi, Jong Uk Won, Jaehoon RohAbstract:Objectives: Social support was previously regarded as acting only a stress modifier, but many recent studies have found a direct effect on stress. The purpose of this study is to evaluate the role of social support on job stress and psychosocial stress to determine whether it acts via direct effect or indirect effect. Methods: This study was performed in May 2003. The study population consisted of 425 Male Workers in an automobile factory in Korea. Data were collected with structured self-administered questionnaires. We used JCQ(Job
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association between job stress on heart rate variability and metabolic syndrome in shipyard Male Workers
Yonsei Medical Journal, 2004Co-Authors: Myung Guen Kang, Jong-ku Park, Sei Jin ChangAbstract:A growing body of literature has documented that job stress is associated with the development of cardiovascular disease. Nevertheless, the pathophysiological mechanism of this association remains unclear. The purpose of this study is to elucidate the relationship between job stress, heart rate variability, and metabolic syndrome. The study design was cross-sectional, and a total of 169 industrial Workers were recruited. A structured-questionnaire was used to assess the general characteristics and job characteristics (work demand, decision latitude). Heart rate variability (HRV) was recorded using SA-2000 (medi-core), and was assessed by time-domain and by frequency-domain analyses. Time domain analysis was performed using SDNN (Standard Deviation of normal to normal interval), and spectral analysis using low-frequency (LF), high-frequency (HF), and total frequency power. Metabolic syndrome was defined on the basis of risk factors being clustered when three or more of the following cardiovascular risk factors were included in the fifth quintile: glucose, systolic blood pressure, high-density lipoprotein cholesterol (bottom quintile), triglyceride, and waist-hip ratio. The results showed that job characteristics were not associated with cardiovascular risk factors. Compared to the lower strain group (low strain+passive+active group), the high strain group had a less favorable cardiovascular risk profile with higher levels of blood pressure, glucose, homocysteine, and clotting factor, but the difference was not statistically significant. The SDNN of HRV was significantly lower in the high strain group than in the low strain group. The prevalence of metabolic syndrome in the lower strain group and high strain group was 13.2% and 23.8%, respectively. In the high strain group, the metabolic syndrome was significantly related to a decreased SDNN. However, we could not find a significant association in LF/HF ratio. This result suggests that decreased HRV found in the high-strain group are not a direct indicator of disease. However, it can induce cardiovascular abnormalities or dysfunctions related to the onset of heart disease among high risk groups.
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job characteristics and blood coagulation factors in korean Male Workers
Journal of Occupational and Environmental Medicine, 2002Co-Authors: Sei Jin Chang, Sang Baek Koh, Bong Suk Cha, Jong-ku ParkAbstract:This study examined the possible relationship between Karasek's job strain model and blood coagulation factors VII and VIII as risk factors for cardiovascular disease in Korean Male Workers. Based on the postulation of the model, we invited 160 Male Workers (40 people each subgroup) using a stratified sampling from the base population (n = 1071). In univariate analyses, decision latitude was negatively related to blood coagulation factors VII and VIII. Work demand was positively related to coagulation factor VIII, but not to factor VII. Hierarchical multiple regression analyses showed that job strain was associated with blood coagulation factor VIII after controlling for smoking, blood pressure, total cholesterol, and HDL cholesterol. These results indicate that job characteristics may be related to blood coagulation, and contribute to the development of cardiovascular disease with other classical risk factors.
David Zaridze - One of the best experts on this subject based on the ideXlab platform.
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cancer mortality among feMale and Male Workers occupationally exposed to inorganic lead in the printing industry
Occupational and Environmental Medicine, 2012Co-Authors: Svetlana A Ilychova, David ZaridzeAbstract:Objective Evaluation of the carcinogenicity of lead for humans has been based primarily on the results of studies on occupationally exposed men, although gender differences in lead metabolism have been reported. In addition, most of the previous studies have been limited by a failure to identify and control for co-exposures to other known occupational carcinogens. The present study follows an industrial cohort of Workers, mostly women, with moderate lead exposure and no confounding by other occupational exposures. Methods Workers, employed at least 2 years between 1950 and 1978 in manual and mechanical (linotype) typesetting and type foundries in 27 printing plants in Moscow, were included in the cohort, which comprised 1423 men and 3102 women. The cohort was followed up during 1979–2003 and contributed 93 682 person-years of observation. Follow-up was 97.7% complete. Standardised mortality ratios (SMRs) and 95% CIs, based on mortality rates of the Moscow general population and adjusted for gender, age and calendar time, were calculated for the total cohort as well as subcohorts stratified by various exposure parameters. Results Among women, mortality from all causes, circulatory diseases and all cancers combined was lower than that in the Moscow general population and was similar across work groups. Among men, there was excess overall mortality, mainly due to increased mortality from ischaemic heart disease. For both sexes, no significant excess risk for any cancer site was observed, although some dose–response patterns were found. In the overall cohort, mortality from cancers of the kidney and pancreas increased up to twofold in the highest tertile of cumulative lead exposure based on duration and a relative ranking of the three subcohorts (9 deaths; SMR=2.12, 95% CI 1.10 to 4.07) and (18 deaths; SMR=2.32, 95% CI 1.46 to 3.68), respectively. Similar mortality trends for these two cancers were found in analyses by gender. Conclusions Consistencies by sex and exposure level make a strong case for a link between exposure to inorganic lead and cancers of the kidney and pancreas.
Jong-ku Park - One of the best experts on this subject based on the ideXlab platform.
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Job stress and cardiovascular risk factors in Male Workers
Preventive Medicine, 2005Co-Authors: Myung Gun Kang, Sang Baek Koh, Bong Suk Cha, Jong-ku Park, Soon Koo Baik, Sei Jin ChangAbstract:Abstract Background . This study examined whether job stress (work demand and decision latitude) is associated with smoking, blood pressure, lipid level (total cholesterol, triglyceride, HDL cholesterol), and homocystein as risk factors for cardiovascular disease in Korean Male Workers. Methods . Study subjects of this study were recruited from a sample of 1,071 Workers in 20 companies of W city and H counties, and they were grouped into four categories (high strain group, active group, passive group, and low strain group) based on the postulation of Karasek's Job Strain Model. Of them, we invited 160 Male Workers (40 people each subgroup) using a stratified sampling, and finally, 152 eligible participants were analyzed. Results . In multivariate analyses, we found that decision latitude was associated with cholesterol, triglyceride, and homocystein and that work demand was related to smoking and systolic blood pressure. Job strain (the combination of high work demand with low decision latitude) was significantly related to higher levels of homocystein after controlling for age, BMI, smoking, and social support at workplace. Conclusions . These results indicate that job stress is associated with cardiovascular risk factors and might contribute to the development of cardiovascular disease. Some considerations for the future research were discussed.
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association between job stress on heart rate variability and metabolic syndrome in shipyard Male Workers
Yonsei Medical Journal, 2004Co-Authors: Myung Guen Kang, Jong-ku Park, Sei Jin ChangAbstract:A growing body of literature has documented that job stress is associated with the development of cardiovascular disease. Nevertheless, the pathophysiological mechanism of this association remains unclear. The purpose of this study is to elucidate the relationship between job stress, heart rate variability, and metabolic syndrome. The study design was cross-sectional, and a total of 169 industrial Workers were recruited. A structured-questionnaire was used to assess the general characteristics and job characteristics (work demand, decision latitude). Heart rate variability (HRV) was recorded using SA-2000 (medi-core), and was assessed by time-domain and by frequency-domain analyses. Time domain analysis was performed using SDNN (Standard Deviation of normal to normal interval), and spectral analysis using low-frequency (LF), high-frequency (HF), and total frequency power. Metabolic syndrome was defined on the basis of risk factors being clustered when three or more of the following cardiovascular risk factors were included in the fifth quintile: glucose, systolic blood pressure, high-density lipoprotein cholesterol (bottom quintile), triglyceride, and waist-hip ratio. The results showed that job characteristics were not associated with cardiovascular risk factors. Compared to the lower strain group (low strain+passive+active group), the high strain group had a less favorable cardiovascular risk profile with higher levels of blood pressure, glucose, homocysteine, and clotting factor, but the difference was not statistically significant. The SDNN of HRV was significantly lower in the high strain group than in the low strain group. The prevalence of metabolic syndrome in the lower strain group and high strain group was 13.2% and 23.8%, respectively. In the high strain group, the metabolic syndrome was significantly related to a decreased SDNN. However, we could not find a significant association in LF/HF ratio. This result suggests that decreased HRV found in the high-strain group are not a direct indicator of disease. However, it can induce cardiovascular abnormalities or dysfunctions related to the onset of heart disease among high risk groups.
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job characteristics and blood coagulation factors in korean Male Workers
Journal of Occupational and Environmental Medicine, 2002Co-Authors: Sei Jin Chang, Sang Baek Koh, Bong Suk Cha, Jong-ku ParkAbstract:This study examined the possible relationship between Karasek's job strain model and blood coagulation factors VII and VIII as risk factors for cardiovascular disease in Korean Male Workers. Based on the postulation of the model, we invited 160 Male Workers (40 people each subgroup) using a stratified sampling from the base population (n = 1071). In univariate analyses, decision latitude was negatively related to blood coagulation factors VII and VIII. Work demand was positively related to coagulation factor VIII, but not to factor VII. Hierarchical multiple regression analyses showed that job strain was associated with blood coagulation factor VIII after controlling for smoking, blood pressure, total cholesterol, and HDL cholesterol. These results indicate that job characteristics may be related to blood coagulation, and contribute to the development of cardiovascular disease with other classical risk factors.
