The Experts below are selected from a list of 297 Experts worldwide ranked by ideXlab platform

S Marani - One of the best experts on this subject based on the ideXlab platform.

  • Zaldaride Maleate (a New Calmodulin Antagonist) Versus Loperamide in the Treatment of Traveler's Diarrhea: Randomized, Placebo-Controlled Trial
    2016
    Co-Authors: Pablo C Okhuysen, H L Dupont, C D Ericsson, S Marani, F. G. Martinez-s, M. A. Olesen, G. P. Ravelli
    Abstract:

    The present study was undertaken to compare the efficacy of a new calmodulin antagonist, zaldaride Maleate, with that of placebo or loperamide in persons with traveler's diarrhea. One hundred seventy-nine patients were randomized to receive loperamide(4 mg followed by 2 mg after each unformed stool), zaldaride Maleate (20 mg four times per day), or placebo. During the initial 48 hours of therapy, zaldaride Maleate decreased the number of unformed stools by 30 % and the duration of illnessby 23%when compared with placebo. Loperamidewas superior to both zaldaride Maleate and placebo during the initial hours of treatment. However, after 48 hours of treatment, loperamide and zaldaride Maleate were equally efficacious, decreasing by>50 % the number of unformed stools passed in a 24-hour interval (P, not significant), and were both superior when compared with placebo (P <.0001 and P =.0048, respectively). The apparent superiority of loperamide early in the course of therapy appeared to be related to a loading-dose effect and not to any differences in antidiarrheal properties. Zaldaride Maleate, a pyrrolo-benoxazepine with calmodulin-inhibiting properties, has previously been shown to be an effec-tive agent when compared with placebo for the treatment of diarrhea during short-term travel in Mexico [1]. Currently available antimotility agents, including loperamide, decrease gastrointestinal transit time, which may be deleterious in the treatment of certain enteric infections [2]. Thus, a distinct ad-vantage of this novel inhibitor is its effective antidiarrheal activity due to its antisecretory properties, which does not inter-fere with gastrointestinal transit time [3]. The objectives of the present study were to confirm the efficacy of zaldaride Maleate for the symptomatic relief of acute diarrhea and to compare its efficacy with that of loperamide, an agent with known antidiar-rheal activity [4]

  • zaldaride Maleate a new calmodulin antagonist versus loperamide in the treatment of traveler s diarrhea randomized placebo controlled trial
    Clinical Infectious Diseases, 1995
    Co-Authors: Pablo C Okhuysen, H L Dupont, C D Ericsson, S Marani
    Abstract:

    The present study was undertaken to compare the efficacy of a new calmodulin antagonist, zaldaride Maleate, with that of placebo or loperamide in persons with traveler's diarrhea. One hundred seventy-nine patients were randomized to receive loperamide (4 mg followed by 2 mg after each unformed stool), zaldaride Maleate (20 mg four times per day), or placebo. During the initial 48 hours of therapy, zaldaride Maleate decreased the number of unformed stools by 30% and the duration of illness by 23% when compared with placebo. Loperamide was superior to both zaldaride Maleate and placebo during the initial hours of treatment. However, after 48 hours of treatment, loperamide and zaldaride Maleate were equally efficacious, decreasing by >50% the number of unformed stools passed in a 24-hour interval (P, not significant), and were both superior when compared with placebo (P <.0001 and P =.0048, respectively). The apparent superiority of loperamide early in the course of therapy appeared to be related to a loading-dose effect and not to any differences in antidiarrheal properties.

Guoliang Ji - One of the best experts on this subject based on the ideXlab platform.

  • effect of low molecular weight organic anions on electrokinetic properties of variable charge soils
    Journal of Colloid and Interface Science, 2004
    Co-Authors: Ren-kou Xu, Chengbao Li, Guoliang Ji
    Abstract:

    Abstract It is known that some inorganic anions can be adsorbed by variable-charge soils specifically, resulting in the lowering of the ζ potential of the clay particle. Reasoning similarly, organic anions should also have such an effect. In this article, the effect of the anions of five low-molecular-weight (LMW) organic acids existing widely in soils on the ζ potentials of two variable-charge soils was examined. The results showed that the presence of organic anions led to a decrease in ζ potential. The effect of different anions on ζ potential followed the order oxalate>citrate>malate>Maleate>acetate. The effect increased with the increase in anion concentration and decreased with the increase in pH. The extent of the effect on different soils was apparently related to their iron oxide content. The presence of organic anions also led to a decrease in the isoelectric point (IEP) of the soil. The IEPs of two soils in organic anion systems followed the order acetate>Maleate>malate>citrate. No IEP was detected for the oxalate system.

  • effect of low molecular weight organic anions on electrokinetic properties of variable charge soils
    Journal of Colloid and Interface Science, 2004
    Co-Authors: Ren-kou Xu, Chengbao Li, Guoliang Ji
    Abstract:

    Abstract It is known that some inorganic anions can be adsorbed by variable-charge soils specifically, resulting in the lowering of the ζ potential of the clay particle. Reasoning similarly, organic anions should also have such an effect. In this article, the effect of the anions of five low-molecular-weight (LMW) organic acids existing widely in soils on the ζ potentials of two variable-charge soils was examined. The results showed that the presence of organic anions led to a decrease in ζ potential. The effect of different anions on ζ potential followed the order oxalate>citrate>malate>Maleate>acetate. The effect increased with the increase in anion concentration and decreased with the increase in pH. The extent of the effect on different soils was apparently related to their iron oxide content. The presence of organic anions also led to a decrease in the isoelectric point (IEP) of the soil. The IEPs of two soils in organic anion systems followed the order acetate>Maleate>malate>citrate. No IEP was detected for the oxalate system.

Ren-kou Xu - One of the best experts on this subject based on the ideXlab platform.

  • effect of low molecular weight organic anions on electrokinetic properties of variable charge soils
    Journal of Colloid and Interface Science, 2004
    Co-Authors: Ren-kou Xu, Chengbao Li, Guoliang Ji
    Abstract:

    Abstract It is known that some inorganic anions can be adsorbed by variable-charge soils specifically, resulting in the lowering of the ζ potential of the clay particle. Reasoning similarly, organic anions should also have such an effect. In this article, the effect of the anions of five low-molecular-weight (LMW) organic acids existing widely in soils on the ζ potentials of two variable-charge soils was examined. The results showed that the presence of organic anions led to a decrease in ζ potential. The effect of different anions on ζ potential followed the order oxalate>citrate>malate>Maleate>acetate. The effect increased with the increase in anion concentration and decreased with the increase in pH. The extent of the effect on different soils was apparently related to their iron oxide content. The presence of organic anions also led to a decrease in the isoelectric point (IEP) of the soil. The IEPs of two soils in organic anion systems followed the order acetate>Maleate>malate>citrate. No IEP was detected for the oxalate system.

  • effect of low molecular weight organic anions on electrokinetic properties of variable charge soils
    Journal of Colloid and Interface Science, 2004
    Co-Authors: Ren-kou Xu, Chengbao Li, Guoliang Ji
    Abstract:

    Abstract It is known that some inorganic anions can be adsorbed by variable-charge soils specifically, resulting in the lowering of the ζ potential of the clay particle. Reasoning similarly, organic anions should also have such an effect. In this article, the effect of the anions of five low-molecular-weight (LMW) organic acids existing widely in soils on the ζ potentials of two variable-charge soils was examined. The results showed that the presence of organic anions led to a decrease in ζ potential. The effect of different anions on ζ potential followed the order oxalate>citrate>malate>Maleate>acetate. The effect increased with the increase in anion concentration and decreased with the increase in pH. The extent of the effect on different soils was apparently related to their iron oxide content. The presence of organic anions also led to a decrease in the isoelectric point (IEP) of the soil. The IEPs of two soils in organic anion systems followed the order acetate>Maleate>malate>citrate. No IEP was detected for the oxalate system.

C D Ericsson - One of the best experts on this subject based on the ideXlab platform.

  • Zaldaride Maleate (a New Calmodulin Antagonist) Versus Loperamide in the Treatment of Traveler's Diarrhea: Randomized, Placebo-Controlled Trial
    2016
    Co-Authors: Pablo C Okhuysen, H L Dupont, C D Ericsson, S Marani, F. G. Martinez-s, M. A. Olesen, G. P. Ravelli
    Abstract:

    The present study was undertaken to compare the efficacy of a new calmodulin antagonist, zaldaride Maleate, with that of placebo or loperamide in persons with traveler's diarrhea. One hundred seventy-nine patients were randomized to receive loperamide(4 mg followed by 2 mg after each unformed stool), zaldaride Maleate (20 mg four times per day), or placebo. During the initial 48 hours of therapy, zaldaride Maleate decreased the number of unformed stools by 30 % and the duration of illnessby 23%when compared with placebo. Loperamidewas superior to both zaldaride Maleate and placebo during the initial hours of treatment. However, after 48 hours of treatment, loperamide and zaldaride Maleate were equally efficacious, decreasing by>50 % the number of unformed stools passed in a 24-hour interval (P, not significant), and were both superior when compared with placebo (P <.0001 and P =.0048, respectively). The apparent superiority of loperamide early in the course of therapy appeared to be related to a loading-dose effect and not to any differences in antidiarrheal properties. Zaldaride Maleate, a pyrrolo-benoxazepine with calmodulin-inhibiting properties, has previously been shown to be an effec-tive agent when compared with placebo for the treatment of diarrhea during short-term travel in Mexico [1]. Currently available antimotility agents, including loperamide, decrease gastrointestinal transit time, which may be deleterious in the treatment of certain enteric infections [2]. Thus, a distinct ad-vantage of this novel inhibitor is its effective antidiarrheal activity due to its antisecretory properties, which does not inter-fere with gastrointestinal transit time [3]. The objectives of the present study were to confirm the efficacy of zaldaride Maleate for the symptomatic relief of acute diarrhea and to compare its efficacy with that of loperamide, an agent with known antidiar-rheal activity [4]

  • zaldaride Maleate a new calmodulin antagonist versus loperamide in the treatment of traveler s diarrhea randomized placebo controlled trial
    Clinical Infectious Diseases, 1995
    Co-Authors: Pablo C Okhuysen, H L Dupont, C D Ericsson, S Marani
    Abstract:

    The present study was undertaken to compare the efficacy of a new calmodulin antagonist, zaldaride Maleate, with that of placebo or loperamide in persons with traveler's diarrhea. One hundred seventy-nine patients were randomized to receive loperamide (4 mg followed by 2 mg after each unformed stool), zaldaride Maleate (20 mg four times per day), or placebo. During the initial 48 hours of therapy, zaldaride Maleate decreased the number of unformed stools by 30% and the duration of illness by 23% when compared with placebo. Loperamide was superior to both zaldaride Maleate and placebo during the initial hours of treatment. However, after 48 hours of treatment, loperamide and zaldaride Maleate were equally efficacious, decreasing by >50% the number of unformed stools passed in a 24-hour interval (P, not significant), and were both superior when compared with placebo (P <.0001 and P =.0048, respectively). The apparent superiority of loperamide early in the course of therapy appeared to be related to a loading-dose effect and not to any differences in antidiarrheal properties.

H L Dupont - One of the best experts on this subject based on the ideXlab platform.

  • Zaldaride Maleate (a New Calmodulin Antagonist) Versus Loperamide in the Treatment of Traveler's Diarrhea: Randomized, Placebo-Controlled Trial
    2016
    Co-Authors: Pablo C Okhuysen, H L Dupont, C D Ericsson, S Marani, F. G. Martinez-s, M. A. Olesen, G. P. Ravelli
    Abstract:

    The present study was undertaken to compare the efficacy of a new calmodulin antagonist, zaldaride Maleate, with that of placebo or loperamide in persons with traveler's diarrhea. One hundred seventy-nine patients were randomized to receive loperamide(4 mg followed by 2 mg after each unformed stool), zaldaride Maleate (20 mg four times per day), or placebo. During the initial 48 hours of therapy, zaldaride Maleate decreased the number of unformed stools by 30 % and the duration of illnessby 23%when compared with placebo. Loperamidewas superior to both zaldaride Maleate and placebo during the initial hours of treatment. However, after 48 hours of treatment, loperamide and zaldaride Maleate were equally efficacious, decreasing by>50 % the number of unformed stools passed in a 24-hour interval (P, not significant), and were both superior when compared with placebo (P <.0001 and P =.0048, respectively). The apparent superiority of loperamide early in the course of therapy appeared to be related to a loading-dose effect and not to any differences in antidiarrheal properties. Zaldaride Maleate, a pyrrolo-benoxazepine with calmodulin-inhibiting properties, has previously been shown to be an effec-tive agent when compared with placebo for the treatment of diarrhea during short-term travel in Mexico [1]. Currently available antimotility agents, including loperamide, decrease gastrointestinal transit time, which may be deleterious in the treatment of certain enteric infections [2]. Thus, a distinct ad-vantage of this novel inhibitor is its effective antidiarrheal activity due to its antisecretory properties, which does not inter-fere with gastrointestinal transit time [3]. The objectives of the present study were to confirm the efficacy of zaldaride Maleate for the symptomatic relief of acute diarrhea and to compare its efficacy with that of loperamide, an agent with known antidiar-rheal activity [4]

  • zaldaride Maleate a new calmodulin antagonist versus loperamide in the treatment of traveler s diarrhea randomized placebo controlled trial
    Clinical Infectious Diseases, 1995
    Co-Authors: Pablo C Okhuysen, H L Dupont, C D Ericsson, S Marani
    Abstract:

    The present study was undertaken to compare the efficacy of a new calmodulin antagonist, zaldaride Maleate, with that of placebo or loperamide in persons with traveler's diarrhea. One hundred seventy-nine patients were randomized to receive loperamide (4 mg followed by 2 mg after each unformed stool), zaldaride Maleate (20 mg four times per day), or placebo. During the initial 48 hours of therapy, zaldaride Maleate decreased the number of unformed stools by 30% and the duration of illness by 23% when compared with placebo. Loperamide was superior to both zaldaride Maleate and placebo during the initial hours of treatment. However, after 48 hours of treatment, loperamide and zaldaride Maleate were equally efficacious, decreasing by >50% the number of unformed stools passed in a 24-hour interval (P, not significant), and were both superior when compared with placebo (P <.0001 and P =.0048, respectively). The apparent superiority of loperamide early in the course of therapy appeared to be related to a loading-dose effect and not to any differences in antidiarrheal properties.