The Experts below are selected from a list of 63 Experts worldwide ranked by ideXlab platform

Jacques Dantal - One of the best experts on this subject based on the ideXlab platform.

  • Clinical, Genetic and Innate Immunity Characteristics of Melanoma in Organ Transplant Recipients.
    Acta dermato-venereologica, 2017
    Co-Authors: Anabelle Brocard, Anne-chantal Knol, Céline Bossard, Marc G. Denis, Gaëlle Quéreux, Mélanie Saint-jean, Lucie Peuvrel, Amir Khammari, Gilles Blancho, Jacques Dantal
    Abstract:

    The aims of this study were to determine the clinical and histological characteristics of melanoma in transplant recipients, the mutation profile (BRAF, NRAS and c-KIT genes), and the immune tolerance of the tumour microenvironment by immunohistochemical study of the expression of indoleamine 2,3-dioxygenase (IDO), PD1, PD-L1, CD8 and FoxP3. The study population comprised patients who had undergone a renal transplant in Nantes University Hospital who developed post-transplantation melanoma. Twenty cases of melanoma out of 4,663 transplant recipients were studied. The results differed from the usual data with respect to melanoma site: 40% were located on the face and were of the Malignant Lentigo type. The mutation profile was concordant with that of the immunocompetent population. IDO was expressed in all the sections tested, while CD8, FoxP3, PD1 and PD-L1 were poorly expressed. This reflected a highly immunodepressed tumour environment, raising the question of the inductive role of IDO on tumour immune tolerance in patients presenting with long-term immunodepression.

  • Clinical, Genetic and Innate Immunity Characteristics of Melanoma in Organ Transplant Recipients
    Acta Dermato-Venereologica, 2016
    Co-Authors: Anabelle Brocard, Céline Bossard, Gaëlle Quéreux, Mélanie Saint-jean, Lucie Peuvrel, Amir Khammari, Gilles Blancho, Ac. Knol, M. Denis, Jacques Dantal
    Abstract:

    The aims of this study were to determine the clinical and histological characteristics of melanoma in transplant recipients, the mutation profile (BRAF, NRAS and c-KIT genes), and the immune tolerance of the tumour microenvironment by immunohistochemical study of the expression of IDO, PD1, PD-L1, CD8 and FoxP3. The study population comprised patients who had undergone a renal transplant in Nantes University Hospital who developed post-transplantation melanoma. Twenty cases of melanoma out of 4,663 transplant recipients were studied. The results differed from the usual data with respect to melanoma site: 40% were located on the face and were of the Malignant Lentigo type. The mutation profile was concordant with that of the immunocompetent population. IDO was expressed in all the sections tested, while CD8, FoxP3, PD1 and PD-L1 were poorly expressed. This reflected a highly immunodepressed tumour environment, raising the question of the inductive role of IDO on tumour immune tolerance in patients presenting with long-term immunodepression.

Anabelle Brocard - One of the best experts on this subject based on the ideXlab platform.

  • Clinical, Genetic and Innate Immunity Characteristics of Melanoma in Organ Transplant Recipients.
    Acta dermato-venereologica, 2017
    Co-Authors: Anabelle Brocard, Anne-chantal Knol, Céline Bossard, Marc G. Denis, Gaëlle Quéreux, Mélanie Saint-jean, Lucie Peuvrel, Amir Khammari, Gilles Blancho, Jacques Dantal
    Abstract:

    The aims of this study were to determine the clinical and histological characteristics of melanoma in transplant recipients, the mutation profile (BRAF, NRAS and c-KIT genes), and the immune tolerance of the tumour microenvironment by immunohistochemical study of the expression of indoleamine 2,3-dioxygenase (IDO), PD1, PD-L1, CD8 and FoxP3. The study population comprised patients who had undergone a renal transplant in Nantes University Hospital who developed post-transplantation melanoma. Twenty cases of melanoma out of 4,663 transplant recipients were studied. The results differed from the usual data with respect to melanoma site: 40% were located on the face and were of the Malignant Lentigo type. The mutation profile was concordant with that of the immunocompetent population. IDO was expressed in all the sections tested, while CD8, FoxP3, PD1 and PD-L1 were poorly expressed. This reflected a highly immunodepressed tumour environment, raising the question of the inductive role of IDO on tumour immune tolerance in patients presenting with long-term immunodepression.

  • Clinical, Genetic and Innate Immunity Characteristics of Melanoma in Organ Transplant Recipients
    Acta Dermato-Venereologica, 2016
    Co-Authors: Anabelle Brocard, Céline Bossard, Gaëlle Quéreux, Mélanie Saint-jean, Lucie Peuvrel, Amir Khammari, Gilles Blancho, Ac. Knol, M. Denis, Jacques Dantal
    Abstract:

    The aims of this study were to determine the clinical and histological characteristics of melanoma in transplant recipients, the mutation profile (BRAF, NRAS and c-KIT genes), and the immune tolerance of the tumour microenvironment by immunohistochemical study of the expression of IDO, PD1, PD-L1, CD8 and FoxP3. The study population comprised patients who had undergone a renal transplant in Nantes University Hospital who developed post-transplantation melanoma. Twenty cases of melanoma out of 4,663 transplant recipients were studied. The results differed from the usual data with respect to melanoma site: 40% were located on the face and were of the Malignant Lentigo type. The mutation profile was concordant with that of the immunocompetent population. IDO was expressed in all the sections tested, while CD8, FoxP3, PD1 and PD-L1 were poorly expressed. This reflected a highly immunodepressed tumour environment, raising the question of the inductive role of IDO on tumour immune tolerance in patients presenting with long-term immunodepression.

Dantal Jacques - One of the best experts on this subject based on the ideXlab platform.

  • Clinical, Genetic and Innate Immunity Characteristics of Melanoma in Organ Transplant Recipients
    'Acta Dermato-Venereologica', 2016
    Co-Authors: Brocard A., Ac. Knol, Bossard C., Denis M., Quereux G., Saint-jean M., Peuvrel L., Khammari Amir, Blancho G., Dantal Jacques
    Abstract:

    International audienceThe aims of this study were to determine the clinical and histological characteristics of melanoma in transplant recipients, the mutation profile (BRAF, NRAS and c-KIT genes), and the immune tolerance of the tumour microenvironment by immunohistochemical study of the expression of IDO, PD1, PD-L1, CD8 and FoxP3. The study population comprised patients who had undergone a renal transplant in Nantes University Hospital who developed post-transplantation melanoma. Twenty cases of melanoma out of 4,663 transplant recipients were studied. The results differed from the usual data with respect to melanoma site: 40% were located on the face and were of the Malignant Lentigo type. The mutation profile was concordant with that of the immunocompetent population. IDO was expressed in all the sections tested, while CD8, FoxP3, PD1 and PD-L1 were poorly expressed. This reflected a highly immunodepressed tumour environment, raising the question of the inductive role of IDO on tumour immune tolerance in patients presenting with long-term immunodepression

Ac. Knol - One of the best experts on this subject based on the ideXlab platform.

  • Clinical, Genetic and Innate Immunity Characteristics of Melanoma in Organ Transplant Recipients
    Acta Dermato-Venereologica, 2016
    Co-Authors: Anabelle Brocard, Céline Bossard, Gaëlle Quéreux, Mélanie Saint-jean, Lucie Peuvrel, Amir Khammari, Gilles Blancho, Ac. Knol, M. Denis, Jacques Dantal
    Abstract:

    The aims of this study were to determine the clinical and histological characteristics of melanoma in transplant recipients, the mutation profile (BRAF, NRAS and c-KIT genes), and the immune tolerance of the tumour microenvironment by immunohistochemical study of the expression of IDO, PD1, PD-L1, CD8 and FoxP3. The study population comprised patients who had undergone a renal transplant in Nantes University Hospital who developed post-transplantation melanoma. Twenty cases of melanoma out of 4,663 transplant recipients were studied. The results differed from the usual data with respect to melanoma site: 40% were located on the face and were of the Malignant Lentigo type. The mutation profile was concordant with that of the immunocompetent population. IDO was expressed in all the sections tested, while CD8, FoxP3, PD1 and PD-L1 were poorly expressed. This reflected a highly immunodepressed tumour environment, raising the question of the inductive role of IDO on tumour immune tolerance in patients presenting with long-term immunodepression.

  • Clinical, Genetic and Innate Immunity Characteristics of Melanoma in Organ Transplant Recipients
    'Acta Dermato-Venereologica', 2016
    Co-Authors: Brocard A., Ac. Knol, Bossard C., Denis M., Quereux G., Saint-jean M., Peuvrel L., Khammari Amir, Blancho G., Dantal Jacques
    Abstract:

    International audienceThe aims of this study were to determine the clinical and histological characteristics of melanoma in transplant recipients, the mutation profile (BRAF, NRAS and c-KIT genes), and the immune tolerance of the tumour microenvironment by immunohistochemical study of the expression of IDO, PD1, PD-L1, CD8 and FoxP3. The study population comprised patients who had undergone a renal transplant in Nantes University Hospital who developed post-transplantation melanoma. Twenty cases of melanoma out of 4,663 transplant recipients were studied. The results differed from the usual data with respect to melanoma site: 40% were located on the face and were of the Malignant Lentigo type. The mutation profile was concordant with that of the immunocompetent population. IDO was expressed in all the sections tested, while CD8, FoxP3, PD1 and PD-L1 were poorly expressed. This reflected a highly immunodepressed tumour environment, raising the question of the inductive role of IDO on tumour immune tolerance in patients presenting with long-term immunodepression

Amir Khammari - One of the best experts on this subject based on the ideXlab platform.

  • Clinical, Genetic and Innate Immunity Characteristics of Melanoma in Organ Transplant Recipients.
    Acta dermato-venereologica, 2017
    Co-Authors: Anabelle Brocard, Anne-chantal Knol, Céline Bossard, Marc G. Denis, Gaëlle Quéreux, Mélanie Saint-jean, Lucie Peuvrel, Amir Khammari, Gilles Blancho, Jacques Dantal
    Abstract:

    The aims of this study were to determine the clinical and histological characteristics of melanoma in transplant recipients, the mutation profile (BRAF, NRAS and c-KIT genes), and the immune tolerance of the tumour microenvironment by immunohistochemical study of the expression of indoleamine 2,3-dioxygenase (IDO), PD1, PD-L1, CD8 and FoxP3. The study population comprised patients who had undergone a renal transplant in Nantes University Hospital who developed post-transplantation melanoma. Twenty cases of melanoma out of 4,663 transplant recipients were studied. The results differed from the usual data with respect to melanoma site: 40% were located on the face and were of the Malignant Lentigo type. The mutation profile was concordant with that of the immunocompetent population. IDO was expressed in all the sections tested, while CD8, FoxP3, PD1 and PD-L1 were poorly expressed. This reflected a highly immunodepressed tumour environment, raising the question of the inductive role of IDO on tumour immune tolerance in patients presenting with long-term immunodepression.

  • Clinical, Genetic and Innate Immunity Characteristics of Melanoma in Organ Transplant Recipients
    Acta Dermato-Venereologica, 2016
    Co-Authors: Anabelle Brocard, Céline Bossard, Gaëlle Quéreux, Mélanie Saint-jean, Lucie Peuvrel, Amir Khammari, Gilles Blancho, Ac. Knol, M. Denis, Jacques Dantal
    Abstract:

    The aims of this study were to determine the clinical and histological characteristics of melanoma in transplant recipients, the mutation profile (BRAF, NRAS and c-KIT genes), and the immune tolerance of the tumour microenvironment by immunohistochemical study of the expression of IDO, PD1, PD-L1, CD8 and FoxP3. The study population comprised patients who had undergone a renal transplant in Nantes University Hospital who developed post-transplantation melanoma. Twenty cases of melanoma out of 4,663 transplant recipients were studied. The results differed from the usual data with respect to melanoma site: 40% were located on the face and were of the Malignant Lentigo type. The mutation profile was concordant with that of the immunocompetent population. IDO was expressed in all the sections tested, while CD8, FoxP3, PD1 and PD-L1 were poorly expressed. This reflected a highly immunodepressed tumour environment, raising the question of the inductive role of IDO on tumour immune tolerance in patients presenting with long-term immunodepression.