The Experts below are selected from a list of 4521 Experts worldwide ranked by ideXlab platform
Yuyu Sun - One of the best experts on this subject based on the ideXlab platform.
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silver sulfadiazine immobilized Celluloses as biocompatible polymeric biocides
Journal of Bioactive and Compatible Polymers, 2013Co-Authors: Zhengbing Cao, Xinbo Sun, Jinrong Yao, Yuyu SunAbstract:Sulfadiazine was immobilized onto cotton Cellulose using ethylene glycol diglycidyl ether as a binder. Upon treatment with diluted silver nitrate aqueous solution, the sulfadiazine moieties in the immobilized Celluloses were transformed into silver–sulfadiazine coordination complexes. The resulting silver sulfadiazine–immobilized Celluloses provided a 6-log reduction of 108 CFU mL−1 of Staphylococcus aureus (Gram-positive bacteria), Escherichia coli (Gram-negative bacteria), methicillin-resistant Staphylococcus aureus (drug-resistant bacteria), vancomycin-resistant Enterococcus faecium (drug-resistant bacteria), and Candida albicans (fungi) in 30–60 minutes, and a 5-log reduction of 107 PFU mL−1 of MS2 virus in 120 minutes. The antibacterial, antifungal, and antiviral activities were both durable and rechargeable. Additionally, trypan blue assay suggested that the new silver sulfadiazine–immobilized Celluloses sustained exCellent Mammal Cell viability, pointing to great potentials of the new materials for...
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Electrospun Composite Nanofiber Fabrics Containing Uniformly Dispersed Antimicrobial Agents As an Innovative Type of Polymeric Materials with Superior Antimicrobial Efficacy
ACS applied materials & interfaces, 2010Co-Authors: Xinbo Sun, Zhengbing Cao, Lifeng Zhang, Ying Deng, Li Liu, Hao Fong, Yuyu SunAbstract:Herein we report that electrospun composite nanofiber fabrics containing uniformly dispersed antimicrobial agents and having large surface-to-mass ratios are an innovative type of antimicrobial polymeric materials with durable, nonleachable, and biocompatible characteristics, and more importantly, superior antimicrobial efficacy. Specifically, electrospun Cellulose acetate (CA) nanofiber fabrics containing an N-halamine antimicrobial agent of bis(N-chloro-2,2,6,6-tetramethyl-4-piperidinyl) sebacate (Cl-BTMP) were prepared and evaluated; the results of antimicrobial efficacy indicated that the electrospun composite nanofiber fabrics substantially outperformed the control samples that were solution-cast films containing identical amounts of CA and Cl-BTMP. Additionally, the results of trypan blue assay test suggested that the electrospun composite nanofiber fabrics also had exCellent Mammal Cell viability. The developed electrospun composite nanofiber fabrics with superior antimicrobial efficacy are expected to find vital applications in biomedical, hygienic, and many other fields.
Xinbo Sun - One of the best experts on this subject based on the ideXlab platform.
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silver sulfadiazine immobilized Celluloses as biocompatible polymeric biocides
Journal of Bioactive and Compatible Polymers, 2013Co-Authors: Zhengbing Cao, Xinbo Sun, Jinrong Yao, Yuyu SunAbstract:Sulfadiazine was immobilized onto cotton Cellulose using ethylene glycol diglycidyl ether as a binder. Upon treatment with diluted silver nitrate aqueous solution, the sulfadiazine moieties in the immobilized Celluloses were transformed into silver–sulfadiazine coordination complexes. The resulting silver sulfadiazine–immobilized Celluloses provided a 6-log reduction of 108 CFU mL−1 of Staphylococcus aureus (Gram-positive bacteria), Escherichia coli (Gram-negative bacteria), methicillin-resistant Staphylococcus aureus (drug-resistant bacteria), vancomycin-resistant Enterococcus faecium (drug-resistant bacteria), and Candida albicans (fungi) in 30–60 minutes, and a 5-log reduction of 107 PFU mL−1 of MS2 virus in 120 minutes. The antibacterial, antifungal, and antiviral activities were both durable and rechargeable. Additionally, trypan blue assay suggested that the new silver sulfadiazine–immobilized Celluloses sustained exCellent Mammal Cell viability, pointing to great potentials of the new materials for...
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Electrospun Composite Nanofiber Fabrics Containing Uniformly Dispersed Antimicrobial Agents As an Innovative Type of Polymeric Materials with Superior Antimicrobial Efficacy
ACS applied materials & interfaces, 2010Co-Authors: Xinbo Sun, Zhengbing Cao, Lifeng Zhang, Ying Deng, Li Liu, Hao Fong, Yuyu SunAbstract:Herein we report that electrospun composite nanofiber fabrics containing uniformly dispersed antimicrobial agents and having large surface-to-mass ratios are an innovative type of antimicrobial polymeric materials with durable, nonleachable, and biocompatible characteristics, and more importantly, superior antimicrobial efficacy. Specifically, electrospun Cellulose acetate (CA) nanofiber fabrics containing an N-halamine antimicrobial agent of bis(N-chloro-2,2,6,6-tetramethyl-4-piperidinyl) sebacate (Cl-BTMP) were prepared and evaluated; the results of antimicrobial efficacy indicated that the electrospun composite nanofiber fabrics substantially outperformed the control samples that were solution-cast films containing identical amounts of CA and Cl-BTMP. Additionally, the results of trypan blue assay test suggested that the electrospun composite nanofiber fabrics also had exCellent Mammal Cell viability. The developed electrospun composite nanofiber fabrics with superior antimicrobial efficacy are expected to find vital applications in biomedical, hygienic, and many other fields.
Zhengbing Cao - One of the best experts on this subject based on the ideXlab platform.
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silver sulfadiazine immobilized Celluloses as biocompatible polymeric biocides
Journal of Bioactive and Compatible Polymers, 2013Co-Authors: Zhengbing Cao, Xinbo Sun, Jinrong Yao, Yuyu SunAbstract:Sulfadiazine was immobilized onto cotton Cellulose using ethylene glycol diglycidyl ether as a binder. Upon treatment with diluted silver nitrate aqueous solution, the sulfadiazine moieties in the immobilized Celluloses were transformed into silver–sulfadiazine coordination complexes. The resulting silver sulfadiazine–immobilized Celluloses provided a 6-log reduction of 108 CFU mL−1 of Staphylococcus aureus (Gram-positive bacteria), Escherichia coli (Gram-negative bacteria), methicillin-resistant Staphylococcus aureus (drug-resistant bacteria), vancomycin-resistant Enterococcus faecium (drug-resistant bacteria), and Candida albicans (fungi) in 30–60 minutes, and a 5-log reduction of 107 PFU mL−1 of MS2 virus in 120 minutes. The antibacterial, antifungal, and antiviral activities were both durable and rechargeable. Additionally, trypan blue assay suggested that the new silver sulfadiazine–immobilized Celluloses sustained exCellent Mammal Cell viability, pointing to great potentials of the new materials for...
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Electrospun Composite Nanofiber Fabrics Containing Uniformly Dispersed Antimicrobial Agents As an Innovative Type of Polymeric Materials with Superior Antimicrobial Efficacy
ACS applied materials & interfaces, 2010Co-Authors: Xinbo Sun, Zhengbing Cao, Lifeng Zhang, Ying Deng, Li Liu, Hao Fong, Yuyu SunAbstract:Herein we report that electrospun composite nanofiber fabrics containing uniformly dispersed antimicrobial agents and having large surface-to-mass ratios are an innovative type of antimicrobial polymeric materials with durable, nonleachable, and biocompatible characteristics, and more importantly, superior antimicrobial efficacy. Specifically, electrospun Cellulose acetate (CA) nanofiber fabrics containing an N-halamine antimicrobial agent of bis(N-chloro-2,2,6,6-tetramethyl-4-piperidinyl) sebacate (Cl-BTMP) were prepared and evaluated; the results of antimicrobial efficacy indicated that the electrospun composite nanofiber fabrics substantially outperformed the control samples that were solution-cast films containing identical amounts of CA and Cl-BTMP. Additionally, the results of trypan blue assay test suggested that the electrospun composite nanofiber fabrics also had exCellent Mammal Cell viability. The developed electrospun composite nanofiber fabrics with superior antimicrobial efficacy are expected to find vital applications in biomedical, hygienic, and many other fields.
Alejandra Ochoazarzosa - One of the best experts on this subject based on the ideXlab platform.
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thionin thi2 1 from arabidopsis thaliana expressed in endothelial Cells shows antibacterial antifungal and cytotoxic activity
Biotechnology Letters, 2008Co-Authors: Heber Loezaangeles, Eduardo Sagrerocisneros, Leticia Larazarate, Erik Villagomezgomez, Joel E Lopezmeza, Alejandra OchoazarzosaAbstract:Thionins are plant antimicrobial peptides with antibacterial and antifungal activities. Thionin Thi2.1 cDNA from Arabidopsis thaliana was expressed in BVE-E6E7 bovine endothelial Cell line and its activity was evaluated against Escherichia coli, Staphylococcus aureus, Candida albicans and different Mammal Cell lines. Total protein (2.5 μg) from conditioned medium (CM) of clone EC-Thi2.1 inhibited the growth of E. coli, S. aureus (>90%) and C. albicans strains (>80%) in relation to the CM from control Cells. Also, CM of EC-Thi2.1 inhibited the viability of several transformed and normal Mammal Cell lines (38–95%). These results suggest that thionin Thi2.1 is an antimicrobial peptide that could be use in the treatment of Mammalian infectious diseases.
Jiři Kopecký - One of the best experts on this subject based on the ideXlab platform.
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The cyanobacterial cyclic lipopeptides puwainaphycins F/G are inducing necrosis via Cell membrane permeabilization and subsequent unusual actin relocalization.
Chemical Research in Toxicology, 2012Co-Authors: Pavel Hrouzek, Marek Kuzma, Radovan Fišer, Petr Šimek, Alena Lukešová, Jan Černý, Petr Novák, Jiři KopeckýAbstract:Puwainaphycins F and G, moderate cytotoxins, which cause necrotic Cell death to Mammalian Cells, were isolated from the soil cyanobacterium Cylindrospermum alatosporum C24/89. Both compounds have been shown to be cyclic decapeptides containing unusual β-amino fatty acid (2-hydroxy-3-amino-4methyl tetradecanoic acid). Described variants differ in the substitution of threonine by glutamine in the fourth position. Their structures differ from the known puwainaphycins in five amino acids positions as well as in the β-amino fatty acid unit. The rapid interaction of these compounds with the plasma membrane of the Mammal Cell leads to an elevation of the concentration of intraCellular Ca2+, with kinetics comparable to the well-established calcium ionophore ionomycin. Subsequently, the induction of tyrosine phosphorylation was observed to be followed by the unique transformation of the actin cytoskeleton into ring structures around the nuclei. All of these alterations in the Cellular morphology and physiology res...
