The Experts below are selected from a list of 48 Experts worldwide ranked by ideXlab platform
Takaki Miwa - One of the best experts on this subject based on the ideXlab platform.
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Thallium Transport and the Evaluation of Olfactory Nerve Connectivity between the Nasal Cavity and Olfactory Bulb
Chemical Senses, 2007Co-Authors: Yayoi Kinoshita, Hideaki Shiga, Kohshin Washiyama, Daisuke Ogawa, Ryohei Amano, Toshiaki Tsukatani, Mitsuru Furukawa, Takaki MiwaAbstract:Little is known regarding how alkali metal ions are transported in the olfactory nerve following their intranasal administration. In this study, we show that an alkali metal ion, thallium is transported in the olfactory nerve fibers to the olfactory bulb in mice. The olfactory nerve fibers of mice were transected on both sides of the body under anesthesia. A double tracer solution (thallium-201, (201)Tl; Manganese-54, (54)Mn) was administered into the nasal cavity the following day. Radioactivity in the olfactory bulb and nasal turbinate was analyzed with gamma spectrometry. Auto radiographic images were obtained from coronal slices of frozen heads of mice administered with (201)Tl or (54)Mn. The transection of the olfactory nerve fibers was confirmed with a neuronal tracer. The transport of intranasal administered (201)Tl/(54)Mn to the olfactory bulb was significantly reduced by the transection of olfactory nerve fibers. The olfactory nerve transection also significantly inhibited the accumulation of fluoro-ruby in the olfactory bulb. Findings indicate that thallium is transported by the olfactory nerve fibers to the olfactory bulb in mice. The assessment of thallium transport following head injury may provide a new diagnostic method for the evaluation of olfactory nerve injury.
E Tomic - One of the best experts on this subject based on the ideXlab platform.
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determination of Manganese 54 in water
China Nuclear Science and Technology Report, 1993Co-Authors: E TomicAbstract:A radiochemical determination procedure has been setup for measuring radioactivity of 54Mn in the water. The procedure is based on the following processes: (1) copre-cipitation of hydroxide of Manganese and iron to concentrate radioactive Manganese in the sample; (2) precipitation of MnO2 to purify Manganese from other impurities; (3) cation exchange chromatography separation in hydrochloric acid-acetone mixture to separate and purify Mn2+ from impurity nuclides in the sample; (4) preparation of Manganese ammonium phosphate precipitate. Finally the gamma radioactivity of 54Mn in the precipitate is counted by low background gamma spectrometer with a HP Ge detector. When 2. 03 Bq 54Mn and 9. 63 mg Mn2+ were added into 10 liters of water, the chemical and radiochemical recovery of the procedure were (76. 4 + 6. 1)% and (77. 1+5. 9)% respectively. The decontamination factors for nuclides of 60Co, 63Ni, 59Fe,65Zn, 51Cr, 137Cs, 90Sr, 95Zr, 106Ru-106Rh, 144Ce-144Pr are greater than 1X104. The minimun detectable concentration for 54Mn in water of the method is 4 X 10-3 Bq/L.
R.j. Macon - One of the best experts on this subject based on the ideXlab platform.
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Treatment of spent electropolishing solution for removal of cobalt-60
1996Co-Authors: P.a. Taylor, E.l. Youngblood, R.j. MaconAbstract:The Irradiated Materials Examination and Testing (IMET) Facility at Oak Ridge National Laboratory electropolishes various types of irradiated metal specimens prior to examination of metallurgical and mechanical properties. The standard electropolishing solution used at IMET for most specimens consists of a 7:1 methanol/sulfuric acid mixture, with smaller amounts of a 3:1 methanol/nitric acid solution and a 10:6:1 methanol/2-butoxyethanol/perchloric acid solution also being used. Cobalt-60 is the primary source of gamma radiation in the spent solutions, with lesser amounts from Manganese-54 and iron-59. A treatment method is needed to remove most of the Co-60 from these solutions to allow the waste solutions to be contact-handled for disposal. A wide range of adsorbents was tested for removing cobalt from the electropolishing solutions. No adsorbent was found that would treat full strength solution, but a complexing ion exchange resin (Chelex 100, BioRad Labs, or Amberlite IRC-718, Rohm and Haas Co.) will remove cobalt and other heavy metals from partially neutralized (pH=3) solution. A 5 wt% sodium hydroxide solution is used for pH adjustment, since more concentrated caustic caused sodium sulfate precipitates to form. Lab-scale column tests have shown that about 10 bed volumes of methanol/sulfuric acid solution, 30 bed volumes of methanol/nitric acid solution or 15 bed volumes of methanol/2-butoxyethanol/perchloric acid solution can be treated prior to initial Co-60 breakthrough.
James R. Connor - One of the best experts on this subject based on the ideXlab platform.
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Distribution of injected iron 59 and Manganese 54 in hypotransferrinemic mice
Journal of Laboratory and Clinical Medicine, 1996Co-Authors: T.k Dickinson, Attila G. Devenyi, James R. ConnorAbstract:Transferrin has been proposed as the mobilization protein for iron and Manganese. To better understand the role of transferrin in the transport of these metals, we studied the tissue distribution of injected iron 59 and Manganese 54 in the hypotransferrinemic (Hp) mouse mutant. The Hp mouse has a mutation in the transferrin gene and produces
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distribution of injected iron 59 and Manganese 54 in hypotransferrinemic mice
Journal of Laboratory and Clinical Medicine, 1996Co-Authors: T.k Dickinson, Attila G. Devenyi, James R. ConnorAbstract:Transferrin has been proposed as the mobilization protein for iron and Manganese. To better understand the role of transferrin in the transport of these metals, we studied the tissue distribution of injected iron 59 and Manganese 54 in the hypotransferrinemic (Hp) mouse mutant. The Hp mouse has a mutation in the transferrin gene and produces <1% of normal transferrin levels. The tissue distribution of 59Fe and 54Mn in Hp mice was compared with that in animals heterozygous for the Hp mutation (50% transferrin levels) and wild-type animals. Formed elements in the brain, liver, spleen, heart, sternum/rib, plasma, and blood were analyzed for isotope incorporation at 24 hours, 7 days, and 4 weeks after injection. Tissue distribution of both 59Fe and 54Mn was similar in wild-type and heterozygote animals, indicating that decreased transferrin concentration and increased saturation did not influence the tissue distribution of the injected metals. The absence of transferrin in the Hp mutant was associated with abnormal tissue distribution of radiolabeled iron; there was 4 times more 59Fe than normal in the Hp liver and 10 times less 59Fe in the spleen and blood formed elements than normal. Injected Manganese also accumulated at abnormally high levels in the Hp mouse liver. Distribution of either metal to the brain, heart, and sternum/rib was not affected by the absence of plasma transferrin. These results reveal that transferrin is required for proper targeting of Manganese and iron, especially from the liver to other organs, but further indicate that nontransferrin transport mechanisms for iron and Manganese must exist.
Yayoi Kinoshita - One of the best experts on this subject based on the ideXlab platform.
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Thallium Transport and the Evaluation of Olfactory Nerve Connectivity between the Nasal Cavity and Olfactory Bulb
Chemical Senses, 2007Co-Authors: Yayoi Kinoshita, Hideaki Shiga, Kohshin Washiyama, Daisuke Ogawa, Ryohei Amano, Toshiaki Tsukatani, Mitsuru Furukawa, Takaki MiwaAbstract:Little is known regarding how alkali metal ions are transported in the olfactory nerve following their intranasal administration. In this study, we show that an alkali metal ion, thallium is transported in the olfactory nerve fibers to the olfactory bulb in mice. The olfactory nerve fibers of mice were transected on both sides of the body under anesthesia. A double tracer solution (thallium-201, (201)Tl; Manganese-54, (54)Mn) was administered into the nasal cavity the following day. Radioactivity in the olfactory bulb and nasal turbinate was analyzed with gamma spectrometry. Auto radiographic images were obtained from coronal slices of frozen heads of mice administered with (201)Tl or (54)Mn. The transection of the olfactory nerve fibers was confirmed with a neuronal tracer. The transport of intranasal administered (201)Tl/(54)Mn to the olfactory bulb was significantly reduced by the transection of olfactory nerve fibers. The olfactory nerve transection also significantly inhibited the accumulation of fluoro-ruby in the olfactory bulb. Findings indicate that thallium is transported by the olfactory nerve fibers to the olfactory bulb in mice. The assessment of thallium transport following head injury may provide a new diagnostic method for the evaluation of olfactory nerve injury.