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Marcelo Guerra Santos - One of the best experts on this subject based on the ideXlab platform.

  • Development of an insecticidal nanoemulsion with Manilkara subsericea (Sapotaceae) extract
    Journal of Nanobiotechnology, 2014
    Co-Authors: Caio Pinho Fernandes, Marcelo Guerra Santos, Amanda Nunes Silveira, Marcelo S. Gonzalez, C.b. Mello, Denise Feder, Raul Apolinario, José Carlos Tavares Carvalho, Fernanda Borges De Almeida, Luis A. C. Tietbohl
    Abstract:

    Background Plants have been recognized as a good source of insecticidal agents, since they are able to produce their own defensives to insect attack. Moreover, there is a growing concern worldwide to develop pesticides with low impact to environment and non-target organisms. Hexane-soluble fraction from ethanolic crude extract from fruits of Manilkara subsericea and its triterpenes were considered active against a cotton pest ( Dysdercus peruvianus ). Several natural products with insecticidal activity have poor water solubility, including triterpenes, and nanotechnology has emerged as a good alternative to solve this main problem. On this context, the aim of the present study was to develop an insecticidal nanoemulsion containing apolar fraction from fruits of Manilkara subsericea. Results It was obtained a formulation constituted by 5% of oil (octyldodecyl myristate), 5% of surfactants (sorbitan monooleate/polysorbate 80), 5% of apolar fraction from M. subsericea and 85% of water. Analysis of mean droplet diameter (155.2 ± 3.8 nm) confirmed this formulation as a nanoemulsion. It was able to induce mortality in D. peruvianus . It was observed no effect against acetylcholinesterase or mortality in mice induced by the formulation, suggesting the safety of this nanoemulsion for non-target organisms. Conclusions The present study suggests that the obtained O/A nanoemulsion may be useful to enhance water solubility of poor water soluble natural products with insecticidal activity, including the hexane-soluble fraction from ethanolic crude extract from fruits of Manilkara subsericea .

  • Development of an insecticidal nanoemulsion with Manilkara subsericea (Sapotaceae) extract
    Journal of nanobiotechnology, 2014
    Co-Authors: Caio P. Fernandes, Fernanda B. De Almeida, Marcelo Guerra Santos, Amanda Nunes Silveira, Marcelo S. Gonzalez, C.b. Mello, Denise Feder, Raul Apolinario, José Carlos Tavares Carvalho, Luis A. C. Tietbohl
    Abstract:

    Background Plants have been recognized as a good source of insecticidal agents, since they are able to produce their own defensives to insect attack. Moreover, there is a growing concern worldwide to develop pesticides with low impact to environment and non-target organisms. Hexane-soluble fraction from ethanolic crude extract from fruits of Manilkara subsericea and its triterpenes were considered active against a cotton pest (Dysdercus peruvianus). Several natural products with insecticidal activity have poor water solubility, including triterpenes, and nanotechnology has emerged as a good alternative to solve this main problem. On this context, the aim of the present study was to develop an insecticidal nanoemulsion containing apolar fraction from fruits of Manilkara subsericea.

  • laboratory evaluation of the effects of Manilkara subsericea mart dubard extracts and triterpenes on the development of dysdercus peruvianus and oncopeltus fasciatus
    Pest Management Science, 2013
    Co-Authors: Caio P. Fernandes, Marcelo Guerra Santos, Alexandre Xavier, Joao Pedro Furtado Pacheco, Rodrigo Mexas, Norman A Ratcliffe, Marcelo S Gonzalez, C B Mello
    Abstract:

    BACKGROUND: Studies were carried out to evaluate the effects of Manilkara subsericea extracts and triterpenes on the development of two species of agricultural pest insects, Oncopelus fasciatus and Dysdercus peruvianus. RESULTS: All treatments of insects with M. subsericea extracts induced mortality, delayed development and inhibited moulting. Some extracts assayed (FH, FB and FD in D. peruvianus, and FH, FB and FEA in O. fasciatus) also produced body deformities in the few adults that emerged. Other extracts (FH, FEA, FB, FD and LET in both insects), however, induced either permanent (overaged) or extranumerary nymphs, both of which were unable to achieve the adult stage and reproductive status. The insects were also treated with triterpenes (α- and β-amyrin acetates) which showed high lethality at 30 days after treatment and delayed the intermoult period so that overaged nymphs were detected. CONCLUSION: The results indicate that extracts and triterpenes from Manilkara subsericea act as potent growth inhibitors of phytophagous hemipteran nymphs. It is also concluded that the mixture of several different molecules in the extracts used produces synergic effects that do not occur after using the triterpenes (PFT) alone. These secondary metabolites in the M. subsericea extracts can potentially be used in integrated control programmes against crop pests. Copyright © 2012 Society of Chemical Industry

  • Triterpene Esters and Biological Activities from Edible Fruits of Manilkara subsericea (Mart.) Dubard, Sapotaceae
    BioMed research international, 2012
    Co-Authors: Caio P. Fernandes, Arthur L. Corrêa, Jonathas Felipe Revoredo Lobo, Otávio P. Caramel, Fernanda B. De Almeida, Elaine Da Silva Castro, Kauê Francisco Correa De Souza E Souza, Patrícia Burth, Lidia Maria Da Fonte De Amorim, Marcelo Guerra Santos
    Abstract:

    Manilkara subsericea (Mart.) Dubard (Sapotaceae) is popularly known in Brazil as “guracica.” Studies with Manilkara spp. indicated the presence of triterpenes, saponins, and flavonoids. Several activities have been attributed to Manilkara spp. such as antimicrobial, antiparasitic and antitumoral, which indicates the great biological potential of this genus. In all, 87.19% of the hexanic extract from fruits relative composition were evaluated, in which 72.81% were beta- and alpha-amyrin esters, suggesting that they may be chemical markers for M. subsericea. Hexadecanoic acid, hexadecanoic acid ethyl ester, (E)-9-octadecenoic acid ethyl ester, and octadecanoic acid ethyl ester were also identified. Ethanolic crude extracts from leaves, stems, and hexanic extract from fruits exhibited antimicrobial activity against Staphylococcus aureus ATCC25923. These extracts had high values against Vero cells, demonstrating weak cytotoxicity. This is the first time, to our knowledge, that beta- and alpha-amyrin caproates and caprylates are described for Manilkara subsericea.

Caio P. Fernandes - One of the best experts on this subject based on the ideXlab platform.

  • Development of an insecticidal nanoemulsion with Manilkara subsericea (Sapotaceae) extract
    Journal of nanobiotechnology, 2014
    Co-Authors: Caio P. Fernandes, Fernanda B. De Almeida, Marcelo Guerra Santos, Amanda Nunes Silveira, Marcelo S. Gonzalez, C.b. Mello, Denise Feder, Raul Apolinario, José Carlos Tavares Carvalho, Luis A. C. Tietbohl
    Abstract:

    Background Plants have been recognized as a good source of insecticidal agents, since they are able to produce their own defensives to insect attack. Moreover, there is a growing concern worldwide to develop pesticides with low impact to environment and non-target organisms. Hexane-soluble fraction from ethanolic crude extract from fruits of Manilkara subsericea and its triterpenes were considered active against a cotton pest (Dysdercus peruvianus). Several natural products with insecticidal activity have poor water solubility, including triterpenes, and nanotechnology has emerged as a good alternative to solve this main problem. On this context, the aim of the present study was to develop an insecticidal nanoemulsion containing apolar fraction from fruits of Manilkara subsericea.

  • laboratory evaluation of the effects of Manilkara subsericea mart dubard extracts and triterpenes on the development of dysdercus peruvianus and oncopeltus fasciatus
    Pest Management Science, 2013
    Co-Authors: Caio P. Fernandes, Marcelo Guerra Santos, Alexandre Xavier, Joao Pedro Furtado Pacheco, Rodrigo Mexas, Norman A Ratcliffe, Marcelo S Gonzalez, C B Mello
    Abstract:

    BACKGROUND: Studies were carried out to evaluate the effects of Manilkara subsericea extracts and triterpenes on the development of two species of agricultural pest insects, Oncopelus fasciatus and Dysdercus peruvianus. RESULTS: All treatments of insects with M. subsericea extracts induced mortality, delayed development and inhibited moulting. Some extracts assayed (FH, FB and FD in D. peruvianus, and FH, FB and FEA in O. fasciatus) also produced body deformities in the few adults that emerged. Other extracts (FH, FEA, FB, FD and LET in both insects), however, induced either permanent (overaged) or extranumerary nymphs, both of which were unable to achieve the adult stage and reproductive status. The insects were also treated with triterpenes (α- and β-amyrin acetates) which showed high lethality at 30 days after treatment and delayed the intermoult period so that overaged nymphs were detected. CONCLUSION: The results indicate that extracts and triterpenes from Manilkara subsericea act as potent growth inhibitors of phytophagous hemipteran nymphs. It is also concluded that the mixture of several different molecules in the extracts used produces synergic effects that do not occur after using the triterpenes (PFT) alone. These secondary metabolites in the M. subsericea extracts can potentially be used in integrated control programmes against crop pests. Copyright © 2012 Society of Chemical Industry

  • Triterpene Esters and Biological Activities from Edible Fruits of Manilkara subsericea (Mart.) Dubard, Sapotaceae
    BioMed research international, 2012
    Co-Authors: Caio P. Fernandes, Arthur L. Corrêa, Jonathas Felipe Revoredo Lobo, Otávio P. Caramel, Fernanda B. De Almeida, Elaine Da Silva Castro, Kauê Francisco Correa De Souza E Souza, Patrícia Burth, Lidia Maria Da Fonte De Amorim, Marcelo Guerra Santos
    Abstract:

    Manilkara subsericea (Mart.) Dubard (Sapotaceae) is popularly known in Brazil as “guracica.” Studies with Manilkara spp. indicated the presence of triterpenes, saponins, and flavonoids. Several activities have been attributed to Manilkara spp. such as antimicrobial, antiparasitic and antitumoral, which indicates the great biological potential of this genus. In all, 87.19% of the hexanic extract from fruits relative composition were evaluated, in which 72.81% were beta- and alpha-amyrin esters, suggesting that they may be chemical markers for M. subsericea. Hexadecanoic acid, hexadecanoic acid ethyl ester, (E)-9-octadecenoic acid ethyl ester, and octadecanoic acid ethyl ester were also identified. Ethanolic crude extracts from leaves, stems, and hexanic extract from fruits exhibited antimicrobial activity against Staphylococcus aureus ATCC25923. These extracts had high values against Vero cells, demonstrating weak cytotoxicity. This is the first time, to our knowledge, that beta- and alpha-amyrin caproates and caprylates are described for Manilkara subsericea.

Luis A. C. Tietbohl - One of the best experts on this subject based on the ideXlab platform.

  • Development of an insecticidal nanoemulsion with Manilkara subsericea (Sapotaceae) extract
    Journal of nanobiotechnology, 2014
    Co-Authors: Caio P. Fernandes, Fernanda B. De Almeida, Marcelo Guerra Santos, Amanda Nunes Silveira, Marcelo S. Gonzalez, C.b. Mello, Denise Feder, Raul Apolinario, José Carlos Tavares Carvalho, Luis A. C. Tietbohl
    Abstract:

    Background Plants have been recognized as a good source of insecticidal agents, since they are able to produce their own defensives to insect attack. Moreover, there is a growing concern worldwide to develop pesticides with low impact to environment and non-target organisms. Hexane-soluble fraction from ethanolic crude extract from fruits of Manilkara subsericea and its triterpenes were considered active against a cotton pest (Dysdercus peruvianus). Several natural products with insecticidal activity have poor water solubility, including triterpenes, and nanotechnology has emerged as a good alternative to solve this main problem. On this context, the aim of the present study was to develop an insecticidal nanoemulsion containing apolar fraction from fruits of Manilkara subsericea.

  • Development of an insecticidal nanoemulsion with Manilkara subsericea (Sapotaceae) extract
    Journal of Nanobiotechnology, 2014
    Co-Authors: Caio Pinho Fernandes, Marcelo Guerra Santos, Amanda Nunes Silveira, Marcelo S. Gonzalez, C.b. Mello, Denise Feder, Raul Apolinario, José Carlos Tavares Carvalho, Fernanda Borges De Almeida, Luis A. C. Tietbohl
    Abstract:

    Background Plants have been recognized as a good source of insecticidal agents, since they are able to produce their own defensives to insect attack. Moreover, there is a growing concern worldwide to develop pesticides with low impact to environment and non-target organisms. Hexane-soluble fraction from ethanolic crude extract from fruits of Manilkara subsericea and its triterpenes were considered active against a cotton pest ( Dysdercus peruvianus ). Several natural products with insecticidal activity have poor water solubility, including triterpenes, and nanotechnology has emerged as a good alternative to solve this main problem. On this context, the aim of the present study was to develop an insecticidal nanoemulsion containing apolar fraction from fruits of Manilkara subsericea. Results It was obtained a formulation constituted by 5% of oil (octyldodecyl myristate), 5% of surfactants (sorbitan monooleate/polysorbate 80), 5% of apolar fraction from M. subsericea and 85% of water. Analysis of mean droplet diameter (155.2 ± 3.8 nm) confirmed this formulation as a nanoemulsion. It was able to induce mortality in D. peruvianus . It was observed no effect against acetylcholinesterase or mortality in mice induced by the formulation, suggesting the safety of this nanoemulsion for non-target organisms. Conclusions The present study suggests that the obtained O/A nanoemulsion may be useful to enhance water solubility of poor water soluble natural products with insecticidal activity, including the hexane-soluble fraction from ethanolic crude extract from fruits of Manilkara subsericea .

C B Mello - One of the best experts on this subject based on the ideXlab platform.

  • laboratory evaluation of the effects of Manilkara subsericea mart dubard extracts and triterpenes on the development of dysdercus peruvianus and oncopeltus fasciatus
    Pest Management Science, 2013
    Co-Authors: Caio P. Fernandes, Marcelo Guerra Santos, Alexandre Xavier, Joao Pedro Furtado Pacheco, Rodrigo Mexas, Norman A Ratcliffe, Marcelo S Gonzalez, C B Mello
    Abstract:

    BACKGROUND: Studies were carried out to evaluate the effects of Manilkara subsericea extracts and triterpenes on the development of two species of agricultural pest insects, Oncopelus fasciatus and Dysdercus peruvianus. RESULTS: All treatments of insects with M. subsericea extracts induced mortality, delayed development and inhibited moulting. Some extracts assayed (FH, FB and FD in D. peruvianus, and FH, FB and FEA in O. fasciatus) also produced body deformities in the few adults that emerged. Other extracts (FH, FEA, FB, FD and LET in both insects), however, induced either permanent (overaged) or extranumerary nymphs, both of which were unable to achieve the adult stage and reproductive status. The insects were also treated with triterpenes (α- and β-amyrin acetates) which showed high lethality at 30 days after treatment and delayed the intermoult period so that overaged nymphs were detected. CONCLUSION: The results indicate that extracts and triterpenes from Manilkara subsericea act as potent growth inhibitors of phytophagous hemipteran nymphs. It is also concluded that the mixture of several different molecules in the extracts used produces synergic effects that do not occur after using the triterpenes (PFT) alone. These secondary metabolites in the M. subsericea extracts can potentially be used in integrated control programmes against crop pests. Copyright © 2012 Society of Chemical Industry

Marcelo S Gonzalez - One of the best experts on this subject based on the ideXlab platform.

  • laboratory evaluation of the effects of Manilkara subsericea mart dubard extracts and triterpenes on the development of dysdercus peruvianus and oncopeltus fasciatus
    Pest Management Science, 2013
    Co-Authors: Caio P. Fernandes, Marcelo Guerra Santos, Alexandre Xavier, Joao Pedro Furtado Pacheco, Rodrigo Mexas, Norman A Ratcliffe, Marcelo S Gonzalez, C B Mello
    Abstract:

    BACKGROUND: Studies were carried out to evaluate the effects of Manilkara subsericea extracts and triterpenes on the development of two species of agricultural pest insects, Oncopelus fasciatus and Dysdercus peruvianus. RESULTS: All treatments of insects with M. subsericea extracts induced mortality, delayed development and inhibited moulting. Some extracts assayed (FH, FB and FD in D. peruvianus, and FH, FB and FEA in O. fasciatus) also produced body deformities in the few adults that emerged. Other extracts (FH, FEA, FB, FD and LET in both insects), however, induced either permanent (overaged) or extranumerary nymphs, both of which were unable to achieve the adult stage and reproductive status. The insects were also treated with triterpenes (α- and β-amyrin acetates) which showed high lethality at 30 days after treatment and delayed the intermoult period so that overaged nymphs were detected. CONCLUSION: The results indicate that extracts and triterpenes from Manilkara subsericea act as potent growth inhibitors of phytophagous hemipteran nymphs. It is also concluded that the mixture of several different molecules in the extracts used produces synergic effects that do not occur after using the triterpenes (PFT) alone. These secondary metabolites in the M. subsericea extracts can potentially be used in integrated control programmes against crop pests. Copyright © 2012 Society of Chemical Industry