The Experts below are selected from a list of 40011 Experts worldwide ranked by ideXlab platform

N Dupin - One of the best experts on this subject based on the ideXlab platform.

  • hhv 8 is associated with a plasmablastic variant of castleman disease that is linked to hhv 8 positive plasmablastic lymphoma
    Blood, 2000
    Co-Authors: N Dupin, Tim L Diss, Paul Kellam, M Tulliez, Didier Sicard, Robin A Weiss, Peter G Isaacson, Chris Boshoff
    Abstract:

    Castleman disease (CD) is a lymphoproliferative disorder of unknown etiology that is associated with the development of secondary tumors, including B-cell lymphoma. Human herpesvirus 8 (HHV-8) (Kaposi's sarcoma-associated herpesvirus) sequences have been described in some cases of multicentric Castleman disease (MCD). Using a monoclonal antibody against an HHV-8-latent nuclear antigen, we show that HHV-8 is specifically associated with a variant of MCD in which HHV-8-positive plasmablasts that show lambda light-chain restriction localize in the Mantle Zone of B-cell follicles and coalesce to form microscopic lymphomas in some cases. Furthermore, we show that the frank plasmablastic lymphoma that develops in patients with this plasmablastic variant of MCD is also positive for HHV-8 and lambda light chain. Plasmablastic lymphoma associated with MCD is a new disease entity associated with HHV-8 infection. (Blood. 2000;95:1406-1412)

  • distribution of human herpesvirus 8 latently infected cells in kaposi s sarcoma multicentric castleman s disease and primary effusion lymphoma
    Proceedings of the National Academy of Sciences of the United States of America, 1999
    Co-Authors: N Dupin, Paul Kellam, M Tulliez, Isabelle Gorin, Cyril Fisher, Samuel Ariad, N Franck, E Van Marck, Dominique Salmon, J P Escande
    Abstract:

    Human herpesvirus 8 (HHV-8, also called KSHV) is linked to the etiopathogenesis of Kaposi’s sarcoma (KS), multicentric Castleman’s disease (MCD), and primary effusion lymphoma (PEL). The universal presence of HHV-8 in early KS has not yet been shown. We used a mAb (LN53) against latent nuclear antigen-1 (LNA-1) of HHV-8 encoded by ORF73 to study the distribution of the cell types latently infected by HHV-8 in patch, plaque, and nodular KS, MCD, and PEL. In early KS, HHV-8 is present in 90% of spindle cells, but not in normal vascular endothelium. In addition, HHV-8 colocalizes with vascular endothelial growth factor receptor-3 (VEGFR-3), a marker of lymphatic and precursor endothelium. In early KS lesions, VEGFR-3 is more extensively expressed than LNA-1, indicating that HHV-8 is not inducing the proliferation of VEGFR-3-positive endothelium directly. In MCD, HHV-8 is present in Mantle Zone large immunoblastic B cells. No staining for LNA-1 is seen in samples from multiple myeloma, prostate cancer, and angiosarcoma, supporting the absence of any etiological link between these diseases and HHV-8.

Paul Kellam - One of the best experts on this subject based on the ideXlab platform.

  • hhv 8 is associated with a plasmablastic variant of castleman disease that is linked to hhv 8 positive plasmablastic lymphoma
    Blood, 2000
    Co-Authors: N Dupin, Tim L Diss, Paul Kellam, M Tulliez, Didier Sicard, Robin A Weiss, Peter G Isaacson, Chris Boshoff
    Abstract:

    Castleman disease (CD) is a lymphoproliferative disorder of unknown etiology that is associated with the development of secondary tumors, including B-cell lymphoma. Human herpesvirus 8 (HHV-8) (Kaposi's sarcoma-associated herpesvirus) sequences have been described in some cases of multicentric Castleman disease (MCD). Using a monoclonal antibody against an HHV-8-latent nuclear antigen, we show that HHV-8 is specifically associated with a variant of MCD in which HHV-8-positive plasmablasts that show lambda light-chain restriction localize in the Mantle Zone of B-cell follicles and coalesce to form microscopic lymphomas in some cases. Furthermore, we show that the frank plasmablastic lymphoma that develops in patients with this plasmablastic variant of MCD is also positive for HHV-8 and lambda light chain. Plasmablastic lymphoma associated with MCD is a new disease entity associated with HHV-8 infection. (Blood. 2000;95:1406-1412)

  • distribution of human herpesvirus 8 latently infected cells in kaposi s sarcoma multicentric castleman s disease and primary effusion lymphoma
    Proceedings of the National Academy of Sciences of the United States of America, 1999
    Co-Authors: N Dupin, Paul Kellam, M Tulliez, Isabelle Gorin, Cyril Fisher, Samuel Ariad, N Franck, E Van Marck, Dominique Salmon, J P Escande
    Abstract:

    Human herpesvirus 8 (HHV-8, also called KSHV) is linked to the etiopathogenesis of Kaposi’s sarcoma (KS), multicentric Castleman’s disease (MCD), and primary effusion lymphoma (PEL). The universal presence of HHV-8 in early KS has not yet been shown. We used a mAb (LN53) against latent nuclear antigen-1 (LNA-1) of HHV-8 encoded by ORF73 to study the distribution of the cell types latently infected by HHV-8 in patch, plaque, and nodular KS, MCD, and PEL. In early KS, HHV-8 is present in 90% of spindle cells, but not in normal vascular endothelium. In addition, HHV-8 colocalizes with vascular endothelial growth factor receptor-3 (VEGFR-3), a marker of lymphatic and precursor endothelium. In early KS lesions, VEGFR-3 is more extensively expressed than LNA-1, indicating that HHV-8 is not inducing the proliferation of VEGFR-3-positive endothelium directly. In MCD, HHV-8 is present in Mantle Zone large immunoblastic B cells. No staining for LNA-1 is seen in samples from multiple myeloma, prostate cancer, and angiosarcoma, supporting the absence of any etiological link between these diseases and HHV-8.

M Tulliez - One of the best experts on this subject based on the ideXlab platform.

  • hhv 8 is associated with a plasmablastic variant of castleman disease that is linked to hhv 8 positive plasmablastic lymphoma
    Blood, 2000
    Co-Authors: N Dupin, Tim L Diss, Paul Kellam, M Tulliez, Didier Sicard, Robin A Weiss, Peter G Isaacson, Chris Boshoff
    Abstract:

    Castleman disease (CD) is a lymphoproliferative disorder of unknown etiology that is associated with the development of secondary tumors, including B-cell lymphoma. Human herpesvirus 8 (HHV-8) (Kaposi's sarcoma-associated herpesvirus) sequences have been described in some cases of multicentric Castleman disease (MCD). Using a monoclonal antibody against an HHV-8-latent nuclear antigen, we show that HHV-8 is specifically associated with a variant of MCD in which HHV-8-positive plasmablasts that show lambda light-chain restriction localize in the Mantle Zone of B-cell follicles and coalesce to form microscopic lymphomas in some cases. Furthermore, we show that the frank plasmablastic lymphoma that develops in patients with this plasmablastic variant of MCD is also positive for HHV-8 and lambda light chain. Plasmablastic lymphoma associated with MCD is a new disease entity associated with HHV-8 infection. (Blood. 2000;95:1406-1412)

  • distribution of human herpesvirus 8 latently infected cells in kaposi s sarcoma multicentric castleman s disease and primary effusion lymphoma
    Proceedings of the National Academy of Sciences of the United States of America, 1999
    Co-Authors: N Dupin, Paul Kellam, M Tulliez, Isabelle Gorin, Cyril Fisher, Samuel Ariad, N Franck, E Van Marck, Dominique Salmon, J P Escande
    Abstract:

    Human herpesvirus 8 (HHV-8, also called KSHV) is linked to the etiopathogenesis of Kaposi’s sarcoma (KS), multicentric Castleman’s disease (MCD), and primary effusion lymphoma (PEL). The universal presence of HHV-8 in early KS has not yet been shown. We used a mAb (LN53) against latent nuclear antigen-1 (LNA-1) of HHV-8 encoded by ORF73 to study the distribution of the cell types latently infected by HHV-8 in patch, plaque, and nodular KS, MCD, and PEL. In early KS, HHV-8 is present in 90% of spindle cells, but not in normal vascular endothelium. In addition, HHV-8 colocalizes with vascular endothelial growth factor receptor-3 (VEGFR-3), a marker of lymphatic and precursor endothelium. In early KS lesions, VEGFR-3 is more extensively expressed than LNA-1, indicating that HHV-8 is not inducing the proliferation of VEGFR-3-positive endothelium directly. In MCD, HHV-8 is present in Mantle Zone large immunoblastic B cells. No staining for LNA-1 is seen in samples from multiple myeloma, prostate cancer, and angiosarcoma, supporting the absence of any etiological link between these diseases and HHV-8.

J P Escande - One of the best experts on this subject based on the ideXlab platform.

  • distribution of human herpesvirus 8 latently infected cells in kaposi s sarcoma multicentric castleman s disease and primary effusion lymphoma
    Proceedings of the National Academy of Sciences of the United States of America, 1999
    Co-Authors: N Dupin, Paul Kellam, M Tulliez, Isabelle Gorin, Cyril Fisher, Samuel Ariad, N Franck, E Van Marck, Dominique Salmon, J P Escande
    Abstract:

    Human herpesvirus 8 (HHV-8, also called KSHV) is linked to the etiopathogenesis of Kaposi’s sarcoma (KS), multicentric Castleman’s disease (MCD), and primary effusion lymphoma (PEL). The universal presence of HHV-8 in early KS has not yet been shown. We used a mAb (LN53) against latent nuclear antigen-1 (LNA-1) of HHV-8 encoded by ORF73 to study the distribution of the cell types latently infected by HHV-8 in patch, plaque, and nodular KS, MCD, and PEL. In early KS, HHV-8 is present in 90% of spindle cells, but not in normal vascular endothelium. In addition, HHV-8 colocalizes with vascular endothelial growth factor receptor-3 (VEGFR-3), a marker of lymphatic and precursor endothelium. In early KS lesions, VEGFR-3 is more extensively expressed than LNA-1, indicating that HHV-8 is not inducing the proliferation of VEGFR-3-positive endothelium directly. In MCD, HHV-8 is present in Mantle Zone large immunoblastic B cells. No staining for LNA-1 is seen in samples from multiple myeloma, prostate cancer, and angiosarcoma, supporting the absence of any etiological link between these diseases and HHV-8.

Silvia Uccella - One of the best experts on this subject based on the ideXlab platform.

  • composite follicular lymphoma and early in situ and Mantle Zone growth pattern Mantle cell neoplasia a rare entity with peculiar cytogenetic and clinical features
    Pathology Research and Practice, 2020
    Co-Authors: Lisa F Vivian, Francesca Magnoli, Leonardo Campiotti, Claudio Chini, Giuseppe Calabrese, Fausto Sessa, Maria Grazia Tibiletti, Silvia Uccella
    Abstract:

    Composite follicular lymphoma (FL) and Mantle cell lymphoma (MCL) is rare and not fully characterized from a genetic and clinicopathological point of view. We report a composite lymphoma (CL) in which a G1-2 FL was associated with an in situ Mantle cell neoplasia (ISMCN) and a Mantle Zone growth pattern (MZGP) MCL, followed-up for six years after the first diagnosis, until the exitus of the patient. We performed a comprehensive immunohistochemical study and a detailed cytogenetic analysis, including conventional karyotyping, SKY FISH, FISH on metaphases and interphasic separated nuclei, and FISH on histological sections. The study was completed by the review of the 13 published composite FL and MCL. Our results show that this entity generally behaves like an indolent lymphoma, with the outcome of patients driven by the progression of the FL component. The MCL component generally does not evolve in an aggressive disease. Indeed, half of the cases present exclusively ISMCN. In our case, Mantle cell neoplasia at diagnosis was represented by ISMCN and MZGP MCL and it was characterized by a simple karyotype, with t(11;14) as the sole cytogenetic abnormality. This cytogenetic aspect well correlates with the indolent behavior of the Mantle cell component. Conversely, the complex karyotype of the FL component was associated with disseminated disease that influenced patient's outcome. Finally, we suggest that not only ISMCN, but also isolated MZGP MCL, may be considered as lesions with low potential of transformation in an aggressive MCL.