The Experts below are selected from a list of 34977 Experts worldwide ranked by ideXlab platform
G. Soldani - One of the best experts on this subject based on the ideXlab platform.
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Silicone based polyurethane materials: a promising biocompatible elastomeric formulation for cardiovascular applications
Journal of Materials Science: Materials in Medicine, 2006Co-Authors: E. Briganti, P. Losi, A. Raffi, M. Scoccianti, A. Munaò, G. SoldaniAbstract:The biocompatibility of a new material for cardiovascular applications constituted by a poly(ether)urethane (PEtU) and a silicone [polydimethylsiloxane (PDMS)] was evaluated. The achieved material shows properties similar to both polyurethanes and silicones. The material was transformed into porous membranes by a spray-deposition technique. Since any material preparation and Manufacturing Procedure may introduce some toxicity, in vitro cytotoxicity screening tests were carried out. Human umbilical vein endothelial cells (HUVECs) and a mouse fibroblasts cell line (L929) were cultivated with extracts obtained from materials containing 10, 40 and 100% (w/w) of PDMS. The commercially available Estane 5714-F1® and Cardiothane 51® were used as controls. Extracts were incubated up to 72 hours with HUVECs and L929 cells. The cytotoxic effect was evaluated by light microscopy, cell viability (MTT reduction and neutral red uptake) and proliferation (5-bromo-2′-deoxyuridine incorporation) tests. In vivo studies were carried out using materials containing the same PDMS percentages as for in vitro experiments. The same commercial controls were used. Results obtained with cell culture studies agreed with those obtained in the in vivo experiments and showed that the material preparation and Manufacturing Procedure do not introduce any toxicity in the products at each PDMS concentration investigated.
Antonio Pizzi - One of the best experts on this subject based on the ideXlab platform.
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Automotive brake pads made with a bioresin matrix
Industrial Crops and Products, 2016Co-Authors: M.c. Lagel, L. Hai, S. Abdalla, Ali Zahed, M. C. Basso, Antonio Pizzi, Luc Delmotte, Fahad M. Al-marzoukiAbstract:By using biosourced raw materials such as condensed tannins and furfuryl alcohol a biosourced thermoset resin was developed and used and tested for a new application: as a resin matrix of automotive brake pads. The Manufacturing Procedure developed is particularly easy. Automotive brake pads based on this green resin were characterized and showed excellent braking properties and wear resistance when used under real car, full scale test conditions. Their mechanical resistance was found to be comparable to that of commercial automotive brake pads bonded with synthetic phenolic resins. They tolerated well the severe stresses induced by a strong braking like an emergency braking: 50 km/h (31 mph) until complete standstill and showed braking distances comparable or shorter than commercial brake pads.
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Cutting and grinding wheels for angle grinders with a bioresin matrix
Industrial Crops and Products, 2015Co-Authors: M.c. Lagel, J Zhang, Antonio PizziAbstract:By using biosourced raw materials such as condensed tannins and furfuryl alcohol a biosourced thermoset resin was developed and used and tested for a new application: as a resin matrix of solid grinding wheels for angle grinders. The Manufacturing Procedure developed is particularly easy. Cutting and grinding discs based on this green resin were used for bonding different sizes of abrasive particles of aluminium trioxide. These discs were characterized and showed excellent abrasiveness and cutting properties. Their mechanical resistance was found to be comparable to that of commercial grinding discs bonded with synthetic phenolic resins. They tolerated well the severe stresses induced on them at 11,000 revolutions per minute (rpm) by operation in an angle grinder when grinding or cutting steel.
Pradeep Kumar Prajapati - One of the best experts on this subject based on the ideXlab platform.
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Standard Manufacturing Procedure for Laghu Malini Vasanta Rasa in context of Bhavana (levigation).
AYU (An International Quarterly Journal of Research in Ayurveda), 2015Co-Authors: Manisha B Walunj, Vinay J Shukla, Biswajyoti Patgiri, Pradeep Kumar PrajapatiAbstract:Introduction: Laghu Malini Vasanta (LMV) Rasa is a well-known Vasanta Kalpa (formulation). As per reference of Yoga Ratnakara , Rasaka and Maricha are chief ingredients in 2:1 proportion. Bhavana (levigation) is said to be given first with Navaneeta (freshly prepared cow's butter) and then with Nimbu Swarasa (lemon juice) until Ghrita Vimukta stage is reached. Quantity of Bhavana Dravya (levigating media) and duration of levigation are not mentioned. Aims: To develop standard Manufacturing Procedure of LMV Rasa. Materials and Methods: The study was carried out in two stages - preparation of Yashada Bhasma and preparation of LMV Rasa and its tablet. A pilot study was carried out to fix quantity of cow's butter as levigation media. Based on results of the pilot study, LMV Rasa was prepared in two groups, that is, LMV 50 (LMV Rasa - prepared with weight of freshly prepared butter in 50% quantity of total ingredients) and LMV 75 (LMV Rasa prepared with weight of freshly prepared butter in 75% quantity of total ingredients). Complete drying of levigated mass and minimal spreading of fatty portion on filter paper was considered as the end point of levigation. Tablets of both samples were prepared by adding Pippali and honey in it and analyzed for their quality control parameters. Results: Twenty-eight hours duration of repeated levigation was required in LMV 50 which was prolonged up to 48 h in batch carried out in rainy season. In LMV 75, comparatively maximum duration of 54 h was required for levigation which was prolonged in the rainy season to 88 h. In both groups, lemon juice required for repeated levigation was 10 times of quantity of butter added initially. Conclusion: From pharmaceutical point of view, preparation of LMV Rasa tablets with quantity of butter in 50% of total ingredients is more convenient.
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Standard Manufacturing Procedure of Shadguna Balijarita Makaradhwaja.
AYU (An International Quarterly Journal of Research in Ayurveda), 2014Co-Authors: Sanjay B Khedekar, Pradeep Kumar PrajapatiAbstract:Background: Makaradhwaja is one of the most potent herbomineral medicines of Ayurveda. Different references for the preparation of Makaradhwaja were reported in classics. According to the proportion of sulfur (Gandhaka), three references were mentioned in classics that is, Dwiguna (2:1 = S: Hg), Triguna (3:1 = S: Hg) and Shadguna (6:1 = S: Hg). Makaradhwaja is prepared by Kupipakwa system of heating. In the preparation of Kupipakwa medicine as the ratio of sulfur to mercury increases it becomes difficult to prepare medicine. Aim: To standardize Manufacturing Procedure of Shadguna Balijarita Makaradhwaja (SBM). Materials and Methods: Total four batches of SBM were prepared by using electrical muffle furnace (EMF). All the involved Procedures were followed as per classical guidelines. Results: Average 13.68% yield of SBM was observed. Conclusion: SBM requires intermittent heating pattern, that is, mild heat (100-125 0 C) for 2.5 hrs, moderate heat (250-450 0 C) for 4.5 hrs and strong heat (450-600 0 C) for 5 hrs for 290.5 g Kajjali.
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Standard Manufacturing Procedure of Tamra Bhasma.
AYU (An International Quarterly Journal of Research in Ayurveda), 2012Co-Authors: Chandrashekhar Y Jagtap, Pradeep Kumar Prajapati, Biswajyoti Patgiri, Vinay J ShuklaAbstract:Tamra Bhasma (incinerated copper) is one of the main weapons in the archery of Ayurvedic practitioners. Though several methods of preparation of Tamra Bhasma (TB) are found in Rasashastra classics, several difficulties occur during the preparation of a good-quality Bhasma. In this study, TB was prepared and analyzed to develop the standard Manufacturing Procedure. Each unit operative Procedure was considered as an independent processing and an attempt was made to validate each Procedure. Wire used for the purpose of electrical earthing was taken for the preparation of Bhasma. Procedures of Shodhana, Marana, and Amritikarana were followed as per the classical references. Specific temperature pattern was adopted for Puta in the electrical muffle furnace. From 500 g of Tamra, 483.4 g of black colored TB was obtained after subjecting to three Putas. Final product was detected to be cupric sulfide in X-ray diffraction. In particle size distribution analysis 10% of the material was below the size of 2 μm, while in inductive coupled plasma - atomic absorption spectrometry 58.56 wt% copper and 22.48 wt% of sulfur were found present in the final product along with the elements such as arsenic, lead, zinc, mercury, and manganese in traces.
Pk Prajapati - One of the best experts on this subject based on the ideXlab platform.
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Validation of standard Manufacturing Procedure of Guḍūcī sattva (aqueous extract of Tinospora cordifolia (Willd.) Miers) and its tablets.
Ancient Science of Life, 2013Co-Authors: Rohit Sharma, Hetal Amin, Galib, Pk PrajapatiAbstract:Introduction: Guḍūci Sattva is a highly valued formulation among ayurvedic physicians, commonly recommended in conditions such as Jvara (fever), Dāha (burning sensation) and other conditions of Pitta predominance. In spite of its numerous medicinal attributes, no published work is available until date on Manufacturing guidelines along with its quality control parameters. Aims and Objectives: The aim of this study is to develop the standard Manufacturing Procedure for preparation of Guḍūci Sattva and its tablets. Materials and Methods: A total of 15 batches of Guḍūci Sattva were prepared in the laboratory. During its preparation, pharmaceutical findings and observations were systematically recorded. To maintain quality control, Guḍūci Sattva tablets were further subjected to analysis such as shape, diameter, width, hardness, weight variation, disintegration time (DT) and friability. Qualitative analysis to detect the presence of various functional groups and high performance thin layer chromatography (HPTLC) profile were also carried out. Results and Conclusion: The average percentage of dried Sattva obtained was 3.8%. The tablets were prepared by direct compression method as per pharmacopoeal specifications. Optimum hardness, weight of tablets, DT and friability of Guḍūci Sattva tablets were found complying with official standards. Alkaloids, carbohydrates and starch were found present in Sattva tablets. Number of peaks obtained in HPTLC also corresponds to this finding. Data obtained by present study may be considered as standard for future studies.
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Standard Manufacturing Procedure for syrup and tablet forms of Jwarahara Dashemani
AYU (An International Quarterly Journal of Research in Ayurveda), 2010Co-Authors: Bharat D Kalsariya, Bj Patgiri, Pk PrajapatiAbstract:Jwarahara Dashemani (JHD) is mentioned by Acharya Charaka under the different categories of Mahakashayas (groups of drugs having similar pharmacological actions). For the present study, syrup and tablet forms of JHDs were prepared and analyzed. The formulations were prepared in various batches by following the standard Manufacturing Procedure (SMP). JHD Kwatha (2200 ml) and 1430 g sugar candy powder were heated (80-90 o C) together for 3.10 hours and 2200 ml syrup was obtained, whereas an average of 446 g of tablet was obtained from the mixture of 285 g Ghana and powder of sugar candy (125 g), JHD Dravyas (55 g) and talc (18 g). These formulations were subjected to various analytical parameters and the results were observed on the basis of preparation.
Singh Azad - One of the best experts on this subject based on the ideXlab platform.
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Importance and standard Manufacturing Procedure protocol for Rasanadi Guggulu
Journal of Pharmacognosy and Phytochemistry, 2019Co-Authors: Chhaya, Singh Azad, Wineet ChawlaAbstract:Guggulu is oleo gum resin (oleo resin) that exudes results of injury from the bark of genus Commiphora mukul Hook. Ex Stocks is belongs to the rosid dicot family. It possesses a huge ethno medical history and represents a phytochemicals reservoir of heuristic medical values. Guggulu is one in all the ingredients of the many imperative formulations utilized in the Ayurveda most of that square measure named with suffix ‘guggulu’. Guggulsterone a main active substance in gugulipid, an extract of the C. mukul, won’t to treat a spread of disorders in human. It is ascertained that pure guggulu is employed in numerous guggulu formulations in varied sickness conditions with or without specific anupana. The formulation conception of guggulu in piece of writing characterized for higher pharmacokinetic and polyvalent effects with multiple mechanism of drug action. Hence, it's would like of gift era to conduct the diagnosing and clinical test to support the therapeutic efficaciousness of Guggulu formulations cited within the ancient literatures. Guggulu preparation is one of the most important classical preparations in ancient literature. Rasana is a wonderful anti-inflammatory and pain relieving herb, helpful in headache, earache, neurologic pains etc. Ginger, Devdaru and Eranda square measure glorious Vatahara herbs balance Vata Dosha. Guggulu formulation being administered over 1000s of years can be generalized; above Ayurvedic formulations of Guggulu has helped treating conditions giving an alternate support to the patients. It discusses in detail, the effects thereof to the patients. It concludes saying neurological conditions can be treated with the help of Guggulu Rasayan.
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STANDARD Manufacturing Procedure PROTOCOL FOR TUTTHA BHASMA AN AYURVEDIC ALCHEMY AND ITS UTILITY
2018Co-Authors: Singh Azad, Desale Varun, Srivastava PrashantAbstract:Objective: Standard operating protocol for Manufacturing of Tuttha bhasma is a precious metal used in Ayurveda Alchemy Rasa Shastra. Methods: The study was facilitated by collecting Tuttha and was procured from Pharmacy IPGT and RA, Gujarat Ayurved University, Jamnagar. With Grahya Lakshanas (qualities as described in the classics), namely, Snigdha (unctuous), Guru (heavy), and Mahaujjala (very bright blue in color) were observed and selected the sample for the study.Results: From the study, we obtained Tuttha after shodhana is 105 g, 102 g, and 105 g, the average 104% while Marana with Gandhaka media it is 39.2% and in Marana without Gandhaka it is 24.8%.Conclusion: The study confirms that the Manufacturings of Tuttha have contained the purification of Gandhak and its utility and the trituratation with Bijora nimbu and heating pattern of Tuttha bhasama.