The Experts below are selected from a list of 54 Experts worldwide ranked by ideXlab platform

Om Prakash Mishra - One of the best experts on this subject based on the ideXlab platform.

  • “Polymorphisms in folate metabolism genes as Maternal Risk Factor for neural tube defects: an updated meta-analysis”
    Metabolic Brain Disease, 2015
    Co-Authors: Upendra Yadav, Pradeep Kumar, Sushil Kumar Yadav, Om Prakash Mishra
    Abstract:

    Epidemiological studies have evaluated the association between Maternal methylenetetrahydrofolate reductase (MTHFR) C677T, A1298C and methionine synthase reductase (MTRR) A66G polymorphisms and Risk of neural tube defects (NTDs) in offspring. However, the results from the published studies on the association between these three polymorphisms and NTD Risk are conflicting. To derive a clearer picture of association between these three Maternal polymorphisms and Risk of NTD, we performed meta-analysis. A comprehensive search was conducted to identify all case–control studies of Maternal MTHFR and MTRR polymorphisms and NTD Risk. We used odds ratios (ORs) with 95 % confidence intervals (CIs) to assess the strength of the association. Overall, we found that Maternal MTHFR C677T polymorphism (OR_TvsC =1.20; 95 % CI = 1.13–1.28) and MTRR A66G polymorphism (OR_GvsA = 1.21; 95 % CI = 0.98–1.49) were Risk Factors for producing offspring with NTD but Maternal MTHFR A1298C polymorphism (OR_CvsA = 0.91; 95 % CI = 0.78–1.07) was not associated with NTD Risk. However, in stratified analysis by geographical regions, we found that the Maternal C677T polymorphism was significantly associated with the Risk of NTD in Asian (OR_TvsC = 1.43; 95 % CI: 1.05–1.94), European (OR_TvsC = 1.13; 95 % CI: 1.04–1.24) and American (OR_TvsC = 1.26; 95 % CI: 1.13–1.41) populations. In conclusion, present meta-analysis supports that the Maternal MTHFR C677T and MTRR A66G are polymorphisms contributory to Risk for NTD.

Upendra Yadav - One of the best experts on this subject based on the ideXlab platform.

  • “Polymorphisms in folate metabolism genes as Maternal Risk Factor for neural tube defects: an updated meta-analysis”
    Metabolic Brain Disease, 2015
    Co-Authors: Upendra Yadav, Pradeep Kumar, Sushil Kumar Yadav, Om Prakash Mishra
    Abstract:

    Epidemiological studies have evaluated the association between Maternal methylenetetrahydrofolate reductase (MTHFR) C677T, A1298C and methionine synthase reductase (MTRR) A66G polymorphisms and Risk of neural tube defects (NTDs) in offspring. However, the results from the published studies on the association between these three polymorphisms and NTD Risk are conflicting. To derive a clearer picture of association between these three Maternal polymorphisms and Risk of NTD, we performed meta-analysis. A comprehensive search was conducted to identify all case–control studies of Maternal MTHFR and MTRR polymorphisms and NTD Risk. We used odds ratios (ORs) with 95 % confidence intervals (CIs) to assess the strength of the association. Overall, we found that Maternal MTHFR C677T polymorphism (OR_TvsC =1.20; 95 % CI = 1.13–1.28) and MTRR A66G polymorphism (OR_GvsA = 1.21; 95 % CI = 0.98–1.49) were Risk Factors for producing offspring with NTD but Maternal MTHFR A1298C polymorphism (OR_CvsA = 0.91; 95 % CI = 0.78–1.07) was not associated with NTD Risk. However, in stratified analysis by geographical regions, we found that the Maternal C677T polymorphism was significantly associated with the Risk of NTD in Asian (OR_TvsC = 1.43; 95 % CI: 1.05–1.94), European (OR_TvsC = 1.13; 95 % CI: 1.04–1.24) and American (OR_TvsC = 1.26; 95 % CI: 1.13–1.41) populations. In conclusion, present meta-analysis supports that the Maternal MTHFR C677T and MTRR A66G are polymorphisms contributory to Risk for NTD.

K. G. Porter - One of the best experts on this subject based on the ideXlab platform.

  • Screening for coeliac disease as a possible Maternal Risk Factor for neural tube defect.
    Clinical genetics, 2008
    Co-Authors: W. Dickey, Fiona Stewart, J. Nelson, G. Mcbreen, S. A. Mcmillan, K. G. Porter
    Abstract:

    Coeliac disease is an important cause of malabsorption, particularly of folic acid, in adults. We investigated the possibility that it might be a Maternal Risk Factor for neural tube defect (NTD)-associated pregnancy by screening affected mothers using serum endomysial antibody (EmA) which has high sensitivity and specificity for coeliac disease. One (1.6%) of 60 patients was EmA positive and had a diagnosis of coeliac disease confirmed by the finding of villous atrophy on jejunal biopsy. In conclusion, the majority of NTD-associated pregnancies are not associated with Maternal coeliac disease and our study is additional evidence that abnormalities of folic acid metabolism rather than absorption are the most important Risk Factors for NTD. Further studies are needed to determine whether the coeliac disease prevalence among women with NTD-affected pregnancy is higher than that of the general population.

Pradeep Kumar - One of the best experts on this subject based on the ideXlab platform.

  • “Polymorphisms in folate metabolism genes as Maternal Risk Factor for neural tube defects: an updated meta-analysis”
    Metabolic Brain Disease, 2015
    Co-Authors: Upendra Yadav, Pradeep Kumar, Sushil Kumar Yadav, Om Prakash Mishra
    Abstract:

    Epidemiological studies have evaluated the association between Maternal methylenetetrahydrofolate reductase (MTHFR) C677T, A1298C and methionine synthase reductase (MTRR) A66G polymorphisms and Risk of neural tube defects (NTDs) in offspring. However, the results from the published studies on the association between these three polymorphisms and NTD Risk are conflicting. To derive a clearer picture of association between these three Maternal polymorphisms and Risk of NTD, we performed meta-analysis. A comprehensive search was conducted to identify all case–control studies of Maternal MTHFR and MTRR polymorphisms and NTD Risk. We used odds ratios (ORs) with 95 % confidence intervals (CIs) to assess the strength of the association. Overall, we found that Maternal MTHFR C677T polymorphism (OR_TvsC =1.20; 95 % CI = 1.13–1.28) and MTRR A66G polymorphism (OR_GvsA = 1.21; 95 % CI = 0.98–1.49) were Risk Factors for producing offspring with NTD but Maternal MTHFR A1298C polymorphism (OR_CvsA = 0.91; 95 % CI = 0.78–1.07) was not associated with NTD Risk. However, in stratified analysis by geographical regions, we found that the Maternal C677T polymorphism was significantly associated with the Risk of NTD in Asian (OR_TvsC = 1.43; 95 % CI: 1.05–1.94), European (OR_TvsC = 1.13; 95 % CI: 1.04–1.24) and American (OR_TvsC = 1.26; 95 % CI: 1.13–1.41) populations. In conclusion, present meta-analysis supports that the Maternal MTHFR C677T and MTRR A66G are polymorphisms contributory to Risk for NTD.

Sushil Kumar Yadav - One of the best experts on this subject based on the ideXlab platform.

  • “Polymorphisms in folate metabolism genes as Maternal Risk Factor for neural tube defects: an updated meta-analysis”
    Metabolic Brain Disease, 2015
    Co-Authors: Upendra Yadav, Pradeep Kumar, Sushil Kumar Yadav, Om Prakash Mishra
    Abstract:

    Epidemiological studies have evaluated the association between Maternal methylenetetrahydrofolate reductase (MTHFR) C677T, A1298C and methionine synthase reductase (MTRR) A66G polymorphisms and Risk of neural tube defects (NTDs) in offspring. However, the results from the published studies on the association between these three polymorphisms and NTD Risk are conflicting. To derive a clearer picture of association between these three Maternal polymorphisms and Risk of NTD, we performed meta-analysis. A comprehensive search was conducted to identify all case–control studies of Maternal MTHFR and MTRR polymorphisms and NTD Risk. We used odds ratios (ORs) with 95 % confidence intervals (CIs) to assess the strength of the association. Overall, we found that Maternal MTHFR C677T polymorphism (OR_TvsC =1.20; 95 % CI = 1.13–1.28) and MTRR A66G polymorphism (OR_GvsA = 1.21; 95 % CI = 0.98–1.49) were Risk Factors for producing offspring with NTD but Maternal MTHFR A1298C polymorphism (OR_CvsA = 0.91; 95 % CI = 0.78–1.07) was not associated with NTD Risk. However, in stratified analysis by geographical regions, we found that the Maternal C677T polymorphism was significantly associated with the Risk of NTD in Asian (OR_TvsC = 1.43; 95 % CI: 1.05–1.94), European (OR_TvsC = 1.13; 95 % CI: 1.04–1.24) and American (OR_TvsC = 1.26; 95 % CI: 1.13–1.41) populations. In conclusion, present meta-analysis supports that the Maternal MTHFR C677T and MTRR A66G are polymorphisms contributory to Risk for NTD.