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Gisele Alves Dos Reis Benatto - One of the best experts on this subject based on the ideXlab platform.

  • Matrix Organization and merit factor evaluation as a method to address the challenge of finding a polymer material for roll coated polymer solar cells
    Advanced Energy Materials, 2015
    Co-Authors: Eva Bundgaard, Francesco Livi, Ole Hagemann, Jon Eggert Carle, Martin Helgesen, Ilona Maria Heckler, Natalia Klaudia Zawacka, Dechan Angmo, Thue Trofod Larsenolsen, Gisele Alves Dos Reis Benatto
    Abstract:

    The results presented demonstrate how the screening of 104 light-absorbing low band gap polymers for suitability in roll coated polymer solar cells can be accomplished through rational synthesis according to a Matrix where 8 donor and 13 acceptor units are organized in rows and columns. Synthesis of all the polymers corresponding to all combinations of donor and acceptor units is followed by characterization of all the materials with respect to molecular weight, electrochemical energy levels, band gaps, photochemical stability, carrier mobility, and photovoltaic parameters. The photovoltaic evaluation is carried out with specific reference to scalable manufacture, which includes large area (1 cm(2)), stable inverted device architecture, an indium-tin-oxide-free fully printed flexible front electrode with ZnO/PEDOT:PSS (poly(3,4-ethylenedioxythiophene):polystyrene sulfonate), and a printed silver comb back electrode structure. The Matrix Organization enables fast identification of active layer materials according to a weighted merit factor that includes more than simply the power conversion efficiency and is used as a method to identify the lead candidates. Based on several characteristics included in the merit factor, it is found that 13 out of the 104 synthesized polymers outperformed poly(3-hexylthiophene) under the chosen processing conditions and thus can be suitable for further development.

  • Matrix Organization and merit factor evaluation as a method to address the challenge of finding a polymer material for roll coated polymer solar cells
    Advanced Energy Materials, 2015
    Co-Authors: Eva Bundgaard, Francesco Livi, Ole Hagemann, Jon Eggert Carle, Martin Helgesen, Ilona Maria Heckler, Natalia Klaudia Zawacka, Dechan Angmo, Thue Trofod Larsenolsen, Gisele Alves Dos Reis Benatto
    Abstract:

    The results presented demonstrate how the screening of 104 light-absorbing low band gap polymers for suitability in roll coated polymer solar cells can be accomplished through rational synthesis according to a Matrix where 8 donor and 13 acceptor units are organized in rows and columns. Synthesis of all the polymers corresponding to all combinations of donor and acceptor units is followed by characterization of all the materials with respect to molecular weight, electrochemical energy levels, band gaps, photochemical stability, carrier mobility, and photovoltaic parameters. The photovoltaic evaluation is carried out with specific reference to scalable manufacture, which includes large area (1 cm(2)), stable inverted device architecture, an indium-tin-oxide-free fully printed flexible front electrode with ZnO/PEDOT:PSS (poly(3,4-ethylenedioxythiophene):polystyrene sulfonate), and a printed silver comb back electrode structure. The Matrix Organization enables fast identification of active layer materials according to a weighted merit factor that includes more than simply the power conversion efficiency and is used as a method to identify the lead candidates. Based on several characteristics included in the merit factor, it is found that 13 out of the 104 synthesized polymers outperformed poly(3-hexylthiophene) under the chosen processing conditions and thus can be suitable for further development.

Eva Bundgaard - One of the best experts on this subject based on the ideXlab platform.

  • Matrix Organization and merit factor evaluation as a method to address the challenge of finding a polymer material for roll coated polymer solar cells
    Advanced Energy Materials, 2015
    Co-Authors: Eva Bundgaard, Francesco Livi, Ole Hagemann, Jon Eggert Carle, Martin Helgesen, Ilona Maria Heckler, Natalia Klaudia Zawacka, Dechan Angmo, Thue Trofod Larsenolsen, Gisele Alves Dos Reis Benatto
    Abstract:

    The results presented demonstrate how the screening of 104 light-absorbing low band gap polymers for suitability in roll coated polymer solar cells can be accomplished through rational synthesis according to a Matrix where 8 donor and 13 acceptor units are organized in rows and columns. Synthesis of all the polymers corresponding to all combinations of donor and acceptor units is followed by characterization of all the materials with respect to molecular weight, electrochemical energy levels, band gaps, photochemical stability, carrier mobility, and photovoltaic parameters. The photovoltaic evaluation is carried out with specific reference to scalable manufacture, which includes large area (1 cm(2)), stable inverted device architecture, an indium-tin-oxide-free fully printed flexible front electrode with ZnO/PEDOT:PSS (poly(3,4-ethylenedioxythiophene):polystyrene sulfonate), and a printed silver comb back electrode structure. The Matrix Organization enables fast identification of active layer materials according to a weighted merit factor that includes more than simply the power conversion efficiency and is used as a method to identify the lead candidates. Based on several characteristics included in the merit factor, it is found that 13 out of the 104 synthesized polymers outperformed poly(3-hexylthiophene) under the chosen processing conditions and thus can be suitable for further development.

  • Matrix Organization and merit factor evaluation as a method to address the challenge of finding a polymer material for roll coated polymer solar cells
    Advanced Energy Materials, 2015
    Co-Authors: Eva Bundgaard, Francesco Livi, Ole Hagemann, Jon Eggert Carle, Martin Helgesen, Ilona Maria Heckler, Natalia Klaudia Zawacka, Dechan Angmo, Thue Trofod Larsenolsen, Gisele Alves Dos Reis Benatto
    Abstract:

    The results presented demonstrate how the screening of 104 light-absorbing low band gap polymers for suitability in roll coated polymer solar cells can be accomplished through rational synthesis according to a Matrix where 8 donor and 13 acceptor units are organized in rows and columns. Synthesis of all the polymers corresponding to all combinations of donor and acceptor units is followed by characterization of all the materials with respect to molecular weight, electrochemical energy levels, band gaps, photochemical stability, carrier mobility, and photovoltaic parameters. The photovoltaic evaluation is carried out with specific reference to scalable manufacture, which includes large area (1 cm(2)), stable inverted device architecture, an indium-tin-oxide-free fully printed flexible front electrode with ZnO/PEDOT:PSS (poly(3,4-ethylenedioxythiophene):polystyrene sulfonate), and a printed silver comb back electrode structure. The Matrix Organization enables fast identification of active layer materials according to a weighted merit factor that includes more than simply the power conversion efficiency and is used as a method to identify the lead candidates. Based on several characteristics included in the merit factor, it is found that 13 out of the 104 synthesized polymers outperformed poly(3-hexylthiophene) under the chosen processing conditions and thus can be suitable for further development.

Krystyn J. Van Vliet - One of the best experts on this subject based on the ideXlab platform.

  • time dependent extracellular Matrix Organization and secretion from vascular endothelial cells due to macromolecular crowding
    MRS Proceedings, 2014
    Co-Authors: Adam S. Zeiger, Krystyn J. Van Vliet, Frances D Liu
    Abstract:

    Interactions between biological cells and surrounding extracellular Matrix (ECM) materials modulate many cell behaviors including adhesion and migration. One key example of this cellMatrix reciprocity is in the context of angiogenesis, the sprouting of new blood vessels from preexisting vasculature. Vascular endothelial cells (VECs) create and remodel the ECM during this process. In vivo , the surrounding fluid environment includes high concentrations of macromolecules, and is considered “crowded” in comparison to in vitro environments. Here, we quantified the amount and Organization of collagen IV, a prominent ECM component of VECs, that was produced by these cells over four weeks in vitro in the presence or absence of macromolecular crowder (MMC) nanoparticles that approximated in vivo crowding. In the presence of MMCs, the amount and degree of alignment of collagen IV was greater. This ECM difference emerged within one week and was sustained for over four weeks. We explored the effect of initial cell density (cells/µm 2 ) on this Matrix production, to consider potential differences at a wound site versus an intact vessel. Moreover, we found the biophysical effect of MMCs to be unmodulated by secretions from an adjacent cell type in microvessels (pericytes). These results suggest that macromolecular crowding plays a direct role in remodeling the basement membrane, and that such crowding can be induced in vitro to more closely approximate the cell microenvironment.

  • Macromolecular crowding directs extracellular Matrix Organization and mesenchymal stem cell behavior.
    PloS one, 2012
    Co-Authors: Adam S. Zeiger, Felicia C. Loe, Michael Raghunath, Krystyn J. Van Vliet
    Abstract:

    Microenvironments of biological cells are dominated in vivo by macromolecular crowding and resultant excluded volume effects. This feature is absent in dilute in vitro cell culture. Here, we induced macromolecular crowding in vitro by using synthetic macromolecular globules of nm-scale radius at physiological levels of fractional volume occupancy. We quantified the impact of induced crowding on the extracellular and intracellular protein Organization of human mesenchymal stem cells (MSCs) via immunocytochemistry, atomic force microscopy (AFM), and AFM-enabled nanoindentation. Macromolecular crowding in extracellular culture media directly induced supramolecular assembly and alignment of extracellular Matrix proteins deposited by cells, which in turn increased alignment of the intracellular actin cytoskeleton. The resulting cell-Matrix reciprocity further affected adhesion, proliferation, and migration behavior of MSCs. Macromolecular crowding can thus aid the design of more physiologically relevant in vitro studies and devices for MSCs and other cells, by increasing the fidelity between materials synthesized by cells in vivo and in vitro.

Alexis Desmouliere - One of the best experts on this subject based on the ideXlab platform.

  • mechanical forces induce scar remodeling study in non pressure treated versus pressure treated hypertrophic scars
    American Journal of Pathology, 1999
    Co-Authors: Andrea Monte Alto Costa, Simone Peyrol, Luis Cristovao Porto, Jeanpierre Comparin, Jeanlouis Foyatier, Alexis Desmouliere
    Abstract:

    Reparative process of second and third degree burns usually results in hypertrophic scar formation that can be treated by pressure. Although this method is efficient, its mechanisms of action are not known. In this work, we have studied the histological Organization of hypertrophic scars submitted to pressure. Skin biopsies were performed 2 to 7 months after the onset of treatment in two adjacent regions of the scar, non-pressure- or pressure-treated and analyzed by immunohistochemistry and transmission electron microscopy for extracellular Matrix Organization and cellular morphology. In non-pressure-treated regions, fibrillin deposits did not present the classical candelabra-like pattern under epidermis and were reduced in dermis; in pressure-treated regions the amount was increased compared to non-pressure-treated regions but the Organization was still disturbed. In non-pressure-treated regions, elastin was present in patch deposits; in pressure-treated regions elastin formed fibers, smaller than in normal dermis. Tenascin was present in the whole dermis in non-pressure-treated regions, whereas in pressure-treated regions it was observed only under epidermis and around vessels, as in normal skin. α-Smooth muscle actin-expressing myofibroblasts were absent in normal skin, present in large amounts in non-pressure-treated regions, and almost absent in pressure-treated regions. The disturbed ultrastructural Organization of dermal-epidermal junction observed in non-pressure-treated regions disappeared after pressure therapy; typical features of apoptosis in fibroblastic cells and morphological aspects of collagen degradation were observed in pressure-treated regions. Our results show that, in hypertrophic scars, pressure therapy restores in part the extracellular Matrix Organization observed in normal scar and induces the disappearance of α-smooth muscle actin-expressing myofibroblasts, probably by apoptosis. We suggest that the pressure acts by accelerating the remission phase of the postburn reparative process.

Ilona Maria Heckler - One of the best experts on this subject based on the ideXlab platform.

  • Matrix Organization and merit factor evaluation as a method to address the challenge of finding a polymer material for roll coated polymer solar cells
    Advanced Energy Materials, 2015
    Co-Authors: Eva Bundgaard, Francesco Livi, Ole Hagemann, Jon Eggert Carle, Martin Helgesen, Ilona Maria Heckler, Natalia Klaudia Zawacka, Dechan Angmo, Thue Trofod Larsenolsen, Gisele Alves Dos Reis Benatto
    Abstract:

    The results presented demonstrate how the screening of 104 light-absorbing low band gap polymers for suitability in roll coated polymer solar cells can be accomplished through rational synthesis according to a Matrix where 8 donor and 13 acceptor units are organized in rows and columns. Synthesis of all the polymers corresponding to all combinations of donor and acceptor units is followed by characterization of all the materials with respect to molecular weight, electrochemical energy levels, band gaps, photochemical stability, carrier mobility, and photovoltaic parameters. The photovoltaic evaluation is carried out with specific reference to scalable manufacture, which includes large area (1 cm(2)), stable inverted device architecture, an indium-tin-oxide-free fully printed flexible front electrode with ZnO/PEDOT:PSS (poly(3,4-ethylenedioxythiophene):polystyrene sulfonate), and a printed silver comb back electrode structure. The Matrix Organization enables fast identification of active layer materials according to a weighted merit factor that includes more than simply the power conversion efficiency and is used as a method to identify the lead candidates. Based on several characteristics included in the merit factor, it is found that 13 out of the 104 synthesized polymers outperformed poly(3-hexylthiophene) under the chosen processing conditions and thus can be suitable for further development.

  • Matrix Organization and merit factor evaluation as a method to address the challenge of finding a polymer material for roll coated polymer solar cells
    Advanced Energy Materials, 2015
    Co-Authors: Eva Bundgaard, Francesco Livi, Ole Hagemann, Jon Eggert Carle, Martin Helgesen, Ilona Maria Heckler, Natalia Klaudia Zawacka, Dechan Angmo, Thue Trofod Larsenolsen, Gisele Alves Dos Reis Benatto
    Abstract:

    The results presented demonstrate how the screening of 104 light-absorbing low band gap polymers for suitability in roll coated polymer solar cells can be accomplished through rational synthesis according to a Matrix where 8 donor and 13 acceptor units are organized in rows and columns. Synthesis of all the polymers corresponding to all combinations of donor and acceptor units is followed by characterization of all the materials with respect to molecular weight, electrochemical energy levels, band gaps, photochemical stability, carrier mobility, and photovoltaic parameters. The photovoltaic evaluation is carried out with specific reference to scalable manufacture, which includes large area (1 cm(2)), stable inverted device architecture, an indium-tin-oxide-free fully printed flexible front electrode with ZnO/PEDOT:PSS (poly(3,4-ethylenedioxythiophene):polystyrene sulfonate), and a printed silver comb back electrode structure. The Matrix Organization enables fast identification of active layer materials according to a weighted merit factor that includes more than simply the power conversion efficiency and is used as a method to identify the lead candidates. Based on several characteristics included in the merit factor, it is found that 13 out of the 104 synthesized polymers outperformed poly(3-hexylthiophene) under the chosen processing conditions and thus can be suitable for further development.