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Medhat Osman - One of the best experts on this subject based on the ideXlab platform.
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proposed reduction in whole body Maximum Permissible Dose for occupational workers awareness and potential impact
The Journal of Nuclear Medicine, 2010Co-Authors: Bridget Kistner, Crystal Botkin, William Hubble, Medhat OsmanAbstract:2102 Objectives Currently, the annual whole body Maximum Permissible Dose (MPD) set by the Nuclear Regulatory Commission (NRC) is 5 rem. A recent International Commission on Radiological Protection (ICRP) Publication 103 recommends an annual MPD of 2 rem. The purpose of this study was to evaluate awareness of radiation workers in different sites, as well as the potential impact of the proposed changes on the radiation workforce. Methods A ten question survey was distributed to nine sites. The sites included community hospitals, academic institutions, and commercial radiopharmacies in the St. Louis Metropolitan area and radiopharmaceutical manufacturers. The questions of the survey addressed awareness and potential impact of the proposed change. A representative from the Radiation Safety Committee in each site responded to the survey. The results were summarized. Results Of the sites surveyed, 6/9 (66.7%) were not aware of the proposed change. None of the surveyed sites had workers with an exposure that exceeded 5 rem; however, 2/9 (22.2%) sites surveyed had workers with an exposure that exceeded 2 rem. Conclusions We are still collecting data; however, initial results reveal that many sites were not aware of the proposed changes. If enforced, the proposed reduction from 5 rem to 2 rem would have a direct impact on the daily operations of these sites and their workers. This is particularly true with workers handling PET isotopes, Iodine-131, or fluoroscopy
Bridget Kistner - One of the best experts on this subject based on the ideXlab platform.
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proposed reduction in whole body Maximum Permissible Dose for occupational workers awareness and potential impact
The Journal of Nuclear Medicine, 2010Co-Authors: Bridget Kistner, Crystal Botkin, William Hubble, Medhat OsmanAbstract:2102 Objectives Currently, the annual whole body Maximum Permissible Dose (MPD) set by the Nuclear Regulatory Commission (NRC) is 5 rem. A recent International Commission on Radiological Protection (ICRP) Publication 103 recommends an annual MPD of 2 rem. The purpose of this study was to evaluate awareness of radiation workers in different sites, as well as the potential impact of the proposed changes on the radiation workforce. Methods A ten question survey was distributed to nine sites. The sites included community hospitals, academic institutions, and commercial radiopharmacies in the St. Louis Metropolitan area and radiopharmaceutical manufacturers. The questions of the survey addressed awareness and potential impact of the proposed change. A representative from the Radiation Safety Committee in each site responded to the survey. The results were summarized. Results Of the sites surveyed, 6/9 (66.7%) were not aware of the proposed change. None of the surveyed sites had workers with an exposure that exceeded 5 rem; however, 2/9 (22.2%) sites surveyed had workers with an exposure that exceeded 2 rem. Conclusions We are still collecting data; however, initial results reveal that many sites were not aware of the proposed changes. If enforced, the proposed reduction from 5 rem to 2 rem would have a direct impact on the daily operations of these sites and their workers. This is particularly true with workers handling PET isotopes, Iodine-131, or fluoroscopy
William Hubble - One of the best experts on this subject based on the ideXlab platform.
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proposed reduction in whole body Maximum Permissible Dose for occupational workers awareness and potential impact
The Journal of Nuclear Medicine, 2010Co-Authors: Bridget Kistner, Crystal Botkin, William Hubble, Medhat OsmanAbstract:2102 Objectives Currently, the annual whole body Maximum Permissible Dose (MPD) set by the Nuclear Regulatory Commission (NRC) is 5 rem. A recent International Commission on Radiological Protection (ICRP) Publication 103 recommends an annual MPD of 2 rem. The purpose of this study was to evaluate awareness of radiation workers in different sites, as well as the potential impact of the proposed changes on the radiation workforce. Methods A ten question survey was distributed to nine sites. The sites included community hospitals, academic institutions, and commercial radiopharmacies in the St. Louis Metropolitan area and radiopharmaceutical manufacturers. The questions of the survey addressed awareness and potential impact of the proposed change. A representative from the Radiation Safety Committee in each site responded to the survey. The results were summarized. Results Of the sites surveyed, 6/9 (66.7%) were not aware of the proposed change. None of the surveyed sites had workers with an exposure that exceeded 5 rem; however, 2/9 (22.2%) sites surveyed had workers with an exposure that exceeded 2 rem. Conclusions We are still collecting data; however, initial results reveal that many sites were not aware of the proposed changes. If enforced, the proposed reduction from 5 rem to 2 rem would have a direct impact on the daily operations of these sites and their workers. This is particularly true with workers handling PET isotopes, Iodine-131, or fluoroscopy
Crystal Botkin - One of the best experts on this subject based on the ideXlab platform.
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proposed reduction in whole body Maximum Permissible Dose for occupational workers awareness and potential impact
The Journal of Nuclear Medicine, 2010Co-Authors: Bridget Kistner, Crystal Botkin, William Hubble, Medhat OsmanAbstract:2102 Objectives Currently, the annual whole body Maximum Permissible Dose (MPD) set by the Nuclear Regulatory Commission (NRC) is 5 rem. A recent International Commission on Radiological Protection (ICRP) Publication 103 recommends an annual MPD of 2 rem. The purpose of this study was to evaluate awareness of radiation workers in different sites, as well as the potential impact of the proposed changes on the radiation workforce. Methods A ten question survey was distributed to nine sites. The sites included community hospitals, academic institutions, and commercial radiopharmacies in the St. Louis Metropolitan area and radiopharmaceutical manufacturers. The questions of the survey addressed awareness and potential impact of the proposed change. A representative from the Radiation Safety Committee in each site responded to the survey. The results were summarized. Results Of the sites surveyed, 6/9 (66.7%) were not aware of the proposed change. None of the surveyed sites had workers with an exposure that exceeded 5 rem; however, 2/9 (22.2%) sites surveyed had workers with an exposure that exceeded 2 rem. Conclusions We are still collecting data; however, initial results reveal that many sites were not aware of the proposed changes. If enforced, the proposed reduction from 5 rem to 2 rem would have a direct impact on the daily operations of these sites and their workers. This is particularly true with workers handling PET isotopes, Iodine-131, or fluoroscopy
Youngkyu Park - One of the best experts on this subject based on the ideXlab platform.
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development and assessment individual Maximum Permissible Dose method of i 131 therapy in high risk patients with differentiated papillary thyroid cancer
The Korean Journal of Nuclear Medicine, 2003Co-Authors: Jeongchul Kim, Junghan Yoon, Heeseung Bom, Youngjong Jaegal, Hochun Song, Jungjoon Min, Heong Jeong, Seongmin Kim, Youngjun Heo, Youngkyu ParkAbstract:Purpose: Radioiodine (I-131) therapy is an effective modality to reduce both recurrence and mortality rates in differentiated thyroid cancer. Whether higher Doses shows higher therapeutic responses was still debatable. The purpose of this study was to validate curve-fitting (CF) method measuring Maximum Permissible Dose (MPD) by a biological dosimetry using metaphase analysis of peripheral blood lymphocytes. Materials and Methods: Therapeutic effects of MPD was evaluated in 58 patients (49 females and 9 males, mean age years) of papillary thyroid cancer. Among them 43 patients were treated with , while 15 patients with . The former was defined as low-Dose group, and the latter high-Dose group. Therapeutic response was defined as complete response when complete disappearance of lesions on follow-up I-131 scan and undetectable serum thyroglobulin levels were found. Statistical comparison between groups were done using chi-square test. P value less than 0.05 was regarded as statistically significant. Results: MPD measured by CF method using tracer and therapeutic Doses were , respectively (p=0.20). They showed a significant correlation (r=0.8, p (p=0.01). They also showed a significant correlation (r=0.86, p=0.01). High-Dose group showed a significantly higher rate of complete response (12/15, 80%) as compared to the low-Dose group (22/43, 51.2%) (p=0.05). While occurrence of side effects was not different between two groups (40% vs. 30.2%, p=0.46). Conclusion: Measurement of MPD using CF method is reliable, and the high-Dose I-131 therapy using MPD gains significantly higher therapeutic effects as compared with low-Dose therapy.