The Experts below are selected from a list of 525 Experts worldwide ranked by ideXlab platform
Ben Zhong Tang - One of the best experts on this subject based on the ideXlab platform.
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amphiphilic tetraphenylethene based pyridinium salt for selective cell membrane imaging and room light induced special reactive oxygen species generation
ACS Applied Materials & Interfaces, 2019Co-Authors: Weijie Zhang, Jianquan Hou, Yuning Hong, Yilong Chen, Yuncong Chen, Sijie Chen, Yuhua Huang, Engui Zhao, Jacky Wing Yip Lam, Ben Zhong TangAbstract:The cell membrane is the protecting frontier of cells, which is crucial for maintaining cell integrity, and has a close relationship with cell growth and death. There is a growing need for cell membrane imaging and monitoring in both living and dying cells. Herein, we report a new amphiphilic tetraphenylethene-based pyridinium salt (TPE-MEM) with aggregation-induced emission features for discriminatory cell membrane imaging. The fluorogenic probe with high yield was synthesized following asymmetric McMurry Reaction, Williamson ether synthesis Reaction, Suzuki coupling, and aldol condensation between a double-charged pyridinium salt and hexyloxytetraphenylethene benzaldehyde. TPE-MEM shows good water solubility, biocompatibility, and cell membrane specificity. Interestingly, a reactive oxygen species (ROS) is produced by the molecule (TPE-MEM) under room-light irradiation, which could destroy the integrity of the plasma membrane and cause cell necrosis. This enables a visible observation of cell necrosis a...
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Amphiphilic Tetraphenylethene-Based Pyridinium Salt for Selective Cell-Membrane Imaging and Room-Light-Induced Special Reactive Oxygen Species Generation
2019Co-Authors: Weijie Zhang, Jianquan Hou, Yuning Hong, Yilong Chen, Yuncong Chen, Sijie Chen, Yuhua Huang, Engui Zhao, Jacky Wing Yip Lam, Ben Zhong TangAbstract:The cell membrane is the protecting frontier of cells, which is crucial for maintaining cell integrity, and has a close relationship with cell growth and death. There is a growing need for cell membrane imaging and monitoring in both living and dying cells. Herein, we report a new amphiphilic tetraphenylethene-based pyridinium salt (TPE-MEM) with aggregation-induced emission features for discriminatory cell membrane imaging. The fluorogenic probe with high yield was synthesized following asymmetric McMurry Reaction, Williamson ether synthesis Reaction, Suzuki coupling, and aldol condensation between a double-charged pyridinium salt and hexyloxytetraphenylethene benzaldehyde. TPE-MEM shows good water solubility, biocompatibility, and cell membrane specificity. Interestingly, a reactive oxygen species (ROS) is produced by the molecule (TPE-MEM) under room-light irradiation, which could destroy the integrity of the plasma membrane and cause cell necrosis. This enables a visible observation of cell necrosis and the phototherapeutic effect under a mild condition. Preliminary animal investigations also demonstrated the photodynamic therapy (PDT) effectiveness of TPE-MEM in tumor growth inhibition. We conclude that TPE-MEM is potentially a cell membrane-selective photosensitizer for PDT and it is worthy of further exploration of the phototherapeutic effect on animals systematically
Weijie Zhang - One of the best experts on this subject based on the ideXlab platform.
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amphiphilic tetraphenylethene based pyridinium salt for selective cell membrane imaging and room light induced special reactive oxygen species generation
ACS Applied Materials & Interfaces, 2019Co-Authors: Weijie Zhang, Jianquan Hou, Yuning Hong, Yilong Chen, Yuncong Chen, Sijie Chen, Yuhua Huang, Engui Zhao, Jacky Wing Yip Lam, Ben Zhong TangAbstract:The cell membrane is the protecting frontier of cells, which is crucial for maintaining cell integrity, and has a close relationship with cell growth and death. There is a growing need for cell membrane imaging and monitoring in both living and dying cells. Herein, we report a new amphiphilic tetraphenylethene-based pyridinium salt (TPE-MEM) with aggregation-induced emission features for discriminatory cell membrane imaging. The fluorogenic probe with high yield was synthesized following asymmetric McMurry Reaction, Williamson ether synthesis Reaction, Suzuki coupling, and aldol condensation between a double-charged pyridinium salt and hexyloxytetraphenylethene benzaldehyde. TPE-MEM shows good water solubility, biocompatibility, and cell membrane specificity. Interestingly, a reactive oxygen species (ROS) is produced by the molecule (TPE-MEM) under room-light irradiation, which could destroy the integrity of the plasma membrane and cause cell necrosis. This enables a visible observation of cell necrosis a...
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Amphiphilic Tetraphenylethene-Based Pyridinium Salt for Selective Cell-Membrane Imaging and Room-Light-Induced Special Reactive Oxygen Species Generation
2019Co-Authors: Weijie Zhang, Jianquan Hou, Yuning Hong, Yilong Chen, Yuncong Chen, Sijie Chen, Yuhua Huang, Engui Zhao, Jacky Wing Yip Lam, Ben Zhong TangAbstract:The cell membrane is the protecting frontier of cells, which is crucial for maintaining cell integrity, and has a close relationship with cell growth and death. There is a growing need for cell membrane imaging and monitoring in both living and dying cells. Herein, we report a new amphiphilic tetraphenylethene-based pyridinium salt (TPE-MEM) with aggregation-induced emission features for discriminatory cell membrane imaging. The fluorogenic probe with high yield was synthesized following asymmetric McMurry Reaction, Williamson ether synthesis Reaction, Suzuki coupling, and aldol condensation between a double-charged pyridinium salt and hexyloxytetraphenylethene benzaldehyde. TPE-MEM shows good water solubility, biocompatibility, and cell membrane specificity. Interestingly, a reactive oxygen species (ROS) is produced by the molecule (TPE-MEM) under room-light irradiation, which could destroy the integrity of the plasma membrane and cause cell necrosis. This enables a visible observation of cell necrosis and the phototherapeutic effect under a mild condition. Preliminary animal investigations also demonstrated the photodynamic therapy (PDT) effectiveness of TPE-MEM in tumor growth inhibition. We conclude that TPE-MEM is potentially a cell membrane-selective photosensitizer for PDT and it is worthy of further exploration of the phototherapeutic effect on animals systematically
Hua Wang - One of the best experts on this subject based on the ideXlab platform.
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syntheses and crystal structures of 2 7 di trimethylsilyl thieno 3 2 e benzothiophene 1 2 5 6 5 tetra trimethylsilyl 1 2 5 6 2 3 tetrathiophenacyclooctaphan 3 z 7 z diene and 2 7 di trimethylsilyl thieno 3 2 e benzothiophene 4 ol
ChemInform, 2014Co-Authors: Zhihua Wang, Jianwu Shi, Xinyong Tian, Hua WangAbstract:McMurry Reaction of dicarbaldehyde (III) efficiently affords the thienobenzothiophene (IV) along with two unexpected compounds (V) and (VI).
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syntheses and crystal structures of 2 7 di trimethylsilyl thieno 3 2 e benzothiophene 1 2 5 6 5 tetra trimethylsilyl 1 2 5 6 2 3 tetrathiophenacyclooctaphan 3 z 7 z diene and 2 7 di trimethylsilyl thieno 3 2 e benzothiophene 4 ol
Journal of Heterocyclic Chemistry, 2013Co-Authors: Zhihua Wang, Jianwu Shi, Xinyong Tian, Hua WangAbstract:With 5,5′-di(trimethylsilanyl)-3,3′-bithiophenyl-2,2′-dicarbaldehyde as precusor, 2,7-di(trimethylsilyl)-thieno[3,2-e]benzothiophene was obtained effiently via intramolecular McMurry Reaction. At the same time, another two unexpected compounds, 1,2,5,6(5)-tetra-(trimethylsilyl)-1,2,5,6(2,3)-tetrathiophena-cyclooctaphan-3(Z),7(Z)-diene and 2,7-di(trimethylsilyl)thieno[3,2-e]-benzothiophene-4-ol were generated as side products. The crystal structures of all three title compounds are described.
Jianquan Hou - One of the best experts on this subject based on the ideXlab platform.
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amphiphilic tetraphenylethene based pyridinium salt for selective cell membrane imaging and room light induced special reactive oxygen species generation
ACS Applied Materials & Interfaces, 2019Co-Authors: Weijie Zhang, Jianquan Hou, Yuning Hong, Yilong Chen, Yuncong Chen, Sijie Chen, Yuhua Huang, Engui Zhao, Jacky Wing Yip Lam, Ben Zhong TangAbstract:The cell membrane is the protecting frontier of cells, which is crucial for maintaining cell integrity, and has a close relationship with cell growth and death. There is a growing need for cell membrane imaging and monitoring in both living and dying cells. Herein, we report a new amphiphilic tetraphenylethene-based pyridinium salt (TPE-MEM) with aggregation-induced emission features for discriminatory cell membrane imaging. The fluorogenic probe with high yield was synthesized following asymmetric McMurry Reaction, Williamson ether synthesis Reaction, Suzuki coupling, and aldol condensation between a double-charged pyridinium salt and hexyloxytetraphenylethene benzaldehyde. TPE-MEM shows good water solubility, biocompatibility, and cell membrane specificity. Interestingly, a reactive oxygen species (ROS) is produced by the molecule (TPE-MEM) under room-light irradiation, which could destroy the integrity of the plasma membrane and cause cell necrosis. This enables a visible observation of cell necrosis a...
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Amphiphilic Tetraphenylethene-Based Pyridinium Salt for Selective Cell-Membrane Imaging and Room-Light-Induced Special Reactive Oxygen Species Generation
2019Co-Authors: Weijie Zhang, Jianquan Hou, Yuning Hong, Yilong Chen, Yuncong Chen, Sijie Chen, Yuhua Huang, Engui Zhao, Jacky Wing Yip Lam, Ben Zhong TangAbstract:The cell membrane is the protecting frontier of cells, which is crucial for maintaining cell integrity, and has a close relationship with cell growth and death. There is a growing need for cell membrane imaging and monitoring in both living and dying cells. Herein, we report a new amphiphilic tetraphenylethene-based pyridinium salt (TPE-MEM) with aggregation-induced emission features for discriminatory cell membrane imaging. The fluorogenic probe with high yield was synthesized following asymmetric McMurry Reaction, Williamson ether synthesis Reaction, Suzuki coupling, and aldol condensation between a double-charged pyridinium salt and hexyloxytetraphenylethene benzaldehyde. TPE-MEM shows good water solubility, biocompatibility, and cell membrane specificity. Interestingly, a reactive oxygen species (ROS) is produced by the molecule (TPE-MEM) under room-light irradiation, which could destroy the integrity of the plasma membrane and cause cell necrosis. This enables a visible observation of cell necrosis and the phototherapeutic effect under a mild condition. Preliminary animal investigations also demonstrated the photodynamic therapy (PDT) effectiveness of TPE-MEM in tumor growth inhibition. We conclude that TPE-MEM is potentially a cell membrane-selective photosensitizer for PDT and it is worthy of further exploration of the phototherapeutic effect on animals systematically
Sijie Chen - One of the best experts on this subject based on the ideXlab platform.
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amphiphilic tetraphenylethene based pyridinium salt for selective cell membrane imaging and room light induced special reactive oxygen species generation
ACS Applied Materials & Interfaces, 2019Co-Authors: Weijie Zhang, Jianquan Hou, Yuning Hong, Yilong Chen, Yuncong Chen, Sijie Chen, Yuhua Huang, Engui Zhao, Jacky Wing Yip Lam, Ben Zhong TangAbstract:The cell membrane is the protecting frontier of cells, which is crucial for maintaining cell integrity, and has a close relationship with cell growth and death. There is a growing need for cell membrane imaging and monitoring in both living and dying cells. Herein, we report a new amphiphilic tetraphenylethene-based pyridinium salt (TPE-MEM) with aggregation-induced emission features for discriminatory cell membrane imaging. The fluorogenic probe with high yield was synthesized following asymmetric McMurry Reaction, Williamson ether synthesis Reaction, Suzuki coupling, and aldol condensation between a double-charged pyridinium salt and hexyloxytetraphenylethene benzaldehyde. TPE-MEM shows good water solubility, biocompatibility, and cell membrane specificity. Interestingly, a reactive oxygen species (ROS) is produced by the molecule (TPE-MEM) under room-light irradiation, which could destroy the integrity of the plasma membrane and cause cell necrosis. This enables a visible observation of cell necrosis a...
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Amphiphilic Tetraphenylethene-Based Pyridinium Salt for Selective Cell-Membrane Imaging and Room-Light-Induced Special Reactive Oxygen Species Generation
2019Co-Authors: Weijie Zhang, Jianquan Hou, Yuning Hong, Yilong Chen, Yuncong Chen, Sijie Chen, Yuhua Huang, Engui Zhao, Jacky Wing Yip Lam, Ben Zhong TangAbstract:The cell membrane is the protecting frontier of cells, which is crucial for maintaining cell integrity, and has a close relationship with cell growth and death. There is a growing need for cell membrane imaging and monitoring in both living and dying cells. Herein, we report a new amphiphilic tetraphenylethene-based pyridinium salt (TPE-MEM) with aggregation-induced emission features for discriminatory cell membrane imaging. The fluorogenic probe with high yield was synthesized following asymmetric McMurry Reaction, Williamson ether synthesis Reaction, Suzuki coupling, and aldol condensation between a double-charged pyridinium salt and hexyloxytetraphenylethene benzaldehyde. TPE-MEM shows good water solubility, biocompatibility, and cell membrane specificity. Interestingly, a reactive oxygen species (ROS) is produced by the molecule (TPE-MEM) under room-light irradiation, which could destroy the integrity of the plasma membrane and cause cell necrosis. This enables a visible observation of cell necrosis and the phototherapeutic effect under a mild condition. Preliminary animal investigations also demonstrated the photodynamic therapy (PDT) effectiveness of TPE-MEM in tumor growth inhibition. We conclude that TPE-MEM is potentially a cell membrane-selective photosensitizer for PDT and it is worthy of further exploration of the phototherapeutic effect on animals systematically