The Experts below are selected from a list of 306 Experts worldwide ranked by ideXlab platform

Toshimitsu Kobayashi - One of the best experts on this subject based on the ideXlab platform.

  • Clinical applicability of the sweep frequency Measuring Apparatus for diagnosis of middle ear diseases
    Ear and hearing, 1998
    Co-Authors: Hiroshi Wada, Takuji Koike, Toshimitsu Kobayashi
    Abstract:

    Objective:To develop a Measuring Apparatus that has the ability to sweep both frequency and external auditory meatus static pressure and can display measurement results in a three-dimensional expression. To measure the middle ear dynamic characteristics of normal-hearing subjects and of patients wit

  • Diagnosis of middle ear disease with eardrum perforation by a newly developed sweep frequency Measuring Apparatus.
    Audiology, 1992
    Co-Authors: Hiroshi Wada, Toshimitsu Kobayashi, Hisashi Tachizaki
    Abstract:

    Dynamic characteristics of an artificial middle ear model with and without eardrum perforations were measured with our newly developed sweep frequency Measuring Apparatus. Then, the dynamic characteristics of patients with chronic otitis media having eardrum perforations and with traumatic perforations were measured with this Apparatus, and the results were compared with those of the artificial middle ear model with an eardrum perforation. The comparison leads to the conclusion that the middle ear condition of patients with eardrum perforations can be distinguished on the basis of their measurement results. Furthermore, the ossicular chain conditions of patients with eardrum perforations can be diagnosed after putting a paper patch on the eardrum perforation. Therefore, this Apparatus seems to be highly useful in the diagnosis of both ossicular chain disorders and eardrum perforations.

Hiroshi Wada - One of the best experts on this subject based on the ideXlab platform.

  • Clinical applicability of the sweep frequency Measuring Apparatus for diagnosis of middle ear diseases
    Ear and hearing, 1998
    Co-Authors: Hiroshi Wada, Takuji Koike, Toshimitsu Kobayashi
    Abstract:

    Objective:To develop a Measuring Apparatus that has the ability to sweep both frequency and external auditory meatus static pressure and can display measurement results in a three-dimensional expression. To measure the middle ear dynamic characteristics of normal-hearing subjects and of patients wit

  • Diagnosis of middle ear disease with eardrum perforation by a newly developed sweep frequency Measuring Apparatus.
    Audiology, 1992
    Co-Authors: Hiroshi Wada, Toshimitsu Kobayashi, Hisashi Tachizaki
    Abstract:

    Dynamic characteristics of an artificial middle ear model with and without eardrum perforations were measured with our newly developed sweep frequency Measuring Apparatus. Then, the dynamic characteristics of patients with chronic otitis media having eardrum perforations and with traumatic perforations were measured with this Apparatus, and the results were compared with those of the artificial middle ear model with an eardrum perforation. The comparison leads to the conclusion that the middle ear condition of patients with eardrum perforations can be distinguished on the basis of their measurement results. Furthermore, the ossicular chain conditions of patients with eardrum perforations can be diagnosed after putting a paper patch on the eardrum perforation. Therefore, this Apparatus seems to be highly useful in the diagnosis of both ossicular chain disorders and eardrum perforations.

Takuji Koike - One of the best experts on this subject based on the ideXlab platform.

A. Motoyoshi - One of the best experts on this subject based on the ideXlab platform.

  • Description of a macroscopic system based on the theory of quantized space-time.
    Il Nuovo Cimento B (1971-1996), 2008
    Co-Authors: A. Motoyoshi
    Abstract:

    By basing on the theory of quantized space-time, it is shown that the alternative description of the macroscopic nature of a Measuring Apparatus is possible, which can reproduce the essential features of the Machida-Namiki theory of measurement for the reduction of wave packet. Making use of this description, we can understand why a usual macroscopic system as a Measuring Apparatus behaves as a classical object under usual conditions for it even if it is described quantum-mechanically. Under some conditions, the macroscopic system realizes the macroscopic coherences as a macroscopic quantum effect. The above criterion for which such cases can occur, is given by the values of a similar parameter for the Bose-Einstein condensation.

  • Description of a macroscopic system based on the theory of quantized space-time. I: A macroscopic system as a Measuring Apparatus
    Il Nuovo Cimento B, 1993
    Co-Authors: A. Motoyoshi
    Abstract:

    By basing on the theory of quantized space-time, it is shown that the alternative description of the macroscopic nature of a Measuring Apparatus is possible, which can reproduce the essential features of the Machida-Namiki theory of measurement for the reduction of wave packet. Making use of this description, we can understand why a usual macroscopic system as a Measuring Apparatus behaves as a classical object under usual conditions for it even if it is described quantummechanically. Under some conditions, the macroscopic system realizes the macroscopic coherences as a macroscopic quantum effect. The above criterion for which such cases can occur, is given by the values of a similar parameter for the Bose-Einstein condensation

Mustafa B. A. Djamgoz - One of the best experts on this subject based on the ideXlab platform.

  • Single cell adhesion Measuring Apparatus (SCAMA): application to cancer cell lines of different metastatic potential and voltage-gated Na^+ channel expression
    European Biophysics Journal, 2008
    Co-Authors: Christopher P. Palmer, Maria E. Mycielska, Hakan Burcu, Kareem Osman, Timothy Collins, Rachel Beckerman, Rebecca Perrett, Helen Johnson, Ebru Aydar, Mustafa B. A. Djamgoz
    Abstract:

    We have developed a simple yet effective Apparatus, based upon negative pressure directed to the tip of a micro-pipette, to measure the adhesiveness of single cells. The “single cell adhesion Measuring Apparatus” (SCAMA) could differentiate between the adhesion of strongly versus weakly metastatic cancer cells as well as normal cells. Adhesion was quantified as “detachment negative pressure” (DNP) or “DNP relative to cell size” (DNPR) where a noticeable difference in cell size was apparent. Thus, for rat and human prostate and human breast cancer cell lines, adhesiveness (DNPR values) decreased in line with increased metastatic potential. Using the SCAMA, we investigated the effect of tetrodotoxin (TTX), a specific blocker of voltage-gated Na^+ channels (VGSCs), on the adhesion of rat and human prostate cancer cell lines of markedly different metastatic potential. Following pretreatment with TTX (48 h with 1 μM), the adhesion values for the Mat-LyLu cells increased significantly 4.3-fold; there was no effect on the AT-2 cells. For the strongly metastatic PC-3M cells, TTX treatment caused a significant (∼30%) increase in adhesion. The adhesion of PNT2-C2 (“normal”) cells was not affected by the TTX pretreatment. The TTX-induced increase in the adhesiveness of the strongly metastatic cells was consistent with the functional VGSC expression in these cells and the proposed role of VGSC activity in metastatic cell behaviour. In conclusion, the SCAMA, which can be constructed easily and cheaply, offers a simple and effective method to characterise single-cell adhesion and its modulation.