The Experts below are selected from a list of 672 Experts worldwide ranked by ideXlab platform
Mark F Jacquin - One of the best experts on this subject based on the ideXlab platform.
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trka modulation of developing somatosensory neurons in oro facial tissues tooth pulp fibers are absent in trka knockout mice
2001Co-Authors: S Matsuo, Hiroyuki Ichikawa, T A Henderson, Inmaculada Silossantiago, M Barbacid, Joop J A Arends, Mark F JacquinAbstract:Abstract To investigate the nerve growth factor requirement of developing oro-facial somatosensory afferents, we have studied the survival of sensory fibers subserving nociception, Mechanoreception or proprioception in receptor tyrosine kinase (trkA) knockout mice using immunohistochemistry. trkA receptor null mutant mice lack nerve fibers in tooth pulp, including sympathetic fibers, and showed only sparse innervation of the periodontal ligament. Ruffini endings were formed definitively in the periodontal ligament of the trkA knockout mice, although calcitonin gene-related peptide- and substance P-immunoreactive fibers were reduced in number or had disappeared completely. trkA gene deletion had also no obvious effect on the formation of Meissner corpuscles in the palate. In the vibrissal follicle, however, some mechanoreceptive afferents were sensitive for trkA gene deletion, confirming a previous report [Fundin et al. (1997) Dev. Biol. 190, 94–116]. Moreover, calretinin-positive fibers innervating longitudinal lanceolate endings were completely lost in trkA knockout mice, as were the calretinin-containing parent cells in the trigeminal ganglion. These results indicate that trkA is indispensable for developing nociceptive neurons innervating oral tissues, but not for developing mechanoreceptive neurons innervating oral tissues (Ruffini endings and Meissner corpuscles), and that calretinin-containing, trkA dependent neurons in the trigeminal ganglion normally participate in Mechanoreception through longitudinal lanceolate endings of the vibrissal follicle.
Karen M Warkentin - One of the best experts on this subject based on the ideXlab platform.
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how do red eyed treefrog embryos sense motion in predator attacks assessing the role of vestibular Mechanoreception
2019Co-Authors: Julie Jung, Su Jin Kim, Sonia Perez M Arias, James Greg Mcdaniel, Karen M WarkentinAbstract:ABSTRACT The widespread ability to alter hatching timing in response to environmental cues can serve as a defense against threats to eggs. Arboreal embryos of red-eyed treefrogs, Agalychnis callidryas, hatch up to 30% prematurely to escape predation. This escape-hatching response is cued by physical disturbance of eggs during attacks, including vibrations or motion, and thus depends critically on mechanosensory ability. Predator-induced hatching appears later in development than flooding-induced, hypoxia-cued hatching; thus, its onset is not constrained by the development of hatching ability. It may, instead, reflect the development of mechanosensor function. We hypothesize that vestibular Mechanoreception mediates escape-hatching in snake attacks, and that the developmental period when hatching-competent embryos fail to flee from snakes reflects a sensory constraint. We assessed the ontogenetic congruence of escape-hatching responses and an indicator of vestibular function, the vestibulo-ocular reflex (VOR), in three ways. First, we measured VOR in two developmental series of embryos 3–7 days old to compare with the published ontogeny of escape success in attacks. Second, during the period of greatest variation in VOR and escape success, we compared hatching responses and VOR across sibships. Finally, in developmental series, we compared the response of individual embryos to a simulated attack cue with their VOR. The onset of VOR and hatching responses were largely concurrent at all three scales. Moreover, latency to hatch in simulated attacks decreased with increasing VOR. These results are consistent with a key role of the vestibular system in the escape-hatching response of A. callidryas embryos to attacks. Red-eyed treefrogs’ hatching responses to predator attacks, vibration playbacks, and egg-jiggling appear when vestibular function develops. Ear development may be a key limiting factor in the onset of mechanosensory-cued hatching.
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how do red eyed treefrog embryos sense motion in predator attacks assessing the role of vestibular Mechanoreception
2019Co-Authors: Julie Jung, Su Jin Kim, Sonia Perez M Arias, James Greg Mcdaniel, Karen M WarkentinAbstract:ABSTRACT The widespread ability to alter timing of hatching in response to environmental cues can serve as a defense against threats to eggs. Arboreal embryos of red-eyed treefrogs, Agalychnis callidryas, can hatch up to 30% prematurely to escape predation. This escape-hatching response is cued by physical disturbance of eggs during attacks, including vibrations or motion, and thus depends critically on mechanosensory ability. Predator-induced hatching appears later in development than flooding-induced, hypoxia-cued hatching; thus, its onset is not constrained by the development of hatching ability. It may, instead, reflect the development of mechanosensor function. We hypothesize that vestibular Mechanoreception mediates escape-hatching in snake attacks, and that the developmental period when hatching-competent embryos fail to flee from snakes reflects a sensory constraint. We assessed the ontogenetic congruence of escape-hatching responses and an indicator of vestibular function, the vestibulo-ocular reflex (VOR), in three ways. First, we measured VOR in two developmental series of embryos 3–7 days old to compare with the published ontogeny of escape success in attacks. Second, during the period of greatest variation in VOR and escape success, we compared hatching responses and VOR across sibships. Finally, in developmental series, we compared the response of individual embryos to a simulated attack cue with their VOR. The onset of VOR and hatching responses were largely concurrent at all three scales. Moreover, latency to hatch in simulated attacks decreased with increasing VOR. These results are consistent with a key role of the vestibular system in the escape-hatching response of A. callidryas embryos to attacks.
S Matsuo - One of the best experts on this subject based on the ideXlab platform.
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trkA MODULATION OF DEVELOPING SOMATOSENSORY NEURONS IN ORO-FACIAL TISSUES: TOOTH PULP FIBERS ARE ABSENT IN trkA KNOCKOUT MICE
2015Co-Authors: S Matsuo, A H. Ichikawa, B T. A. Henderson, A I. Silos-santiago, C M. Barbacid, J. J. A. Arendsa, M. F. JacquinaAbstract:AbstractöTo investigate the nerve growth factor requirement of developing oro-facial somatosensory a¡erents, we have studied the survival of sensory ¢bers subserving nociception, Mechanoreception or proprioception in receptor tyrosine kinase (trkA) knockout mice using immunohistochemistry. trkA receptor null mutant mice lack nerve ¢bers in tooth pulp, including sympathetic ¢bers, and showed only sparse innervation of the periodontal ligament. Ru⁄ni endings were formed de¢nitively in the periodontal ligament of the trkA knockout mice, although calcitonin gene-related peptide- and substance P-immunoreactive ¢bers were reduced in number or had disappeared completely. trkA gene deletion had also no obvious e¡ect on the formation of Meissner corpuscles in the palate. In the vibrissal follicle, however, some mecha-noreceptive a¡erents were sensitive for trkA gene deletion, con¢rming a previous report [Fundin et al. (1997) Dev. Biol. 190, 94^116]. Moreover, calretinin-positive ¢bers innervating longitudinal lanceolate endings were completely lost in trkA knockout mice, as were the calretinin-containing parent cells in the trigeminal ganglion. These results indicate that trkA is indispensable for developing nociceptive neurons innervating oral tissues, but not for developing mechanoreceptive neurons innervating oral tissues (Ru⁄ni endings and Meissner corpuscles), and that calre-tinin-containing, trkA dependent neurons in the trigeminal ganglion normally participate in Mechanoreception throug
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trka modulation of developing somatosensory neurons in oro facial tissues tooth pulp fibers are absent in trka knockout mice
2001Co-Authors: S Matsuo, Hiroyuki Ichikawa, T A Henderson, Inmaculada Silossantiago, M Barbacid, Joop J A Arends, Mark F JacquinAbstract:Abstract To investigate the nerve growth factor requirement of developing oro-facial somatosensory afferents, we have studied the survival of sensory fibers subserving nociception, Mechanoreception or proprioception in receptor tyrosine kinase (trkA) knockout mice using immunohistochemistry. trkA receptor null mutant mice lack nerve fibers in tooth pulp, including sympathetic fibers, and showed only sparse innervation of the periodontal ligament. Ruffini endings were formed definitively in the periodontal ligament of the trkA knockout mice, although calcitonin gene-related peptide- and substance P-immunoreactive fibers were reduced in number or had disappeared completely. trkA gene deletion had also no obvious effect on the formation of Meissner corpuscles in the palate. In the vibrissal follicle, however, some mechanoreceptive afferents were sensitive for trkA gene deletion, confirming a previous report [Fundin et al. (1997) Dev. Biol. 190, 94–116]. Moreover, calretinin-positive fibers innervating longitudinal lanceolate endings were completely lost in trkA knockout mice, as were the calretinin-containing parent cells in the trigeminal ganglion. These results indicate that trkA is indispensable for developing nociceptive neurons innervating oral tissues, but not for developing mechanoreceptive neurons innervating oral tissues (Ruffini endings and Meissner corpuscles), and that calretinin-containing, trkA dependent neurons in the trigeminal ganglion normally participate in Mechanoreception through longitudinal lanceolate endings of the vibrissal follicle.
Inmaculada Silossantiago - One of the best experts on this subject based on the ideXlab platform.
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trka modulation of developing somatosensory neurons in oro facial tissues tooth pulp fibers are absent in trka knockout mice
2001Co-Authors: S Matsuo, Hiroyuki Ichikawa, T A Henderson, Inmaculada Silossantiago, M Barbacid, Joop J A Arends, Mark F JacquinAbstract:Abstract To investigate the nerve growth factor requirement of developing oro-facial somatosensory afferents, we have studied the survival of sensory fibers subserving nociception, Mechanoreception or proprioception in receptor tyrosine kinase (trkA) knockout mice using immunohistochemistry. trkA receptor null mutant mice lack nerve fibers in tooth pulp, including sympathetic fibers, and showed only sparse innervation of the periodontal ligament. Ruffini endings were formed definitively in the periodontal ligament of the trkA knockout mice, although calcitonin gene-related peptide- and substance P-immunoreactive fibers were reduced in number or had disappeared completely. trkA gene deletion had also no obvious effect on the formation of Meissner corpuscles in the palate. In the vibrissal follicle, however, some mechanoreceptive afferents were sensitive for trkA gene deletion, confirming a previous report [Fundin et al. (1997) Dev. Biol. 190, 94–116]. Moreover, calretinin-positive fibers innervating longitudinal lanceolate endings were completely lost in trkA knockout mice, as were the calretinin-containing parent cells in the trigeminal ganglion. These results indicate that trkA is indispensable for developing nociceptive neurons innervating oral tissues, but not for developing mechanoreceptive neurons innervating oral tissues (Ruffini endings and Meissner corpuscles), and that calretinin-containing, trkA dependent neurons in the trigeminal ganglion normally participate in Mechanoreception through longitudinal lanceolate endings of the vibrissal follicle.
M Barbacid - One of the best experts on this subject based on the ideXlab platform.
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trka modulation of developing somatosensory neurons in oro facial tissues tooth pulp fibers are absent in trka knockout mice
2001Co-Authors: S Matsuo, Hiroyuki Ichikawa, T A Henderson, Inmaculada Silossantiago, M Barbacid, Joop J A Arends, Mark F JacquinAbstract:Abstract To investigate the nerve growth factor requirement of developing oro-facial somatosensory afferents, we have studied the survival of sensory fibers subserving nociception, Mechanoreception or proprioception in receptor tyrosine kinase (trkA) knockout mice using immunohistochemistry. trkA receptor null mutant mice lack nerve fibers in tooth pulp, including sympathetic fibers, and showed only sparse innervation of the periodontal ligament. Ruffini endings were formed definitively in the periodontal ligament of the trkA knockout mice, although calcitonin gene-related peptide- and substance P-immunoreactive fibers were reduced in number or had disappeared completely. trkA gene deletion had also no obvious effect on the formation of Meissner corpuscles in the palate. In the vibrissal follicle, however, some mechanoreceptive afferents were sensitive for trkA gene deletion, confirming a previous report [Fundin et al. (1997) Dev. Biol. 190, 94–116]. Moreover, calretinin-positive fibers innervating longitudinal lanceolate endings were completely lost in trkA knockout mice, as were the calretinin-containing parent cells in the trigeminal ganglion. These results indicate that trkA is indispensable for developing nociceptive neurons innervating oral tissues, but not for developing mechanoreceptive neurons innervating oral tissues (Ruffini endings and Meissner corpuscles), and that calretinin-containing, trkA dependent neurons in the trigeminal ganglion normally participate in Mechanoreception through longitudinal lanceolate endings of the vibrissal follicle.