The Experts below are selected from a list of 270 Experts worldwide ranked by ideXlab platform

Atsushi Kuhara - One of the best experts on this subject based on the ideXlab platform.

  • the Mechanoreceptor deg 1 regulates cold tolerance in caenorhabditis elegans
    EMBO Reports, 2020
    Co-Authors: Natsune Takagaki, Akane Ohta, Kohei Ohnishi, Yohei Minakuchi, Atsushi Toyoda, Yuichiro Fujiwara, Akira Kawanabe, Atsushi Kuhara
    Abstract:

    : Caenorhabditis elegans Mechanoreceptors located in ASG sensory neurons have been found to sense ambient temperature, which is a key trait for animal survival. Here, we show that experimental loss of xanthine dehydrogenase (XDH-1) function in AIN and AVJ interneurons results in reduced cold tolerance and atypical neuronal response to changes in temperature. These interneurons connect with upstream neurons such as the Mechanoreceptor-expressing ASG. Ca2+ imaging revealed that ASG neurons respond to warm temperature via the Mechanoreceptor DEG-1, a degenerin/epithelial Na+ channel (DEG/ENaC), which in turn affects downstream AIN and AVJ circuits. Ectopic expression of DEG-1 in the ASE gustatory neuron results in the acquisition of warm sensitivity, while electrophysiological analysis revealed that DEG-1 and human MDEG1 were involved in warm sensation. Taken together, these results suggest that cold tolerance is regulated by Mechanoreceptor-mediated circuit calculation.

  • Mechanoreceptor mediated circuit regulates cold tolerance in caenorhabditis elegans
    bioRxiv, 2019
    Co-Authors: Natsune Takagaki, Akane Ohta, Kohei Ohnishi, Yohei Minakuchi, Atsushi Toyoda, Yuichiro Fujiwara, Atsushi Kuhara
    Abstract:

    C. elegans Mechanoreceptors located in the ASG sensoryneuron have been found to sense temperature - a key trait for animal survival. Experimental loss of xanthine dehydrogenase (XDH-1) function in the AIN and AVJ interneurons resulted in reduced cold tolerance and atypical neuronal response to changes in temperature. These interneurons are synapse with upstream neurons such as the Mechanoreceptor-expressing ASG. Ca2+ imaging revealed that ASG responsiveness to temperature change via Mechanoreceptor DEG-1, a Degenerin/Epithelial Sodium Channel (DEG/ENaC), affects downstream AIN and AVJ circuits. Ectopic expression of DEG-1 in the ASE gustatory neuron resulted in acquisition of thermosensitivity, while electrophysiological analysis revealed that DEG-1 was involved in temperature sensation. Together, these results suggest that cold tolerance is regulated by Mechanoreceptor-mediated circuit calculation.

Natsune Takagaki - One of the best experts on this subject based on the ideXlab platform.

  • the Mechanoreceptor deg 1 regulates cold tolerance in caenorhabditis elegans
    EMBO Reports, 2020
    Co-Authors: Natsune Takagaki, Akane Ohta, Kohei Ohnishi, Yohei Minakuchi, Atsushi Toyoda, Yuichiro Fujiwara, Akira Kawanabe, Atsushi Kuhara
    Abstract:

    : Caenorhabditis elegans Mechanoreceptors located in ASG sensory neurons have been found to sense ambient temperature, which is a key trait for animal survival. Here, we show that experimental loss of xanthine dehydrogenase (XDH-1) function in AIN and AVJ interneurons results in reduced cold tolerance and atypical neuronal response to changes in temperature. These interneurons connect with upstream neurons such as the Mechanoreceptor-expressing ASG. Ca2+ imaging revealed that ASG neurons respond to warm temperature via the Mechanoreceptor DEG-1, a degenerin/epithelial Na+ channel (DEG/ENaC), which in turn affects downstream AIN and AVJ circuits. Ectopic expression of DEG-1 in the ASE gustatory neuron results in the acquisition of warm sensitivity, while electrophysiological analysis revealed that DEG-1 and human MDEG1 were involved in warm sensation. Taken together, these results suggest that cold tolerance is regulated by Mechanoreceptor-mediated circuit calculation.

  • Mechanoreceptor mediated circuit regulates cold tolerance in caenorhabditis elegans
    bioRxiv, 2019
    Co-Authors: Natsune Takagaki, Akane Ohta, Kohei Ohnishi, Yohei Minakuchi, Atsushi Toyoda, Yuichiro Fujiwara, Atsushi Kuhara
    Abstract:

    C. elegans Mechanoreceptors located in the ASG sensoryneuron have been found to sense temperature - a key trait for animal survival. Experimental loss of xanthine dehydrogenase (XDH-1) function in the AIN and AVJ interneurons resulted in reduced cold tolerance and atypical neuronal response to changes in temperature. These interneurons are synapse with upstream neurons such as the Mechanoreceptor-expressing ASG. Ca2+ imaging revealed that ASG responsiveness to temperature change via Mechanoreceptor DEG-1, a Degenerin/Epithelial Sodium Channel (DEG/ENaC), affects downstream AIN and AVJ circuits. Ectopic expression of DEG-1 in the ASE gustatory neuron resulted in acquisition of thermosensitivity, while electrophysiological analysis revealed that DEG-1 was involved in temperature sensation. Together, these results suggest that cold tolerance is regulated by Mechanoreceptor-mediated circuit calculation.

Simon J Archibald - One of the best experts on this subject based on the ideXlab platform.

  • f29 recovery of sensory modalities after peripheral nerve lesions associated with Mechanoreceptor and sensory nerve fiber function
    Clinical Neurophysiology, 2018
    Co-Authors: Christian Krarup, Birgitta Rosen, Michel E H Boeckstyns, Allan Ibsen Sorensen, Goran Lundborg, Mihai Moldovan, Simon J Archibald
    Abstract:

    Introduction Sensation is essential for recovery after peripheral nerve injury. However, the relationship between sensory modalities and function of regenerated fibers and reinnervated sensory receptors is uncertain. We have investigated the relationships between touch threshold, tactile gnosis and Mechanoreceptor and sensory fiber function after nerve regeneration. Methods Twenty-one median or ulnar nerve lesions were repaired by a collagen nerve conduit or direct suture. Quantitative sensory hand function using a modified Rosen score and sensory conduction studies by near-nerve needle technique including tactile stimulation of Mechanoreceptors were followed for 2 years, and results were compared to non-injured hands. Results At both repair methods, touch thresholds at the finger tips recovered to 81 ± 3% whereas tactile gnosis only recovered to 20 ± 4% (P  Conclusion The recovered function of regenerated peripheral nerve fibers and reinnervated Mechanoreceptors may differentially influence recovery of sensory modalities. Touch was affected by the number and function of regenerated fibers and Mechanoreceptors. In contrast, tactile gnosis depends on the input and plasticity of the CNS, which may explain the absence of a direct relation between electrophysiological parameters and poor recovery. Dispersed maturation of sensory nerve fibers with desynchronized inputs to the CNS also contributes to the poor recovery of tactile gnosis.

  • sensation Mechanoreceptor and nerve fiber function after nerve regeneration
    Annals of Neurology, 2017
    Co-Authors: Christian Krarup, Birgitta Rosen, Michel E H Boeckstyns, Allan Ibsen Sorensen, Goran Lundborg, Mihai Moldovan, Simon J Archibald
    Abstract:

    Objective: Sensation is essential for recovery after peripheral nerve injury. However, the relationship between sensory modalities and function of regenerated fibers is uncertain. We have investigated the relationships between touch threshold, tactile gnosis, and Mechanoreceptor and sensory fiber function after nerve regeneration. Methods: Twenty-one median or ulnar nerve lesions were repaired by a collagen nerve conduit or direct suture. Quantitative sensory hand function and sensory conduction studies by near-nerve technique, including tactile stimulation of Mechanoreceptors, were followed for 2 years, and results were compared to noninjured hands. Results: At both repair methods, touch thresholds at the finger tips recovered to 81 ± 3% and tactile gnosis only to 20 ± 4% (p < 0.001) of control. The sensory nerve action potentials (SNAPs) remained dispersed and areas recovered to 23 ± 2% and the amplitudes only to 7 ± 1% (P < 0.001). The areas of SNAPs after tactile stimulation recovered to 61 ± 11% and remained slowed. Touch sensation correlated with SNAP areas (p < 0.005) and was negatively related to the prolongation of tactile latencies (p < 0.01); tactile gnosis was not related to electrophysiological parameters. Interpretation: The recovered function of regenerated peripheral nerve fibers and reinnervated Mechanoreceptors may differentially influence recovery of sensory modalities. Touch was affected by the number and function of regenerated fibers and Mechanoreceptors. In contrast, tactile gnosis depends on the input and plasticity of the central nervous system (CNS), which may explain the absence of a direct relation between electrophysiological parameters and poor recovery. Dispersed maturation of sensory nerve fibers with desynchronized inputs to the CNS also contributes to the poor recovery of tactile gnosis. Ann Neurol 2017. Ann Neurol 2017;82:940–950. (Less)

Yuichiro Fujiwara - One of the best experts on this subject based on the ideXlab platform.

  • the Mechanoreceptor deg 1 regulates cold tolerance in caenorhabditis elegans
    EMBO Reports, 2020
    Co-Authors: Natsune Takagaki, Akane Ohta, Kohei Ohnishi, Yohei Minakuchi, Atsushi Toyoda, Yuichiro Fujiwara, Akira Kawanabe, Atsushi Kuhara
    Abstract:

    : Caenorhabditis elegans Mechanoreceptors located in ASG sensory neurons have been found to sense ambient temperature, which is a key trait for animal survival. Here, we show that experimental loss of xanthine dehydrogenase (XDH-1) function in AIN and AVJ interneurons results in reduced cold tolerance and atypical neuronal response to changes in temperature. These interneurons connect with upstream neurons such as the Mechanoreceptor-expressing ASG. Ca2+ imaging revealed that ASG neurons respond to warm temperature via the Mechanoreceptor DEG-1, a degenerin/epithelial Na+ channel (DEG/ENaC), which in turn affects downstream AIN and AVJ circuits. Ectopic expression of DEG-1 in the ASE gustatory neuron results in the acquisition of warm sensitivity, while electrophysiological analysis revealed that DEG-1 and human MDEG1 were involved in warm sensation. Taken together, these results suggest that cold tolerance is regulated by Mechanoreceptor-mediated circuit calculation.

  • Mechanoreceptor mediated circuit regulates cold tolerance in caenorhabditis elegans
    bioRxiv, 2019
    Co-Authors: Natsune Takagaki, Akane Ohta, Kohei Ohnishi, Yohei Minakuchi, Atsushi Toyoda, Yuichiro Fujiwara, Atsushi Kuhara
    Abstract:

    C. elegans Mechanoreceptors located in the ASG sensoryneuron have been found to sense temperature - a key trait for animal survival. Experimental loss of xanthine dehydrogenase (XDH-1) function in the AIN and AVJ interneurons resulted in reduced cold tolerance and atypical neuronal response to changes in temperature. These interneurons are synapse with upstream neurons such as the Mechanoreceptor-expressing ASG. Ca2+ imaging revealed that ASG responsiveness to temperature change via Mechanoreceptor DEG-1, a Degenerin/Epithelial Sodium Channel (DEG/ENaC), affects downstream AIN and AVJ circuits. Ectopic expression of DEG-1 in the ASE gustatory neuron resulted in acquisition of thermosensitivity, while electrophysiological analysis revealed that DEG-1 was involved in temperature sensation. Together, these results suggest that cold tolerance is regulated by Mechanoreceptor-mediated circuit calculation.

Atsushi Toyoda - One of the best experts on this subject based on the ideXlab platform.

  • the Mechanoreceptor deg 1 regulates cold tolerance in caenorhabditis elegans
    EMBO Reports, 2020
    Co-Authors: Natsune Takagaki, Akane Ohta, Kohei Ohnishi, Yohei Minakuchi, Atsushi Toyoda, Yuichiro Fujiwara, Akira Kawanabe, Atsushi Kuhara
    Abstract:

    : Caenorhabditis elegans Mechanoreceptors located in ASG sensory neurons have been found to sense ambient temperature, which is a key trait for animal survival. Here, we show that experimental loss of xanthine dehydrogenase (XDH-1) function in AIN and AVJ interneurons results in reduced cold tolerance and atypical neuronal response to changes in temperature. These interneurons connect with upstream neurons such as the Mechanoreceptor-expressing ASG. Ca2+ imaging revealed that ASG neurons respond to warm temperature via the Mechanoreceptor DEG-1, a degenerin/epithelial Na+ channel (DEG/ENaC), which in turn affects downstream AIN and AVJ circuits. Ectopic expression of DEG-1 in the ASE gustatory neuron results in the acquisition of warm sensitivity, while electrophysiological analysis revealed that DEG-1 and human MDEG1 were involved in warm sensation. Taken together, these results suggest that cold tolerance is regulated by Mechanoreceptor-mediated circuit calculation.

  • Mechanoreceptor mediated circuit regulates cold tolerance in caenorhabditis elegans
    bioRxiv, 2019
    Co-Authors: Natsune Takagaki, Akane Ohta, Kohei Ohnishi, Yohei Minakuchi, Atsushi Toyoda, Yuichiro Fujiwara, Atsushi Kuhara
    Abstract:

    C. elegans Mechanoreceptors located in the ASG sensoryneuron have been found to sense temperature - a key trait for animal survival. Experimental loss of xanthine dehydrogenase (XDH-1) function in the AIN and AVJ interneurons resulted in reduced cold tolerance and atypical neuronal response to changes in temperature. These interneurons are synapse with upstream neurons such as the Mechanoreceptor-expressing ASG. Ca2+ imaging revealed that ASG responsiveness to temperature change via Mechanoreceptor DEG-1, a Degenerin/Epithelial Sodium Channel (DEG/ENaC), affects downstream AIN and AVJ circuits. Ectopic expression of DEG-1 in the ASE gustatory neuron resulted in acquisition of thermosensitivity, while electrophysiological analysis revealed that DEG-1 was involved in temperature sensation. Together, these results suggest that cold tolerance is regulated by Mechanoreceptor-mediated circuit calculation.