The Experts below are selected from a list of 177 Experts worldwide ranked by ideXlab platform
Thomas Naumann - One of the best experts on this subject based on the ideXlab platform.
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Transient Up‐regulation of Ciliary Neurotrophic Factor Receptor‐α mRNA in Axotomized Rat Septa1 Neurons
European Journal of Neuroscience, 1997Co-Authors: Thomas Naumann, Michael Frotscher, Matthias Kirsch, Hans-dieter HofmannAbstract:Using non-radioactive in situ hybridization we investigated the effect of fimbria-fornix transection on the expression of ciliary neurotrophic factor receptor α (CNTFRα) mRNA in axotomized septohippocampal neurons of the rat Septal complex. Whereas CNTFRα expression was undetectable in the Medial Septal Nucleus/diagonal band complex (MSDB) of control animals, specific up-regulation was observed in MSDB neurons after fimbria-fornix transection. CNTFRα expression was maximal 7–10 days after the lesion and had returned to control levels after 3 weeks. Following unilateral fimbria-fornix transection, CNTFRα up-regulation was restricted to the MSDB ipsilateral to the lesion. When cholinergic Septal neurons were selectively eliminated by immunolesioning with 192 IgG-saporin prior to fimbria-fornix transection, the lesion-induced expression of CNTFRα was still observed in many Medial Septal Nucleus neurons. These results demonstrate that after fimbria-fornix transection CNTFRα expression is transiently induced in axotomized, non-cholinergic neurons of the Medial Septal Nucleus, suggesting a postlesion function of locally supplied CNTF.
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activity of choline acetyltransferase in the rat Medial Septal Nucleus following fimbria fornix transection or selective immunolesioning with 192 igg saporin
Neuroscience Letters, 1996Co-Authors: Beate Hage, Michael Frotscher, Thomas NaumannAbstract:Changes in the biochemical activity of choline acetyltransferase in the Medial Septal Nucleus, diagonal band and hippocampus were determined following bilateral fimbria-fornix transection or selective immunolesioning of cholinergic septohippocampal neurons with 192 IgG-saporin. Following axotomy, choline acetyltransferase activity in the Medial Septal Nucleus not only persisted but increased much above control values 6 months postlesion, confirming that many cholinergic neurons survive the transection of their axons. In contrast, immunolesioning led to a significant decrease in enzyme activity in the Medial Septal Nucleus corresponding to the selective loss of Septal cholinergic neurons in this lesion paradigm.
F. Nürnberger - One of the best experts on this subject based on the ideXlab platform.
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The efferent connections of the lateral Septal Nucleus in the guinea pig: intrinsic connectivity of the septum and projections to other telencephalic areas
Cell and Tissue Research, 1991Co-Authors: J. F. Staiger, F. NürnbergerAbstract:The distribution of efferent fibers originating in the lateral Septal Nucleus was investigated in guinea pigs by means of anterograde tracing with Phaseolus vulgaris -leucoagglutinin (PHA-L). Special emphasis was placed on the intraSeptal fiber systems. The fibers originating from the different subnuclei of the lateral Septal Nucleus formed massive horizontal connections in the rostrocaudal axis. Projections to the contralateral, congruent subnuclei were also detected. In the Medial septum/diagonal band of Broca complex the largest number of PHA-L-stained fibers was found after application of the tracer into the dorsal subNucleus of the lateral Septal Nucleus; the density of the efferent fibers decreased progressively after injection into the intermediate or ventral subnuclei. In all cases the diagonal band contained a much higher number of efferent fibers from the lateral Septal Nucleus than from the Medial Septal Nucleus. In the Medial Septal Nucleus, terminal labeling was generally sparse. Other telencephalic areas (organum vasculosum of the lamina terminalis, Nucleus accumbens, bed Nucleus of the stria terminalis, amygdala, hippocampal complex, and other cortical areas) contained varying numbers of labeled projections. In double-labeling experiments, a close spatial relationship between PHA-L-stained fibers and vasoactive intestinal polypeptide-immunoreactive perikarya was observed in several of these target areas.
Joel P Gallagher - One of the best experts on this subject based on the ideXlab platform.
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a distinct group of non cholinergic neurons along the mid line of the septum and within the rat Medial Septal Nucleus
Neuroscience Letters, 2006Co-Authors: Massashi Tsurusaki, Joel P GallagherAbstract:The septum is a critical and integral component of the limbic brain that serves as a link between diverse brain structures while being necessary for human cognition and emotionality. A major anatomical component of the septum is designated as the Medial septum/diagonal band of Broca complex (MS/DB). A primary focus of much research has been to investigate cholinergic neurons within the MS/DB, as these are the rodent brain's main source of acetylcholine to the cortex and hippocampus. On the other hand, we have chosen to investigate a specific group of neurons that lie on the midline of the MS/DB in an area distinguished anatomically as the Medial Septal Nucleus (MSN). Based on somatic morphology and electrophysiological characteristics we conclude that these neurons, characterized into three different types, are non-cholinergic.
Kiarash Shahlaie - One of the best experts on this subject based on the ideXlab platform.
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Medial Septal Nucleus theta frequency deep brain stimulation improves spatial working memory after traumatic brain injury
Journal of Neurotrauma, 2013Co-Authors: Gene G Gurkoff, Ali Izadi, Robert F Berman, Arne D Ekstrom, Paul J Muizelaar, Bruce G Lyeth, Kiarash ShahlaieAbstract:Abstract More than 5,000,000 survivors of traumatic brain injury (TBI) live with persistent cognitive deficits, some of which likely derive from hippocampal dysfunction. Oscillatory activity in the hippocampus is critical for normal learning and memory functions, and can be modulated using deep brain stimulation techniques. In this pre-clinical study, we demonstrate that lateral fluid percussion TBI results in the attenuation of hippocampal theta oscillations in the first 6 days after injury, which correlate with deficits in the Barnes maze spatial working memory task. Theta band stimulation of the Medial Septal Nucleus (MSN) results in a transient increase in hippocampal theta activity, and when delivered 1 min prior to training in the Barnes maze, it significantly improves spatial working memory. These results suggest that MSN theta stimulation may be an effective neuromodulatory technique for treatment of persistent learning and memory deficits after TBI.
Beate Hage - One of the best experts on this subject based on the ideXlab platform.
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activity of choline acetyltransferase in the rat Medial Septal Nucleus following fimbria fornix transection or selective immunolesioning with 192 igg saporin
Neuroscience Letters, 1996Co-Authors: Beate Hage, Michael Frotscher, Thomas NaumannAbstract:Changes in the biochemical activity of choline acetyltransferase in the Medial Septal Nucleus, diagonal band and hippocampus were determined following bilateral fimbria-fornix transection or selective immunolesioning of cholinergic septohippocampal neurons with 192 IgG-saporin. Following axotomy, choline acetyltransferase activity in the Medial Septal Nucleus not only persisted but increased much above control values 6 months postlesion, confirming that many cholinergic neurons survive the transection of their axons. In contrast, immunolesioning led to a significant decrease in enzyme activity in the Medial Septal Nucleus corresponding to the selective loss of Septal cholinergic neurons in this lesion paradigm.