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Saul Suster - One of the best experts on this subject based on the ideXlab platform.

  • sclerosing paraganglioma report of 19 cases of an unusual variant of neuroendocrine Tumor that may be mistaken for an aggressive malignant neoplasm
    The American Journal of Surgical Pathology, 2006
    Co-Authors: Jose A. Plaza, Paul E Wakely, Christopher D M Fletcher, Cesar A. Moran, Saul Suster
    Abstract:

    : Nineteen cases of a distinctive variant of paraganglioma characterized by extensive collagen deposition resulting in a pattern of growth that resembled an invasive malignant neoplasm are described. The patients were 3 men and 16 women, 32 to 69 years of age (mean, 50.5 years). The Tumors were located in the carotid body region, parapharyngeal region, and Mediastinum. Tumor size ranged from 2 to 6 cm in greatest diameter. Grossly, the Tumors were described as rubbery to firm, tan-red, and with extensive areas of sclerosis. Histologic examination showed nests and cords of Tumor cells separated by broad bands of fibrous tissue. The Tumor cells ranged from round to polygonal with abundant cytoplasm to elongated spindle cells with scant cytoplasm. Nuclear cytomegaly was present focally enhancing the atypical appearance of the Tumor cell population in 17 cases. Mitoses were sparse (<1 x 10 HPF), and there was no evidence of necrosis in any of the cases. Foci of vascular and perineural invasion were present in 2 and 4 cases, respectively. The most striking morphologic feature was the presence of irregular cords and bands of hyalinized fibrous tissue that compartmentalized the lesion into irregular nests, islands, or cords of Tumor cells, imparting them with an infiltrative appearance. All the Tumors showed positive immunostaining for chromogranin, synaptophysin, and monoclonal neuron specific enolase. S-100 protein stains identified a sustentacular cell network, whereas cytokeratin AE1/AE3 was negative in all cases. Clinical follow-up in 14 cases, ranging from 2 months to 20 years (mean follow-up, 6.6 years) showed evidence of local recurrence in 2 cases and the development of a separate Tumor in the contralateral neck in 1 case. The remainder of patients were free of recurrence or metastasis following simple local excision. Because of the prominent sclerosis, a diagnosis of an invasive malignant neoplasm was initially considered in the majority of cases. Sclerosing paraganglioma should be included in the differential diagnosis of sclerosing lesions of the head and neck region and Mediastinum. Appropriate immunohistochemical stains may be of aid for establishing the correct diagnosis.

  • Sclerosing paraganglioma: Report of 19 cases of an unusual variant of neuroendocrine Tumor that may be mistaken for an aggressive malignant neoplasm
    The American Journal of Surgical Pathology, 2006
    Co-Authors: Jose A. Plaza, Paul E Wakely, Christopher D M Fletcher, Cesar A. Moran, Saul Suster
    Abstract:

    Nineteen cases of a distinctive variant of paraganglioma characterized by extensive collagen deposition resulting in a pattern of growth that resembled an invasive malignant neoplasm are described. The patients were 3 men and 16 women, 32 to 69 years of age (mean, 50.5 years). The Tumors were located in the carotid body region, parapharyngeal region, and Mediastinum. Tumor size ranged from 2 to 6 cm in greatest diameter. Grossly, the Tumors were described as rubbery to firm, tan-red, and with extensive areas of sclerosis. Histologic examination showed nests and cords of Tumor cells separated by broad bands of fibrous tissue. The Tumor cells ranged from round to polygonal with abundant cytoplasm to elongated spindle cells with scant cytoplasm. Nuclear cytomegaly was present focally enhancing the atypical appearance of the Tumor cell population in 17 cases. Mitoses were sparse (

Jose A. Plaza - One of the best experts on this subject based on the ideXlab platform.

  • sclerosing paraganglioma report of 19 cases of an unusual variant of neuroendocrine Tumor that may be mistaken for an aggressive malignant neoplasm
    The American Journal of Surgical Pathology, 2006
    Co-Authors: Jose A. Plaza, Paul E Wakely, Christopher D M Fletcher, Cesar A. Moran, Saul Suster
    Abstract:

    : Nineteen cases of a distinctive variant of paraganglioma characterized by extensive collagen deposition resulting in a pattern of growth that resembled an invasive malignant neoplasm are described. The patients were 3 men and 16 women, 32 to 69 years of age (mean, 50.5 years). The Tumors were located in the carotid body region, parapharyngeal region, and Mediastinum. Tumor size ranged from 2 to 6 cm in greatest diameter. Grossly, the Tumors were described as rubbery to firm, tan-red, and with extensive areas of sclerosis. Histologic examination showed nests and cords of Tumor cells separated by broad bands of fibrous tissue. The Tumor cells ranged from round to polygonal with abundant cytoplasm to elongated spindle cells with scant cytoplasm. Nuclear cytomegaly was present focally enhancing the atypical appearance of the Tumor cell population in 17 cases. Mitoses were sparse (<1 x 10 HPF), and there was no evidence of necrosis in any of the cases. Foci of vascular and perineural invasion were present in 2 and 4 cases, respectively. The most striking morphologic feature was the presence of irregular cords and bands of hyalinized fibrous tissue that compartmentalized the lesion into irregular nests, islands, or cords of Tumor cells, imparting them with an infiltrative appearance. All the Tumors showed positive immunostaining for chromogranin, synaptophysin, and monoclonal neuron specific enolase. S-100 protein stains identified a sustentacular cell network, whereas cytokeratin AE1/AE3 was negative in all cases. Clinical follow-up in 14 cases, ranging from 2 months to 20 years (mean follow-up, 6.6 years) showed evidence of local recurrence in 2 cases and the development of a separate Tumor in the contralateral neck in 1 case. The remainder of patients were free of recurrence or metastasis following simple local excision. Because of the prominent sclerosis, a diagnosis of an invasive malignant neoplasm was initially considered in the majority of cases. Sclerosing paraganglioma should be included in the differential diagnosis of sclerosing lesions of the head and neck region and Mediastinum. Appropriate immunohistochemical stains may be of aid for establishing the correct diagnosis.

  • Sclerosing paraganglioma: Report of 19 cases of an unusual variant of neuroendocrine Tumor that may be mistaken for an aggressive malignant neoplasm
    The American Journal of Surgical Pathology, 2006
    Co-Authors: Jose A. Plaza, Paul E Wakely, Christopher D M Fletcher, Cesar A. Moran, Saul Suster
    Abstract:

    Nineteen cases of a distinctive variant of paraganglioma characterized by extensive collagen deposition resulting in a pattern of growth that resembled an invasive malignant neoplasm are described. The patients were 3 men and 16 women, 32 to 69 years of age (mean, 50.5 years). The Tumors were located in the carotid body region, parapharyngeal region, and Mediastinum. Tumor size ranged from 2 to 6 cm in greatest diameter. Grossly, the Tumors were described as rubbery to firm, tan-red, and with extensive areas of sclerosis. Histologic examination showed nests and cords of Tumor cells separated by broad bands of fibrous tissue. The Tumor cells ranged from round to polygonal with abundant cytoplasm to elongated spindle cells with scant cytoplasm. Nuclear cytomegaly was present focally enhancing the atypical appearance of the Tumor cell population in 17 cases. Mitoses were sparse (

Ricardo García-luján - One of the best experts on this subject based on the ideXlab platform.

  • FDG-PET parameters predicting mediastinal malignancy in lung cancer.
    BMC Pulmonary Medicine, 2016
    Co-Authors: M. Serra Fortuny, Miguel Gallego, Ll Berna, Concepción Montón, L. Vigil, M. J. Masdeu, Alberto Fernández-villar, Maribel Botana, Rosa Cordovilla, Ricardo García-luján
    Abstract:

    Staging of mediastinal lymph nodes in non-small cell lung cancer (NSCLC) is mandatory. The maximum Standard Uptake Value (SUVmax) obtained using F-18 fluorodeoxyglucose positron emission tomography (FDG-PET) is the best non-invasive technique available for this evaluation, but its performance varies from center to center. The aim of the present study was to identify FDG-PET predictors of mediastinal malignancy that are able to minimize intercenter variability and improve the selection of subsequent staging procedures. A multicenter study of NSCLC patients staged through FDG-PET and endobronchial ultrasonography with needle aspiration (EBUS-NA) was performed using therapeutic surgery with systematic nodal dissection as gold standard. Intercenter variability and predictive power for mediastinal malignancy of different FDG-PET measures were assessed, as well as the role of these measures for selecting additional staging procedures. One hundred and twenty-one NSCLC patients, of whom 94 (72%) had ≥1 hypermetabolic spots in the Mediastinum, were included in the study. Mean SUVmax of the primary Tumor was 12.3 (SD 6.3), and median SUVmax of the highest hypermetabolic spots in the Mediastinum was 3.9 (IQR 2.4-7). Variability of FDG-PET measures between hospitals was statistically significant (p = 0.016 and p  3 cm and/or a SUVmax Mediastinum/Tumor ratio >0.4. The SUVmax Mediastinum/Tumor ratio is a good predictor of regional Tumor extension in NSCLC. This measure is not influenced by intercenter variability and has an accuracy of over 70% for the identification of malignancy when using a 0.4 cutoff.

  • FDG-PET parameters predicting mediastinal malignancy in lung cancer
    BMC Pulmonary Medicine, 2016
    Co-Authors: M. Serra Fortuny, Miguel Gallego, Ll Berna, Concepción Montón, L. Vigil, M. J. Masdeu, Alberto Fernández-villar, Maribel Botana, Rosa Cordovilla, Ricardo García-luján
    Abstract:

    Background Staging of mediastinal lymph nodes in non-small cell lung cancer (NSCLC) is mandatory. The maximum Standard Uptake Value (SUVmax) obtained using F-18 fluorodeoxyglucose positron emission tomography (FDG-PET) is the best non-invasive technique available for this evaluation, but its performance varies from center to center. The aim of the present study was to identify FDG-PET predictors of mediastinal malignancy that are able to minimize intercenter variability and improve the selection of subsequent staging procedures. Method A multicenter study of NSCLC patients staged through FDG-PET and endobronchial ultrasonography with needle aspiration (EBUS-NA) was performed using therapeutic surgery with systematic nodal dissection as gold standard. Intercenter variability and predictive power for mediastinal malignancy of different FDG-PET measures were assessed, as well as the role of these measures for selecting additional staging procedures. Results One hundred and twenty-one NSCLC patients, of whom 94 (72%) had ≥1 hypermetabolic spots in the Mediastinum, were included in the study. Mean SUVmax of the primary Tumor was 12.3 (SD 6.3), and median SUVmax of the highest hypermetabolic spots in the Mediastinum was 3.9 (IQR 2.4-7). Variability of FDG-PET measures between hospitals was statistically significant ( p  = 0.016 and p  0.4. Conclusion The SUVmax Mediastinum/Tumor ratio is a good predictor of regional Tumor extension in NSCLC. This measure is not influenced by intercenter variability and has an accuracy of over 70% for the identification of malignancy when using a 0.4 cutoff.

Cesar A. Moran - One of the best experts on this subject based on the ideXlab platform.

  • sclerosing paraganglioma report of 19 cases of an unusual variant of neuroendocrine Tumor that may be mistaken for an aggressive malignant neoplasm
    The American Journal of Surgical Pathology, 2006
    Co-Authors: Jose A. Plaza, Paul E Wakely, Christopher D M Fletcher, Cesar A. Moran, Saul Suster
    Abstract:

    : Nineteen cases of a distinctive variant of paraganglioma characterized by extensive collagen deposition resulting in a pattern of growth that resembled an invasive malignant neoplasm are described. The patients were 3 men and 16 women, 32 to 69 years of age (mean, 50.5 years). The Tumors were located in the carotid body region, parapharyngeal region, and Mediastinum. Tumor size ranged from 2 to 6 cm in greatest diameter. Grossly, the Tumors were described as rubbery to firm, tan-red, and with extensive areas of sclerosis. Histologic examination showed nests and cords of Tumor cells separated by broad bands of fibrous tissue. The Tumor cells ranged from round to polygonal with abundant cytoplasm to elongated spindle cells with scant cytoplasm. Nuclear cytomegaly was present focally enhancing the atypical appearance of the Tumor cell population in 17 cases. Mitoses were sparse (<1 x 10 HPF), and there was no evidence of necrosis in any of the cases. Foci of vascular and perineural invasion were present in 2 and 4 cases, respectively. The most striking morphologic feature was the presence of irregular cords and bands of hyalinized fibrous tissue that compartmentalized the lesion into irregular nests, islands, or cords of Tumor cells, imparting them with an infiltrative appearance. All the Tumors showed positive immunostaining for chromogranin, synaptophysin, and monoclonal neuron specific enolase. S-100 protein stains identified a sustentacular cell network, whereas cytokeratin AE1/AE3 was negative in all cases. Clinical follow-up in 14 cases, ranging from 2 months to 20 years (mean follow-up, 6.6 years) showed evidence of local recurrence in 2 cases and the development of a separate Tumor in the contralateral neck in 1 case. The remainder of patients were free of recurrence or metastasis following simple local excision. Because of the prominent sclerosis, a diagnosis of an invasive malignant neoplasm was initially considered in the majority of cases. Sclerosing paraganglioma should be included in the differential diagnosis of sclerosing lesions of the head and neck region and Mediastinum. Appropriate immunohistochemical stains may be of aid for establishing the correct diagnosis.

  • Sclerosing paraganglioma: Report of 19 cases of an unusual variant of neuroendocrine Tumor that may be mistaken for an aggressive malignant neoplasm
    The American Journal of Surgical Pathology, 2006
    Co-Authors: Jose A. Plaza, Paul E Wakely, Christopher D M Fletcher, Cesar A. Moran, Saul Suster
    Abstract:

    Nineteen cases of a distinctive variant of paraganglioma characterized by extensive collagen deposition resulting in a pattern of growth that resembled an invasive malignant neoplasm are described. The patients were 3 men and 16 women, 32 to 69 years of age (mean, 50.5 years). The Tumors were located in the carotid body region, parapharyngeal region, and Mediastinum. Tumor size ranged from 2 to 6 cm in greatest diameter. Grossly, the Tumors were described as rubbery to firm, tan-red, and with extensive areas of sclerosis. Histologic examination showed nests and cords of Tumor cells separated by broad bands of fibrous tissue. The Tumor cells ranged from round to polygonal with abundant cytoplasm to elongated spindle cells with scant cytoplasm. Nuclear cytomegaly was present focally enhancing the atypical appearance of the Tumor cell population in 17 cases. Mitoses were sparse (

Christopher D M Fletcher - One of the best experts on this subject based on the ideXlab platform.

  • sclerosing paraganglioma report of 19 cases of an unusual variant of neuroendocrine Tumor that may be mistaken for an aggressive malignant neoplasm
    The American Journal of Surgical Pathology, 2006
    Co-Authors: Jose A. Plaza, Paul E Wakely, Christopher D M Fletcher, Cesar A. Moran, Saul Suster
    Abstract:

    : Nineteen cases of a distinctive variant of paraganglioma characterized by extensive collagen deposition resulting in a pattern of growth that resembled an invasive malignant neoplasm are described. The patients were 3 men and 16 women, 32 to 69 years of age (mean, 50.5 years). The Tumors were located in the carotid body region, parapharyngeal region, and Mediastinum. Tumor size ranged from 2 to 6 cm in greatest diameter. Grossly, the Tumors were described as rubbery to firm, tan-red, and with extensive areas of sclerosis. Histologic examination showed nests and cords of Tumor cells separated by broad bands of fibrous tissue. The Tumor cells ranged from round to polygonal with abundant cytoplasm to elongated spindle cells with scant cytoplasm. Nuclear cytomegaly was present focally enhancing the atypical appearance of the Tumor cell population in 17 cases. Mitoses were sparse (<1 x 10 HPF), and there was no evidence of necrosis in any of the cases. Foci of vascular and perineural invasion were present in 2 and 4 cases, respectively. The most striking morphologic feature was the presence of irregular cords and bands of hyalinized fibrous tissue that compartmentalized the lesion into irregular nests, islands, or cords of Tumor cells, imparting them with an infiltrative appearance. All the Tumors showed positive immunostaining for chromogranin, synaptophysin, and monoclonal neuron specific enolase. S-100 protein stains identified a sustentacular cell network, whereas cytokeratin AE1/AE3 was negative in all cases. Clinical follow-up in 14 cases, ranging from 2 months to 20 years (mean follow-up, 6.6 years) showed evidence of local recurrence in 2 cases and the development of a separate Tumor in the contralateral neck in 1 case. The remainder of patients were free of recurrence or metastasis following simple local excision. Because of the prominent sclerosis, a diagnosis of an invasive malignant neoplasm was initially considered in the majority of cases. Sclerosing paraganglioma should be included in the differential diagnosis of sclerosing lesions of the head and neck region and Mediastinum. Appropriate immunohistochemical stains may be of aid for establishing the correct diagnosis.

  • Sclerosing paraganglioma: Report of 19 cases of an unusual variant of neuroendocrine Tumor that may be mistaken for an aggressive malignant neoplasm
    The American Journal of Surgical Pathology, 2006
    Co-Authors: Jose A. Plaza, Paul E Wakely, Christopher D M Fletcher, Cesar A. Moran, Saul Suster
    Abstract:

    Nineteen cases of a distinctive variant of paraganglioma characterized by extensive collagen deposition resulting in a pattern of growth that resembled an invasive malignant neoplasm are described. The patients were 3 men and 16 women, 32 to 69 years of age (mean, 50.5 years). The Tumors were located in the carotid body region, parapharyngeal region, and Mediastinum. Tumor size ranged from 2 to 6 cm in greatest diameter. Grossly, the Tumors were described as rubbery to firm, tan-red, and with extensive areas of sclerosis. Histologic examination showed nests and cords of Tumor cells separated by broad bands of fibrous tissue. The Tumor cells ranged from round to polygonal with abundant cytoplasm to elongated spindle cells with scant cytoplasm. Nuclear cytomegaly was present focally enhancing the atypical appearance of the Tumor cell population in 17 cases. Mitoses were sparse (