The Experts below are selected from a list of 247356 Experts worldwide ranked by ideXlab platform
Akira Onuki - One of the best experts on this subject based on the ideXlab platform.
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theory of nonionic hydrophobic solutes in mixture solvent solvent Mediated Interaction and solute induced phase separation
Journal of Chemical Physics, 2018Co-Authors: Ryuichi Okamoto, Akira OnukiAbstract:We present a theory of nonionic solutes in a mixture solvent composed of water-like and alcohol-like species. First, we show the relationship among the solvation chemical potential, the partial volumes vi, the Kirkwood-Buff integrals, the second osmotic virial coefficient, and the Gibbs transfer free energy. We examine how the solute density n3 is coupled to the solvent densities n1 and n2 in thermodynamics. In the limit of small compressibility, we show that the space-filling condition ∑i vini = 1 nearly holds for inhomogeneous densities ni, where the concentration fluctuations of the solvent can give rise to a large solute-solute attractive Interaction. We also derive a solute spinodal density n3spi for solute-induced instability. Next, we examine gas-liquid and liquid-liquid phase transitions induced by a small amount of a solute using the Mansoori, Carnahan, Starling, and Leland model for hard-sphere mixtures [J. Chem. Phys. 54, 1523–1525 (1971)]. Here, we assume that the solvent is close to its gas-liquid coexistence and the solute interacts repulsively with the water-like species but attractively with the alcohol-like one. We calculate the binodal and spinodal curves in the phase diagrams and examine nucleation for these two phase transitions.We present a theory of nonionic solutes in a mixture solvent composed of water-like and alcohol-like species. First, we show the relationship among the solvation chemical potential, the partial volumes vi, the Kirkwood-Buff integrals, the second osmotic virial coefficient, and the Gibbs transfer free energy. We examine how the solute density n3 is coupled to the solvent densities n1 and n2 in thermodynamics. In the limit of small compressibility, we show that the space-filling condition ∑i vini = 1 nearly holds for inhomogeneous densities ni, where the concentration fluctuations of the solvent can give rise to a large solute-solute attractive Interaction. We also derive a solute spinodal density n3spi for solute-induced instability. Next, we examine gas-liquid and liquid-liquid phase transitions induced by a small amount of a solute using the Mansoori, Carnahan, Starling, and Leland model for hard-sphere mixtures [J. Chem. Phys. 54, 1523–1525 (1971)]. Here, we assume that the solvent is close to its gas-l...
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theory of nonionic hydrophobic solutes in mixture solvent solvent Mediated Interaction and solute induced phase separation
arXiv: Soft Condensed Matter, 2018Co-Authors: Ryuichi Okamoto, Akira OnukiAbstract:We present a theory of nonionic solutes in a mixture solvent composed of water-like and alcohol-like species. First, we show relationship among the solvation chemical potential, the partial volumes $v_i$, the Kirkwood-Buff integrals, the second osmotic virial coefficient, and the Gibbs transfer free energy. We examine how the solute density $n_3$ is coupled to the solvent densities $n_1$ and $n_2$ in thermodynamics. In the limit of small compressibility, we show that the space-filling condition $\sum_i v_i n_i=1$ nearly holds for inhomogeneous densities $n_i$, where the concentration fluctuations of the solvent can give rise to a large solute-solute attractive Interaction. We also derive a solute spinodal density $n_3^{\rm spi}$ for solute-induced instability. Next, we examine gas-liquid and liquid-liquid phase transitions induced by a small amount of a solute using the Mansoori, Carnahan, Starling, and Leland model for hard-sphere mixtures $[${ J. Chem. Phys.} {\bf 54}, 1523 (1971)$]$. Here, we assume that the solvent is close to its gas-liquid coexistence and the solute interacts repulsively with the water-like species but attractively with the alcohol-like one. We calculate the binodal and spinodal curves in the phase diagrams and examine nucleation for these two phase transitions.
Kieran F. Harvey - One of the best experts on this subject based on the ideXlab platform.
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ww domain Mediated Interaction with wbp2 is important for the oncogenic property of taz
Oncogene, 2011Co-Authors: Siew Wee Chan, Y F Chong, H J Gunaratne, K A Hogue, W P Blackstock, Kieran F. Harvey, C. HuangAbstract:The transcriptional co-activators YAP and TAZ are downstream targets inhibited by the Hippo tumor suppressor pathway. YAP and TAZ both possess WW domains, which are important protein–protein Interaction modules that mediate Interaction with proline-rich motifs, most commonly PPXY. The WW domains of YAP have complex regulatory roles as exemplified by recent reports showing that they can positively or negatively influence YAP activity in a cell and context-specific manner. In this study, we show that the WW domain of TAZ is important for it to transform both MCF10A and NIH3T3 cells and to activate transcription of ITGB2 but not CTGF, as introducing point mutations into the WW domain of TAZ (WWm) abolished its transforming and transcription-promoting ability. Using a proteomic approach, we discovered potential regulatory proteins that interact with TAZ WW domain and identified Wbp2. The Interaction of Wbp2 with TAZ is dependent on the WW domain of TAZ and the PPXY-containing C-terminal region of Wbp2. Knockdown of endogenous Wbp2 suppresses, whereas overexpression of Wbp2 enhances, TAZ-driven transformation. Forced Interaction of WWm with Wbp2 by direct C-terminal fusion of full-length Wbp2 or its TAZ-interacting C-terminal domain restored the transforming and transcription-promoting ability of TAZ. These results suggest that the WW domain-Mediated Interaction with Wbp2 promotes the transforming ability of TAZ.
Gary A. Koretzky - One of the best experts on this subject based on the ideXlab platform.
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SH3 domain-Mediated Interaction of dystroglycan and Grb2.
The Journal of biological chemistry, 1995Co-Authors: Bin Yang, Daniel Jung, David G. Motto, J. Meyer, Gary A. KoretzkyAbstract:Dystroglycan is a novel laminin receptor that links the extracellular matrix and sarcolemma in skeletal muscle. The dystroglycan complex containing alpha- and beta-dystroglycan also serves as an agrin receptor in muscle, where it may regulate agrin-induced acetylcholine receptor clustering at the neuromuscular junction. beta-Dystroglycan has now been expressed in vitro and shown to directly interact with Grb2, an adapter protein involved in signal transduction and cytoskeletal organization. Protein binding assays with two Grb2 mutants, Grb2/P49L and Grb2/G203R, which correspond to the loss-of-function mutants in the Caenorhabditis elegans sem-5, demonstrated that the dystroglycan-Grb2 association is through beta-dystroglycan C-terminal proline-rich domains and Grb2 Src homology 3 domains. Affinity chromatography has also shown endogenous skeletal muscle Grb2 interacts with beta-dystroglycan. Immunoprecipitation experiments have demonstrated that Grb2 associates with alpha/beta-dystroglycan in vivo in both skeletal muscle and brain. The specific dystroglycan-Grb2 Interaction may play an important role in extracellular matrix-Mediated signal transduction and/or cytoskeleton organization in skeletal muscle that may be essential for muscle cell viability.
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sh3 domain Mediated Interaction of dystroglycan and grb2
Journal of Biological Chemistry, 1995Co-Authors: Bin Yang, Daniel Jung, David G. Motto, J. Meyer, Gary A. KoretzkyAbstract:Abstract Dystroglycan is a novel laminin receptor that links the extracellular matrix and sarcolemma in skeletal muscle. The dystroglycan complex containing α- and β-dystroglycan also serves as an agrin receptor in muscle, where it may regulate agrin-induced acetylcholine receptor clustering at the neuromuscular junction. β-Dystroglycan has now been expressed in vitro and shown to directly interact with Grb2, an adapter protein involved in signal transduction and cytoskeletal organization. Protein binding assays with two Grb2 mutants, Grb2/P49L and Grb2/G203R, which correspond to the loss-of-function mutants in the Caenorhabditis elegans sem -5, demonstrated that the dystroglycan-Grb2 association is through β-dystroglycan C-terminal proline-rich domains and Grb2 Src homology 3 domains. Affinity chromatography has also shown endogenous skeletal muscle Grb2 interacts with β-dystroglycan. Immunoprecipitation experiments have demonstrated that Grb2 associates with α/β-dystroglycan in vivo in both skeletal muscle and brain. The specific dystroglycan-Grb2 Interaction may play an important role in extracellular matrix-Mediated signal transduction and/or cytoskeleton organization in skeletal muscle that may be essential for muscle cell viability.
Ryuichi Okamoto - One of the best experts on this subject based on the ideXlab platform.
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theory of nonionic hydrophobic solutes in mixture solvent solvent Mediated Interaction and solute induced phase separation
Journal of Chemical Physics, 2018Co-Authors: Ryuichi Okamoto, Akira OnukiAbstract:We present a theory of nonionic solutes in a mixture solvent composed of water-like and alcohol-like species. First, we show the relationship among the solvation chemical potential, the partial volumes vi, the Kirkwood-Buff integrals, the second osmotic virial coefficient, and the Gibbs transfer free energy. We examine how the solute density n3 is coupled to the solvent densities n1 and n2 in thermodynamics. In the limit of small compressibility, we show that the space-filling condition ∑i vini = 1 nearly holds for inhomogeneous densities ni, where the concentration fluctuations of the solvent can give rise to a large solute-solute attractive Interaction. We also derive a solute spinodal density n3spi for solute-induced instability. Next, we examine gas-liquid and liquid-liquid phase transitions induced by a small amount of a solute using the Mansoori, Carnahan, Starling, and Leland model for hard-sphere mixtures [J. Chem. Phys. 54, 1523–1525 (1971)]. Here, we assume that the solvent is close to its gas-liquid coexistence and the solute interacts repulsively with the water-like species but attractively with the alcohol-like one. We calculate the binodal and spinodal curves in the phase diagrams and examine nucleation for these two phase transitions.We present a theory of nonionic solutes in a mixture solvent composed of water-like and alcohol-like species. First, we show the relationship among the solvation chemical potential, the partial volumes vi, the Kirkwood-Buff integrals, the second osmotic virial coefficient, and the Gibbs transfer free energy. We examine how the solute density n3 is coupled to the solvent densities n1 and n2 in thermodynamics. In the limit of small compressibility, we show that the space-filling condition ∑i vini = 1 nearly holds for inhomogeneous densities ni, where the concentration fluctuations of the solvent can give rise to a large solute-solute attractive Interaction. We also derive a solute spinodal density n3spi for solute-induced instability. Next, we examine gas-liquid and liquid-liquid phase transitions induced by a small amount of a solute using the Mansoori, Carnahan, Starling, and Leland model for hard-sphere mixtures [J. Chem. Phys. 54, 1523–1525 (1971)]. Here, we assume that the solvent is close to its gas-l...
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theory of nonionic hydrophobic solutes in mixture solvent solvent Mediated Interaction and solute induced phase separation
arXiv: Soft Condensed Matter, 2018Co-Authors: Ryuichi Okamoto, Akira OnukiAbstract:We present a theory of nonionic solutes in a mixture solvent composed of water-like and alcohol-like species. First, we show relationship among the solvation chemical potential, the partial volumes $v_i$, the Kirkwood-Buff integrals, the second osmotic virial coefficient, and the Gibbs transfer free energy. We examine how the solute density $n_3$ is coupled to the solvent densities $n_1$ and $n_2$ in thermodynamics. In the limit of small compressibility, we show that the space-filling condition $\sum_i v_i n_i=1$ nearly holds for inhomogeneous densities $n_i$, where the concentration fluctuations of the solvent can give rise to a large solute-solute attractive Interaction. We also derive a solute spinodal density $n_3^{\rm spi}$ for solute-induced instability. Next, we examine gas-liquid and liquid-liquid phase transitions induced by a small amount of a solute using the Mansoori, Carnahan, Starling, and Leland model for hard-sphere mixtures $[${ J. Chem. Phys.} {\bf 54}, 1523 (1971)$]$. Here, we assume that the solvent is close to its gas-liquid coexistence and the solute interacts repulsively with the water-like species but attractively with the alcohol-like one. We calculate the binodal and spinodal curves in the phase diagrams and examine nucleation for these two phase transitions.
Joseph B Walther - One of the best experts on this subject based on the ideXlab platform.
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interpersonal effects in computer Mediated Interaction a meta analysis of social and antisocial communication
Communication Research, 1994Co-Authors: Joseph B Walther, Jeffrey F Anderson, David W ParkAbstract:This study examined the effects of time restriction on social Interaction in computer-Mediated communication through a meta-analysis of applicable research. Time was defined as whether subjects were restricted or unrestricted in their opportunity to exchange messages. Studies were included that assessed either of two outcome variables: socially oriented (as opposed to task-oriented) communication, and negative / uninhibited communication. Hypotheses were derived from Walther's social information processing perspective. Meta-analytic tests supported the hypotheses on social communication. Although no effects were found on negative / uninhibited communication, a reexamination of original studies suggests caution regarding previous findings.
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anticipated ongoing Interaction versus channel effects on relational communication in computer Mediated Interaction
Human Communication Research, 1994Co-Authors: Joseph B WaltherAbstract:Previous research on the interpersonal tone of computer-Mediated communication shows different effects using longitudinal computer-Mediated groups than are found in research using one-shot groups, even before the developmental aspects associated with time can accrue. One factor distinguishing these approaches is the anticipation of future Interaction experienced by longitudinal groups. This research reports an experiment assessing the relative effects of anticipated future Interaction and different communication media (computer-Mediated versus face-to-face communication) on the communication of relational intimacy and composure. Asynchronous and synchronous computer conferencing and face-to-face groups were examined. Results show that the assignment of long-term versus short-term partnerships has a larger impact on anticipated future Interaction reported by computer-Mediated, rather than face-to-face, partners. Evidence also shows that anticipation is a more potent predictor of several relational communication dimensions than is communication condition. Implications for theory and practice are identified.
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interpersonal effects in computer Mediated Interaction a relational perspective
Communication Research, 1992Co-Authors: Joseph B WaltherAbstract:Several theories and much experimental research on relational tone in computer-Mediated communication (CMC) points to the lack of nonverbal cues in this channel as a cause of impersonal and task-oriented messages. Field research in CMC often reports more positive relational behavior. This article examines the assumptions, methods, and findings of such research and suggests that negative relational effects are confined to narrow situational boundary conditions. Alternatively, it is suggested that communicators develop individuating impressions of others through accumulated CMC messages. Based upon these impressions, users may develop relationships and express multidimensional relational messages through verbal or textual cues. Predictions regarding these processes are suggested, and future research incorporating these points is urged.