The Experts below are selected from a list of 186333 Experts worldwide ranked by ideXlab platform
Norhayati Soin - One of the best experts on this subject based on the ideXlab platform.
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A review of MEMS drug delivery in Medical Application
3rd Kuala Lumpur International Conference on Biomedical Engineering 2006, 2007Co-Authors: Salmah B. Karman, Fatimah Ibrahim, Norhayati SoinAbstract:This paper overviews various components of MEMS drug delivery devices in Medical Application such as micropumps, microvalves, microactuator and microneedles, using biocompatible material such as silicon. The review will focus on micropumps structures in different actuators. The electrostatic actuated micropumps and circular bossed membrane were found out to be the most suitable device for Medical Application and offer better linearity pumping rate respectively.
Thomas Egli - One of the best experts on this subject based on the ideXlab platform.
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occurrence synthesis and Medical Application of bacterial polyhydroxyalkanoate
Advanced Drug Delivery Reviews, 2001Co-Authors: Manfred Zinn, Bernard Witholt, Thomas EgliAbstract:Polyhydroxyalkanoates (PHAs) comprise a large class of polyesters that are synthesized by many bacteria as an intracellular carbon and energy compound. Analysis of isolated PHAs reveal interesting properties such as biodegradability and biocompatibility. Research was focused only recently on the Application of PHA in implants, scaffolds in tissue engineering, or as drug carriers. Such Applications require that PHA be produced at a constant and reproducible quality. To date this can be achieved best through bacterial production in continuous culture where growth conditions are kept constant (chemostat). Recently, it was found that PHA producing bacteria are able to grow simultaneously limited by carbon and nitrogen substrates. Thus, it became possible to produce PHA at high yields on toxic substrate and also control its composition accurately (tailor-made synthesis). Finally, Applications of PHA in medicine are discussed.
Masashige Shinkai - One of the best experts on this subject based on the ideXlab platform.
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Medical Application of functionalized magnetic nanoparticles
Journal of Bioscience and Bioengineering, 2005Co-Authors: Akira Ito, Masashige Shinkai, Hiroyuki Honda, Takeshi KobayashiAbstract:Since magnetic particles have unique features, the development of a variety of Medical Applications has been possible. The most unique feature of magnetic particles is their reaction to a magnetic force, and this feature has been utilized in Applications such as drug targeting and bioseparation including cell sorting. Recently, magnetic nanoparticles have attracted attention because of their potential as contrast agents for magnetic resonance imaging (MRI) and heating mediators for cancer therapy (hyperthermia). Magnetite cationic liposomes (MCLs), one of the groups of cationic magnetic particles, can be used as carriers to introduce magnetite nanoparticles into target cells since their positively charged surface interacts with the negatively charged cell surface; furthermore, they find Applications to hyperthermic treatments. Magnetite nanoparticles conjugated with antibodies (antibody-conjugated magnetoliposomes, AMLs) are also applied to hyperthermia and have enabled tumor-specific contrast enhancement in MRI via systemic administration. Since magnetic nanoparticles are attracted to a high magnetic flux density, it is possible to manipulate cells labeled with magnetic nanoparticles using magnets; this feature has been applied in tissue engineering. Magnetic force and MCLs were used to construct multilayered cell structures and a heterotypic layered 3D coculture system. Thus, the Applications of these functionalized magnetic nanoparticles with their unique features will further improve Medical techniques.
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Functional magnetic particles for Medical Application.
Advances in Biochemical Engineering \ Biotechnology, 2004Co-Authors: Masashige ShinkaiAbstract:: Magnetic particles for Medical Applications have been developed by many researchers. Since magnetic particles have unique magnetic features not present in other materials, they can be applied to special Medical techniques. Separation, immunoassay, magnetic resonance imaging (MRI), drug delivery, and hyperthermia are enhanced by the use of magnetic particles. Magnetite cationic liposomes (MCLs), one of the groups of cationic magnetic particles, can be used as carriers to introduce DNA into cells since their positively charged surface associates with the negatively charged DNA. MCLs can also be used as heat mediators for cancer therapy. Magnetic particles conjugated with tumor-specific antibodies have enabled tumor-specific contrast enhancement in MRI. In addition, antibody-conjugated magnetic particles were shown to target renal cell carcinoma cells, and are applicable to the hyperthermic treatment of carcinomas. It was also found that the hyperthermic treatment using magnetic particles induced an antitumor immunity. Thus, the use of magnetic particles with their unique features will further improve Medical techniques.
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Functional magnetic particles for Medical Application.
Journal of Bioscience and Bioengineering, 2002Co-Authors: Masashige ShinkaiAbstract:Magnetic particles for Medical Applications have been developed by many researchers. Since magnetic particles have unique magnetic features not present in other materials, they can be applied to special Medical techniques. Separation, immunoassay, magnetic resonance imaging (MRI), drug delivery, and hyperthermia are enhanced by the use of magnetic particles. Magnetite cationic liposomes (MCLs), one of the group of cationic magnetic particles, can be used as carriers to introduce DNA into cells since their positively charged surface associates with the negatively charged DNA. They can also be used as heat mediators for cancer therapy. Magnetic particles conjugated with tumor-specific antibodies have enabled tumor-specific contrast enhancement in MRI. In addition, antibody-conjugated magnetic particles were shown to target renal cell carcinoma cells, and are applicable to the hyperthermic treatment of carcinomas. The use of magnetic particles with their unique features will further improve Medical techniques.
Salmah B. Karman - One of the best experts on this subject based on the ideXlab platform.
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A review of MEMS drug delivery in Medical Application
3rd Kuala Lumpur International Conference on Biomedical Engineering 2006, 2007Co-Authors: Salmah B. Karman, Fatimah Ibrahim, Norhayati SoinAbstract:This paper overviews various components of MEMS drug delivery devices in Medical Application such as micropumps, microvalves, microactuator and microneedles, using biocompatible material such as silicon. The review will focus on micropumps structures in different actuators. The electrostatic actuated micropumps and circular bossed membrane were found out to be the most suitable device for Medical Application and offer better linearity pumping rate respectively.
Krzysztof J. Kurzydłowski - One of the best experts on this subject based on the ideXlab platform.
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Glow discharge assisted oxynitriding process of titanium for Medical Application
Applied Surface Science, 2015Co-Authors: Tadeusz Wierzchoń, Elżbieta Czarnowska, Justyna Grzonka, Agnieszka Sowińska, M. Tarnowski, Janusz Kamiński, Krzysztof Kulikowski, Tomasz Borowski, Krzysztof J. KurzydłowskiAbstract:Abstract The plasma oxynitriding process is a prospective method of producing titanium oxides as an integral part of a diffusive nitrided surface layer on titanium implants. This hybrid process, which combines glow discharge assisted nitriding and oxidizing, permits producing TiO2 + Ti2N + αTi(N)-type diffusive surface layers. The oxynitrided surface layers improve the corrosion and wear resistance of the substrate material. Additionally, the nanocrystalline titanium oxide TiO2 (rutile) improves the biological properties of titanium and its alloys when in contact with blood, whereas the TiN + Ti2N + αTi(N) zone eliminates the effect of metalosis.