The Experts below are selected from a list of 45 Experts worldwide ranked by ideXlab platform

John D. Sutherland - One of the best experts on this subject based on the ideXlab platform.

  • Length-Selective Synthesis of Acylglycerol-Phosphates through Energy-Dissipative Cycling
    Journal of the American Chemical Society, 2019
    Co-Authors: Claudia Bonfio, Cécile Caumes, Colm D. Duffy, Bhavesh H. Patel, Claudia Percivalle, Maria Tsanakopoulou, John D. Sutherland
    Abstract:

    The main aim of origins of life research is to find a plausible sequence of transitions from prebiotic chemistry to nascent biology. In this context, understanding how and when phospholipid membranes appeared on early Earth is critical to elucidating the prebiotic pathways that led to the emergence of primitive cells. Here we show that exposing glycerol-2-phosphate to acylating agents leads to the formation of a library of Acylglycerol-phosphates. Medium-Chain Acylglycerol-phosphates were found to self-assemble into vesicles stable across a wide range of conditions and capable of retaining mono- and oligonucleotides. Starting with a mixture of activated carboxylic acids of different lengths, iterative cycling of acylation and hydrolysis steps allowed for the selection of longer-Chain Acylglycerol-phosphates. Our results suggest that a selection pathway based on energy-dissipative cycling could have driven the selective synthesis of phospholipids on early Earth.

  • Length-Selective Synthesis of Acylglycerol-Phosphates through Energy-Dissipative Cycling
    2019
    Co-Authors: Claudia Bonfio, Cécile Caumes, Colm D. Duffy, Bhavesh H. Patel, Claudia Percivalle, Maria Tsanakopoulou, John D. Sutherland
    Abstract:

    The main aim of origins of life research is to find a plausible sequence of transitions from prebiotic chemistry to nascent biology. In this context, understanding how and when phospholipid membranes appeared on early Earth is critical to elucidating the prebiotic pathways that led to the emergence of primitive cells. Here we show that exposing glycerol-2-phosphate to acylating agents leads to the formation of a library of Acylglycerol-phosphates. Medium-Chain Acylglycerol-phosphates were found to self-assemble into vesicles stable across a wide range of conditions and capable of retaining mono- and oligonucleotides. Starting with a mixture of activated carboxylic acids of different lengths, iterative cycling of acylation and hydrolysis steps allowed for the selection of longer-Chain Acylglycerol-phosphates. Our results suggest that a selection pathway based on energy-dissipative cycling could have driven the selective synthesis of phospholipids on early Earth

Claudia Bonfio - One of the best experts on this subject based on the ideXlab platform.

  • Length-Selective Synthesis of Acylglycerol-Phosphates through Energy-Dissipative Cycling
    Journal of the American Chemical Society, 2019
    Co-Authors: Claudia Bonfio, Cécile Caumes, Colm D. Duffy, Bhavesh H. Patel, Claudia Percivalle, Maria Tsanakopoulou, John D. Sutherland
    Abstract:

    The main aim of origins of life research is to find a plausible sequence of transitions from prebiotic chemistry to nascent biology. In this context, understanding how and when phospholipid membranes appeared on early Earth is critical to elucidating the prebiotic pathways that led to the emergence of primitive cells. Here we show that exposing glycerol-2-phosphate to acylating agents leads to the formation of a library of Acylglycerol-phosphates. Medium-Chain Acylglycerol-phosphates were found to self-assemble into vesicles stable across a wide range of conditions and capable of retaining mono- and oligonucleotides. Starting with a mixture of activated carboxylic acids of different lengths, iterative cycling of acylation and hydrolysis steps allowed for the selection of longer-Chain Acylglycerol-phosphates. Our results suggest that a selection pathway based on energy-dissipative cycling could have driven the selective synthesis of phospholipids on early Earth.

  • Length-Selective Synthesis of Acylglycerol-Phosphates through Energy-Dissipative Cycling
    2019
    Co-Authors: Claudia Bonfio, Cécile Caumes, Colm D. Duffy, Bhavesh H. Patel, Claudia Percivalle, Maria Tsanakopoulou, John D. Sutherland
    Abstract:

    The main aim of origins of life research is to find a plausible sequence of transitions from prebiotic chemistry to nascent biology. In this context, understanding how and when phospholipid membranes appeared on early Earth is critical to elucidating the prebiotic pathways that led to the emergence of primitive cells. Here we show that exposing glycerol-2-phosphate to acylating agents leads to the formation of a library of Acylglycerol-phosphates. Medium-Chain Acylglycerol-phosphates were found to self-assemble into vesicles stable across a wide range of conditions and capable of retaining mono- and oligonucleotides. Starting with a mixture of activated carboxylic acids of different lengths, iterative cycling of acylation and hydrolysis steps allowed for the selection of longer-Chain Acylglycerol-phosphates. Our results suggest that a selection pathway based on energy-dissipative cycling could have driven the selective synthesis of phospholipids on early Earth

Cécile Caumes - One of the best experts on this subject based on the ideXlab platform.

  • Length-Selective Synthesis of Acylglycerol-Phosphates through Energy-Dissipative Cycling
    Journal of the American Chemical Society, 2019
    Co-Authors: Claudia Bonfio, Cécile Caumes, Colm D. Duffy, Bhavesh H. Patel, Claudia Percivalle, Maria Tsanakopoulou, John D. Sutherland
    Abstract:

    The main aim of origins of life research is to find a plausible sequence of transitions from prebiotic chemistry to nascent biology. In this context, understanding how and when phospholipid membranes appeared on early Earth is critical to elucidating the prebiotic pathways that led to the emergence of primitive cells. Here we show that exposing glycerol-2-phosphate to acylating agents leads to the formation of a library of Acylglycerol-phosphates. Medium-Chain Acylglycerol-phosphates were found to self-assemble into vesicles stable across a wide range of conditions and capable of retaining mono- and oligonucleotides. Starting with a mixture of activated carboxylic acids of different lengths, iterative cycling of acylation and hydrolysis steps allowed for the selection of longer-Chain Acylglycerol-phosphates. Our results suggest that a selection pathway based on energy-dissipative cycling could have driven the selective synthesis of phospholipids on early Earth.

  • Length-Selective Synthesis of Acylglycerol-Phosphates through Energy-Dissipative Cycling
    2019
    Co-Authors: Claudia Bonfio, Cécile Caumes, Colm D. Duffy, Bhavesh H. Patel, Claudia Percivalle, Maria Tsanakopoulou, John D. Sutherland
    Abstract:

    The main aim of origins of life research is to find a plausible sequence of transitions from prebiotic chemistry to nascent biology. In this context, understanding how and when phospholipid membranes appeared on early Earth is critical to elucidating the prebiotic pathways that led to the emergence of primitive cells. Here we show that exposing glycerol-2-phosphate to acylating agents leads to the formation of a library of Acylglycerol-phosphates. Medium-Chain Acylglycerol-phosphates were found to self-assemble into vesicles stable across a wide range of conditions and capable of retaining mono- and oligonucleotides. Starting with a mixture of activated carboxylic acids of different lengths, iterative cycling of acylation and hydrolysis steps allowed for the selection of longer-Chain Acylglycerol-phosphates. Our results suggest that a selection pathway based on energy-dissipative cycling could have driven the selective synthesis of phospholipids on early Earth

Colm D. Duffy - One of the best experts on this subject based on the ideXlab platform.

  • Length-Selective Synthesis of Acylglycerol-Phosphates through Energy-Dissipative Cycling
    Journal of the American Chemical Society, 2019
    Co-Authors: Claudia Bonfio, Cécile Caumes, Colm D. Duffy, Bhavesh H. Patel, Claudia Percivalle, Maria Tsanakopoulou, John D. Sutherland
    Abstract:

    The main aim of origins of life research is to find a plausible sequence of transitions from prebiotic chemistry to nascent biology. In this context, understanding how and when phospholipid membranes appeared on early Earth is critical to elucidating the prebiotic pathways that led to the emergence of primitive cells. Here we show that exposing glycerol-2-phosphate to acylating agents leads to the formation of a library of Acylglycerol-phosphates. Medium-Chain Acylglycerol-phosphates were found to self-assemble into vesicles stable across a wide range of conditions and capable of retaining mono- and oligonucleotides. Starting with a mixture of activated carboxylic acids of different lengths, iterative cycling of acylation and hydrolysis steps allowed for the selection of longer-Chain Acylglycerol-phosphates. Our results suggest that a selection pathway based on energy-dissipative cycling could have driven the selective synthesis of phospholipids on early Earth.

  • Length-Selective Synthesis of Acylglycerol-Phosphates through Energy-Dissipative Cycling
    2019
    Co-Authors: Claudia Bonfio, Cécile Caumes, Colm D. Duffy, Bhavesh H. Patel, Claudia Percivalle, Maria Tsanakopoulou, John D. Sutherland
    Abstract:

    The main aim of origins of life research is to find a plausible sequence of transitions from prebiotic chemistry to nascent biology. In this context, understanding how and when phospholipid membranes appeared on early Earth is critical to elucidating the prebiotic pathways that led to the emergence of primitive cells. Here we show that exposing glycerol-2-phosphate to acylating agents leads to the formation of a library of Acylglycerol-phosphates. Medium-Chain Acylglycerol-phosphates were found to self-assemble into vesicles stable across a wide range of conditions and capable of retaining mono- and oligonucleotides. Starting with a mixture of activated carboxylic acids of different lengths, iterative cycling of acylation and hydrolysis steps allowed for the selection of longer-Chain Acylglycerol-phosphates. Our results suggest that a selection pathway based on energy-dissipative cycling could have driven the selective synthesis of phospholipids on early Earth

Bhavesh H. Patel - One of the best experts on this subject based on the ideXlab platform.

  • Length-Selective Synthesis of Acylglycerol-Phosphates through Energy-Dissipative Cycling
    Journal of the American Chemical Society, 2019
    Co-Authors: Claudia Bonfio, Cécile Caumes, Colm D. Duffy, Bhavesh H. Patel, Claudia Percivalle, Maria Tsanakopoulou, John D. Sutherland
    Abstract:

    The main aim of origins of life research is to find a plausible sequence of transitions from prebiotic chemistry to nascent biology. In this context, understanding how and when phospholipid membranes appeared on early Earth is critical to elucidating the prebiotic pathways that led to the emergence of primitive cells. Here we show that exposing glycerol-2-phosphate to acylating agents leads to the formation of a library of Acylglycerol-phosphates. Medium-Chain Acylglycerol-phosphates were found to self-assemble into vesicles stable across a wide range of conditions and capable of retaining mono- and oligonucleotides. Starting with a mixture of activated carboxylic acids of different lengths, iterative cycling of acylation and hydrolysis steps allowed for the selection of longer-Chain Acylglycerol-phosphates. Our results suggest that a selection pathway based on energy-dissipative cycling could have driven the selective synthesis of phospholipids on early Earth.

  • Length-Selective Synthesis of Acylglycerol-Phosphates through Energy-Dissipative Cycling
    2019
    Co-Authors: Claudia Bonfio, Cécile Caumes, Colm D. Duffy, Bhavesh H. Patel, Claudia Percivalle, Maria Tsanakopoulou, John D. Sutherland
    Abstract:

    The main aim of origins of life research is to find a plausible sequence of transitions from prebiotic chemistry to nascent biology. In this context, understanding how and when phospholipid membranes appeared on early Earth is critical to elucidating the prebiotic pathways that led to the emergence of primitive cells. Here we show that exposing glycerol-2-phosphate to acylating agents leads to the formation of a library of Acylglycerol-phosphates. Medium-Chain Acylglycerol-phosphates were found to self-assemble into vesicles stable across a wide range of conditions and capable of retaining mono- and oligonucleotides. Starting with a mixture of activated carboxylic acids of different lengths, iterative cycling of acylation and hydrolysis steps allowed for the selection of longer-Chain Acylglycerol-phosphates. Our results suggest that a selection pathway based on energy-dissipative cycling could have driven the selective synthesis of phospholipids on early Earth