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Rajinder Kumar - One of the best experts on this subject based on the ideXlab platform.

  • Melanotic Medullary Carcinoma of thyroid – report of a rare case with brief review of literature
    Diagnostic Pathology, 2008
    Co-Authors: Kamaljeet Singh, Mehar C Sharma, Deepali Jain, Rajinder Kumar
    Abstract:

    Background Melanin production in Medullary Carcinoma is extremely uncommon. Case presentation We report a rare variant of Medullary Carcinoma of thyroid with melanin production in a 52-year-old woman who presented with swelling in the thyroid of 3 months duration. This tumor recurred thrice in two years after surgery and patient died with metastasis. Microscopic examination showed typical morphology of Medullary Carcinoma with numerous cells loaded with melanin pigment as confirmed by bleached Fontana-Masson, negative iron and immunohistochemical stains. Tumor cells were diffusely immunopositive for calcitonin, HMB-45, chromogranin, synaptophysin, CEA but showed focal paranuclear dot positivity for cytokeratin. No C-cell hyperplasia was seen in the adjacent thyroid gland. Nature of the pigment was further confirmed on ultra structural examination. Conclusion Melanotic Medullary Carcinoma is an extremely uncommon entity. There is a need to report more number of cases in the literature for exact categorization and prognostication of this subtype of Medullary Carcinoma.

  • Melanotic Medullary Carcinoma of thyroid – report of a rare case with brief review of literature
    Diagnostic pathology, 2008
    Co-Authors: Kamaljeet Singh, Mehar C Sharma, Deepali Jain, Rajinder Kumar
    Abstract:

    Melanin production in Medullary Carcinoma is extremely uncommon. We report a rare variant of Medullary Carcinoma of thyroid with melanin production in a 52-year-old woman who presented with swelling in the thyroid of 3 months duration. This tumor recurred thrice in two years after surgery and patient died with metastasis. Microscopic examination showed typical morphology of Medullary Carcinoma with numerous cells loaded with melanin pigment as confirmed by bleached Fontana-Masson, negative iron and immunohistochemical stains. Tumor cells were diffusely immunopositive for calcitonin, HMB-45, chromogranin, synaptophysin, CEA but showed focal paranuclear dot positivity for cytokeratin. No C-cell hyperplasia was seen in the adjacent thyroid gland. Nature of the pigment was further confirmed on ultra structural examination. Melanotic Medullary Carcinoma is an extremely uncommon entity. There is a need to report more number of cases in the literature for exact categorization and prognostication of this subtype of Medullary Carcinoma.

Kamaljeet Singh - One of the best experts on this subject based on the ideXlab platform.

  • Melanotic Medullary Carcinoma of thyroid – report of a rare case with brief review of literature
    Diagnostic Pathology, 2008
    Co-Authors: Kamaljeet Singh, Mehar C Sharma, Deepali Jain, Rajinder Kumar
    Abstract:

    Background Melanin production in Medullary Carcinoma is extremely uncommon. Case presentation We report a rare variant of Medullary Carcinoma of thyroid with melanin production in a 52-year-old woman who presented with swelling in the thyroid of 3 months duration. This tumor recurred thrice in two years after surgery and patient died with metastasis. Microscopic examination showed typical morphology of Medullary Carcinoma with numerous cells loaded with melanin pigment as confirmed by bleached Fontana-Masson, negative iron and immunohistochemical stains. Tumor cells were diffusely immunopositive for calcitonin, HMB-45, chromogranin, synaptophysin, CEA but showed focal paranuclear dot positivity for cytokeratin. No C-cell hyperplasia was seen in the adjacent thyroid gland. Nature of the pigment was further confirmed on ultra structural examination. Conclusion Melanotic Medullary Carcinoma is an extremely uncommon entity. There is a need to report more number of cases in the literature for exact categorization and prognostication of this subtype of Medullary Carcinoma.

  • Melanotic Medullary Carcinoma of thyroid – report of a rare case with brief review of literature
    Diagnostic pathology, 2008
    Co-Authors: Kamaljeet Singh, Mehar C Sharma, Deepali Jain, Rajinder Kumar
    Abstract:

    Melanin production in Medullary Carcinoma is extremely uncommon. We report a rare variant of Medullary Carcinoma of thyroid with melanin production in a 52-year-old woman who presented with swelling in the thyroid of 3 months duration. This tumor recurred thrice in two years after surgery and patient died with metastasis. Microscopic examination showed typical morphology of Medullary Carcinoma with numerous cells loaded with melanin pigment as confirmed by bleached Fontana-Masson, negative iron and immunohistochemical stains. Tumor cells were diffusely immunopositive for calcitonin, HMB-45, chromogranin, synaptophysin, CEA but showed focal paranuclear dot positivity for cytokeratin. No C-cell hyperplasia was seen in the adjacent thyroid gland. Nature of the pigment was further confirmed on ultra structural examination. Melanotic Medullary Carcinoma is an extremely uncommon entity. There is a need to report more number of cases in the literature for exact categorization and prognostication of this subtype of Medullary Carcinoma.

Deepali Jain - One of the best experts on this subject based on the ideXlab platform.

  • Melanotic Medullary Carcinoma of thyroid – report of a rare case with brief review of literature
    Diagnostic Pathology, 2008
    Co-Authors: Kamaljeet Singh, Mehar C Sharma, Deepali Jain, Rajinder Kumar
    Abstract:

    Background Melanin production in Medullary Carcinoma is extremely uncommon. Case presentation We report a rare variant of Medullary Carcinoma of thyroid with melanin production in a 52-year-old woman who presented with swelling in the thyroid of 3 months duration. This tumor recurred thrice in two years after surgery and patient died with metastasis. Microscopic examination showed typical morphology of Medullary Carcinoma with numerous cells loaded with melanin pigment as confirmed by bleached Fontana-Masson, negative iron and immunohistochemical stains. Tumor cells were diffusely immunopositive for calcitonin, HMB-45, chromogranin, synaptophysin, CEA but showed focal paranuclear dot positivity for cytokeratin. No C-cell hyperplasia was seen in the adjacent thyroid gland. Nature of the pigment was further confirmed on ultra structural examination. Conclusion Melanotic Medullary Carcinoma is an extremely uncommon entity. There is a need to report more number of cases in the literature for exact categorization and prognostication of this subtype of Medullary Carcinoma.

  • Melanotic Medullary Carcinoma of thyroid – report of a rare case with brief review of literature
    Diagnostic pathology, 2008
    Co-Authors: Kamaljeet Singh, Mehar C Sharma, Deepali Jain, Rajinder Kumar
    Abstract:

    Melanin production in Medullary Carcinoma is extremely uncommon. We report a rare variant of Medullary Carcinoma of thyroid with melanin production in a 52-year-old woman who presented with swelling in the thyroid of 3 months duration. This tumor recurred thrice in two years after surgery and patient died with metastasis. Microscopic examination showed typical morphology of Medullary Carcinoma with numerous cells loaded with melanin pigment as confirmed by bleached Fontana-Masson, negative iron and immunohistochemical stains. Tumor cells were diffusely immunopositive for calcitonin, HMB-45, chromogranin, synaptophysin, CEA but showed focal paranuclear dot positivity for cytokeratin. No C-cell hyperplasia was seen in the adjacent thyroid gland. Nature of the pigment was further confirmed on ultra structural examination. Melanotic Medullary Carcinoma is an extremely uncommon entity. There is a need to report more number of cases in the literature for exact categorization and prognostication of this subtype of Medullary Carcinoma.

Mehar C Sharma - One of the best experts on this subject based on the ideXlab platform.

  • Melanotic Medullary Carcinoma of thyroid – report of a rare case with brief review of literature
    Diagnostic Pathology, 2008
    Co-Authors: Kamaljeet Singh, Mehar C Sharma, Deepali Jain, Rajinder Kumar
    Abstract:

    Background Melanin production in Medullary Carcinoma is extremely uncommon. Case presentation We report a rare variant of Medullary Carcinoma of thyroid with melanin production in a 52-year-old woman who presented with swelling in the thyroid of 3 months duration. This tumor recurred thrice in two years after surgery and patient died with metastasis. Microscopic examination showed typical morphology of Medullary Carcinoma with numerous cells loaded with melanin pigment as confirmed by bleached Fontana-Masson, negative iron and immunohistochemical stains. Tumor cells were diffusely immunopositive for calcitonin, HMB-45, chromogranin, synaptophysin, CEA but showed focal paranuclear dot positivity for cytokeratin. No C-cell hyperplasia was seen in the adjacent thyroid gland. Nature of the pigment was further confirmed on ultra structural examination. Conclusion Melanotic Medullary Carcinoma is an extremely uncommon entity. There is a need to report more number of cases in the literature for exact categorization and prognostication of this subtype of Medullary Carcinoma.

  • Melanotic Medullary Carcinoma of thyroid – report of a rare case with brief review of literature
    Diagnostic pathology, 2008
    Co-Authors: Kamaljeet Singh, Mehar C Sharma, Deepali Jain, Rajinder Kumar
    Abstract:

    Melanin production in Medullary Carcinoma is extremely uncommon. We report a rare variant of Medullary Carcinoma of thyroid with melanin production in a 52-year-old woman who presented with swelling in the thyroid of 3 months duration. This tumor recurred thrice in two years after surgery and patient died with metastasis. Microscopic examination showed typical morphology of Medullary Carcinoma with numerous cells loaded with melanin pigment as confirmed by bleached Fontana-Masson, negative iron and immunohistochemical stains. Tumor cells were diffusely immunopositive for calcitonin, HMB-45, chromogranin, synaptophysin, CEA but showed focal paranuclear dot positivity for cytokeratin. No C-cell hyperplasia was seen in the adjacent thyroid gland. Nature of the pigment was further confirmed on ultra structural examination. Melanotic Medullary Carcinoma is an extremely uncommon entity. There is a need to report more number of cases in the literature for exact categorization and prognostication of this subtype of Medullary Carcinoma.

Thomas G. Matkov - One of the best experts on this subject based on the ideXlab platform.

  • Renal Medullary Carcinoma in Patients with Sickle Cell Trait
    Urology, 1998
    Co-Authors: Christopher L. Coogan, Charles F. Mckiel, Malachi J. Flanagan, Thomas P. Bormes, Thomas G. Matkov
    Abstract:

    Renal Medullary Carcinoma has recently been described as an aggressive neoplasm affecting young African Americans with sickle cell disease or sickle cell trait. We report the presentation, treatment, and outcome in 3 patients with renal Medullary Carcinoma along with a description of the unsuccessful treatment attempts. A brief discussion and review of the literature is included.