The Experts below are selected from a list of 243 Experts worldwide ranked by ideXlab platform
Heesun J Rogers - One of the best experts on this subject based on the ideXlab platform.
-
severe Megaloblastic Anemia vitamin deficiency and other causes
Cleveland Clinic Journal of Medicine, 2020Co-Authors: Daniel S Socha, Sherwin I Desouza, Aron Flagg, Mikkael A Sekeres, Heesun J RogersAbstract:Megaloblastic Anemia causes macrocytic Anemia from ineffective red blood cell production and intramedullary hemolysis. The most common causes are folate (vitamin B9) deficiency and cobalamin (vitamin B12) deficiency. Megaloblastic Anemia can be diagnosed based on characteristic morphologic and laboratory findings. However, other benign and neoplastic diseases need to be considered, particularly in severe cases. Therapy involves treating the underlying cause—eg, with vitamin supplementation in cases of deficiency, or with discontinuation of a suspected medication.
Dan L Longo - One of the best experts on this subject based on the ideXlab platform.
-
drug induced Megaloblastic Anemia
The New England Journal of Medicine, 2015Co-Authors: Charles Hesdorffer, Dan L LongoAbstract:Many common drugs induce Megaloblastic Anemia by interfering with folate or vitamin B12 absorption, altering B12 metabolism, or blocking pathways in which these vitamins play a role. Supplements to overcome these effects or discontinuation of the drug may be necessary.
Charles Hesdorffer - One of the best experts on this subject based on the ideXlab platform.
-
drug induced Megaloblastic Anemia
The New England Journal of Medicine, 2015Co-Authors: Charles Hesdorffer, Dan L LongoAbstract:Many common drugs induce Megaloblastic Anemia by interfering with folate or vitamin B12 absorption, altering B12 metabolism, or blocking pathways in which these vitamins play a role. Supplements to overcome these effects or discontinuation of the drug may be necessary.
David T Yang - One of the best experts on this subject based on the ideXlab platform.
-
laboratory testing for cobalamin deficiency in Megaloblastic Anemia
American Journal of Hematology, 2013Co-Authors: Matthew J Oberley, David T YangAbstract:Cobalamin (vitamin B12) deficiency is a common cause of Megaloblastic Anemia in Western populations. Laboratory evaluation of Megaloblastic Anemia frequently includes the assessment of patient cobalamin and folate status. Current total serum cobalamin measurements are performed in the clinical laboratory with competitive binding luminescence assays, whose results may not always accurately reflect actual cobalamin stores. Surrogate markers of cobalamin deficiency such as methylmalonic acid and homocysteine have been utilized to improve diagnostic accuracy; however, the specificity of these tests by themselves is rather low. Measurement of the biologically active fraction of cobalamin, holotranscobalamin, has been proposed as a replacement for current total cobalamin assays. Although holotranscobalamin measurements appear to have slighter better sensitivity, the specificity of this assay remains to be determined. The relative merits and demerits of commonly available methods to assess cobalamin deficiency in patients with suspected Megaloblastic Anemia are discussed. Am. J. Hematol. 88:522–526, 2013. © 2013 Wiley Periodicals, Inc.
Mikkael A Sekeres - One of the best experts on this subject based on the ideXlab platform.
-
severe Megaloblastic Anemia vitamin deficiency and other causes
Cleveland Clinic Journal of Medicine, 2020Co-Authors: Daniel S Socha, Sherwin I Desouza, Aron Flagg, Mikkael A Sekeres, Heesun J RogersAbstract:Megaloblastic Anemia causes macrocytic Anemia from ineffective red blood cell production and intramedullary hemolysis. The most common causes are folate (vitamin B9) deficiency and cobalamin (vitamin B12) deficiency. Megaloblastic Anemia can be diagnosed based on characteristic morphologic and laboratory findings. However, other benign and neoplastic diseases need to be considered, particularly in severe cases. Therapy involves treating the underlying cause—eg, with vitamin supplementation in cases of deficiency, or with discontinuation of a suspected medication.