The Experts below are selected from a list of 1572 Experts worldwide ranked by ideXlab platform
Cynthia M Magro - One of the best experts on this subject based on the ideXlab platform.
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oral atypical cellular blue nevus an infiltrative Melanocytic Proliferation
Head and Neck Pathology, 2013Co-Authors: Brian S Shumway, Yeshwant B Rawal, Carl M Allen, John R Kalmar, Cynthia M MagroAbstract:The atypical cellular blue nevus is an extremely rare nevoMelanocytic lesion which lacks precise histologic characterization in the current literature. Given the potential for significant architectural and cytologic overlap with melanoma, further study, including molecular analysis, is needed. This is the first description of an atypical cellular blue nevus of the oral cavity.
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genital Melanocytic nevus arising in a background of lichen sclerosus in a 7 year old female the diagnostic pitfall with malignant melanoma a literature review
American Journal of Dermatopathology, 2012Co-Authors: Andre Pinto, Son H Mclaren, Dix P Poppas, Cynthia M MagroAbstract:Genital Melanocytic nevus represents a distinct form of Melanocytic Proliferation, which can exhibit significant atypia, both clinically and histologically. In a background of lichen sclerosus (LS), the histologic changes could be misconstrued as indicative of malignant melanoma. We present herein a case of the atypical genital nevus of childhood complicated by LS, and a review of the literature is performed. Tissue was available for routine light microscopy and immunohistochemical evaluation to assess the expression of soluble adenylyl cyclase. Fluorescent in situ hybridization studies were conducted to assess for abnormalities in Myb1, CCND1, RREB1 and CEP6. The specimen showed an atypical compound Melanocytic Proliferation arising in a background of LS. The lesion exhibited significant architectural atypia based on the high-density confluent nature of the junctional Melanocytic Proliferation with epidermal effacement, rare areas of pagetoid ascent, and the heavily pigmented epithelioid quality of the melanocytes. Fluorescent in situ hybridization studies were normal. The soluble adenylyl cyclase antibody preparation demonstrated a benign nevus-like pattern. The lesion was felt to represent an atypical genital Melanocytic nevus, which can resemble a partially regressed melanoma in a background of LS. It is very important for the pathologist to be aware of this entity to avoid misdiagnosis.
Mandeep S Sagoo - One of the best experts on this subject based on the ideXlab platform.
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bilateral diffuse uveal Melanocytic Proliferation bdump associated with b cell lymphoma report of a rare case
BMC Cancer, 2015Co-Authors: Maria Pefkianaki, Rupesh Agrawal, Parul Desai, Carlos Pavesio, Mandeep S SagooAbstract:Bilateral diffuse uveal Melanocytic Proliferation (BDUMP) is a paraneoplastic ocular syndrome occurring in patients with systemic, often occult but advanced carcinoma and is the hallmark of poor prognosis. Ocular signs precede manifestation of systemic carcinoma by 3–12 months, highlighting the need for appropriate index of suspicion and prompt evaluation. Treatment options for BDUMP are limited. Investigations are aimed at finding the occult primary malignancy, which can be challenging. Modalities for treatment of the ocular findings include corticosteroids, surgery, external beam radiotherapy, and treatment of the underlying malignant neoplasm. However, it is uncertain whether earlier intervention for the systemic malignancy will impact survival, as this paraneoplastic phenomenon is thought to occur in advanced malignancy. We report a unique rare atypical case with BDUMP causing visual loss in a 62-year-old female as the presenting sign of central nervous system (CNS) B-cell lymphoma. Multiple grey or grey brown subretinal lesions with pigment clumps were present in both eyes on fundoscopy and multimodal imaging demonstrated multiple discrete lesions at the level of retinal pigment epithelium. Neuroimaging revealed presence of brainstem and cerebellopontine lesions suggestive of CNS lymphoma, which was further confirmed on biopsy. In the current atypical case, prompt diagnosis and immediate referral was key, with detailed systemic evaluation by an internist and oncologist. The reported case is distinct for the reason that BDUMP occurred secondary to primary CNS lymphoma, a hitherto unreported association.
Martin C. Mihm - One of the best experts on this subject based on the ideXlab platform.
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Atypical Cellular Blue Nevus of the Foot: A Case Report.
Dermatopathology (Basel Switzerland), 2019Co-Authors: Caroline De Lorenzi, Martin C. Mihm, Sandrine Quenan, Yasmine Lucile Ibrahim, Guerkan KayaAbstract:Blue nevus is a congenital and acquired Melanocytic Proliferation that includes different histological types. The atypical cellular type has been rarely described and it classically has a benign course. However, because of its intermediate features between common blue nevus and malignant blue nevus, long-term clinical follow-up is required. Here we report the case of a 28-year-old woman who presented with an atypical cellular blue nevus on the right foot.
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pathology of Melanocytic skin tumors
2014Co-Authors: Claudio Clemente, Martin C. MihmAbstract:In this chapter a review of Melanocytic lesions from simple pigmented lesions with minimal Melanocytic Proliferation to malignant lesions is presented. The clinical and histological features of the lesions are emphasized. Where appropriate, the most recent findings are reported with regard to better understanding of the development and the diagnosis of these lesions. The emphasis of the chapter is to present as clearly as possible the histological diagnostic features of each lesion along with the most important differential diagnostic considerations. The chapter is divided into the following subdivisions: Melanocytic nevi, spindle and epithelioid cell nevi, dermal melanocytosis, dysplastic nevus, atypical Melanocytic tumors, and melanoma. Finally, there is a review of prognostication with emphasis on the latest recommendations of the American Joint Committee on Cancer, Melanoma subcommittee.
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Lentiginous melanoma: a histologic pattern of melanoma to be distinguished from lentiginous nevus
Modern Pathology, 2005Co-Authors: Roy King, Paul B Googe, Robert N Page, Martin C. MihmAbstract:Atypical lentiginous Melanocytic Proliferations in elderly patients continue to pose a diagnostic dilemma with lesions variably categorized as dysplastic nevus, atypical junctional nevus, melanoma in situ (early or evolving) and premalignant melanosis. We present pigmented lesions from 16 patients (seven male and nine female) and with the exception of one case, all were older than 50 years of age. The anatomical sites included trunk (7), head and neck (6) and upper extremity (3). The clinical diagnosis was variable and included lentigo maligna, atypical nevus, pigmented basal cell carcinoma, seborrheic keratosis and lentigo. The initial biopsies mimicked lentiginous nevus or dysplastic nevus and were characterized by a lentiginous Proliferation of melanocytes at the dermoepidermal junction both as single cells and as small nests with areas of confluent growth, extending to the edges of the biopsy. The retiform epidermis was maintained and pagetoid spread of melanocytes was not prominent in hematoxylin- and eosin- stained sections. Dermal fibrosis was variably present and the Melanocytic Proliferation demonstrated cytological atypia. The subsequent re-excisions demonstrated similar atypical Melanocytic Proliferation occurring over a broad area flanking the prior biopsy sites. The diagnosis of melanoma was more easily recognized in the complete excision specimens. Immunohistochemical stains for Mitf and Mart-1 highlighted the extent of the basalar Melanocytic Proliferation as well as foci of pagetoid spread by melanocytes. Familiarity with this pattern of early melanoma should facilitate proper classification of lentiginous Melanocytic Proliferations in biopsies from older adults.
Brian S Shumway - One of the best experts on this subject based on the ideXlab platform.
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oral atypical cellular blue nevus an infiltrative Melanocytic Proliferation
Head and Neck Pathology, 2013Co-Authors: Brian S Shumway, Yeshwant B Rawal, Carl M Allen, John R Kalmar, Cynthia M MagroAbstract:The atypical cellular blue nevus is an extremely rare nevoMelanocytic lesion which lacks precise histologic characterization in the current literature. Given the potential for significant architectural and cytologic overlap with melanoma, further study, including molecular analysis, is needed. This is the first description of an atypical cellular blue nevus of the oral cavity.
Rupesh Agrawal - One of the best experts on this subject based on the ideXlab platform.
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bilateral diffuse uveal Melanocytic Proliferation bdump
In: Gupta V and Nguyen QD and LeHoang P and Herbort CPH (eds.) The Uveitis Atlas. Springer: New Delhi India. (2019) (In press)., 2019Co-Authors: Rohan Bir Singh, Aniruddha Agarwal, Rupesh Agrawal, Kanika AggarwalAbstract:Bilateral diffuse uveal Melanocytic Proliferation (BDUMP) is a rare paraneoplastic syndrome characterized by multiple subretinal, round, red patches in the retinal pigment epithelium; hyperfluorescence on fluorescein angiography; multiple elevated pigmented and nonpigmented uveal Melanocytic tumors with diffuse uveal tract thickening; exudative retinal detachments; and rapid cataract development leading to progressive loss of vision. BDUMP is predictive of an occult or undiagnosed systemic malignancies and a marker for poor prognosis. The index chapter describes an illustrative case of BDUMP with multimodal imaging.
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bilateral diffuse uveal Melanocytic Proliferation bdump associated with b cell lymphoma report of a rare case
BMC Cancer, 2015Co-Authors: Maria Pefkianaki, Rupesh Agrawal, Parul Desai, Carlos Pavesio, Mandeep S SagooAbstract:Bilateral diffuse uveal Melanocytic Proliferation (BDUMP) is a paraneoplastic ocular syndrome occurring in patients with systemic, often occult but advanced carcinoma and is the hallmark of poor prognosis. Ocular signs precede manifestation of systemic carcinoma by 3–12 months, highlighting the need for appropriate index of suspicion and prompt evaluation. Treatment options for BDUMP are limited. Investigations are aimed at finding the occult primary malignancy, which can be challenging. Modalities for treatment of the ocular findings include corticosteroids, surgery, external beam radiotherapy, and treatment of the underlying malignant neoplasm. However, it is uncertain whether earlier intervention for the systemic malignancy will impact survival, as this paraneoplastic phenomenon is thought to occur in advanced malignancy. We report a unique rare atypical case with BDUMP causing visual loss in a 62-year-old female as the presenting sign of central nervous system (CNS) B-cell lymphoma. Multiple grey or grey brown subretinal lesions with pigment clumps were present in both eyes on fundoscopy and multimodal imaging demonstrated multiple discrete lesions at the level of retinal pigment epithelium. Neuroimaging revealed presence of brainstem and cerebellopontine lesions suggestive of CNS lymphoma, which was further confirmed on biopsy. In the current atypical case, prompt diagnosis and immediate referral was key, with detailed systemic evaluation by an internist and oncologist. The reported case is distinct for the reason that BDUMP occurred secondary to primary CNS lymphoma, a hitherto unreported association.