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Siti Surdijati - One of the best experts on this subject based on the ideXlab platform.
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Studi penggunaan omeprazole pada pasien sirosis hati dengan hematemesis Melena rawat inap di RSUD Kabupaten Sidoarjo
2017Co-Authors: I Made Wiranata, Didik Hasmono, Siti SurdijatiAbstract:Sirosis hati adalah proses stadium akhir kerusakan sel-sel hati yang kemudian menjadi jaringan fibrosis. Selanjutnya, terjadinya distorsi struktur hepar dan adanya peningkatan vaskularisasi ke hati sehingga terjadi varises atau pelebaran pembuluh darah di bagian gastrointestinal maupun esofagus. Pada pasien dengan varises esofagus akan berisiko terjadi perdarahan karena ruptur esofagus dan mengalami hematemesis (muntah darah) dan Melena (BAB hitam). Terapi yang digunakan untuk mengurangi perdarahan pada saluran cerna adalah obat tukak lambung seperti golongan H2Ras dan PPI. Penelitian dilakukan bertujuan untuk mengetahui pola penggunaan omeprazole pada pasien sirosis hati dengan hematemesis Melena di Instalasi Rawat Inap RSUD Kabupaten Sidoarjo. Metode penelitian yang digunakan adalah observasional retrospektif pada RMK pasien. Pengambilan sampel dilakukan secara consecutive sampling, periode 1 Juli 2015 sampai 31 Desember 2015. Hasil yang diperoleh dari penelitian tersebut adalah penggunaan omeprazole tunggal dengan dosis (2x40mg)i.v digunakan paling banyak oleh 22 pasien (73,3%). Penggunaan omeprazole dengan dosis (2x40mg)i.v dikombinasi dengan obat tukak lambung lain sebanyak 7 pasien (23,3%), yaitu pada omeprazole dengan ranitidin sebanyak 6 pasien, omeprazole dengan antasida (p.o) sebanyak 1 pasien. Penggunaan omeprazole dengan dosis 2x40mg diganti dengan ranitidin 2x25mg/ml sebanyak 1 pasien (3,3%). Penggunaan omeprazole yang diberikan pada pasien sirosis hati dengan hematemesis Melena di Instalasi Rawat Inap RSUD Kabupaten Sidoarjo, terkait dosis, rute, frekuensi, interval, dan lama pemberian sudah sesuai dengan guidelines yang ada dalam Formularium Nasional.
Jae Young Kim - One of the best experts on this subject based on the ideXlab platform.
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Availability of blood urea nitrogen/creatinine ratio in gastrointestinal bleeding with Melena in children.
Pediatric Gastroenterology Hepatology & Nutrition, 2015Co-Authors: Kyu Seon Kim, Chan Ho Kang, Jae Young KimAbstract:Purpose The aims of our study were to evaluate the blood urea nitrogen to creatinine ratio (BUN/Cr ratio) for distinguishing between an upper and lower gastrointestinal bleeding (GIB), and differentiating between the two most common causes of upper gastrointestinal bleeding (UGIB) presenting with Melena in children. Methods Retrospective data of patients with GIB presenting with Melena were analyzed. The data from 60 cases were reviewed including demographics, laboratory findings, diagnostic modalities and results, treatments, and transfusions. Results Among the 60 cases, UGIB and lower gastrointestinal bleeding (LGIB) were found in 35 cases (58.3%) and 14 cases (23.3%), respectively. The two common causes of UGIB were varices (37.1%), and peptic ulcer diseases (PUD) (31.4%). The BUN/Cr ratio of 30 or greater was higher in UGIB than LGIB (odds ratio [OR], 6.9; 95% confidence interval [95% CI], 1.3-37.2). In UGIB, the BUN/Cr ratio of the varices group was higher than that of the PUD group (p=0.015). The OR for the BUN/Cr ratio appeared as 1.2 per unit increase in the varices group than the PUD group (95% CI, 1.03-1.3). There was no difference between the PUD group and Meckel's diverticulum group. Conclusion The BUN/Cr ratio was not uneven in differentiating UGIB from LGIB of children with Melena in our study. This suggests that BUN/Cr ratio should be interpreted carefully.
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availability of blood urea nitrogen creatinine ratio in gastrointestinal bleeding with Melena in children
Pediatric Gastroenterology Hepatology & Nutrition, 2015Co-Authors: Kyu Seon Kim, Chan Ho Kang, Jae Young KimAbstract:Purpose The aims of our study were to evaluate the blood urea nitrogen to creatinine ratio (BUN/Cr ratio) for distinguishing between an upper and lower gastrointestinal bleeding (GIB), and differentiating between the two most common causes of upper gastrointestinal bleeding (UGIB) presenting with Melena in children. Methods Retrospective data of patients with GIB presenting with Melena were analyzed. The data from 60 cases were reviewed including demographics, laboratory findings, diagnostic modalities and results, treatments, and transfusions. Results Among the 60 cases, UGIB and lower gastrointestinal bleeding (LGIB) were found in 35 cases (58.3%) and 14 cases (23.3%), respectively. The two common causes of UGIB were varices (37.1%), and peptic ulcer diseases (PUD) (31.4%). The BUN/Cr ratio of 30 or greater was higher in UGIB than LGIB (odds ratio [OR], 6.9; 95% confidence interval [95% CI], 1.3-37.2). In UGIB, the BUN/Cr ratio of the varices group was higher than that of the PUD group (p=0.015). The OR for the BUN/Cr ratio appeared as 1.2 per unit increase in the varices group than the PUD group (95% CI, 1.03-1.3). There was no difference between the PUD group and Meckel's diverticulum group. Conclusion The BUN/Cr ratio was not uneven in differentiating UGIB from LGIB of children with Melena in our study. This suggests that BUN/Cr ratio should be interpreted carefully.
I Made Wiranata - One of the best experts on this subject based on the ideXlab platform.
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Studi penggunaan omeprazole pada pasien sirosis hati dengan hematemesis Melena rawat inap di RSUD Kabupaten Sidoarjo
2017Co-Authors: I Made Wiranata, Didik Hasmono, Siti SurdijatiAbstract:Sirosis hati adalah proses stadium akhir kerusakan sel-sel hati yang kemudian menjadi jaringan fibrosis. Selanjutnya, terjadinya distorsi struktur hepar dan adanya peningkatan vaskularisasi ke hati sehingga terjadi varises atau pelebaran pembuluh darah di bagian gastrointestinal maupun esofagus. Pada pasien dengan varises esofagus akan berisiko terjadi perdarahan karena ruptur esofagus dan mengalami hematemesis (muntah darah) dan Melena (BAB hitam). Terapi yang digunakan untuk mengurangi perdarahan pada saluran cerna adalah obat tukak lambung seperti golongan H2Ras dan PPI. Penelitian dilakukan bertujuan untuk mengetahui pola penggunaan omeprazole pada pasien sirosis hati dengan hematemesis Melena di Instalasi Rawat Inap RSUD Kabupaten Sidoarjo. Metode penelitian yang digunakan adalah observasional retrospektif pada RMK pasien. Pengambilan sampel dilakukan secara consecutive sampling, periode 1 Juli 2015 sampai 31 Desember 2015. Hasil yang diperoleh dari penelitian tersebut adalah penggunaan omeprazole tunggal dengan dosis (2x40mg)i.v digunakan paling banyak oleh 22 pasien (73,3%). Penggunaan omeprazole dengan dosis (2x40mg)i.v dikombinasi dengan obat tukak lambung lain sebanyak 7 pasien (23,3%), yaitu pada omeprazole dengan ranitidin sebanyak 6 pasien, omeprazole dengan antasida (p.o) sebanyak 1 pasien. Penggunaan omeprazole dengan dosis 2x40mg diganti dengan ranitidin 2x25mg/ml sebanyak 1 pasien (3,3%). Penggunaan omeprazole yang diberikan pada pasien sirosis hati dengan hematemesis Melena di Instalasi Rawat Inap RSUD Kabupaten Sidoarjo, terkait dosis, rute, frekuensi, interval, dan lama pemberian sudah sesuai dengan guidelines yang ada dalam Formularium Nasional.
Surdijati Siti - One of the best experts on this subject based on the ideXlab platform.
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Studi Penggunaan Omeprazole pada Pasien Sirosis Hati dengan Hemetamesis Melena Rawat Inap di RSUD Kabupaten Sidoarjo
'Universitas Katolik Widya Mandala Surabaya', 2019Co-Authors: Wiranata I Made, Hasmono Didik, Surdijati SitiAbstract:Liver cirrhosis is a process of liver cell damage which later becomes fibrosis tissue. Then, the occurrence of liver structural distortion and increased vascularization to the liver resulting in varicose veins or dilation of blood vessels in the gastrointestinal and esophageal areas. Patients with esophageal varices, there is a risk of bleeding from esophageal rupture, the undergone hematemesis (vomiting of blood) and Melena (blackish defecate). The therapies used to reduce gastrointestinal bleeding are gastric ulcers drugs such as H2Ras and PPI. The study aimed to determine the pattern of omeprazole use in liver cirrhosis patients with hematemesis Melena. The method used was an observational retrospective study in medic record data patients. Sampling was done by consecutive sampling, the period of Juli 1, 2015 until Descember 31, 2015. The results obtained from the study were single use of omeprazole with a dose of 2x40mg/i.v used the most by 22 patients (73.3%). The use of omeprazole with a dose of 2x40mg/i.v combined with other gastric ulcer drugs was 7 patients (23.3%), omeprazole with ranitidin 6 patients, omeprazole with antacid for 1 patient. The use of omeprazole with a dose of 2x40mg was replaced with ranitidin 2x25mg/ml was 1 patient (3.3%). The use of omeprazole given in liver cirrhosis patients with hematemesis Melena at the Inpatient Installation of Regional Hospital of Sidoarjo, related dose, route, frequency, interval, and duration of giving was in appropriate with the guidelines contained in the National Formulary
Kyu Seon Kim - One of the best experts on this subject based on the ideXlab platform.
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Availability of blood urea nitrogen/creatinine ratio in gastrointestinal bleeding with Melena in children.
Pediatric Gastroenterology Hepatology & Nutrition, 2015Co-Authors: Kyu Seon Kim, Chan Ho Kang, Jae Young KimAbstract:Purpose The aims of our study were to evaluate the blood urea nitrogen to creatinine ratio (BUN/Cr ratio) for distinguishing between an upper and lower gastrointestinal bleeding (GIB), and differentiating between the two most common causes of upper gastrointestinal bleeding (UGIB) presenting with Melena in children. Methods Retrospective data of patients with GIB presenting with Melena were analyzed. The data from 60 cases were reviewed including demographics, laboratory findings, diagnostic modalities and results, treatments, and transfusions. Results Among the 60 cases, UGIB and lower gastrointestinal bleeding (LGIB) were found in 35 cases (58.3%) and 14 cases (23.3%), respectively. The two common causes of UGIB were varices (37.1%), and peptic ulcer diseases (PUD) (31.4%). The BUN/Cr ratio of 30 or greater was higher in UGIB than LGIB (odds ratio [OR], 6.9; 95% confidence interval [95% CI], 1.3-37.2). In UGIB, the BUN/Cr ratio of the varices group was higher than that of the PUD group (p=0.015). The OR for the BUN/Cr ratio appeared as 1.2 per unit increase in the varices group than the PUD group (95% CI, 1.03-1.3). There was no difference between the PUD group and Meckel's diverticulum group. Conclusion The BUN/Cr ratio was not uneven in differentiating UGIB from LGIB of children with Melena in our study. This suggests that BUN/Cr ratio should be interpreted carefully.
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availability of blood urea nitrogen creatinine ratio in gastrointestinal bleeding with Melena in children
Pediatric Gastroenterology Hepatology & Nutrition, 2015Co-Authors: Kyu Seon Kim, Chan Ho Kang, Jae Young KimAbstract:Purpose The aims of our study were to evaluate the blood urea nitrogen to creatinine ratio (BUN/Cr ratio) for distinguishing between an upper and lower gastrointestinal bleeding (GIB), and differentiating between the two most common causes of upper gastrointestinal bleeding (UGIB) presenting with Melena in children. Methods Retrospective data of patients with GIB presenting with Melena were analyzed. The data from 60 cases were reviewed including demographics, laboratory findings, diagnostic modalities and results, treatments, and transfusions. Results Among the 60 cases, UGIB and lower gastrointestinal bleeding (LGIB) were found in 35 cases (58.3%) and 14 cases (23.3%), respectively. The two common causes of UGIB were varices (37.1%), and peptic ulcer diseases (PUD) (31.4%). The BUN/Cr ratio of 30 or greater was higher in UGIB than LGIB (odds ratio [OR], 6.9; 95% confidence interval [95% CI], 1.3-37.2). In UGIB, the BUN/Cr ratio of the varices group was higher than that of the PUD group (p=0.015). The OR for the BUN/Cr ratio appeared as 1.2 per unit increase in the varices group than the PUD group (95% CI, 1.03-1.3). There was no difference between the PUD group and Meckel's diverticulum group. Conclusion The BUN/Cr ratio was not uneven in differentiating UGIB from LGIB of children with Melena in our study. This suggests that BUN/Cr ratio should be interpreted carefully.