The Experts below are selected from a list of 111954 Experts worldwide ranked by ideXlab platform

Anthony Savidis - One of the best experts on this subject based on the ideXlab platform.

  • dynamic imperative languages for runtime extensible semantics and polymorphic meta programming
    Lecture Notes in Computer Science, 2006
    Co-Authors: Anthony Savidis
    Abstract:

    Dynamically typed languages imply runtime resolution for type matching, setting-up an effectible ground for type-polymorphic Functions. In statically typed object-oriented languages, operator overloading signifies the capability to statically extend the language semantics in the target program context. We show how the same can be accomplished dynamically in the Delta dynamic language, through simple Member-Function naming contracts. Additionally, we provide a software-pattem for dynamically extensible Function semantics, something that cannot be accommodated with static Function overloading. We demonstrate how meta-programming, i.e. crafting of parametric program capsules solving generic problems known as meta-algorithms or meta-components, become truly polymorphic, i.e. can accept an open set of parameter values, as far as those dynamically bind to eligible elements compliant to the meta-program design contract. In Delta, inheritance is dynamically supported as a runtime Function, without any compile-time semantics, while all Member Function calls are resolved through late binding. We employ those features to show how Delta supports the imperative programming of polymorphic higher-order Functions, such as generic Function composers or the map Function.

James G Patton - One of the best experts on this subject based on the ideXlab platform.

  • mir 8 micrornas regulate the response to osmotic stress in zebrafish embryos
    Journal of Cell Biology, 2009
    Co-Authors: Alex S Flynt, Elizabeth J Thatcher, Kristopher Burkewitz, Nan Li, James G Patton
    Abstract:

    MicroRNAs (miRNAs) are highly conserved small RNAs that act as translational regulators of gene expression, exerting their influence by selectively targeting mRNAs bearing complementary sequence elements. These RNAs Function in diverse aspects of animal development and physiology. Because of an ability to act as rapid responders at the level of translation, miRNAs may also influence stress response. In this study, we show that the miR-8 family of miRNAs regulates osmoregulation in zebrafish embryos. Ionocytes, which are a specialized cell type scattered throughout the epidermis, are responsible for pH and ion homeostasis during early development before gill formation. The highly conserved miR-8 family is expressed in ionocytes and enables precise control of ion transport by modulating the expression of Nherf1, which is a regulator of apical trafficking of transmembrane ion transporters. Ultimately, disruption of miR-8 family Member Function leads to an inability to respond to osmotic stress and blocks the ability to properly traffic and/or cluster transmembrane glycoproteins at the apical surface of ionocytes.

Maurizio Memo - One of the best experts on this subject based on the ideXlab platform.

  • activation of cell cycle associated proteins in neuronal death a mandatory or dispensable path
    Trends in Neurosciences, 2001
    Co-Authors: Agata Copani, Maria Angela Sortino, Ferdinando Nicoletti, Valeria Bruno, Daniela Ubertia, Maurizio Memo
    Abstract:

    In conclusion, in vitro data suggest that cell-cycle activation in neurons becomes an obligatory component of the cell death pathway when combined with other mechanisms that are not sufficient to reach the threshold for cell death. According to this hypothesis, the re-expression of cell-cycle proteins observed in pathological brains is not interpreted as an epiphenomenon, but rather as an essential component of the death program. This hypothesis must be validated by solid in vivo data, which is currently lacking. Some evidence is provided by the observation that neuronal apoptosis follows abnormally-induced DNA synthesis in RB-null mice 63xLoss of Rb activates both p53-dependent and independent cell death pathways in the developing mouse nervous system. Macleod, K.F. et al. EMBO J. 1996; 15: 6178–6188PubMedSee all References63 or in transgenic mice overexpressing the RB-binding protein SV40 T antigen 64xIn vivo viability of postmitotic Purkinje neurons requires pRb family Member Function. Feddersen, R.M. et al. Mol. Cell Neurosci. 1995; 6: 153–167Crossref | PubMed | Scopus (58)See all References64. If the model shown in Fig. 4Fig. 4 is proven to be correct, it is expected that neurons that are slowly degenerating at the periphery of an ischemic focus in response to low concentrations of environmental toxins or in chronic diseases, will be rescued by cytostatic drugs that do not cause DNA damage, such as CDK inhibitors. These drugs would not prevent ‘healthy’ apoptosis of cells carrying extensive DNA damage (as opposed to caspase inhibitors) but, similar to classical anti-tumor agents, will still cause adverse effects (e.g. depression of the bone marrow or reduced turnover of the enteric mucosa) unless specifically targeted to the CNS.

Alex S Flynt - One of the best experts on this subject based on the ideXlab platform.

  • mir 8 micrornas regulate the response to osmotic stress in zebrafish embryos
    Journal of Cell Biology, 2009
    Co-Authors: Alex S Flynt, Elizabeth J Thatcher, Kristopher Burkewitz, Nan Li, James G Patton
    Abstract:

    MicroRNAs (miRNAs) are highly conserved small RNAs that act as translational regulators of gene expression, exerting their influence by selectively targeting mRNAs bearing complementary sequence elements. These RNAs Function in diverse aspects of animal development and physiology. Because of an ability to act as rapid responders at the level of translation, miRNAs may also influence stress response. In this study, we show that the miR-8 family of miRNAs regulates osmoregulation in zebrafish embryos. Ionocytes, which are a specialized cell type scattered throughout the epidermis, are responsible for pH and ion homeostasis during early development before gill formation. The highly conserved miR-8 family is expressed in ionocytes and enables precise control of ion transport by modulating the expression of Nherf1, which is a regulator of apical trafficking of transmembrane ion transporters. Ultimately, disruption of miR-8 family Member Function leads to an inability to respond to osmotic stress and blocks the ability to properly traffic and/or cluster transmembrane glycoproteins at the apical surface of ionocytes.

Agata Copani - One of the best experts on this subject based on the ideXlab platform.

  • activation of cell cycle associated proteins in neuronal death a mandatory or dispensable path
    Trends in Neurosciences, 2001
    Co-Authors: Agata Copani, Maria Angela Sortino, Ferdinando Nicoletti, Valeria Bruno, Daniela Ubertia, Maurizio Memo
    Abstract:

    In conclusion, in vitro data suggest that cell-cycle activation in neurons becomes an obligatory component of the cell death pathway when combined with other mechanisms that are not sufficient to reach the threshold for cell death. According to this hypothesis, the re-expression of cell-cycle proteins observed in pathological brains is not interpreted as an epiphenomenon, but rather as an essential component of the death program. This hypothesis must be validated by solid in vivo data, which is currently lacking. Some evidence is provided by the observation that neuronal apoptosis follows abnormally-induced DNA synthesis in RB-null mice 63xLoss of Rb activates both p53-dependent and independent cell death pathways in the developing mouse nervous system. Macleod, K.F. et al. EMBO J. 1996; 15: 6178–6188PubMedSee all References63 or in transgenic mice overexpressing the RB-binding protein SV40 T antigen 64xIn vivo viability of postmitotic Purkinje neurons requires pRb family Member Function. Feddersen, R.M. et al. Mol. Cell Neurosci. 1995; 6: 153–167Crossref | PubMed | Scopus (58)See all References64. If the model shown in Fig. 4Fig. 4 is proven to be correct, it is expected that neurons that are slowly degenerating at the periphery of an ischemic focus in response to low concentrations of environmental toxins or in chronic diseases, will be rescued by cytostatic drugs that do not cause DNA damage, such as CDK inhibitors. These drugs would not prevent ‘healthy’ apoptosis of cells carrying extensive DNA damage (as opposed to caspase inhibitors) but, similar to classical anti-tumor agents, will still cause adverse effects (e.g. depression of the bone marrow or reduced turnover of the enteric mucosa) unless specifically targeted to the CNS.