The Experts below are selected from a list of 288 Experts worldwide ranked by ideXlab platform

Sarah D. Breedin - One of the best experts on this subject based on the ideXlab platform.

Randi C. Martin - One of the best experts on this subject based on the ideXlab platform.

Ulya R. Karpuzcu - One of the best experts on this subject based on the ideXlab platform.

  • Spintronic In-Memory Pattern Matching
    IEEE Journal on Exploratory Solid-State Computational Devices and Circuits, 2019
    Co-Authors: Zamshed I. Chowdhury, S. Karen Khatamifard, Zhengyang Zhao, Masoud Zabihi, Salonik Resch, Meisam Razaviyayn, Jian-ping Wang, Sachin S. Sapatnekar, Ulya R. Karpuzcu
    Abstract:

    Traditional Von Neumann computing is falling apart in the era of exploding data volumes as the overhead of data transfer becomes forbidding. Instead, it is more energy-efficient to fuse compute capability with Memory where the data reside. This is particularly critical to Pattern matching, a key computational step in large-scale data analytics, which involves repetitive search over very large databases residing in Memory. Emerging spintronic technologies show remarkable versatility for the tight integration of logic and Memory. In this article, we introduce SpinPM, a novel high-density, reconfigurable spintronic in-Memory Pattern matching spin–orbit torque (SOT)—specifically spin Hall effect (SHE)—substrate, and demonstrate the performance benefit SpinPM can achieve over conventional and near-Memory processing systems.

Jill L Silverman - One of the best experts on this subject based on the ideXlab platform.

  • cyclin d2 knock out mice with attenuated dentate gyrus neurogenesis have robust deficits in long term Memory formation
    Scientific Reports, 2020
    Co-Authors: Stela P Petkova, Michael C Pride, Carolyn Klocke, Timothy A Fenton, Jeannine White, Pamela J Lein, Jacob Ellegood, Jason P Lerch, Jill L Silverman
    Abstract:

    Neurobehavioral studies have produced contradictory findings concerning the function of neurogenesis in the adult dentate gyrus. Previous studies have proved inconsistent across several behavioral endpoints thought to be dependent on dentate neurogenesis, including Memory acquisition, short-term and long-term retention of Memory, Pattern separation, and reversal learning. We hypothesized that the main function of dentate neurogenesis is long-term Memory formation because we assumed that a newly formed and integrated neuron would have a long-term impact on the local neural network. We used a cyclin D2-knock-out (cyclin D2-/-) mouse model of endogenously deficient dentate neurogenesis to test this hypothesis. We found that cyclin D2-/- mice had robust and sustained loss of long-term Memory in two separate behavioral tasks, Morris water maze (MWM) and touchscreen intermediate Pattern separation. Moreover, after adjusting for differences in brain volumes determined by magnetic resonance (MR) imaging, reduced dentate neurogenesis moderately correlated with deficits in Memory retention after 24 hours. Importantly, cyclin D2-/- mice did not show deficits in learning acquisition in a touchscreen paradigm of intermediate Pattern separation or MWM platform location, indicating intact short-term Memory. Further evaluation of cyclin D2-/- mice is necessary to confirm that deficits are specifically linked to dentate gyrus neurogenesis since cyclin D2-/- mice also have a reduced size of the olfactory bulb, hippocampus, cerebellum and cortex besides reduced dentate gyrus neurogenesis.

Pamela J Lein - One of the best experts on this subject based on the ideXlab platform.

  • cyclin d2 knock out mice with attenuated dentate gyrus neurogenesis have robust deficits in long term Memory formation
    Scientific Reports, 2020
    Co-Authors: Stela P Petkova, Michael C Pride, Carolyn Klocke, Timothy A Fenton, Jeannine White, Pamela J Lein, Jacob Ellegood, Jason P Lerch, Jill L Silverman
    Abstract:

    Neurobehavioral studies have produced contradictory findings concerning the function of neurogenesis in the adult dentate gyrus. Previous studies have proved inconsistent across several behavioral endpoints thought to be dependent on dentate neurogenesis, including Memory acquisition, short-term and long-term retention of Memory, Pattern separation, and reversal learning. We hypothesized that the main function of dentate neurogenesis is long-term Memory formation because we assumed that a newly formed and integrated neuron would have a long-term impact on the local neural network. We used a cyclin D2-knock-out (cyclin D2-/-) mouse model of endogenously deficient dentate neurogenesis to test this hypothesis. We found that cyclin D2-/- mice had robust and sustained loss of long-term Memory in two separate behavioral tasks, Morris water maze (MWM) and touchscreen intermediate Pattern separation. Moreover, after adjusting for differences in brain volumes determined by magnetic resonance (MR) imaging, reduced dentate neurogenesis moderately correlated with deficits in Memory retention after 24 hours. Importantly, cyclin D2-/- mice did not show deficits in learning acquisition in a touchscreen paradigm of intermediate Pattern separation or MWM platform location, indicating intact short-term Memory. Further evaluation of cyclin D2-/- mice is necessary to confirm that deficits are specifically linked to dentate gyrus neurogenesis since cyclin D2-/- mice also have a reduced size of the olfactory bulb, hippocampus, cerebellum and cortex besides reduced dentate gyrus neurogenesis.