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Alison Venn - One of the best experts on this subject based on the ideXlab platform.
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Associations of childhood adiposity with Menstrual Irregularity and polycystic ovary syndrome in adulthood: the Childhood Determinants of Adult Health Study and the Bogalusa Heart Study.
Human Reproduction, 2020Co-Authors: Jing Tian, Terence Dwyer, Wh Oddy, Ew Harville, Leigh Blizzard, Lydia A. Bazzano, Martha Hickey, Alison VennAbstract:STUDY QUESTION Is high adiposity in childhood associated with Menstrual Irregularity and polycystic ovary syndrome (PCOS) in later life? SUMMARY ANSWER Overall, greater childhood BMI was associated with Menstrual Irregularity, and greater childhood BMI and waist/height ratio (WHtR) in white but not black participants were associated with PCOS in adulthood. WHAT IS KNOWN ALREADY Increased childhood BMI has been associated with irregular Menstrual cycles and PCOS symptoms in adulthood in two longitudinal population-based studies, but no study has reported on associations with childhood abdominal obesity. Few studies have investigated whether there are racial differences in the associations of adiposity with PCOS though there has been some suggestion that associations with high BMI may be stronger in white girls than in black girls. STUDY DESIGN, SIZE, DURATION The study included 1516 participants (aged 26-41 years) from the Australian Childhood Determinants of Adult Health study (CDAH) and 1247 participants (aged 26-57 years) from the biracial USA Babies substudy of the Bogalusa Heart Study (BBS) who were aged 7-15 years at baseline. At follow-up, questions were asked about menstruation (current for CDAH or before age 40 years for BBS), ever having had a diagnosis of PCOS and symptoms of PCOS. PARTICIPANTS/MATERIALS, SETTING, METHODS In CDAH, a single childhood visit was conducted in 1985. In BBS, multiple childhood visits occurred from 1973 to 2000 and race was reported (59% white; 41% black). In childhood, overweight and obesity were defined by international age-sex-specific standards for BMI and WHtR was considered as an indicator of abdominal obesity. Multilevel mixed-effects Poisson regression estimated relative risks (RRs) adjusting for childhood age, highest parental and own education and age at menarche. MAIN RESULTS AND THE ROLE OF CHANCE The prevalence of childhood obesity was 1.1% in CDAH and 7.5% in BBS. At follow-up, Menstrual Irregularity was reported by 16.7% of CDAH and 24.5% of BBS participants. The prevalence of PCOS was 7.4% in CDAH and 8.0% in BBS participants. In CDAH, childhood obesity was associated with Menstrual Irregularity (RR = 2.84, 95% CI: 1.63-4.96) and PCOS (RR = 4.05, 95% CI: 1.10-14.83) in adulthood. With each 0.01 unit increase in childhood WHtR there was a 6% (95% CI: 1-11%) greater likelihood of PCOS. Overall, in BBS, childhood obesity was associated with increased risk of Menstrual Irregularity (RR = 1.44, 95% CI: 1.08-1.92) in adulthood. Significant interaction effects between race and childhood adiposity were detected in associations with PCOS. In BBS white participants, childhood obesity was associated with PCOS (RR = 2.93, 95% CI: 1.65-5.22) and a 0.01 unit increase in childhood WHtR was associated with an 11% (95% CI: 5-17%) greater likelihood of PCOS in adulthood. In BBS black participants, no statistically significant associations of childhood adiposity measures with PCOS were observed. LIMITATIONS, REASONS FOR CAUTION The classification of Menstrual Irregularity and PCOS was based on self-report by questionnaire, which may have led to misclassification of these outcomes. However, despite the limitations of the study, the prevalence of Menstrual Irregularity and PCOS in the two cohorts was consistent with the literature. While the study samples at baseline were population-based, loss to follow-up means the generalizability of the findings is uncertain. WIDER IMPLICATIONS OF THE FINDINGS Greater childhood adiposity indicates a higher risk of Menstrual Irregularity and PCOS in adulthood. Whether this is causal or an early indicator of underlying hormonal or metabolic disorders needs clarification. The stronger associations of adiposity with PCOS in white than black participants suggest that there are racial differences in childhood adiposity predisposing to the development of PCOS and other environmental or genetic factors are also important. STUDY FUNDING/COMPETING INTEREST(S) The CDAH study was supported by grants from the Australian National Health and Medical Research Council (grants 211316, 544923 and 1128373). The Bogalusa Heart Study is supported by US National Institutes of Health grants R01HD069587, AG16592, HL121230, HD032194 and P50HL015103. No competing interests existed.
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6 authors, including:
2016Co-Authors: Graeme Jones, Shuying Wei, Russell Thomson, Petr Otahal, Terry Dwyer, See Profile, Alison VennAbstract:Menstrual Irregularity and bone mass in premenopausal women: Cross-sectional associations with testosterone and SHB
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Menstrual Irregularity and bone mass in premenopausal women: Cross-sectional associations with testosterone and SHBG
BMC Musculoskeletal Disorders, 2010Co-Authors: Shuying Wei, Graeme Jones, Russell Thomson, Petr Otahal, Terry Dwyer, Alison VennAbstract:Background There have been few studies examining the associations between Menstrual Irregularity, androgens and bone mass in population-based samples of premenopausal women. This study aimed to describe the associations between Menstrual pattern, testosterone, sex hormone binding globulin (SHBG) and bone mass in a population-based sample of premenopausal women.
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Menstrual Irregularity is associated with higher bone mass in young women which is mediated through alterations in endogenous androgens
Bone, 2009Co-Authors: W. Shuying, Alison Venn, Russell James Thomson, P. Olahal, Terence Dwyer, Graeme JonesAbstract:Background: There have been few studies examining the association between Menstrual Irregularity, androgens and bone mineral density in premenopausal women. Objective: To describe the association between Menstrual Irregularity, androgens and bone mass measured by quantitative ultrasound (QUS) in premenopausal women who were not taking hormonal contraceptives. Methods: Australia wide cross-sectional study (N=382, mean age 31 years). Menstrual Irregularity was assessed based on selfadministered questionnaire. Bone mass was measured by Hologic Sahara densitometer. Total testosterone and SHBG were assessed by fasting blood sample and free androgen index was derived. Results: Women with irregular cycles (n=41, 11%) had higher SOS and QUI (median difference 6 m/s and 7.2% respectively, p
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Menstrual Irregularity is associated with higher bone mass in young women which is mediated through alterations in endogenous androgens
Bone, 2009Co-Authors: W. Shuying, Alison Venn, P. Olahal, Terence Dwyer, R Thomson, Graeme JonesAbstract:Background: There have been few studies examining the association between Menstrual Irregularity, androgens and bone mineral density in premenopausal women. Objective: To describe the association between Menstrual Irregularity, androgens and bone mass measured by quantitative ultrasound (QUS) in premenopausal women who were not taking hormonal contraceptives. Methods: Australia wide cross-sectional study (N=382, mean age 31 years). Menstrual Irregularity was assessed based on selfadministered questionnaire. Bone mass was measured by Hologic Sahara densitometer. Total testosterone and SHBG were assessed by fasting blood sample and free androgen index was derived. Results: Women with irregular cycles (n=41, 11%) had higher SOS and QUI (median difference 6 m/s and 7.2% respectively, p<0.05) and a trend to higher BUA (5.1 dB/MHz, p=0.10). These associations persisted after adjustment for ambient temperature, age, BMI and smoking. Total testosterone, free androgen index and SHBG were associated with all QUS measures (testosterone and FAI r +0.11 to +0.21, all p<0.05; SHBG r −0.14 to −0.16, all p<0.05) and the associations remained significant after adjustment. However, the associations between Menstrual Irregularity and QUS were partially attenuated after adjustment for hormonal factors especially FAI becoming non significant at all sites. Conclusion: In our increasingly obesogenic society, irregular cycles are now associated with higher bone mass in a populationbased sample of premenopausal women. The association between Menstrual Irregularity and bone mass is, at least, partially mediated by free testosterone while total testosterone, FAI, and SHBG are independently associated with bone mass.
Helena J Teede - One of the best experts on this subject based on the ideXlab platform.
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obesity Menstrual Irregularity and polycystic ovary syndrome in young women with type 1 diabetes a population based study
Clinical Endocrinology, 2020Co-Authors: Eleanor P Thong, Frances Milat, Anju E Joham, Gita D Mishra, Helena J TeedeAbstract:BACKGROUND Type 1 diabetes (T1D) is associated with reproductive dysfunction, particularly in the setting of poor metabolic control. Improvements in contemporary management ameliorate these problems, albeit at the cost of increased exogenous insulin and rising obesity, with emerging reproductive implications. OBJECTIVE To evaluate changes in body mass index (BMI) and the relationship between obesity, Menstrual Irregularity and polycystic ovary syndrome (PCOS) in young women with T1D, compared with controls. METHODS Longitudinal observational study using data from the Australian Longitudinal Study in Women's Health of the cohort born in 1989-95, from 2013 to 2015. Three questionnaires administered at baseline and yearly intervals were used to evaluate self-reported Menstrual Irregularity, PCOS and BMI. RESULTS Overall, 15 926 women were included at baseline (T1D, n = 115; controls, n = 15 811). 61 women with T1D and 8332 controls remained at Year 2. Median BMI was higher in women with type 1 diabetes (25.5 vs 22.9 kg/m2 , P < .001), where over half were overweight or obese (54.4% vs 32.9%, P < .001). Median BMI increased by 1.11 and 0.45 kg/m2 , in the T1D and control groups, respectively. T1D was independently associated with an increased risk of Menstrual Irregularity (RR 1.22, 95% CI 1.02-1.46) and PCOS (RR 2.41, 95% CI 1.70-3.42). Obesity conferred a 4-fold increased risk of PCOS, compared to those with normal BMI (RR 3.93, 95% CI 3.51-4.42). CONCLUSIONS Obesity is prevalent amongst women with T1D and may be a key contributor to the higher risk of Menstrual Irregularity and PCOS in this cohort, representing an important opportunity for prevention and intervention.
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Obesity, Menstrual Irregularity and polycystic ovary syndrome in young women with type 1 diabetes: A population-based study.
Clinical Endocrinology, 2020Co-Authors: Eleanor P Thong, Frances Milat, Anju E Joham, Gita D Mishra, Helena J TeedeAbstract:BACKGROUND Type 1 diabetes (T1D) is associated with reproductive dysfunction, particularly in the setting of poor metabolic control. Improvements in contemporary management ameliorate these problems, albeit at the cost of increased exogenous insulin and rising obesity, with emerging reproductive implications. OBJECTIVE To evaluate changes in body mass index (BMI) and the relationship between obesity, Menstrual Irregularity and polycystic ovary syndrome (PCOS) in young women with T1D, compared with controls. METHODS Longitudinal observational study using data from the Australian Longitudinal Study in Women's Health of the cohort born in 1989-95, from 2013 to 2015. Three questionnaires administered at baseline and yearly intervals were used to evaluate self-reported Menstrual Irregularity, PCOS and BMI. RESULTS Overall, 15 926 women were included at baseline (T1D, n = 115; controls, n = 15 811). 61 women with T1D and 8332 controls remained at Year 2. Median BMI was higher in women with type 1 diabetes (25.5 vs 22.9 kg/m2 , P
D Guzick - One of the best experts on this subject based on the ideXlab platform.
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polycystic ovary syndrome symptomatology pathophysiology and epidemiology
American Journal of Obstetrics and Gynecology, 1998Co-Authors: D GuzickAbstract:Abstract Women with polycystic ovary syndrome seek health care for 3 major reasons: infertility, Menstrual Irregularity, and androgen excess. The infertility is associated with anovulation. The Menstrual Irregularity is typically chronic, beginning with menarche. Although amenorrhea may sometimes occur, the more common presentation is irregular bleeding characteristic of anovulation. Androgen excess may be manifested by varying degrees of hirsutism. Patients may also report acne. The rapid development of virilizing signs, such as deepening of the voice, increased muscle mass, and temporal balding, should prompt a search for a tumor and lead one away from a diagnosis of polycystic ovary syndrome. Typically treatment is directed at alleviating the symptoms: ovulation induction for infertility, oral contraceptives or a progestin for Menstrual Irregularity, and oral contraceptives or spironolactone for hirsutism. On the basis of recent epidemiologic data suggestive of increased cardiovascular risk among women with polycystic ovary syndrome, such treatment might be complemented by a long-term approach that addresses the underlying pathophysiology of insulin resistance. (Am J Obstet Gynecol 1998;179:S89-93.)
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Polycystic ovary syndrome: Symptomatology, pathophysiology, and epidemiology ☆ ☆☆
American Journal of Obstetrics and Gynecology, 1998Co-Authors: D GuzickAbstract:Abstract Women with polycystic ovary syndrome seek health care for 3 major reasons: infertility, Menstrual Irregularity, and androgen excess. The infertility is associated with anovulation. The Menstrual Irregularity is typically chronic, beginning with menarche. Although amenorrhea may sometimes occur, the more common presentation is irregular bleeding characteristic of anovulation. Androgen excess may be manifested by varying degrees of hirsutism. Patients may also report acne. The rapid development of virilizing signs, such as deepening of the voice, increased muscle mass, and temporal balding, should prompt a search for a tumor and lead one away from a diagnosis of polycystic ovary syndrome. Typically treatment is directed at alleviating the symptoms: ovulation induction for infertility, oral contraceptives or a progestin for Menstrual Irregularity, and oral contraceptives or spironolactone for hirsutism. On the basis of recent epidemiologic data suggestive of increased cardiovascular risk among women with polycystic ovary syndrome, such treatment might be complemented by a long-term approach that addresses the underlying pathophysiology of insulin resistance. (Am J Obstet Gynecol 1998;179:S89-93.)
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Polycystic ovary syndrome: symptomatology, pathophysiology, and epidemiology.
American journal of obstetrics and gynecology, 1998Co-Authors: D GuzickAbstract:Women with polycystic ovary syndrome seek health care for 3 major reasons: infertility, Menstrual Irregularity, and androgen excess. The infertility is associated with anovulation. The Menstrual Irregularity is typically chronic, beginning with menarche. Although amenorrhea may sometimes occur, the more common presentation is irregular bleeding characteristic of anovulation. Androgen excess may be manifested by varying degrees of hirsutism. Patients may also report acne. The rapid development of virilizing signs, such as deepening of the voice, increased muscle mass, and temporal balding, should prompt a search for a tumor and lead one away from a diagnosis of polycystic ovary syndrome. Typically treatment is directed at alleviating the symptoms: ovulation induction for infertility, oral contraceptives or a progestin for Menstrual Irregularity, and oral contraceptives or spironolactone for hirsutism. On the basis of recent epidemiologic data suggestive of increased cardiovascular risk among women with polycystic ovary syndrome, such treatment might be complemented by a long-term approach that addresses the underlying pathophysiology of insulin resistance.
Jill M Theinnissenbaum - One of the best experts on this subject based on the ideXlab platform.
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Menstrual Irregularity and musculoskeletal injury in female high school athletes
Journal of Athletic Training, 2012Co-Authors: Jill M Theinnissenbaum, Kathleen E Carr, Keith J Loud, Mitchell J Rauh, Timothy A McguineAbstract:Context: The female athlete triad describes the interrelatedness of energy availability, Menstrual function, and bone density. Although associations between triad components and musculoskeletal injury (INJ) have been reported in collegiate athletes, limited information exists about Menstrual Irregularity (MI) and INJ in the high school population. Objective: To determine the prevalence of and relationship between MI and INJ in high school athletes. Design: Cross-sectional study. Setting: High schools. Patients or Other Participants: The sample consisted of 249 female athletes from 3 high schools who competed in 33 interscholastic, school-sponsored sport teams, dance teams, and cheerleading or pom-pon squad during the 2006–2007 school year. Each athlete remained on the roster throughout the season. Main Outcome Measure(s): Participants completed a survey regarding injury type, number of days of sport participation missed, and Menstrual history in the past year. Results: The prevalences of MI and INJ were 1...
Eleanor P Thong - One of the best experts on this subject based on the ideXlab platform.
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obesity Menstrual Irregularity and polycystic ovary syndrome in young women with type 1 diabetes a population based study
Clinical Endocrinology, 2020Co-Authors: Eleanor P Thong, Frances Milat, Anju E Joham, Gita D Mishra, Helena J TeedeAbstract:BACKGROUND Type 1 diabetes (T1D) is associated with reproductive dysfunction, particularly in the setting of poor metabolic control. Improvements in contemporary management ameliorate these problems, albeit at the cost of increased exogenous insulin and rising obesity, with emerging reproductive implications. OBJECTIVE To evaluate changes in body mass index (BMI) and the relationship between obesity, Menstrual Irregularity and polycystic ovary syndrome (PCOS) in young women with T1D, compared with controls. METHODS Longitudinal observational study using data from the Australian Longitudinal Study in Women's Health of the cohort born in 1989-95, from 2013 to 2015. Three questionnaires administered at baseline and yearly intervals were used to evaluate self-reported Menstrual Irregularity, PCOS and BMI. RESULTS Overall, 15 926 women were included at baseline (T1D, n = 115; controls, n = 15 811). 61 women with T1D and 8332 controls remained at Year 2. Median BMI was higher in women with type 1 diabetes (25.5 vs 22.9 kg/m2 , P < .001), where over half were overweight or obese (54.4% vs 32.9%, P < .001). Median BMI increased by 1.11 and 0.45 kg/m2 , in the T1D and control groups, respectively. T1D was independently associated with an increased risk of Menstrual Irregularity (RR 1.22, 95% CI 1.02-1.46) and PCOS (RR 2.41, 95% CI 1.70-3.42). Obesity conferred a 4-fold increased risk of PCOS, compared to those with normal BMI (RR 3.93, 95% CI 3.51-4.42). CONCLUSIONS Obesity is prevalent amongst women with T1D and may be a key contributor to the higher risk of Menstrual Irregularity and PCOS in this cohort, representing an important opportunity for prevention and intervention.
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Obesity, Menstrual Irregularity and polycystic ovary syndrome in young women with type 1 diabetes: A population-based study.
Clinical Endocrinology, 2020Co-Authors: Eleanor P Thong, Frances Milat, Anju E Joham, Gita D Mishra, Helena J TeedeAbstract:BACKGROUND Type 1 diabetes (T1D) is associated with reproductive dysfunction, particularly in the setting of poor metabolic control. Improvements in contemporary management ameliorate these problems, albeit at the cost of increased exogenous insulin and rising obesity, with emerging reproductive implications. OBJECTIVE To evaluate changes in body mass index (BMI) and the relationship between obesity, Menstrual Irregularity and polycystic ovary syndrome (PCOS) in young women with T1D, compared with controls. METHODS Longitudinal observational study using data from the Australian Longitudinal Study in Women's Health of the cohort born in 1989-95, from 2013 to 2015. Three questionnaires administered at baseline and yearly intervals were used to evaluate self-reported Menstrual Irregularity, PCOS and BMI. RESULTS Overall, 15 926 women were included at baseline (T1D, n = 115; controls, n = 15 811). 61 women with T1D and 8332 controls remained at Year 2. Median BMI was higher in women with type 1 diabetes (25.5 vs 22.9 kg/m2 , P