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Sorush Niknamian - One of the best experts on this subject based on the ideXlab platform.
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identifying the Mental Pattern of housing demand by grounded theory the cognitive science approach
Social Science Research Network, 2019Co-Authors: Sorush NiknamianAbstract:One of the main challenges of housing demand is the optimal selection of housing that almost everyone faces. A model that can measure the role and impact of all factors affecting the demand for housing is not presented unambiguously and has not been dramatically formulated explicitly. Considering the centrality of budget, behavioral and control factors in housing demand, the present study seeks to explain and design the Mental Pattern of consumer demand, capital and housing leases with a cognitive and behavioral approach in Tabriz. The present study is based on the qualitative approach and using the grounded theory method. The data collection method was semi-structured interviews. In order to collect information, an interview was carried out using a targeted sampling method with 12 experts in the field of housing. Data analysis was performed in three stages: open coding, axial coding, selective coding, and a qualitative research model has been designed. The results of this study indicate that extraction of more than 250 codes, along with an inventory of more than 20 concepts and 4 categories, are presented in the form of a paradigmatic model including budget constraints as axial categories and causal conditions (as reasons for selection), underlying factors (physical factor) and interventional conditions (control and behavioral factors).
Neil H Shubin - One of the best experts on this subject based on the ideXlab platform.
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limb chondrogenesis of the seepage salamander desmognathus aeneus amphibia plethodontidae
Journal of Morphology, 2005Co-Authors: Adam R Franssen, David B. Wake, Sharyn B Marks, Neil H ShubinAbstract:Salamanders are infrequently mentioned in analyses of tetrapod limb formation, as their development varies considerably from that of amniotes. However, urodeles provide an opportunity to study how limb ontog- eny varies with major differences in life history. Here we assess limb development in Desmognathus aeneus ,a direct-developing salamander, and compare it to Patterns seen in salamanders with larval stages (e.g., Ambystoma mexicanum). Both modes of development result in a limb that is morphologically indistinct from an amniote limb. DevelopMental series of A. mexicanum and D. aeneus were investigated using Type II collagen immunochemistry, Al- cian Blue staining, and whole-mount TUNEL staining. In A. mexicanum, as each digit bud extends from the limb palette Type II collagen and proteoglycan secretion occur almost simultaneously with mesenchyme condensation. Conversely, collagen and proteoglycan secretion in digits of D. aeneus occur only after the formation of an amniote- like paddle. Within each species, Type II collagen expres- sion Patterns resemble those of proteoglycans. In both, distal structures form before more proximal structures. This observation is contrary to the proximodistal develop- Mental Pattern of other tetrapods and may be unique to urodeles. In support of previous findings, no cell death was observed during limb development in A. mexicanum. How- ever, apoptotic cells that may play a role in digit ontogeny occur in the limbs of D. aeneus, thereby suggesting that programmed cell death has evolved as a developMental mechanism at least twice in tetrapod limb evolution. J. Morphol. 265:87-101, 2005. © 2005 Wiley-Liss, Inc.
Adam R Franssen - One of the best experts on this subject based on the ideXlab platform.
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limb chondrogenesis of the seepage salamander desmognathus aeneus amphibia plethodontidae
Journal of Morphology, 2005Co-Authors: Adam R Franssen, David B. Wake, Sharyn B Marks, Neil H ShubinAbstract:Salamanders are infrequently mentioned in analyses of tetrapod limb formation, as their development varies considerably from that of amniotes. However, urodeles provide an opportunity to study how limb ontog- eny varies with major differences in life history. Here we assess limb development in Desmognathus aeneus ,a direct-developing salamander, and compare it to Patterns seen in salamanders with larval stages (e.g., Ambystoma mexicanum). Both modes of development result in a limb that is morphologically indistinct from an amniote limb. DevelopMental series of A. mexicanum and D. aeneus were investigated using Type II collagen immunochemistry, Al- cian Blue staining, and whole-mount TUNEL staining. In A. mexicanum, as each digit bud extends from the limb palette Type II collagen and proteoglycan secretion occur almost simultaneously with mesenchyme condensation. Conversely, collagen and proteoglycan secretion in digits of D. aeneus occur only after the formation of an amniote- like paddle. Within each species, Type II collagen expres- sion Patterns resemble those of proteoglycans. In both, distal structures form before more proximal structures. This observation is contrary to the proximodistal develop- Mental Pattern of other tetrapods and may be unique to urodeles. In support of previous findings, no cell death was observed during limb development in A. mexicanum. How- ever, apoptotic cells that may play a role in digit ontogeny occur in the limbs of D. aeneus, thereby suggesting that programmed cell death has evolved as a developMental mechanism at least twice in tetrapod limb evolution. J. Morphol. 265:87-101, 2005. © 2005 Wiley-Liss, Inc.
Klaus-peter Lesch - One of the best experts on this subject based on the ideXlab platform.
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the brain specific protein mlc1 implicated in megalencephalic leukoencephalopathy with subcortical cysts is expressed in glial cells in the murine brain
Glia, 2003Co-Authors: Angelika Schmitt, Jobst Meyer, Rainald Mossner, Viktor Gofferje, Melanie Weber, Klaus-peter LeschAbstract:The human MLC1 gene (also known as KIAA0027 and WKL1) and its murine orthologue (Mlc1) encode a putative transmembrane protein expressed primarily in brain. Recessive mutations within human MLC1 cause megalencephalic leukoencephalop- athy with subcortical cysts (MLC), whereas a missense mutation resulting in a methionine substitution within a transmembrane leucine string of MLC has been implicated in cata- tonic schizophrenia in a large pedigree. To gain insight into the function of the MLC protein and to elucidate the pathophysiology of these severe neurodegenerative disorders, informa- tion on the cellular and regional distribution of the murine Mlc1, as well as the develop- Mental Pattern of Mlc1 expression in brain, is required. Using in situ hybridization (ISH), Mlc1 mRNA was exclusively detected in glial cells of the adult murine brain, such as astrocytes, Bergmann glia, and ependymal cells. ISH, Northern blot analysis, and quanti- tative real-time polymerase chain reaction (PCR) demonstrated that Mlc1 mRNA is broadly distributed in the adult mouse brain, with highest concentrations of expression in the cerebellum and olfactory bulb. Furthermore, differential expression Patterns during brain development were revealed. Overall brain Mlc1 mRNA concentrations exhibited a substan- tial increase in the perinatal period reaching adult concentrations at postnatal day 5. At the cellular level, highest Mlc1 expression was found during the pre- and perinatal period in multipotential neural precursor cells, especially in the subventricular zone of the lateral ventricle, whereas in adulthood highest Mlc1 mRNA concentrations were revealed in Berg- mann glia cells. Because the temproal expression profile of Mlc1 indicates that, in contrast to developing and mature astrocytes, oligodendrocytes are devoid of Mlc1 expression, white matter tract abnormalities observed in these disorders may result from a primary astrocytic defect. Detailed information on Mlc1 expression in brain is likely to lead to a better understanding of Mlc1 involvement in the pathogenesis of both MLC and catatonic schizophrenia. © 2003 Wiley-Liss, Inc.
David B. Wake - One of the best experts on this subject based on the ideXlab platform.
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limb chondrogenesis of the seepage salamander desmognathus aeneus amphibia plethodontidae
Journal of Morphology, 2005Co-Authors: Adam R Franssen, David B. Wake, Sharyn B Marks, Neil H ShubinAbstract:Salamanders are infrequently mentioned in analyses of tetrapod limb formation, as their development varies considerably from that of amniotes. However, urodeles provide an opportunity to study how limb ontog- eny varies with major differences in life history. Here we assess limb development in Desmognathus aeneus ,a direct-developing salamander, and compare it to Patterns seen in salamanders with larval stages (e.g., Ambystoma mexicanum). Both modes of development result in a limb that is morphologically indistinct from an amniote limb. DevelopMental series of A. mexicanum and D. aeneus were investigated using Type II collagen immunochemistry, Al- cian Blue staining, and whole-mount TUNEL staining. In A. mexicanum, as each digit bud extends from the limb palette Type II collagen and proteoglycan secretion occur almost simultaneously with mesenchyme condensation. Conversely, collagen and proteoglycan secretion in digits of D. aeneus occur only after the formation of an amniote- like paddle. Within each species, Type II collagen expres- sion Patterns resemble those of proteoglycans. In both, distal structures form before more proximal structures. This observation is contrary to the proximodistal develop- Mental Pattern of other tetrapods and may be unique to urodeles. In support of previous findings, no cell death was observed during limb development in A. mexicanum. How- ever, apoptotic cells that may play a role in digit ontogeny occur in the limbs of D. aeneus, thereby suggesting that programmed cell death has evolved as a developMental mechanism at least twice in tetrapod limb evolution. J. Morphol. 265:87-101, 2005. © 2005 Wiley-Liss, Inc.