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Douglas Carroll - One of the best experts on this subject based on the ideXlab platform.

  • Mental Stress induced hemoconcentration sex differences and mechanisms
    Psychophysiology, 2004
    Co-Authors: Jet Veldhuijzen J C S Van Zanten, Victoria E Burns, Kate M Edwards, Mark Drayson, Christopher Ring, Douglas Carroll
    Abstract:

    Given the possible role of hemoconcentration in myocardial infarction and apparent sex differences in susceptibility, three studies examined sex differences in Mental Stress-induced hemoconcentration, and explored possible underlying mechanisms. Blood pressure, heart rate, and hematocrit were monitored at rest and in response to a Mental Stress task that was contrived to be increasingly provocative across the three studies. This was confirmed by self-report, performance, and cardiovascular reactivity data. The most convincing evidence for hemoconcentration effects and sex differences in hemoconcentration emerged from exposure to the more provocative of the Stress tasks, with men also showing greater hemoconcentration than women. Blood pressure reactivity was a strong and consistent predictor of Stress-induced hemoconcentration. These findings may help to explain sex differences in susceptibility to myocardial infarction.

  • Mental Stress‐induced hemoconcentration: Sex differences and mechanisms
    Psychophysiology, 2004
    Co-Authors: Jet Veldhuijzen J C S Van Zanten, Victoria E Burns, Kate M Edwards, Mark Drayson, Christopher Ring, Douglas Carroll
    Abstract:

    Given the possible role of hemoconcentration in myocardial infarction and apparent sex differences in susceptibility, three studies examined sex differences in Mental Stress-induced hemoconcentration, and explored possible underlying mechanisms. Blood pressure, heart rate, and hematocrit were monitored at rest and in response to a Mental Stress task that was contrived to be increasingly provocative across the three studies. This was confirmed by self-report, performance, and cardiovascular reactivity data. The most convincing evidence for hemoconcentration effects and sex differences in hemoconcentration emerged from exposure to the more provocative of the Stress tasks, with men also showing greater hemoconcentration than women. Blood pressure reactivity was a strong and consistent predictor of Stress-induced hemoconcentration. These findings may help to explain sex differences in susceptibility to myocardial infarction.

Kobina Wilmot - One of the best experts on this subject based on the ideXlab platform.

  • Chest Pain and Mental Stress-Induced Myocardial Ischemia: Sex Differences.
    The American journal of medicine, 2017
    Co-Authors: Pratik Pimple, Muhammad Hammadah, Samaah Sullivan, Ibhar Al Mheid, Kobina Wilmot, Ronnie Ramadan, Ernest V. Garcia, Jonathon A. Nye, Oleksiy Levantsevych, Amit J. Shah
    Abstract:

    Abstract Background Mental Stress–induced myocardial ischemia is a frequent phenomenon in patients with coronary artery disease. Women with coronary artery disease tend to have more Mental Stress–induced myocardial ischemia and more chest pain/anginal symptoms than men, but whether the association between Mental Stress–induced myocardial ischemia and angina burden differs in women and men is unknown. Methods This was a cross-sectional study with experiMental manipulation of 950 individuals with stable coronary artery disease. Chest pain/angina frequency in the previous 4 weeks was assessed with the Seattle Angina Questionnaire's angina-frequency subscale. Mental Stress–induced myocardial ischemia was assessed with myocardial perfusion imaging during Mental Stress (standardized public speaking task). Presence of Mental Stress–induced myocardial ischemia was based on expert readers and established criteria. A conventional (exercise or pharmacologic) Stress test was used as a control condition. Results Overall, 338 individuals (37%) reported angina; 112 (12%) developed Mental Stress–induced myocardial ischemia, and 256 (29%) developed conventional Stress ischemia. Women who reported angina had almost double the probability to develop Mental Stress–induced myocardial ischemia (19% vs 10%, adjusted prevalence rate ratio, 1.90; 95% confidence interval, 1.04-3.46), whereas there was no such difference in men (11% vs 11%, adjusted prevalence rate ratio, 1.09; 95% confidence interval, 0.66-1.82). No association was found between angina symptoms and conventional Stress ischemia for women or men. Results for ischemia as a continuous variable were similar. Conclusions In women, but not in men, anginal symptoms may be a marker of vulnerability toward ischemia induced by psychologic Stress. These results highlight the psychosocial origins of angina in women and may have important implications for the management and prognosis of women with angina.

  • Inflammatory response to Mental Stress and Mental Stress induced myocardial ischemia.
    Brain behavior and immunity, 2017
    Co-Authors: Muhammad Hammadah, Samaah Sullivan, Brad D. Pearce, Ibhar Al Mheid, Kobina Wilmot, Ronnie Ramadan, Ayman Samman Tahhan, Wesley T. O'neal, Malik Obideen, Ayman Alkhoder
    Abstract:

    Abstract Background Mental Stress-induced myocardial ischemia (MSIMI) is associated with increased risk of adverse cardiovascular outcomes, yet the underlying mechanisms are not well understood. We measured the inflammatory response to acute laboratory Mental Stress in patients with coronary artery disease (CAD) and its association with MSIMI. We hypothesized that patients with MSIMI would have a higher inflammatory response to Mental Stress in comparison to those without ischemia. Methods Patients with stable CAD underwent 99mTc sestamibi myocardial perfusion imaging during Mental Stress testing using a public speaking Stressor. MSIMI was determined as impaired myocardial perfusion using a 17-segment model. Inflammatory markers including interleukin-6 (IL-6), monocyte chemoattractant protein-1 (MCP-1), matrix metallopeptidase 9 (MMP-9) and high-sensitivity C reactive protein (hsCRP) were measured at rest and 90 min after Mental Stress. Results were validated in an independent sample of 228 post-myocardial infarction patients. Results Of 607 patients analyzed in this study, (mean age 63 ± 9 years, 76% male), 99 (16.3%) developed MSIMI. Mental Stress resulted in a significant increase in IL-6, MCP-1, and MMP-9 (all p  Conclusion Mental Stress is associated with acute increases in several inflammatory markers. However, neither the baseline inflammatory status nor the magnitude of the inflammatory response to Mental Stress over 90 min were significantly associated with MSIMI.

  • INFLAMMATORY RESPONSE TO Mental Stress AND Mental Stress INDUCED MYOCARDIAL ISCHEMIA
    Journal of the American College of Cardiology, 2017
    Co-Authors: Muhammad Hammadah, Brad D. Pearce, Ibhar Al Mheid, Malik Obideen, Ayman Alkhoder, Naser Abdelhadi, Mazen Ghafeer, Oleksiy Levantsevych, Lie Weng, Kobina Wilmot
    Abstract:

    Background: Mental Stress (MS)-induced myocardial ischemia (MSIMI) is associated with increased risk of adverse cardiovascular outcomes, yet the underlying mechanisms are not well understood. We measured the inflammatory response to acute laboratory MS in patients with CAD and its correlation with

  • abstract 11582 vascular hemodynamic and hormonal response to Mental Stress and risk of Mental Stress induced myocardial ischemia
    Circulation, 2016
    Co-Authors: Muhammad Hammadah, Ibhar Al Mheid, Malik Obideen, Ayman Alkhoder, Nino Isakadze, Naser Abdelhadi, Zakaria Almuwaqqat, Mouwafak Moureiden, Mohamad Mazen Gafeer, Kobina Wilmot
    Abstract:

    Introduction: Mental Stress-induced myocardial ischemia (MSIMI) has been linked to adverse cardiovascular outcomes in patients with stable CAD. However, the underlying mechanisms are not well under...

Georg Noll - One of the best experts on this subject based on the ideXlab platform.

  • Mental Stress induces prolonged endothelial dysfunction via endothelin-A receptors
    Circulation, 2002
    Co-Authors: Lukas E. Spieker, David Hürlimann, Frank Ruschitzka, Roberto Corti, Frank Enseleit, Sidney Shaw, Daniel Hayoz, John E. Deanfield, Thomas F. Lüscher, Georg Noll
    Abstract:

    Background— Mental Stress is a risk factor for atherosclerosis and may precipitate myocardial ischemia and infarction. Because endothelial dysfunction is an early manifestation of atherosclerosis, we investigated the impact of Mental Stress on endothelial function. Methods and Results— The effects of a 3-minute Mental Stress task on endothelium-dependent vasodilation were studied in healthy subjects without cardiovascular risk factors. Flow-mediated (FMD) and nitroglycerin (0.4 mg sublingual)-induced vasodilation were studied before and after Mental Stress by high-resolution ultrasound of the radial artery. Additionally, FMD was assessed before and 10 to 45 minutes after Mental Stress during intraarterial infusion of a selective endothelin A receptor antagonist (BQ-123, 1 nmol/min) or saline, respectively. Endothelium-dependent vasodilation was reduced by half for about 45 minutes (8.0±1.1% versus 4.1±1.0%; P

  • Mental Stress induces prolonged endothelial dysfunction via endothelin a receptors
    Circulation, 2002
    Co-Authors: Lukas E. Spieker, David Hürlimann, Frank Ruschitzka, Roberto Corti, Frank Enseleit, Sidney Shaw, Daniel Hayoz, John E. Deanfield, Thomas F. Lüscher, Georg Noll
    Abstract:

    Background— Mental Stress is a risk factor for atherosclerosis and may precipitate myocardial ischemia and infarction. Because endothelial dysfunction is an early manifestation of atherosclerosis, we investigated the impact of Mental Stress on endothelial function. Methods and Results— The effects of a 3-minute Mental Stress task on endothelium-dependent vasodilation were studied in healthy subjects without cardiovascular risk factors. Flow-mediated (FMD) and nitroglycerin (0.4 mg sublingual)-induced vasodilation were studied before and after Mental Stress by high-resolution ultrasound of the radial artery. Additionally, FMD was assessed before and 10 to 45 minutes after Mental Stress during intraarterial infusion of a selective endothelin A receptor antagonist (BQ-123, 1 nmol/min) or saline, respectively. Endothelium-dependent vasodilation was reduced by half for about 45 minutes (8.0±1.1% versus 4.1±1.0%; P<0.002), whereas endothelium-independent vasodilation to nitroglycerin remained unaffected (15.6±1...

Muhammad Hammadah - One of the best experts on this subject based on the ideXlab platform.

  • Chest Pain and Mental Stress-Induced Myocardial Ischemia: Sex Differences.
    The American journal of medicine, 2017
    Co-Authors: Pratik Pimple, Muhammad Hammadah, Samaah Sullivan, Ibhar Al Mheid, Kobina Wilmot, Ronnie Ramadan, Ernest V. Garcia, Jonathon A. Nye, Oleksiy Levantsevych, Amit J. Shah
    Abstract:

    Abstract Background Mental Stress–induced myocardial ischemia is a frequent phenomenon in patients with coronary artery disease. Women with coronary artery disease tend to have more Mental Stress–induced myocardial ischemia and more chest pain/anginal symptoms than men, but whether the association between Mental Stress–induced myocardial ischemia and angina burden differs in women and men is unknown. Methods This was a cross-sectional study with experiMental manipulation of 950 individuals with stable coronary artery disease. Chest pain/angina frequency in the previous 4 weeks was assessed with the Seattle Angina Questionnaire's angina-frequency subscale. Mental Stress–induced myocardial ischemia was assessed with myocardial perfusion imaging during Mental Stress (standardized public speaking task). Presence of Mental Stress–induced myocardial ischemia was based on expert readers and established criteria. A conventional (exercise or pharmacologic) Stress test was used as a control condition. Results Overall, 338 individuals (37%) reported angina; 112 (12%) developed Mental Stress–induced myocardial ischemia, and 256 (29%) developed conventional Stress ischemia. Women who reported angina had almost double the probability to develop Mental Stress–induced myocardial ischemia (19% vs 10%, adjusted prevalence rate ratio, 1.90; 95% confidence interval, 1.04-3.46), whereas there was no such difference in men (11% vs 11%, adjusted prevalence rate ratio, 1.09; 95% confidence interval, 0.66-1.82). No association was found between angina symptoms and conventional Stress ischemia for women or men. Results for ischemia as a continuous variable were similar. Conclusions In women, but not in men, anginal symptoms may be a marker of vulnerability toward ischemia induced by psychologic Stress. These results highlight the psychosocial origins of angina in women and may have important implications for the management and prognosis of women with angina.

  • Inflammatory response to Mental Stress and Mental Stress induced myocardial ischemia.
    Brain behavior and immunity, 2017
    Co-Authors: Muhammad Hammadah, Samaah Sullivan, Brad D. Pearce, Ibhar Al Mheid, Kobina Wilmot, Ronnie Ramadan, Ayman Samman Tahhan, Wesley T. O'neal, Malik Obideen, Ayman Alkhoder
    Abstract:

    Abstract Background Mental Stress-induced myocardial ischemia (MSIMI) is associated with increased risk of adverse cardiovascular outcomes, yet the underlying mechanisms are not well understood. We measured the inflammatory response to acute laboratory Mental Stress in patients with coronary artery disease (CAD) and its association with MSIMI. We hypothesized that patients with MSIMI would have a higher inflammatory response to Mental Stress in comparison to those without ischemia. Methods Patients with stable CAD underwent 99mTc sestamibi myocardial perfusion imaging during Mental Stress testing using a public speaking Stressor. MSIMI was determined as impaired myocardial perfusion using a 17-segment model. Inflammatory markers including interleukin-6 (IL-6), monocyte chemoattractant protein-1 (MCP-1), matrix metallopeptidase 9 (MMP-9) and high-sensitivity C reactive protein (hsCRP) were measured at rest and 90 min after Mental Stress. Results were validated in an independent sample of 228 post-myocardial infarction patients. Results Of 607 patients analyzed in this study, (mean age 63 ± 9 years, 76% male), 99 (16.3%) developed MSIMI. Mental Stress resulted in a significant increase in IL-6, MCP-1, and MMP-9 (all p  Conclusion Mental Stress is associated with acute increases in several inflammatory markers. However, neither the baseline inflammatory status nor the magnitude of the inflammatory response to Mental Stress over 90 min were significantly associated with MSIMI.

  • INFLAMMATORY RESPONSE TO Mental Stress AND Mental Stress INDUCED MYOCARDIAL ISCHEMIA
    Journal of the American College of Cardiology, 2017
    Co-Authors: Muhammad Hammadah, Brad D. Pearce, Ibhar Al Mheid, Malik Obideen, Ayman Alkhoder, Naser Abdelhadi, Mazen Ghafeer, Oleksiy Levantsevych, Lie Weng, Kobina Wilmot
    Abstract:

    Background: Mental Stress (MS)-induced myocardial ischemia (MSIMI) is associated with increased risk of adverse cardiovascular outcomes, yet the underlying mechanisms are not well understood. We measured the inflammatory response to acute laboratory MS in patients with CAD and its correlation with

  • abstract 11582 vascular hemodynamic and hormonal response to Mental Stress and risk of Mental Stress induced myocardial ischemia
    Circulation, 2016
    Co-Authors: Muhammad Hammadah, Ibhar Al Mheid, Malik Obideen, Ayman Alkhoder, Nino Isakadze, Naser Abdelhadi, Zakaria Almuwaqqat, Mouwafak Moureiden, Mohamad Mazen Gafeer, Kobina Wilmot
    Abstract:

    Introduction: Mental Stress-induced myocardial ischemia (MSIMI) has been linked to adverse cardiovascular outcomes in patients with stable CAD. However, the underlying mechanisms are not well under...

Ibhar Al Mheid - One of the best experts on this subject based on the ideXlab platform.

  • Chest Pain and Mental Stress-Induced Myocardial Ischemia: Sex Differences.
    The American journal of medicine, 2017
    Co-Authors: Pratik Pimple, Muhammad Hammadah, Samaah Sullivan, Ibhar Al Mheid, Kobina Wilmot, Ronnie Ramadan, Ernest V. Garcia, Jonathon A. Nye, Oleksiy Levantsevych, Amit J. Shah
    Abstract:

    Abstract Background Mental Stress–induced myocardial ischemia is a frequent phenomenon in patients with coronary artery disease. Women with coronary artery disease tend to have more Mental Stress–induced myocardial ischemia and more chest pain/anginal symptoms than men, but whether the association between Mental Stress–induced myocardial ischemia and angina burden differs in women and men is unknown. Methods This was a cross-sectional study with experiMental manipulation of 950 individuals with stable coronary artery disease. Chest pain/angina frequency in the previous 4 weeks was assessed with the Seattle Angina Questionnaire's angina-frequency subscale. Mental Stress–induced myocardial ischemia was assessed with myocardial perfusion imaging during Mental Stress (standardized public speaking task). Presence of Mental Stress–induced myocardial ischemia was based on expert readers and established criteria. A conventional (exercise or pharmacologic) Stress test was used as a control condition. Results Overall, 338 individuals (37%) reported angina; 112 (12%) developed Mental Stress–induced myocardial ischemia, and 256 (29%) developed conventional Stress ischemia. Women who reported angina had almost double the probability to develop Mental Stress–induced myocardial ischemia (19% vs 10%, adjusted prevalence rate ratio, 1.90; 95% confidence interval, 1.04-3.46), whereas there was no such difference in men (11% vs 11%, adjusted prevalence rate ratio, 1.09; 95% confidence interval, 0.66-1.82). No association was found between angina symptoms and conventional Stress ischemia for women or men. Results for ischemia as a continuous variable were similar. Conclusions In women, but not in men, anginal symptoms may be a marker of vulnerability toward ischemia induced by psychologic Stress. These results highlight the psychosocial origins of angina in women and may have important implications for the management and prognosis of women with angina.

  • Inflammatory response to Mental Stress and Mental Stress induced myocardial ischemia.
    Brain behavior and immunity, 2017
    Co-Authors: Muhammad Hammadah, Samaah Sullivan, Brad D. Pearce, Ibhar Al Mheid, Kobina Wilmot, Ronnie Ramadan, Ayman Samman Tahhan, Wesley T. O'neal, Malik Obideen, Ayman Alkhoder
    Abstract:

    Abstract Background Mental Stress-induced myocardial ischemia (MSIMI) is associated with increased risk of adverse cardiovascular outcomes, yet the underlying mechanisms are not well understood. We measured the inflammatory response to acute laboratory Mental Stress in patients with coronary artery disease (CAD) and its association with MSIMI. We hypothesized that patients with MSIMI would have a higher inflammatory response to Mental Stress in comparison to those without ischemia. Methods Patients with stable CAD underwent 99mTc sestamibi myocardial perfusion imaging during Mental Stress testing using a public speaking Stressor. MSIMI was determined as impaired myocardial perfusion using a 17-segment model. Inflammatory markers including interleukin-6 (IL-6), monocyte chemoattractant protein-1 (MCP-1), matrix metallopeptidase 9 (MMP-9) and high-sensitivity C reactive protein (hsCRP) were measured at rest and 90 min after Mental Stress. Results were validated in an independent sample of 228 post-myocardial infarction patients. Results Of 607 patients analyzed in this study, (mean age 63 ± 9 years, 76% male), 99 (16.3%) developed MSIMI. Mental Stress resulted in a significant increase in IL-6, MCP-1, and MMP-9 (all p  Conclusion Mental Stress is associated with acute increases in several inflammatory markers. However, neither the baseline inflammatory status nor the magnitude of the inflammatory response to Mental Stress over 90 min were significantly associated with MSIMI.

  • INFLAMMATORY RESPONSE TO Mental Stress AND Mental Stress INDUCED MYOCARDIAL ISCHEMIA
    Journal of the American College of Cardiology, 2017
    Co-Authors: Muhammad Hammadah, Brad D. Pearce, Ibhar Al Mheid, Malik Obideen, Ayman Alkhoder, Naser Abdelhadi, Mazen Ghafeer, Oleksiy Levantsevych, Lie Weng, Kobina Wilmot
    Abstract:

    Background: Mental Stress (MS)-induced myocardial ischemia (MSIMI) is associated with increased risk of adverse cardiovascular outcomes, yet the underlying mechanisms are not well understood. We measured the inflammatory response to acute laboratory MS in patients with CAD and its correlation with

  • abstract 11582 vascular hemodynamic and hormonal response to Mental Stress and risk of Mental Stress induced myocardial ischemia
    Circulation, 2016
    Co-Authors: Muhammad Hammadah, Ibhar Al Mheid, Malik Obideen, Ayman Alkhoder, Nino Isakadze, Naser Abdelhadi, Zakaria Almuwaqqat, Mouwafak Moureiden, Mohamad Mazen Gafeer, Kobina Wilmot
    Abstract:

    Introduction: Mental Stress-induced myocardial ischemia (MSIMI) has been linked to adverse cardiovascular outcomes in patients with stable CAD. However, the underlying mechanisms are not well under...

  • Abstract 17545: Vasoconstriction During Mental Stress Predicts Severity of Mental Stress Induced Myocardial Ischemia
    Circulation, 2015
    Co-Authors: Nino Isakadze, Ibhar Al Mheid, Ayman Alkhoder, Arshed A. Quyyumi, Viola Vaccarino, J. Douglas Bremner, Ernest V. Garcia, Jonathon A. Nye, Kobina Wilmont, Paolo Raggi
    Abstract:

    Background: Evidence supports that peripheral vasoconstriction during Mental Stress predicts Mental Stress induced ischemia (MSIMI). However, whether a dose response relationship exists with ischem...