The Experts below are selected from a list of 69 Experts worldwide ranked by ideXlab platform
Gonul Kunt - One of the best experts on this subject based on the ideXlab platform.
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simultaneous determination of Mepyramine Maleate lidocaine hydrochloride and dexpanthenol in pharmaceutical preparations by partial least squares multivariate calibration
Analytical Letters, 2006Co-Authors: Ozlem Aksu, Abdurrezzak Bozdogan, Gonul KuntAbstract:Abstract A partial least‐squares calibration (PLS) method has been developed for simultaneous quantitative determination of Mepyramine Maleate (MAM), lidocaine hydrochloride (LIH), and dexpanthenol (DPA) in pharmaceutical preparations. The resolution of these mixtures has been accomplished by using partial least‐squares (PLS‐2) regression analysis of electronic absorption spectral data without prior separation or derivatization. The experimental calibration matrix was constructed with 27 samples. The concentration ranges considered were 2, 3, 4 µg mL−1 for MAM, 2, 3, 4 µg mL−1 for LIH, and 8, 10, 12 µg mL−1 for DPA. The absorbances were recorded between 190 and 340 nm every 5 nm. The results show that PLS‐2 is a simple, rapid, and accurate method applied to the determination of these compounds in pharmaceuticals.
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Simultaneous Determination of Mepyramine Maleate, Lidocaine Hydrochloride, and Dexpanthenol in Pharmaceutical Preparations by Partial Least‐Squares Multivariate Calibration
Analytical Letters, 2006Co-Authors: Ozlem Aksu, Abdurrezzak Bozdogan, Gonul KuntAbstract:Abstract A partial least‐squares calibration (PLS) method has been developed for simultaneous quantitative determination of Mepyramine Maleate (MAM), lidocaine hydrochloride (LIH), and dexpanthenol (DPA) in pharmaceutical preparations. The resolution of these mixtures has been accomplished by using partial least‐squares (PLS‐2) regression analysis of electronic absorption spectral data without prior separation or derivatization. The experimental calibration matrix was constructed with 27 samples. The concentration ranges considered were 2, 3, 4 µg mL−1 for MAM, 2, 3, 4 µg mL−1 for LIH, and 8, 10, 12 µg mL−1 for DPA. The absorbances were recorded between 190 and 340 nm every 5 nm. The results show that PLS‐2 is a simple, rapid, and accurate method applied to the determination of these compounds in pharmaceuticals.
Bulent Ulutas - One of the best experts on this subject based on the ideXlab platform.
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Mepyramine Maleate treatment of urticaria in horses; a multi-centered, randomized, placebo controlled, double blinded clinical trial
2010Co-Authors: Kerem Ural, Bulent UlutasAbstract:The aim of the present study was to investigate the efficacy of Mepyramine Maleate in horses with urticaria. A total of 31 horses, between the ages of 1 and 8 years, were enrolled and randomly assigned to either a placebo or an intramuscular Mepyramine Maleate group. Clinical evaluations were done by the same investigator, who scored clinical healing, throughout the study and was blinded to the allocation to the groups. At the end of the trial, Mepyramine Maleate treatment significantly decreased (P
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Mepyramine Maleate treatment of urticaria in horses a multi centered randomized placebo controlled double blinded clinical trial maleato de mepiramine como tratamiento de la urticaria en caballos un estudio multicentrico aleatorizado y controlado con
2010Co-Authors: Kerem Ural, Bulent UlutasAbstract:The aim of the present study was to investigate the efficacy of Mepyramine Maleate in horses with urticaria. A total of 31 horses, between the ages of 1 and 8 years, were enrolled and randomly assigned to either a placebo or an intramuscular Mepyramine Maleate group. Clinical evaluations were done by the same investigator, who scored clinical healing, throughout the study and was blinded to the allocation to the groups. At the end of the trial, Mepyramine Maleate treatment significantly decreased (P<0.001) the investigator’s clinical scores and while weak changes were detected in the placebo treatment group. In all of the horses treated, the lesions improved gradually within 6 hours after treatment. Complete clinical remission was detected within 6 to 18 hours and all treated horses completely cured within 24 hours of starting treatment. Urticaria was still evident in 8 out of 14 untreated control horses throughout the study. No recurrency was observed in treated horses within 1 week after therapy. Results of the present study indicate that Mepyramine Maleate may be a safe and effective therapy for horses with urticaria.
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Mepyramine Maleate treatment of urticaria in horses a multi centered randomized placebo controlled double blinded clinical trial
Revista Cientifica Facultad de Ciencias Veterinarias Universidad del Zulia, 2010Co-Authors: Kerem Ural, Bulent UlutasAbstract:The aim of the present study was to investigate the efficacy of Mepyramine Maleate in horses with urticaria. A total of 31 horses, between the ages of 1 and 8 years, were enrolled and randomly assigned to either a placebo or an intramuscular Mepyramine Maleate group. Clinical evaluations were done by the same investigator, who scored clinical healing, throughout the study and was blinded to the allocation to the groups. At the end of the trial, Mepyramine Maleate treatment significantly decreased (P<0.001) the investigator’ s clinical scores and while weak changes were detected in the placebo treatment group. In all of the horses treated, the lesions improved gradually within 6 hours after treatment. Complete clinical remission was detected within 6 to 18 hours and all treated horses completely cured within 24 hours of starting treatment. Urticaria was still evident in 8 out of 14 untreated control horses throughout the study. No recurrency was observed in treated horses within 1 week after therapy. Results of the present study indicate that Mepyramine Maleate may be a safe and effective therapy for horses with urticaria.
Kerem Ural - One of the best experts on this subject based on the ideXlab platform.
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Mepyramine Maleate treatment of urticaria in horses; a multi-centered, randomized, placebo controlled, double blinded clinical trial
2010Co-Authors: Kerem Ural, Bulent UlutasAbstract:The aim of the present study was to investigate the efficacy of Mepyramine Maleate in horses with urticaria. A total of 31 horses, between the ages of 1 and 8 years, were enrolled and randomly assigned to either a placebo or an intramuscular Mepyramine Maleate group. Clinical evaluations were done by the same investigator, who scored clinical healing, throughout the study and was blinded to the allocation to the groups. At the end of the trial, Mepyramine Maleate treatment significantly decreased (P
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Mepyramine Maleate treatment of urticaria in horses a multi centered randomized placebo controlled double blinded clinical trial maleato de mepiramine como tratamiento de la urticaria en caballos un estudio multicentrico aleatorizado y controlado con
2010Co-Authors: Kerem Ural, Bulent UlutasAbstract:The aim of the present study was to investigate the efficacy of Mepyramine Maleate in horses with urticaria. A total of 31 horses, between the ages of 1 and 8 years, were enrolled and randomly assigned to either a placebo or an intramuscular Mepyramine Maleate group. Clinical evaluations were done by the same investigator, who scored clinical healing, throughout the study and was blinded to the allocation to the groups. At the end of the trial, Mepyramine Maleate treatment significantly decreased (P<0.001) the investigator’s clinical scores and while weak changes were detected in the placebo treatment group. In all of the horses treated, the lesions improved gradually within 6 hours after treatment. Complete clinical remission was detected within 6 to 18 hours and all treated horses completely cured within 24 hours of starting treatment. Urticaria was still evident in 8 out of 14 untreated control horses throughout the study. No recurrency was observed in treated horses within 1 week after therapy. Results of the present study indicate that Mepyramine Maleate may be a safe and effective therapy for horses with urticaria.
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Mepyramine Maleate treatment of urticaria in horses a multi centered randomized placebo controlled double blinded clinical trial
Revista Cientifica Facultad de Ciencias Veterinarias Universidad del Zulia, 2010Co-Authors: Kerem Ural, Bulent UlutasAbstract:The aim of the present study was to investigate the efficacy of Mepyramine Maleate in horses with urticaria. A total of 31 horses, between the ages of 1 and 8 years, were enrolled and randomly assigned to either a placebo or an intramuscular Mepyramine Maleate group. Clinical evaluations were done by the same investigator, who scored clinical healing, throughout the study and was blinded to the allocation to the groups. At the end of the trial, Mepyramine Maleate treatment significantly decreased (P<0.001) the investigator’ s clinical scores and while weak changes were detected in the placebo treatment group. In all of the horses treated, the lesions improved gradually within 6 hours after treatment. Complete clinical remission was detected within 6 to 18 hours and all treated horses completely cured within 24 hours of starting treatment. Urticaria was still evident in 8 out of 14 untreated control horses throughout the study. No recurrency was observed in treated horses within 1 week after therapy. Results of the present study indicate that Mepyramine Maleate may be a safe and effective therapy for horses with urticaria.
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Efficacy of Mepyramine Maleate treatment in dogs with angioedema
Polish journal of veterinary sciences, 2010Co-Authors: Cenker Cagri Cingi, Kerem Ural, Abuzer Acar, Erdoğan UzluAbstract:Twenty-seven dogs with angioedema, were enrolled in this clinical study. The cases were randomly assigned to the treatment group (n=15) and untreated placebo control group (n=12). It was concluded that Mepyramine Maleate has the potential to be helpful for dogs with angioedema.
Ozlem Aksu - One of the best experts on this subject based on the ideXlab platform.
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simultaneous determination of Mepyramine Maleate lidocaine hydrochloride and dexpanthenol in pharmaceutical preparations by partial least squares multivariate calibration
Analytical Letters, 2006Co-Authors: Ozlem Aksu, Abdurrezzak Bozdogan, Gonul KuntAbstract:Abstract A partial least‐squares calibration (PLS) method has been developed for simultaneous quantitative determination of Mepyramine Maleate (MAM), lidocaine hydrochloride (LIH), and dexpanthenol (DPA) in pharmaceutical preparations. The resolution of these mixtures has been accomplished by using partial least‐squares (PLS‐2) regression analysis of electronic absorption spectral data without prior separation or derivatization. The experimental calibration matrix was constructed with 27 samples. The concentration ranges considered were 2, 3, 4 µg mL−1 for MAM, 2, 3, 4 µg mL−1 for LIH, and 8, 10, 12 µg mL−1 for DPA. The absorbances were recorded between 190 and 340 nm every 5 nm. The results show that PLS‐2 is a simple, rapid, and accurate method applied to the determination of these compounds in pharmaceuticals.
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Simultaneous Determination of Mepyramine Maleate, Lidocaine Hydrochloride, and Dexpanthenol in Pharmaceutical Preparations by Partial Least‐Squares Multivariate Calibration
Analytical Letters, 2006Co-Authors: Ozlem Aksu, Abdurrezzak Bozdogan, Gonul KuntAbstract:Abstract A partial least‐squares calibration (PLS) method has been developed for simultaneous quantitative determination of Mepyramine Maleate (MAM), lidocaine hydrochloride (LIH), and dexpanthenol (DPA) in pharmaceutical preparations. The resolution of these mixtures has been accomplished by using partial least‐squares (PLS‐2) regression analysis of electronic absorption spectral data without prior separation or derivatization. The experimental calibration matrix was constructed with 27 samples. The concentration ranges considered were 2, 3, 4 µg mL−1 for MAM, 2, 3, 4 µg mL−1 for LIH, and 8, 10, 12 µg mL−1 for DPA. The absorbances were recorded between 190 and 340 nm every 5 nm. The results show that PLS‐2 is a simple, rapid, and accurate method applied to the determination of these compounds in pharmaceuticals.
Abdurrezzak Bozdogan - One of the best experts on this subject based on the ideXlab platform.
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simultaneous determination of Mepyramine Maleate lidocaine hydrochloride and dexpanthenol in pharmaceutical preparations by partial least squares multivariate calibration
Analytical Letters, 2006Co-Authors: Ozlem Aksu, Abdurrezzak Bozdogan, Gonul KuntAbstract:Abstract A partial least‐squares calibration (PLS) method has been developed for simultaneous quantitative determination of Mepyramine Maleate (MAM), lidocaine hydrochloride (LIH), and dexpanthenol (DPA) in pharmaceutical preparations. The resolution of these mixtures has been accomplished by using partial least‐squares (PLS‐2) regression analysis of electronic absorption spectral data without prior separation or derivatization. The experimental calibration matrix was constructed with 27 samples. The concentration ranges considered were 2, 3, 4 µg mL−1 for MAM, 2, 3, 4 µg mL−1 for LIH, and 8, 10, 12 µg mL−1 for DPA. The absorbances were recorded between 190 and 340 nm every 5 nm. The results show that PLS‐2 is a simple, rapid, and accurate method applied to the determination of these compounds in pharmaceuticals.
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Simultaneous Determination of Mepyramine Maleate, Lidocaine Hydrochloride, and Dexpanthenol in Pharmaceutical Preparations by Partial Least‐Squares Multivariate Calibration
Analytical Letters, 2006Co-Authors: Ozlem Aksu, Abdurrezzak Bozdogan, Gonul KuntAbstract:Abstract A partial least‐squares calibration (PLS) method has been developed for simultaneous quantitative determination of Mepyramine Maleate (MAM), lidocaine hydrochloride (LIH), and dexpanthenol (DPA) in pharmaceutical preparations. The resolution of these mixtures has been accomplished by using partial least‐squares (PLS‐2) regression analysis of electronic absorption spectral data without prior separation or derivatization. The experimental calibration matrix was constructed with 27 samples. The concentration ranges considered were 2, 3, 4 µg mL−1 for MAM, 2, 3, 4 µg mL−1 for LIH, and 8, 10, 12 µg mL−1 for DPA. The absorbances were recorded between 190 and 340 nm every 5 nm. The results show that PLS‐2 is a simple, rapid, and accurate method applied to the determination of these compounds in pharmaceuticals.