The Experts below are selected from a list of 72 Experts worldwide ranked by ideXlab platform
J F Chissell - One of the best experts on this subject based on the ideXlab platform.
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colorimetric method for the estimation of norethynodrel in tablets containing Mestranol
Journal of Pharmacy and Pharmacology, 2011Co-Authors: J F ChissellAbstract:The colour method proposed for the estimation of norethynodrel in tablets with Mestranol utilises a reaction similar to the well known Zimmerman reaction, the reagents employed being m-dinitrobenzene and benzyltrimethylammonium hydroxide solution and a solvent mixture consisting of ethyl acetate and ethanol. Maximum extinction was at a wavelength of 510 mμ and Beer's law is obeyed for a concentration range 5 to 20μg norethynodrel per ml final solution.
Yvonne Dragan - One of the best experts on this subject based on the ideXlab platform.
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NMR-based metabonomic evaluation of livers from rats chronically treated with tamoxifen, Mestranol, and phenobarbital
Metabolomics, 2005Co-Authors: Laura Schnackenberg, Richard D. Beger, Yvonne DraganAbstract:In this study, we look at the metabolic effects of long-term dosing with tamoxifen, Mestranol or phenobarbital on the liver. Tamoxifen, Mestranol and phenobarbital have all been reported to act as promoters of hepatic tumors. While tamoxifen and Mestranol are known to have estrogenic activity, in the liver phenobarbital is a non-estrogenic compound. Aqueous and lipophilic liver extracts from control and chronically treated Fisher 344 rats were evaluated by nuclear magnetic resonance spectroscopy (NMR). In both the aqueous and lipophilic sample sets, the estrogenic action of Mestranol appears to be responsible for the clustering of these samples with those animals treated with tamoxifen. Phenobarbital does not have estrogenic activity and, therefore, clusters away from the estrogenic and control groups. In the lipophilic samples, the fatty acid peak (CH_2)_ n was higher in tamoxifen-treated rats than in control, phenobarbital- or Mestranol-treated rats. In the aqueous samples, serine and choline levels were higher in phenobarbital-treated rats than controls, which may be an indication that the folate–homocysteine metabolic pathways were altered.
Xianfu Peng - One of the best experts on this subject based on the ideXlab platform.
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improved synthesis of Mestranol and ethinyl estradiol ee related degradation products as authentic references
Steroids, 2008Co-Authors: Yanxi Song, Xianfu PengAbstract:Preparative chemical methods for the synthesis of 10 degradation or photodecomposition products of Mestranol and ethinyl estradiol (EE) are described. The synthesized compounds are useful as reference materials and standards for pharmaceutical analysis of Mestranol and EE as bulk chemical or in formulated product. New synthetic methods were presented and the known synthetic procedures were improved. Detailed structural characterization of the degradation or photodecomposition products of Mestranol and EE and related compounds was reported.
Laura Schnackenberg - One of the best experts on this subject based on the ideXlab platform.
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NMR-based metabonomic evaluation of livers from rats chronically treated with tamoxifen, Mestranol, and phenobarbital
Metabolomics, 2005Co-Authors: Laura Schnackenberg, Richard D. Beger, Yvonne DraganAbstract:In this study, we look at the metabolic effects of long-term dosing with tamoxifen, Mestranol or phenobarbital on the liver. Tamoxifen, Mestranol and phenobarbital have all been reported to act as promoters of hepatic tumors. While tamoxifen and Mestranol are known to have estrogenic activity, in the liver phenobarbital is a non-estrogenic compound. Aqueous and lipophilic liver extracts from control and chronically treated Fisher 344 rats were evaluated by nuclear magnetic resonance spectroscopy (NMR). In both the aqueous and lipophilic sample sets, the estrogenic action of Mestranol appears to be responsible for the clustering of these samples with those animals treated with tamoxifen. Phenobarbital does not have estrogenic activity and, therefore, clusters away from the estrogenic and control groups. In the lipophilic samples, the fatty acid peak (CH_2)_ n was higher in tamoxifen-treated rats than in control, phenobarbital- or Mestranol-treated rats. In the aqueous samples, serine and choline levels were higher in phenobarbital-treated rats than controls, which may be an indication that the folate–homocysteine metabolic pathways were altered.
Jorg W Metzger - One of the best experts on this subject based on the ideXlab platform.
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substances with estrogenic activity in effluents of sewage treatment plants in southwestern germany 2 biological analysis
Environmental Toxicology and Chemistry, 2001Co-Authors: Peter Spengler, Wolfgang Korner, Jorg W MetzgerAbstract:A gas chromatography/mass spectrometry method for the simultaneous quantitative determination of natural and synthetic estrogens (17β-estradiol, estrone, 17α-ethinylestradiol, and Mestranol), phytoestrogens (genistein and β-sitosterol), and xenoestrogens (benzyl butyl phthalate, dibutyl phthalate, bisphenol A, 4-nonylphenol [NP], 4-nonylphenoxyacetic acid [NP1EC], 4-nonyl-phenol diethoxylate [NP2EO], and α-endosulfan) in effluents of sewage treatment plants (STPs) was developed. Identification and quantification were carried out with the standard addition method using analyte-specific and, in some cases, deuterium-labeled internal standards. The effluents of 18 STPs were investigated. Apart from α-endosulfan and Mestranol, all selected substances were detected in the majority of samples. The median concentrations of steroidal estrogens were between 0.4 ng/L (17α-ethiny-lestradiol) and 1.6 ng/L (17β-estradiol). The metabolites of the nonylphenol polyethoxylates, NP, NP1EC, and NP2EO were found in concentrations ranging from the upper-ng/L-range (NP) to the lower-μg/L range (NP1EC). For all substances except Mestranol and α-endosulfan, median values were calculated and compared to the results of other investigations in Europe and the United States. Possible dependencies of measured concentrations on the geographical location, the capacity, the influent composition, and the technical fitting of the STPs are discussed.