The Experts below are selected from a list of 1337970 Experts worldwide ranked by ideXlab platform
Steven M Haffner - One of the best experts on this subject based on the ideXlab platform.
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ncep defined Metabolic syndrome diabetes and prevalence of coronary heart disease among nhanes iii participants age 50 years and older
Diabetes, 2003Co-Authors: Charles M Alexander, Pamela B Landsman, Steven M Teutsch, Steven M HaffnerAbstract:Although the individual components of the Metabolic syndrome are clearly associated with increased risk for coronary heart disease (CHD), we wanted to quantify the increased prevalence of CHD among people with Metabolic syndrome. The Third National Health and Nutrition Examination Survey (NHANES III) was used to categorize adults over 50 years of age by presence of Metabolic syndrome (National Cholesterol Education Program [NCEP] definition) with or without diabetes. Demographic and risk factor information was determined for each group, as well as the proportion of each group meeting specific criteria for Metabolic syndrome. The prevalence of CHD for each group was then determined. Metabolic syndrome is very common, with ∼44% of the U.S. population over 50 years of age meeting the NCEP criteria. In contrast, diabetes without Metabolic syndrome is uncommon (13% of those with diabetes). Older Americans over 50 years of age without Metabolic syndrome regardless of diabetes status had the lowest CHD prevalence (8.7% without diabetes, 7.5% with diabetes). Compared with those with Metabolic syndrome, people with diabetes without Metabolic syndrome did not have an increase in CHD prevalence. Those with Metabolic syndrome without diabetes had higher CHD prevalence (13.9%), and those with both Metabolic syndrome and diabetes had the highest prevalence of CHD (19.2%) compared with those with neither. Metabolic syndrome was a significant univariate predictor of prevalent CHD (OR 2.07, 95% CI 1.66–2.59). However, blood pressure, HDL cholesterol, and diabetes, but not presence of Metabolic syndrome, were significant multivariate predictors of prevalent CHD. The prevalence of CHD markedly increased with the presence of Metabolic syndrome. Among people with diabetes, the prevalence of Metabolic syndrome was very high, and those with diabetes and Metabolic syndrome had the highest prevalence of CHD. Among all individuals with diabetes, prevalence of CHD was increased compared with those with Metabolic syndrome without diabetes. However, individuals with diabetes without Metabolic syndrome had no greater prevalence of CHD compared with those with neither.
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ncep defined Metabolic syndrome diabetes and prevalence of coronary heart disease among nhanes iii participants age 50 years and older
Diabetes, 2003Co-Authors: Charles M Alexander, Pamela B Landsman, Steven M Teutsch, Steven M HaffnerAbstract:Although the individual components of the Metabolic syndrome are clearly associated with increased risk for coronary heart disease (CHD), we wanted to quantify the increased prevalence of CHD among people with Metabolic syndrome. The Third National Health and Nutrition Examination Survey (NHANES III) was used to categorize adults over 50 years of age by presence of Metabolic syndrome (National Cholesterol Education Program [NCEP] definition) with or without diabetes. Demographic and risk factor information was determined for each group, as well as the proportion of each group meeting specific criteria for Metabolic syndrome. The prevalence of CHD for each group was then determined. Metabolic syndrome is very common, with approximately 44% of the U.S. population over 50 years of age meeting the NCEP criteria. In contrast, diabetes without Metabolic syndrome is uncommon (13% of those with diabetes). Older Americans over 50 years of age without Metabolic syndrome regardless of diabetes status had the lowest CHD prevalence (8.7% without diabetes, 7.5% with diabetes). Compared with those with Metabolic syndrome, people with diabetes without Metabolic syndrome did not have an increase in CHD prevalence. Those with Metabolic syndrome without diabetes had higher CHD prevalence (13.9%), and those with both Metabolic syndrome and diabetes had the highest prevalence of CHD (19.2%) compared with those with neither. Metabolic syndrome was a significant univariate predictor of prevalent CHD (OR 2.07, 95% CI 1.66-2.59). However, blood pressure, HDL cholesterol, and diabetes, but not presence of Metabolic syndrome, were significant multivariate predictors of prevalent CHD. The prevalence of CHD markedly increased with the presence of Metabolic syndrome. Among people with diabetes, the prevalence of Metabolic syndrome was very high, and those with diabetes and Metabolic syndrome had the highest prevalence of CHD. Among all individuals with diabetes, prevalence of CHD was increased compared with those with Metabolic syndrome without diabetes. However, individuals with diabetes without Metabolic syndrome had no greater prevalence of CHD compared with those with neither.
Charles M Alexander - One of the best experts on this subject based on the ideXlab platform.
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ncep defined Metabolic syndrome diabetes and prevalence of coronary heart disease among nhanes iii participants age 50 years and older
Diabetes, 2003Co-Authors: Charles M Alexander, Pamela B Landsman, Steven M Teutsch, Steven M HaffnerAbstract:Although the individual components of the Metabolic syndrome are clearly associated with increased risk for coronary heart disease (CHD), we wanted to quantify the increased prevalence of CHD among people with Metabolic syndrome. The Third National Health and Nutrition Examination Survey (NHANES III) was used to categorize adults over 50 years of age by presence of Metabolic syndrome (National Cholesterol Education Program [NCEP] definition) with or without diabetes. Demographic and risk factor information was determined for each group, as well as the proportion of each group meeting specific criteria for Metabolic syndrome. The prevalence of CHD for each group was then determined. Metabolic syndrome is very common, with ∼44% of the U.S. population over 50 years of age meeting the NCEP criteria. In contrast, diabetes without Metabolic syndrome is uncommon (13% of those with diabetes). Older Americans over 50 years of age without Metabolic syndrome regardless of diabetes status had the lowest CHD prevalence (8.7% without diabetes, 7.5% with diabetes). Compared with those with Metabolic syndrome, people with diabetes without Metabolic syndrome did not have an increase in CHD prevalence. Those with Metabolic syndrome without diabetes had higher CHD prevalence (13.9%), and those with both Metabolic syndrome and diabetes had the highest prevalence of CHD (19.2%) compared with those with neither. Metabolic syndrome was a significant univariate predictor of prevalent CHD (OR 2.07, 95% CI 1.66–2.59). However, blood pressure, HDL cholesterol, and diabetes, but not presence of Metabolic syndrome, were significant multivariate predictors of prevalent CHD. The prevalence of CHD markedly increased with the presence of Metabolic syndrome. Among people with diabetes, the prevalence of Metabolic syndrome was very high, and those with diabetes and Metabolic syndrome had the highest prevalence of CHD. Among all individuals with diabetes, prevalence of CHD was increased compared with those with Metabolic syndrome without diabetes. However, individuals with diabetes without Metabolic syndrome had no greater prevalence of CHD compared with those with neither.
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ncep defined Metabolic syndrome diabetes and prevalence of coronary heart disease among nhanes iii participants age 50 years and older
Diabetes, 2003Co-Authors: Charles M Alexander, Pamela B Landsman, Steven M Teutsch, Steven M HaffnerAbstract:Although the individual components of the Metabolic syndrome are clearly associated with increased risk for coronary heart disease (CHD), we wanted to quantify the increased prevalence of CHD among people with Metabolic syndrome. The Third National Health and Nutrition Examination Survey (NHANES III) was used to categorize adults over 50 years of age by presence of Metabolic syndrome (National Cholesterol Education Program [NCEP] definition) with or without diabetes. Demographic and risk factor information was determined for each group, as well as the proportion of each group meeting specific criteria for Metabolic syndrome. The prevalence of CHD for each group was then determined. Metabolic syndrome is very common, with approximately 44% of the U.S. population over 50 years of age meeting the NCEP criteria. In contrast, diabetes without Metabolic syndrome is uncommon (13% of those with diabetes). Older Americans over 50 years of age without Metabolic syndrome regardless of diabetes status had the lowest CHD prevalence (8.7% without diabetes, 7.5% with diabetes). Compared with those with Metabolic syndrome, people with diabetes without Metabolic syndrome did not have an increase in CHD prevalence. Those with Metabolic syndrome without diabetes had higher CHD prevalence (13.9%), and those with both Metabolic syndrome and diabetes had the highest prevalence of CHD (19.2%) compared with those with neither. Metabolic syndrome was a significant univariate predictor of prevalent CHD (OR 2.07, 95% CI 1.66-2.59). However, blood pressure, HDL cholesterol, and diabetes, but not presence of Metabolic syndrome, were significant multivariate predictors of prevalent CHD. The prevalence of CHD markedly increased with the presence of Metabolic syndrome. Among people with diabetes, the prevalence of Metabolic syndrome was very high, and those with diabetes and Metabolic syndrome had the highest prevalence of CHD. Among all individuals with diabetes, prevalence of CHD was increased compared with those with Metabolic syndrome without diabetes. However, individuals with diabetes without Metabolic syndrome had no greater prevalence of CHD compared with those with neither.
Maciek R. Antoniewicz - One of the best experts on this subject based on the ideXlab platform.
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A guide to Metabolic flux analysis in Metabolic engineering: Methods, tools and applications.
Metabolic engineering, 2020Co-Authors: Maciek R. AntoniewiczAbstract:Abstract The field of Metabolic engineering is primarily concerned with improving the biological production of value-added chemicals, fuels and pharmaceuticals through the design, construction and optimization of Metabolic pathways, redirection of intracellular fluxes, and refinement of cellular properties relevant for industrial bioprocess implementation. Metabolic network models and Metabolic fluxes are central concepts in Metabolic engineering, as was emphasized in the first paper published in this journal, “Metabolic fluxes and Metabolic engineering” (Metabolic Engineering, 1: 1–11, 1999). In the past two decades, a wide range of computational, analytical and experimental approaches have been developed to interrogate the capabilities of biological systems through analysis of Metabolic network models using techniques such as flux balance analysis (FBA), and quantify Metabolic fluxes using constrained-based modeling approaches such as Metabolic flux analysis (MFA) and more advanced experimental techniques based on the use of stable-isotope tracers, i.e. 13C-Metabolic flux analysis (13C-MFA). In this review, we describe the basic principles of Metabolic flux analysis, discuss current best practices in flux quantification, highlight potential pitfalls and alternative approaches in the application of these tools, and give a broad overview of pragmatic applications of flux analysis in Metabolic engineering practice.
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Methods and advances in Metabolic flux analysis: a mini-review
Journal of Industrial Microbiology & Biotechnology, 2015Co-Authors: Maciek R. AntoniewiczAbstract:Metabolic flux analysis (MFA) is one of the pillars of Metabolic engineering. Over the past three decades, it has been widely used to quantify intracellular Metabolic fluxes in both native (wild type) and engineered biological systems. Through MFA, changes in Metabolic pathway fluxes are quantified that result from genetic and/or environmental interventions. This information, in turn, provides insights into the regulation of Metabolic pathways and may suggest new targets for further Metabolic engineering of the strains. In this mini-review, we discuss and classify the various methods of MFA that have been developed, which include stoichiometric MFA, ^13C Metabolic flux analysis, isotopic non-stationary ^13C Metabolic flux analysis, dynamic Metabolic flux analysis, and ^13C dynamic Metabolic flux analysis. For each method, we discuss key advantages and limitations and conclude by highlighting important recent advances in flux analysis approaches.
Pamela B Landsman - One of the best experts on this subject based on the ideXlab platform.
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ncep defined Metabolic syndrome diabetes and prevalence of coronary heart disease among nhanes iii participants age 50 years and older
Diabetes, 2003Co-Authors: Charles M Alexander, Pamela B Landsman, Steven M Teutsch, Steven M HaffnerAbstract:Although the individual components of the Metabolic syndrome are clearly associated with increased risk for coronary heart disease (CHD), we wanted to quantify the increased prevalence of CHD among people with Metabolic syndrome. The Third National Health and Nutrition Examination Survey (NHANES III) was used to categorize adults over 50 years of age by presence of Metabolic syndrome (National Cholesterol Education Program [NCEP] definition) with or without diabetes. Demographic and risk factor information was determined for each group, as well as the proportion of each group meeting specific criteria for Metabolic syndrome. The prevalence of CHD for each group was then determined. Metabolic syndrome is very common, with ∼44% of the U.S. population over 50 years of age meeting the NCEP criteria. In contrast, diabetes without Metabolic syndrome is uncommon (13% of those with diabetes). Older Americans over 50 years of age without Metabolic syndrome regardless of diabetes status had the lowest CHD prevalence (8.7% without diabetes, 7.5% with diabetes). Compared with those with Metabolic syndrome, people with diabetes without Metabolic syndrome did not have an increase in CHD prevalence. Those with Metabolic syndrome without diabetes had higher CHD prevalence (13.9%), and those with both Metabolic syndrome and diabetes had the highest prevalence of CHD (19.2%) compared with those with neither. Metabolic syndrome was a significant univariate predictor of prevalent CHD (OR 2.07, 95% CI 1.66–2.59). However, blood pressure, HDL cholesterol, and diabetes, but not presence of Metabolic syndrome, were significant multivariate predictors of prevalent CHD. The prevalence of CHD markedly increased with the presence of Metabolic syndrome. Among people with diabetes, the prevalence of Metabolic syndrome was very high, and those with diabetes and Metabolic syndrome had the highest prevalence of CHD. Among all individuals with diabetes, prevalence of CHD was increased compared with those with Metabolic syndrome without diabetes. However, individuals with diabetes without Metabolic syndrome had no greater prevalence of CHD compared with those with neither.
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ncep defined Metabolic syndrome diabetes and prevalence of coronary heart disease among nhanes iii participants age 50 years and older
Diabetes, 2003Co-Authors: Charles M Alexander, Pamela B Landsman, Steven M Teutsch, Steven M HaffnerAbstract:Although the individual components of the Metabolic syndrome are clearly associated with increased risk for coronary heart disease (CHD), we wanted to quantify the increased prevalence of CHD among people with Metabolic syndrome. The Third National Health and Nutrition Examination Survey (NHANES III) was used to categorize adults over 50 years of age by presence of Metabolic syndrome (National Cholesterol Education Program [NCEP] definition) with or without diabetes. Demographic and risk factor information was determined for each group, as well as the proportion of each group meeting specific criteria for Metabolic syndrome. The prevalence of CHD for each group was then determined. Metabolic syndrome is very common, with approximately 44% of the U.S. population over 50 years of age meeting the NCEP criteria. In contrast, diabetes without Metabolic syndrome is uncommon (13% of those with diabetes). Older Americans over 50 years of age without Metabolic syndrome regardless of diabetes status had the lowest CHD prevalence (8.7% without diabetes, 7.5% with diabetes). Compared with those with Metabolic syndrome, people with diabetes without Metabolic syndrome did not have an increase in CHD prevalence. Those with Metabolic syndrome without diabetes had higher CHD prevalence (13.9%), and those with both Metabolic syndrome and diabetes had the highest prevalence of CHD (19.2%) compared with those with neither. Metabolic syndrome was a significant univariate predictor of prevalent CHD (OR 2.07, 95% CI 1.66-2.59). However, blood pressure, HDL cholesterol, and diabetes, but not presence of Metabolic syndrome, were significant multivariate predictors of prevalent CHD. The prevalence of CHD markedly increased with the presence of Metabolic syndrome. Among people with diabetes, the prevalence of Metabolic syndrome was very high, and those with diabetes and Metabolic syndrome had the highest prevalence of CHD. Among all individuals with diabetes, prevalence of CHD was increased compared with those with Metabolic syndrome without diabetes. However, individuals with diabetes without Metabolic syndrome had no greater prevalence of CHD compared with those with neither.
Steven M Teutsch - One of the best experts on this subject based on the ideXlab platform.
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ncep defined Metabolic syndrome diabetes and prevalence of coronary heart disease among nhanes iii participants age 50 years and older
Diabetes, 2003Co-Authors: Charles M Alexander, Pamela B Landsman, Steven M Teutsch, Steven M HaffnerAbstract:Although the individual components of the Metabolic syndrome are clearly associated with increased risk for coronary heart disease (CHD), we wanted to quantify the increased prevalence of CHD among people with Metabolic syndrome. The Third National Health and Nutrition Examination Survey (NHANES III) was used to categorize adults over 50 years of age by presence of Metabolic syndrome (National Cholesterol Education Program [NCEP] definition) with or without diabetes. Demographic and risk factor information was determined for each group, as well as the proportion of each group meeting specific criteria for Metabolic syndrome. The prevalence of CHD for each group was then determined. Metabolic syndrome is very common, with ∼44% of the U.S. population over 50 years of age meeting the NCEP criteria. In contrast, diabetes without Metabolic syndrome is uncommon (13% of those with diabetes). Older Americans over 50 years of age without Metabolic syndrome regardless of diabetes status had the lowest CHD prevalence (8.7% without diabetes, 7.5% with diabetes). Compared with those with Metabolic syndrome, people with diabetes without Metabolic syndrome did not have an increase in CHD prevalence. Those with Metabolic syndrome without diabetes had higher CHD prevalence (13.9%), and those with both Metabolic syndrome and diabetes had the highest prevalence of CHD (19.2%) compared with those with neither. Metabolic syndrome was a significant univariate predictor of prevalent CHD (OR 2.07, 95% CI 1.66–2.59). However, blood pressure, HDL cholesterol, and diabetes, but not presence of Metabolic syndrome, were significant multivariate predictors of prevalent CHD. The prevalence of CHD markedly increased with the presence of Metabolic syndrome. Among people with diabetes, the prevalence of Metabolic syndrome was very high, and those with diabetes and Metabolic syndrome had the highest prevalence of CHD. Among all individuals with diabetes, prevalence of CHD was increased compared with those with Metabolic syndrome without diabetes. However, individuals with diabetes without Metabolic syndrome had no greater prevalence of CHD compared with those with neither.
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ncep defined Metabolic syndrome diabetes and prevalence of coronary heart disease among nhanes iii participants age 50 years and older
Diabetes, 2003Co-Authors: Charles M Alexander, Pamela B Landsman, Steven M Teutsch, Steven M HaffnerAbstract:Although the individual components of the Metabolic syndrome are clearly associated with increased risk for coronary heart disease (CHD), we wanted to quantify the increased prevalence of CHD among people with Metabolic syndrome. The Third National Health and Nutrition Examination Survey (NHANES III) was used to categorize adults over 50 years of age by presence of Metabolic syndrome (National Cholesterol Education Program [NCEP] definition) with or without diabetes. Demographic and risk factor information was determined for each group, as well as the proportion of each group meeting specific criteria for Metabolic syndrome. The prevalence of CHD for each group was then determined. Metabolic syndrome is very common, with approximately 44% of the U.S. population over 50 years of age meeting the NCEP criteria. In contrast, diabetes without Metabolic syndrome is uncommon (13% of those with diabetes). Older Americans over 50 years of age without Metabolic syndrome regardless of diabetes status had the lowest CHD prevalence (8.7% without diabetes, 7.5% with diabetes). Compared with those with Metabolic syndrome, people with diabetes without Metabolic syndrome did not have an increase in CHD prevalence. Those with Metabolic syndrome without diabetes had higher CHD prevalence (13.9%), and those with both Metabolic syndrome and diabetes had the highest prevalence of CHD (19.2%) compared with those with neither. Metabolic syndrome was a significant univariate predictor of prevalent CHD (OR 2.07, 95% CI 1.66-2.59). However, blood pressure, HDL cholesterol, and diabetes, but not presence of Metabolic syndrome, were significant multivariate predictors of prevalent CHD. The prevalence of CHD markedly increased with the presence of Metabolic syndrome. Among people with diabetes, the prevalence of Metabolic syndrome was very high, and those with diabetes and Metabolic syndrome had the highest prevalence of CHD. Among all individuals with diabetes, prevalence of CHD was increased compared with those with Metabolic syndrome without diabetes. However, individuals with diabetes without Metabolic syndrome had no greater prevalence of CHD compared with those with neither.
