The Experts below are selected from a list of 1899 Experts worldwide ranked by ideXlab platform

Nayan Lamba - One of the best experts on this subject based on the ideXlab platform.

  • Stereotactic radiosurgery versus whole-brain radiotherapy after intracranial Metastasis Resection: a systematic review and meta-analysis
    Radiation Oncology, 2017
    Co-Authors: Nayan Lamba, Ivo S. Muskens, Aislyn C. Dirisio, Louise Meijer, Vanessa Briceno, Heba Edrees, Bilal Aslam, Sadia Minhas, Joost J.c. Verhoeff, Catharina E. Kleynen
    Abstract:

    In patients with one to three brain metastases who undergo Resection, options for post-operative treatments include whole-brain radiotherapy (WBRT) or stereotactic radiosurgery (SRS) of the Resection cavity. In this meta-analysis, we sought to compare the efficacy of each post-operative radiation modality with respect to tumor recurrence and survival. Pubmed, Embase and Cochrane databases were searched through June 2016 for cohort studies reporting outcomes of SRS or WBRT after Metastasis Resection. Pooled effect estimates were calculated using fixed-effect and random-effect models for local recurrence, distant recurrence, and overall survival. Eight retrospective cohort studies with 646 patients (238 with SRS versus 408 with WBRT) were included in the analysis. Comparing SRS to WBRT, the overall crude risk ratio using the fixed-effect model was 0.59 for local recurrence (95%-CI: 0.32–1.09, I2: 3.35%, P-heterogeneity = 0.36, 3 studies), 1.09 for distant recurrence (95%-CI: 0.74–1.60, I2: 50.5%, P-heterogeneity = 0.13; 3 studies), and 2.99 for leptomeningeal disease (95% CI 1.55–5.76; I2: 14.4% p-heterogeneity: 0.28; 2 studies). For the same comparison, the risk ratio for median overall survival was 0.47 (95% CI: 0.41–0.54; I2: 79.1%, P-heterogeneity 

  • stereotactic radiosurgery versus whole brain radiotherapy after intracranial Metastasis Resection a systematic review and meta analysis
    Radiation Oncology, 2017
    Co-Authors: Nayan Lamba, Ivo S. Muskens, Aislyn C. Dirisio, Louise Meijer, Vanessa Briceno, Heba Edrees, Bilal Aslam, Sadia Minhas
    Abstract:

    In patients with one to three brain metastases who undergo Resection, options for post-operative treatments include whole-brain radiotherapy (WBRT) or stereotactic radiosurgery (SRS) of the Resection cavity. In this meta-analysis, we sought to compare the efficacy of each post-operative radiation modality with respect to tumor recurrence and survival. Pubmed, Embase and Cochrane databases were searched through June 2016 for cohort studies reporting outcomes of SRS or WBRT after Metastasis Resection. Pooled effect estimates were calculated using fixed-effect and random-effect models for local recurrence, distant recurrence, and overall survival. Eight retrospective cohort studies with 646 patients (238 with SRS versus 408 with WBRT) were included in the analysis. Comparing SRS to WBRT, the overall crude risk ratio using the fixed-effect model was 0.59 for local recurrence (95%-CI: 0.32–1.09, I2: 3.35%, P-heterogeneity = 0.36, 3 studies), 1.09 for distant recurrence (95%-CI: 0.74–1.60, I2: 50.5%, P-heterogeneity = 0.13; 3 studies), and 2.99 for leptomeningeal disease (95% CI 1.55–5.76; I2: 14.4% p-heterogeneity: 0.28; 2 studies). For the same comparison, the risk ratio for median overall survival was 0.47 (95% CI: 0.41–0.54; I2: 79.1%, P-heterogeneity < 0.01; 4 studies) in a fixed-effect model, but was no longer significant (0.63; 95%-CI: 0.40–1.00) in a random-effect model. SRS was associated with a lower risk of leukoencephalopathy (RR: 0.15, 95% CI: 0.07–0.33, 1 study), yet with a higher risk of radiation-necrosis (RR: 19.4, 95% CI: 1.21–310, 1 study). Based on retrospective cohort studies, the results of this study suggest that SRS of the Resection cavity may offer comparable survival and similar local and distant control as adjuvant WBRT, yet may be associated with a higher risk for developing leptomeningeal disease. Future research on SRS should focus on achieving a better understanding of the various factors that may favor SRS over WBRT.

Stephanie E. Combs - One of the best experts on this subject based on the ideXlab platform.

  • Cavity volume changes after surgery of a brain Metastasis—consequences for stereotactic radiation therapy
    Strahlentherapie und Onkologie, 2019
    Co-Authors: Sophia Scharl, Anna Kirstein, Kerstin A. Kessel, Marciana-nona Duma, Markus Oechsner, Christoph Straube, Stephanie E. Combs
    Abstract:

    Purpose For a large or symptomatic brain Metastasis, Resection and adjuvant radiotherapy are recommended. Hypofractionated stereotactic radiotherapy (HFSRT) is increasingly applied in patients with a limited number of lesions. Exact target volume definition is critical given the small safety margins. Whilst technical advances have minimized inaccuracy due to patient positioning and radiation targeting, little is known about changes in target volume. This study sought to evaluate potential changes in the Resection cavity of a brain Metastasis. Methods In all, 57 patients treated with HFSRT after surgical Resection of one brain Metastasis between 2008 and 2015 in our institution were included in this study. Gross tumor volume (GTV) of the initial Metastasis and the volume of the Resection cavity in the post-operative, planning, and follow-up MRIs were measured and compared. Results The mean cavity size decreased after surgery with the greatest change of −23.4% (±41.5%) occurring between post-operative MRI and planning MRI ( p  

  • Cavity volume changes after surgery of a brain Metastasis-consequences for stereotactic radiation therapy.
    Strahlentherapie Und Onkologie, 2018
    Co-Authors: Sophia Scharl, Anna Kirstein, Kerstin A. Kessel, Marciana-nona Duma, Markus Oechsner, Christoph Straube, Stephanie E. Combs
    Abstract:

    Purpose For a large or symptomatic brain Metastasis, Resection and adjuvant radiotherapy are recommended. Hypofractionated stereotactic radiotherapy (HFSRT) is increasingly applied in patients with a limited number of lesions. Exact target volume definition is critical given the small safety margins. Whilst technical advances have minimized inaccuracy due to patient positioning and radiation targeting, little is known about changes in target volume. This study sought to evaluate potential changes in the Resection cavity of a brain Metastasis.

Sadia Minhas - One of the best experts on this subject based on the ideXlab platform.

  • Stereotactic radiosurgery versus whole-brain radiotherapy after intracranial Metastasis Resection: a systematic review and meta-analysis
    Radiation Oncology, 2017
    Co-Authors: Nayan Lamba, Ivo S. Muskens, Aislyn C. Dirisio, Louise Meijer, Vanessa Briceno, Heba Edrees, Bilal Aslam, Sadia Minhas, Joost J.c. Verhoeff, Catharina E. Kleynen
    Abstract:

    In patients with one to three brain metastases who undergo Resection, options for post-operative treatments include whole-brain radiotherapy (WBRT) or stereotactic radiosurgery (SRS) of the Resection cavity. In this meta-analysis, we sought to compare the efficacy of each post-operative radiation modality with respect to tumor recurrence and survival. Pubmed, Embase and Cochrane databases were searched through June 2016 for cohort studies reporting outcomes of SRS or WBRT after Metastasis Resection. Pooled effect estimates were calculated using fixed-effect and random-effect models for local recurrence, distant recurrence, and overall survival. Eight retrospective cohort studies with 646 patients (238 with SRS versus 408 with WBRT) were included in the analysis. Comparing SRS to WBRT, the overall crude risk ratio using the fixed-effect model was 0.59 for local recurrence (95%-CI: 0.32–1.09, I2: 3.35%, P-heterogeneity = 0.36, 3 studies), 1.09 for distant recurrence (95%-CI: 0.74–1.60, I2: 50.5%, P-heterogeneity = 0.13; 3 studies), and 2.99 for leptomeningeal disease (95% CI 1.55–5.76; I2: 14.4% p-heterogeneity: 0.28; 2 studies). For the same comparison, the risk ratio for median overall survival was 0.47 (95% CI: 0.41–0.54; I2: 79.1%, P-heterogeneity 

  • stereotactic radiosurgery versus whole brain radiotherapy after intracranial Metastasis Resection a systematic review and meta analysis
    Radiation Oncology, 2017
    Co-Authors: Nayan Lamba, Ivo S. Muskens, Aislyn C. Dirisio, Louise Meijer, Vanessa Briceno, Heba Edrees, Bilal Aslam, Sadia Minhas
    Abstract:

    In patients with one to three brain metastases who undergo Resection, options for post-operative treatments include whole-brain radiotherapy (WBRT) or stereotactic radiosurgery (SRS) of the Resection cavity. In this meta-analysis, we sought to compare the efficacy of each post-operative radiation modality with respect to tumor recurrence and survival. Pubmed, Embase and Cochrane databases were searched through June 2016 for cohort studies reporting outcomes of SRS or WBRT after Metastasis Resection. Pooled effect estimates were calculated using fixed-effect and random-effect models for local recurrence, distant recurrence, and overall survival. Eight retrospective cohort studies with 646 patients (238 with SRS versus 408 with WBRT) were included in the analysis. Comparing SRS to WBRT, the overall crude risk ratio using the fixed-effect model was 0.59 for local recurrence (95%-CI: 0.32–1.09, I2: 3.35%, P-heterogeneity = 0.36, 3 studies), 1.09 for distant recurrence (95%-CI: 0.74–1.60, I2: 50.5%, P-heterogeneity = 0.13; 3 studies), and 2.99 for leptomeningeal disease (95% CI 1.55–5.76; I2: 14.4% p-heterogeneity: 0.28; 2 studies). For the same comparison, the risk ratio for median overall survival was 0.47 (95% CI: 0.41–0.54; I2: 79.1%, P-heterogeneity < 0.01; 4 studies) in a fixed-effect model, but was no longer significant (0.63; 95%-CI: 0.40–1.00) in a random-effect model. SRS was associated with a lower risk of leukoencephalopathy (RR: 0.15, 95% CI: 0.07–0.33, 1 study), yet with a higher risk of radiation-necrosis (RR: 19.4, 95% CI: 1.21–310, 1 study). Based on retrospective cohort studies, the results of this study suggest that SRS of the Resection cavity may offer comparable survival and similar local and distant control as adjuvant WBRT, yet may be associated with a higher risk for developing leptomeningeal disease. Future research on SRS should focus on achieving a better understanding of the various factors that may favor SRS over WBRT.

Ivo S. Muskens - One of the best experts on this subject based on the ideXlab platform.

  • Stereotactic radiosurgery versus whole-brain radiotherapy after intracranial Metastasis Resection: a systematic review and meta-analysis
    Radiation Oncology, 2017
    Co-Authors: Nayan Lamba, Ivo S. Muskens, Aislyn C. Dirisio, Louise Meijer, Vanessa Briceno, Heba Edrees, Bilal Aslam, Sadia Minhas, Joost J.c. Verhoeff, Catharina E. Kleynen
    Abstract:

    In patients with one to three brain metastases who undergo Resection, options for post-operative treatments include whole-brain radiotherapy (WBRT) or stereotactic radiosurgery (SRS) of the Resection cavity. In this meta-analysis, we sought to compare the efficacy of each post-operative radiation modality with respect to tumor recurrence and survival. Pubmed, Embase and Cochrane databases were searched through June 2016 for cohort studies reporting outcomes of SRS or WBRT after Metastasis Resection. Pooled effect estimates were calculated using fixed-effect and random-effect models for local recurrence, distant recurrence, and overall survival. Eight retrospective cohort studies with 646 patients (238 with SRS versus 408 with WBRT) were included in the analysis. Comparing SRS to WBRT, the overall crude risk ratio using the fixed-effect model was 0.59 for local recurrence (95%-CI: 0.32–1.09, I2: 3.35%, P-heterogeneity = 0.36, 3 studies), 1.09 for distant recurrence (95%-CI: 0.74–1.60, I2: 50.5%, P-heterogeneity = 0.13; 3 studies), and 2.99 for leptomeningeal disease (95% CI 1.55–5.76; I2: 14.4% p-heterogeneity: 0.28; 2 studies). For the same comparison, the risk ratio for median overall survival was 0.47 (95% CI: 0.41–0.54; I2: 79.1%, P-heterogeneity 

  • stereotactic radiosurgery versus whole brain radiotherapy after intracranial Metastasis Resection a systematic review and meta analysis
    Radiation Oncology, 2017
    Co-Authors: Nayan Lamba, Ivo S. Muskens, Aislyn C. Dirisio, Louise Meijer, Vanessa Briceno, Heba Edrees, Bilal Aslam, Sadia Minhas
    Abstract:

    In patients with one to three brain metastases who undergo Resection, options for post-operative treatments include whole-brain radiotherapy (WBRT) or stereotactic radiosurgery (SRS) of the Resection cavity. In this meta-analysis, we sought to compare the efficacy of each post-operative radiation modality with respect to tumor recurrence and survival. Pubmed, Embase and Cochrane databases were searched through June 2016 for cohort studies reporting outcomes of SRS or WBRT after Metastasis Resection. Pooled effect estimates were calculated using fixed-effect and random-effect models for local recurrence, distant recurrence, and overall survival. Eight retrospective cohort studies with 646 patients (238 with SRS versus 408 with WBRT) were included in the analysis. Comparing SRS to WBRT, the overall crude risk ratio using the fixed-effect model was 0.59 for local recurrence (95%-CI: 0.32–1.09, I2: 3.35%, P-heterogeneity = 0.36, 3 studies), 1.09 for distant recurrence (95%-CI: 0.74–1.60, I2: 50.5%, P-heterogeneity = 0.13; 3 studies), and 2.99 for leptomeningeal disease (95% CI 1.55–5.76; I2: 14.4% p-heterogeneity: 0.28; 2 studies). For the same comparison, the risk ratio for median overall survival was 0.47 (95% CI: 0.41–0.54; I2: 79.1%, P-heterogeneity < 0.01; 4 studies) in a fixed-effect model, but was no longer significant (0.63; 95%-CI: 0.40–1.00) in a random-effect model. SRS was associated with a lower risk of leukoencephalopathy (RR: 0.15, 95% CI: 0.07–0.33, 1 study), yet with a higher risk of radiation-necrosis (RR: 19.4, 95% CI: 1.21–310, 1 study). Based on retrospective cohort studies, the results of this study suggest that SRS of the Resection cavity may offer comparable survival and similar local and distant control as adjuvant WBRT, yet may be associated with a higher risk for developing leptomeningeal disease. Future research on SRS should focus on achieving a better understanding of the various factors that may favor SRS over WBRT.

Sophia Scharl - One of the best experts on this subject based on the ideXlab platform.

  • Cavity volume changes after surgery of a brain Metastasis—consequences for stereotactic radiation therapy
    Strahlentherapie und Onkologie, 2019
    Co-Authors: Sophia Scharl, Anna Kirstein, Kerstin A. Kessel, Marciana-nona Duma, Markus Oechsner, Christoph Straube, Stephanie E. Combs
    Abstract:

    Purpose For a large or symptomatic brain Metastasis, Resection and adjuvant radiotherapy are recommended. Hypofractionated stereotactic radiotherapy (HFSRT) is increasingly applied in patients with a limited number of lesions. Exact target volume definition is critical given the small safety margins. Whilst technical advances have minimized inaccuracy due to patient positioning and radiation targeting, little is known about changes in target volume. This study sought to evaluate potential changes in the Resection cavity of a brain Metastasis. Methods In all, 57 patients treated with HFSRT after surgical Resection of one brain Metastasis between 2008 and 2015 in our institution were included in this study. Gross tumor volume (GTV) of the initial Metastasis and the volume of the Resection cavity in the post-operative, planning, and follow-up MRIs were measured and compared. Results The mean cavity size decreased after surgery with the greatest change of −23.4% (±41.5%) occurring between post-operative MRI and planning MRI ( p  

  • Cavity volume changes after surgery of a brain Metastasis-consequences for stereotactic radiation therapy.
    Strahlentherapie Und Onkologie, 2018
    Co-Authors: Sophia Scharl, Anna Kirstein, Kerstin A. Kessel, Marciana-nona Duma, Markus Oechsner, Christoph Straube, Stephanie E. Combs
    Abstract:

    Purpose For a large or symptomatic brain Metastasis, Resection and adjuvant radiotherapy are recommended. Hypofractionated stereotactic radiotherapy (HFSRT) is increasingly applied in patients with a limited number of lesions. Exact target volume definition is critical given the small safety margins. Whilst technical advances have minimized inaccuracy due to patient positioning and radiation targeting, little is known about changes in target volume. This study sought to evaluate potential changes in the Resection cavity of a brain Metastasis.