The Experts below are selected from a list of 26196 Experts worldwide ranked by ideXlab platform

Hiroki Ureshino - One of the best experts on this subject based on the ideXlab platform.

  • N-myc Downstream Regulated Gene 1 (NDRG1) Promotes Metastasis of Human Scirrhous Gastric Cancer Cells
    2016
    Co-Authors: Through Epithelial Mesenchymal Transition, Hiroki Ureshino, Yuichi Murakami, Kosuke Watari, Hiroto Izumi, Akihiko Kawahara, Masayoshi Kage, Tokuzo Arao, Kazuto Nishio, Kazuyoshi Yanagihara
    Abstract:

    Our recent study demonstrated that higher expression of N-myc downregulated gene 1 (NDRG1) is closely correlated with poor prognosis in gastric cancer patients. In this study, we asked whether NDRG1 has pivotal roles in malignant progression including metastasis of gastric cancer Cells. By gene expression microarray analysis expression of NDRG1 showed the higher increase among a total of 3691 up-regulated genes in a highly Metastatic gastric cancer Cell Line (58As1) than their parental low Metastatic counterpart (HSC-58). The highly Metastatic Cell Lines showed decreased expression of E-cadherin, together with enhanced expression of vimentin and Snail. This decreased expression of E-cadherin was restored by Snail knockdown in highly Metastatic Cell Lines. We next established stable NDRG1 knockdown Cell Lines (As1/Sic50 and As1/Sic54) from the highly Metastatic Cell Line, and both of these Cell Lines showed enhanced expression of E-cadherin and decreased expression of vimentin and Snail. And also, E-cadherin promoter-driven luciferase activity was found to be increased by NDRG1 knockdown in the highly Metastatic Cell Line. NDRG1 knockdown in gastric cancer Cell showed suppressed invasion of cancer Cells into surround tissues, suppressed metastasis to the peritoneum and decreased ascites accumulation in mic

  • n myc downstream regulated gene 1 ndrg1 promotes metastasis of human scirrhous gastric cancer Cells through epithelial mesenchymal transition
    PLOS ONE, 2012
    Co-Authors: Hiroki Ureshino, Yuichi Murakami, Kosuke Watari, Hiroto Izumi, Akihiko Kawahara, Masayoshi Kage, Tokuzo Arao, Kazuto Nishio, Kazuyoshi Yanagihara
    Abstract:

    Our recent study demonstrated that higher expression of N-myc downregulated gene 1 (NDRG1) is closely correlated with poor prognosis in gastric cancer patients. In this study, we asked whether NDRG1 has pivotal roles in malignant progression including metastasis of gastric cancer Cells. By gene expression microarray analysis expression of NDRG1 showed the higher increase among a total of 3691 up-regulated genes in a highly Metastatic gastric cancer Cell Line (58As1) than their parental low Metastatic counterpart (HSC-58). The highly Metastatic Cell Lines showed decreased expression of E-cadherin, together with enhanced expression of vimentin and Snail. This decreased expression of E-cadherin was restored by Snail knockdown in highly Metastatic Cell Lines. We next established stable NDRG1 knockdown Cell Lines (As1/Sic50 and As1/Sic54) from the highly Metastatic Cell Line, and both of these Cell Lines showed enhanced expression of E-cadherin and decreased expression of vimentin and Snail. And also, E-cadherin promoter-driven luciferase activity was found to be increased by NDRG1 knockdown in the highly Metastatic Cell Line. NDRG1 knockdown in gastric cancer Cell showed suppressed invasion of cancer Cells into surround tissues, suppressed metastasis to the peritoneum and decreased ascites accumulation in mice with significantly improved survival rates. This is the first study to demonstrate that NDRG1 plays its pivotal role in the malignant progression of gastric cancer through epithelial mesenchymal transition.

Eugene Lukanidin - One of the best experts on this subject based on the ideXlab platform.

  • the differentiation antigen ly 6e 1 is expressed in mouse Metastatic tumor Cell Lines
    FEBS Letters, 1997
    Co-Authors: Martin A Cohn, Dmitri A Kramerov, Egil F Hulgaard, Eugene Lukanidin
    Abstract:

    Abstract We report the cloning of the mouse surface GPI-anchored Ly-6E.1 protein from a highly Metastatic mouse adenocarcinoma Cell Line CSML-100 by differential display. The expression is specific for the Metastatic Cell Line as the closely related, non-Metastatic mouse adenocarcinoma Cell Line CSML-0 does not express Ly-6E.1. Northern blot analysis reveals expression in a number of mouse tumour Cell Lines, exclusively Metastatic ones. To date, active Ly-6A/E has only been described in lymphoid Cells. The correlation between Ly-6E.1 expression, and the ability to metastasize, is discussed. © Federation of European Biochemical Societies.

  • the differentiation antigen ly 6e 1 is expressed in mouse Metastatic tumor Cell Lines
    FEBS Letters, 1997
    Co-Authors: Martin A Cohn, Dmitri A Kramerov, Egil F Hulgaard, Eugene Lukanidin
    Abstract:

    We report the cloning of the mouse surface GPI-anchored Ly-6E.1 protein from a highly Metastatic mouse adenocarcinoma Cell Line CSML-100 by differential display. The expression is specific for the Metastatic Cell Line as the closely related, non-Metastatic mouse adenocarcinoma Cell Line CSML-0 does not express Ly-6E.1. Northern blot analysis reveals expression in a number of mouse tumour Cell Lines, exclusively Metastatic ones. To date, active Ly-6A/E has only been described in lymphoid Cells. The correlation between Ly-6E.1 expression, and the ability to metastasize, is discussed.

Kazuyoshi Yanagihara - One of the best experts on this subject based on the ideXlab platform.

  • N-myc Downstream Regulated Gene 1 (NDRG1) Promotes Metastasis of Human Scirrhous Gastric Cancer Cells
    2016
    Co-Authors: Through Epithelial Mesenchymal Transition, Hiroki Ureshino, Yuichi Murakami, Kosuke Watari, Hiroto Izumi, Akihiko Kawahara, Masayoshi Kage, Tokuzo Arao, Kazuto Nishio, Kazuyoshi Yanagihara
    Abstract:

    Our recent study demonstrated that higher expression of N-myc downregulated gene 1 (NDRG1) is closely correlated with poor prognosis in gastric cancer patients. In this study, we asked whether NDRG1 has pivotal roles in malignant progression including metastasis of gastric cancer Cells. By gene expression microarray analysis expression of NDRG1 showed the higher increase among a total of 3691 up-regulated genes in a highly Metastatic gastric cancer Cell Line (58As1) than their parental low Metastatic counterpart (HSC-58). The highly Metastatic Cell Lines showed decreased expression of E-cadherin, together with enhanced expression of vimentin and Snail. This decreased expression of E-cadherin was restored by Snail knockdown in highly Metastatic Cell Lines. We next established stable NDRG1 knockdown Cell Lines (As1/Sic50 and As1/Sic54) from the highly Metastatic Cell Line, and both of these Cell Lines showed enhanced expression of E-cadherin and decreased expression of vimentin and Snail. And also, E-cadherin promoter-driven luciferase activity was found to be increased by NDRG1 knockdown in the highly Metastatic Cell Line. NDRG1 knockdown in gastric cancer Cell showed suppressed invasion of cancer Cells into surround tissues, suppressed metastasis to the peritoneum and decreased ascites accumulation in mic

  • n myc downstream regulated gene 1 ndrg1 promotes metastasis of human scirrhous gastric cancer Cells through epithelial mesenchymal transition
    PLOS ONE, 2012
    Co-Authors: Hiroki Ureshino, Yuichi Murakami, Kosuke Watari, Hiroto Izumi, Akihiko Kawahara, Masayoshi Kage, Tokuzo Arao, Kazuto Nishio, Kazuyoshi Yanagihara
    Abstract:

    Our recent study demonstrated that higher expression of N-myc downregulated gene 1 (NDRG1) is closely correlated with poor prognosis in gastric cancer patients. In this study, we asked whether NDRG1 has pivotal roles in malignant progression including metastasis of gastric cancer Cells. By gene expression microarray analysis expression of NDRG1 showed the higher increase among a total of 3691 up-regulated genes in a highly Metastatic gastric cancer Cell Line (58As1) than their parental low Metastatic counterpart (HSC-58). The highly Metastatic Cell Lines showed decreased expression of E-cadherin, together with enhanced expression of vimentin and Snail. This decreased expression of E-cadherin was restored by Snail knockdown in highly Metastatic Cell Lines. We next established stable NDRG1 knockdown Cell Lines (As1/Sic50 and As1/Sic54) from the highly Metastatic Cell Line, and both of these Cell Lines showed enhanced expression of E-cadherin and decreased expression of vimentin and Snail. And also, E-cadherin promoter-driven luciferase activity was found to be increased by NDRG1 knockdown in the highly Metastatic Cell Line. NDRG1 knockdown in gastric cancer Cell showed suppressed invasion of cancer Cells into surround tissues, suppressed metastasis to the peritoneum and decreased ascites accumulation in mice with significantly improved survival rates. This is the first study to demonstrate that NDRG1 plays its pivotal role in the malignant progression of gastric cancer through epithelial mesenchymal transition.

Martin A Cohn - One of the best experts on this subject based on the ideXlab platform.

  • the differentiation antigen ly 6e 1 is expressed in mouse Metastatic tumor Cell Lines
    FEBS Letters, 1997
    Co-Authors: Martin A Cohn, Dmitri A Kramerov, Egil F Hulgaard, Eugene Lukanidin
    Abstract:

    Abstract We report the cloning of the mouse surface GPI-anchored Ly-6E.1 protein from a highly Metastatic mouse adenocarcinoma Cell Line CSML-100 by differential display. The expression is specific for the Metastatic Cell Line as the closely related, non-Metastatic mouse adenocarcinoma Cell Line CSML-0 does not express Ly-6E.1. Northern blot analysis reveals expression in a number of mouse tumour Cell Lines, exclusively Metastatic ones. To date, active Ly-6A/E has only been described in lymphoid Cells. The correlation between Ly-6E.1 expression, and the ability to metastasize, is discussed. © Federation of European Biochemical Societies.

  • the differentiation antigen ly 6e 1 is expressed in mouse Metastatic tumor Cell Lines
    FEBS Letters, 1997
    Co-Authors: Martin A Cohn, Dmitri A Kramerov, Egil F Hulgaard, Eugene Lukanidin
    Abstract:

    We report the cloning of the mouse surface GPI-anchored Ly-6E.1 protein from a highly Metastatic mouse adenocarcinoma Cell Line CSML-100 by differential display. The expression is specific for the Metastatic Cell Line as the closely related, non-Metastatic mouse adenocarcinoma Cell Line CSML-0 does not express Ly-6E.1. Northern blot analysis reveals expression in a number of mouse tumour Cell Lines, exclusively Metastatic ones. To date, active Ly-6A/E has only been described in lymphoid Cells. The correlation between Ly-6E.1 expression, and the ability to metastasize, is discussed.

Egil F Hulgaard - One of the best experts on this subject based on the ideXlab platform.

  • the differentiation antigen ly 6e 1 is expressed in mouse Metastatic tumor Cell Lines
    FEBS Letters, 1997
    Co-Authors: Martin A Cohn, Dmitri A Kramerov, Egil F Hulgaard, Eugene Lukanidin
    Abstract:

    Abstract We report the cloning of the mouse surface GPI-anchored Ly-6E.1 protein from a highly Metastatic mouse adenocarcinoma Cell Line CSML-100 by differential display. The expression is specific for the Metastatic Cell Line as the closely related, non-Metastatic mouse adenocarcinoma Cell Line CSML-0 does not express Ly-6E.1. Northern blot analysis reveals expression in a number of mouse tumour Cell Lines, exclusively Metastatic ones. To date, active Ly-6A/E has only been described in lymphoid Cells. The correlation between Ly-6E.1 expression, and the ability to metastasize, is discussed. © Federation of European Biochemical Societies.

  • the differentiation antigen ly 6e 1 is expressed in mouse Metastatic tumor Cell Lines
    FEBS Letters, 1997
    Co-Authors: Martin A Cohn, Dmitri A Kramerov, Egil F Hulgaard, Eugene Lukanidin
    Abstract:

    We report the cloning of the mouse surface GPI-anchored Ly-6E.1 protein from a highly Metastatic mouse adenocarcinoma Cell Line CSML-100 by differential display. The expression is specific for the Metastatic Cell Line as the closely related, non-Metastatic mouse adenocarcinoma Cell Line CSML-0 does not express Ly-6E.1. Northern blot analysis reveals expression in a number of mouse tumour Cell Lines, exclusively Metastatic ones. To date, active Ly-6A/E has only been described in lymphoid Cells. The correlation between Ly-6E.1 expression, and the ability to metastasize, is discussed.