The Experts below are selected from a list of 6 Experts worldwide ranked by ideXlab platform

David A Relman - One of the best experts on this subject based on the ideXlab platform.

  • lethal Infection by a previously unrecognised Metazoan parasite
    The Lancet, 1996
    Co-Authors: Monica Santamariafries, Luis F Fajardo, Mitchell L Sogin, Peter D Olson, David A Relman
    Abstract:

    Abstract Summary Background New microbial pathogens or variant clinical manifestations of known organisms may be first found in immunodeficient patients. An HIV-infected man developed a rapidly-enlarging abdominal mass, suggestive of a neoplasm, that subsequently invaded his liver and caused death. Initial studies showed unusual tissue morphology that could not be matched with any known disease process. Methods Tissues obtained from biopsy at laparotomy and necropsy were studied by light microscopy, immunohistochemistry, electron microscopy, and broad-range ribosomal DNA-amplification and sequence analysis. Findings Tissue lesions were characterised by peculiar cytoplasmic sacs containing minute cells with very prominent nucleoli. The pathological process was recognised as a parasitic Infection, although its features were different from those of any known eukaryotic pathogen. Phylogenetic analysis of a 357 bp 18S rDNA sequence amplified directly from the involved tissue indicated that the causative agent was a previously-uncharacterised cestode. Interpretation Fatal disease produced by this newly recognised cestode may not be limited to immunodeficient hosts. Awareness of this Metazoan Infection may allow early diagnosis—by morphology and DNA sequence analysis—and perhaps successful treatment of subsequent cases.

Luis F Fajardo - One of the best experts on this subject based on the ideXlab platform.

  • lethal Infection by a previously unrecognised Metazoan parasite
    The Lancet, 1996
    Co-Authors: Monica Santamariafries, Luis F Fajardo, Mitchell L Sogin, Peter D Olson, David A Relman
    Abstract:

    Abstract Summary Background New microbial pathogens or variant clinical manifestations of known organisms may be first found in immunodeficient patients. An HIV-infected man developed a rapidly-enlarging abdominal mass, suggestive of a neoplasm, that subsequently invaded his liver and caused death. Initial studies showed unusual tissue morphology that could not be matched with any known disease process. Methods Tissues obtained from biopsy at laparotomy and necropsy were studied by light microscopy, immunohistochemistry, electron microscopy, and broad-range ribosomal DNA-amplification and sequence analysis. Findings Tissue lesions were characterised by peculiar cytoplasmic sacs containing minute cells with very prominent nucleoli. The pathological process was recognised as a parasitic Infection, although its features were different from those of any known eukaryotic pathogen. Phylogenetic analysis of a 357 bp 18S rDNA sequence amplified directly from the involved tissue indicated that the causative agent was a previously-uncharacterised cestode. Interpretation Fatal disease produced by this newly recognised cestode may not be limited to immunodeficient hosts. Awareness of this Metazoan Infection may allow early diagnosis—by morphology and DNA sequence analysis—and perhaps successful treatment of subsequent cases.

Gistyar Owen Avignam - One of the best experts on this subject based on the ideXlab platform.

  • The Correlation Between Physical Parameters And Parasitological Index Of Metazoan From Red Snapper (Lutjanus Bitaeniatus)In East Java
    2020
    Co-Authors: Gistyar Owen Avignam
    Abstract:

    The research purpose is to analyze the correlation between physical parameters and parasitological index of Metazoan from red snapper (Lutjanus bitaeniatus) in East Java. This type of research is survey research. This research using 60 samples of obtained from East Java. The first step was sampling, followed by measuring the physical parameters. The next step was red snapper necroption, and then identifying larva with a natif method and carmine coloring which was observed with light microscope 100x and drawn by microscope camera lucida, and the last step are make parasitological index of Metazoan and data analyzing. The results of the study explain that it can be seen that the greater the physical parameters of red snapper (Lutjanus bitaeniatus) the higher the rate of Metazoan Infection with a strong correlation coefficient

Monica Santamariafries - One of the best experts on this subject based on the ideXlab platform.

  • lethal Infection by a previously unrecognised Metazoan parasite
    The Lancet, 1996
    Co-Authors: Monica Santamariafries, Luis F Fajardo, Mitchell L Sogin, Peter D Olson, David A Relman
    Abstract:

    Abstract Summary Background New microbial pathogens or variant clinical manifestations of known organisms may be first found in immunodeficient patients. An HIV-infected man developed a rapidly-enlarging abdominal mass, suggestive of a neoplasm, that subsequently invaded his liver and caused death. Initial studies showed unusual tissue morphology that could not be matched with any known disease process. Methods Tissues obtained from biopsy at laparotomy and necropsy were studied by light microscopy, immunohistochemistry, electron microscopy, and broad-range ribosomal DNA-amplification and sequence analysis. Findings Tissue lesions were characterised by peculiar cytoplasmic sacs containing minute cells with very prominent nucleoli. The pathological process was recognised as a parasitic Infection, although its features were different from those of any known eukaryotic pathogen. Phylogenetic analysis of a 357 bp 18S rDNA sequence amplified directly from the involved tissue indicated that the causative agent was a previously-uncharacterised cestode. Interpretation Fatal disease produced by this newly recognised cestode may not be limited to immunodeficient hosts. Awareness of this Metazoan Infection may allow early diagnosis—by morphology and DNA sequence analysis—and perhaps successful treatment of subsequent cases.

Mitchell L Sogin - One of the best experts on this subject based on the ideXlab platform.

  • lethal Infection by a previously unrecognised Metazoan parasite
    The Lancet, 1996
    Co-Authors: Monica Santamariafries, Luis F Fajardo, Mitchell L Sogin, Peter D Olson, David A Relman
    Abstract:

    Abstract Summary Background New microbial pathogens or variant clinical manifestations of known organisms may be first found in immunodeficient patients. An HIV-infected man developed a rapidly-enlarging abdominal mass, suggestive of a neoplasm, that subsequently invaded his liver and caused death. Initial studies showed unusual tissue morphology that could not be matched with any known disease process. Methods Tissues obtained from biopsy at laparotomy and necropsy were studied by light microscopy, immunohistochemistry, electron microscopy, and broad-range ribosomal DNA-amplification and sequence analysis. Findings Tissue lesions were characterised by peculiar cytoplasmic sacs containing minute cells with very prominent nucleoli. The pathological process was recognised as a parasitic Infection, although its features were different from those of any known eukaryotic pathogen. Phylogenetic analysis of a 357 bp 18S rDNA sequence amplified directly from the involved tissue indicated that the causative agent was a previously-uncharacterised cestode. Interpretation Fatal disease produced by this newly recognised cestode may not be limited to immunodeficient hosts. Awareness of this Metazoan Infection may allow early diagnosis—by morphology and DNA sequence analysis—and perhaps successful treatment of subsequent cases.